IMP
Process View
4 hydroxyproline metabolic process
The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "4 hydroxyproline metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 1.000 | ||
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.981 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.970 | ||
| ERO1L | ERO1-like (S. cerevisiae) | 0.799 | Mouse | |
| CALR | calreticulin | 0.632 | ||
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.585 | ||
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.513 | ||
| EPAS1 | endothelial PAS domain protein 1 | 0.194 | ||
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.189 | ||
| DUSP23 | dual specificity phosphatase 23 | 0.180 | ||
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.144 | ||
| GANAB | glucosidase, alpha; neutral AB | 0.064 | ||
| VHL | von Hippel-Lindau tumor suppressor | 0.057 | ||
| PLOD1 | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 0.035 | ||
| HM13 | histocompatibility (minor) 13 | 0.031 | ||
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.024 | ||
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.016 | ||
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.015 | ||
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.014 | ||
| HIF1AN | hypoxia inducible factor 1, alpha subunit inhibitor | 0.012 | ||
| ERO1LB | ERO1-like beta (S. cerevisiae) | 0.011 |