IMP

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Homo sapiens

1 genes annotated in human

dimeric g protein coupled receptor signaling pathway

A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dimeric g protein coupled receptor signaling pathway"

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Name	Description	Probability	Func Analog Organism
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.719
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.514
GPR6	G protein-coupled receptor 6	0.429
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.353
AFF2	AF4/FMR2 family, member 2	0.319
FSTL4	follistatin-like 4	0.228
CA10	carbonic anhydrase X	0.187
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.166
ACRV1	acrosomal vesicle protein 1	0.138
ACTL6B	actin-like 6B	0.127
CRHR2	corticotropin releasing hormone receptor 2	0.115
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.112
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.102
GRM7	glutamate receptor, metabotropic 7	0.092	Human
MYT1	myelin transcription factor 1	0.088
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.086
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.084
CDH12	cadherin 12, type 2 (N-cadherin 2)	0.080
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.078
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.077
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.071
NEUROD1	neurogenic differentiation 1	0.070
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.067
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.064
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.062
SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)	0.062
PICK1	protein interacting with PRKCA 1	0.057
GRIK1	glutamate receptor, ionotropic, kainate 1	0.055
ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.053
FEZF2	FEZ family zinc finger 2	0.052
GDF10	growth differentiation factor 10	0.050
PCDHAC1	protocadherin alpha subfamily C, 1	0.048
SYN2	synapsin II	0.046
RGS7	regulator of G-protein signaling 7	0.045
COL2A1	collagen, type II, alpha 1	0.045
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.045
GRIP1	glutamate receptor interacting protein 1	0.044
PRMT8	protein arginine methyltransferase 8	0.044
SV2C	synaptic vesicle glycoprotein 2C	0.043
ACSL6	acyl-CoA synthetase long-chain family member 6	0.042
TMEM151B	transmembrane protein 151B	0.040
KIF1A	kinesin family member 1A	0.038
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.037
CELF3	CUGBP, Elav-like family member 3	0.037
CCKBR	cholecystokinin B receptor	0.036
NELL1	NEL-like 1 (chicken)	0.036
NEUROD2	neurogenic differentiation 2	0.036
T	T, brachyury homolog (mouse)	0.036
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.035
GRM3	glutamate receptor, metabotropic 3	0.035	Human
OPRK1	opioid receptor, kappa 1	0.034
UNC5C	unc-5 homolog C (C. elegans)	0.033
SEZ6L	seizure related 6 homolog (mouse)-like	0.033
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.031
GJD2	gap junction protein, delta 2, 36kDa	0.028
DCC	deleted in colorectal carcinoma	0.028
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.027
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.027
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.027
KIAA1045	KIAA1045	0.027
FAM5B	family with sequence similarity 5, member B	0.026
OPCML	opioid binding protein/cell adhesion molecule-like	0.025
GRIK4	glutamate receptor, ionotropic, kainate 4	0.025
ZMAT4	zinc finger, matrin-type 4	0.024
POU4F2	POU class 4 homeobox 2	0.023
RIT2	Ras-like without CAAX 2	0.023
NPY	neuropeptide Y	0.023
DRD1	dopamine receptor D1	0.022
GRM5	glutamate receptor, metabotropic 5	0.021	Human
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.021
ST8SIA3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.021
GAP43	growth associated protein 43	0.021
FGF4	fibroblast growth factor 4	0.021
HMP19	HMP19 protein	0.020
CDH8	cadherin 8, type 2	0.020
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.020
SNCB	synuclein, beta	0.020
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.020
NRXN1	neurexin 1	0.020
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.019
ATP8A2	ATPase, aminophospholipid transporter, class I, type 8A, member 2	0.019
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.019
MMD2	monocyte to macrophage differentiation-associated 2	0.019
RIMS1	regulating synaptic membrane exocytosis 1	0.019
POU3F2	POU class 3 homeobox 2	0.019
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.019
SYT13	synaptotagmin XIII	0.019
ACHE	acetylcholinesterase	0.019
FAM123C	family with sequence similarity 123C	0.019
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.019
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.018
SSTR2	somatostatin receptor 2	0.018
VGF	VGF nerve growth factor inducible	0.018
KCNC2	potassium voltage-gated channel, Shaw-related subfamily, member 2	0.018
EPHA8	EPH receptor A8	0.018
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.018
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.017
CHRM2	cholinergic receptor, muscarinic 2	0.017
BCAN	brevican	0.017
TAGLN3	transgelin 3	0.017
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.017
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.017
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.017
KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	0.017
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.017
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
NOL4	nucleolar protein 4	0.017
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.017
MYT1L	myelin transcription factor 1-like	0.017
LPPR1	lipid phosphate phosphatase-related protein type 1	0.016
HOXD12	homeobox D12	0.016
KHDRBS2	KH domain containing, RNA binding, signal transduction associated 2	0.016
KCNK10	potassium channel, subfamily K, member 10	0.016
SLITRK3	SLIT and NTRK-like family, member 3	0.016
B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.016
SLC7A10	solute carrier family 7, (neutral amino acid transporter, y+ system) member 10	0.016
SORCS3	sortilin-related VPS10 domain containing receptor 3	0.016
SRRM4	serine/arginine repetitive matrix 4	0.016
FAM155B	family with sequence similarity 155, member B	0.016
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.016
EMX1	empty spiracles homeobox 1	0.016
CXorf1	chromosome X open reading frame 1	0.016
HRH3	histamine receptor H3	0.015
TMEM59L	transmembrane protein 59-like	0.015
NMBR	neuromedin B receptor	0.015
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.015
MYO16	myosin XVI	0.015
MAG	myelin associated glycoprotein	0.015
RHO	rhodopsin	0.015
ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	0.015
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.015
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.015
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.015
CADPS	Ca++-dependent secretion activator	0.015
FAM123A	family with sequence similarity 123A	0.015
NXPH2	neurexophilin 2	0.014
SCN2B	sodium channel, voltage-gated, type II, beta	0.014
PRKCG	protein kinase C, gamma	0.014
NT5C1A	5'-nucleotidase, cytosolic IA	0.014
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.014
RIMBP2	RIMS binding protein 2	0.014
KCNB2	potassium voltage-gated channel, Shab-related subfamily, member 2	0.014
C7orf16	chromosome 7 open reading frame 16	0.014
SSTR4	somatostatin receptor 4	0.014
GLRA2	glycine receptor, alpha 2	0.013
EPHA5	EPH receptor A5	0.013
SYN1	synapsin I	0.013
PGLYRP4	peptidoglycan recognition protein 4	0.013
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.013
PEX5L	peroxisomal biogenesis factor 5-like	0.013
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.013
MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.013
TTPA	tocopherol (alpha) transfer protein	0.013
CTNNA2	catenin (cadherin-associated protein), alpha 2	0.013
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.013
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	0.013
NECAB2	N-terminal EF-hand calcium binding protein 2	0.013
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.013
FXYD7	FXYD domain containing ion transport regulator 7	0.013
ACCN1	amiloride-sensitive cation channel 1, neuronal	0.013
AJAP1	adherens junctions associated protein 1	0.013
GPR98	G protein-coupled receptor 98	0.013
STMN4	stathmin-like 4	0.013
ST8SIA5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.013
GPC5	glypican 5	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
PCSK2	proprotein convertase subtilisin/kexin type 2	0.012
ADORA1	adenosine A1 receptor	0.012
CALB1	calbindin 1, 28kDa	0.012
SMR3A	submaxillary gland androgen regulated protein 3A	0.012
LRRTM1	leucine rich repeat transmembrane neuronal 1	0.012
KIAA0319	KIAA0319	0.012
CALY	calcyon neuron-specific vesicular protein	0.012
SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	0.012
KCNK2	potassium channel, subfamily K, member 2	0.012
SST	somatostatin	0.012
GALR3	galanin receptor 3	0.012
C9orf4	chromosome 9 open reading frame 4	0.012
DRD2	dopamine receptor D2	0.012
MCF2	MCF.2 cell line derived transforming sequence	0.011
SULT4A1	sulfotransferase family 4A, member 1	0.011
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	0.011
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.011
CNTNAP5	contactin associated protein-like 5	0.011
CLSTN2	calsyntenin 2	0.011
FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.011
DPP6	dipeptidyl-peptidase 6	0.011
NEUROD6	neurogenic differentiation 6	0.011
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.011
SLC7A3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.011
PAH	phenylalanine hydroxylase	0.011
SLC13A4	solute carrier family 13 (sodium/sulfate symporters), member 4	0.011
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.011
SYT5	synaptotagmin V	0.011
ADAM30	ADAM metallopeptidase domain 30	0.011
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.011
RALYL	RALY RNA binding protein-like	0.011
FABP6	fatty acid binding protein 6, ileal	0.011
OCA2	oculocutaneous albinism II	0.011
GPR26	G protein-coupled receptor 26	0.011
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	0.011
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.011
KLHDC8A	kelch domain containing 8A	0.011
ADCY8	adenylate cyclase 8 (brain)	0.011
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.010
LRRC7	leucine rich repeat containing 7	0.010
NHLH2	nescient helix loop helix 2	0.010
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.010
SLITRK1	SLIT and NTRK-like family, member 1	0.010
ZNF157	zinc finger protein 157	0.010
OTX2	orthodenticle homeobox 2	0.010
PRPH2	peripherin 2 (retinal degeneration, slow)	0.010
GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	0.010
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.010
GLRA1	glycine receptor, alpha 1	0.010
ZBBX	zinc finger, B-box domain containing	0.010
GUCA1A	guanylate cyclase activator 1A (retina)	0.010