IMP

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Rattus norvegicus

2 genes annotated in rat

adenylate cyclase inhibiting opioid receptor signaling pathway

The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "adenylate cyclase inhibiting opioid receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "adenylate cyclase inhibiting opioid receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Cacna1i	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.505
Calcr	calcitonin receptor	0.338
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.324
Grm1	glutamate receptor, metabotropic 1	0.298
Shank2	SH3 and multiple ankyrin repeat domains 2	0.242
Bcan	brevican	0.232
Chrna3	cholinergic receptor, nicotinic, alpha 3	0.218
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.183
Chrna4	cholinergic receptor, nicotinic, alpha 4	0.154
RGD1564664	similar to LOC387763 protein	0.142
Nmbr	neuromedin B receptor	0.112
Glra1	glycine receptor, alpha 1	0.106
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.103
Sstr1	somatostatin receptor 1	0.100
Arhgap23	Rho GTPase activating protein 23	0.098
Gad1	glutamate decarboxylase 1	0.094
Oprl1	opiate receptor-like 1	0.094	Rat
Syp	synaptophysin	0.085
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.084
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.083
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.080
Hrh3	histamine receptor H3	0.080
Glp1r	glucagon-like peptide 1 receptor	0.079
Gpr83	G protein-coupled receptor 83	0.068
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.066
Capn8	calpain 8	0.064
Kl	Klotho	0.061
RT1-A3	RT1 class I, locus A3	0.057
Zg16	zymogen granule protein 16	0.056
Grm6	glutamate receptor, metabotropic 6	0.055
Pcdhb12	protocadherin beta 12	0.055
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.054
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.053
Kif6	kinesin family member 6	0.053
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.050
Snap91	synaptosomal-associated protein 91	0.050
Nmur2	neuromedin U receptor 2	0.050
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.048
Hpca	hippocalcin	0.048
Ccr3	chemokine (C-C motif) receptor 3	0.047
Avpr1b	arginine vasopressin receptor 1B	0.047
Tagln3	transgelin 3	0.043
Prl	prolactin	0.043
Cdc2l5	cell division cycle 2-like 5 (cholinesterase-related cell division controller)	0.043
Oprk1	opioid receptor, kappa 1	0.042	Human Rat
Grpr	gastrin releasing peptide receptor	0.042
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.042
Th	tyrosine hydroxylase	0.042
Grp	gastrin releasing peptide	0.041
Clstn3	calsyntenin 3	0.041
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.040
Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	0.040
Ifna1	interferon-alpha 1	0.039
Prph2	peripherin 2	0.039
Cartpt	CART prepropeptide	0.038
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.037
Scnn1g	sodium channel, nonvoltage-gated 1, gamma	0.037
Grm8	glutamate receptor, metabotropic 8	0.034
Adra2c	adrenergic, alpha-2C-, receptor	0.034
Mapk15	mitogen-activated protein kinase 15	0.034
LOC680122	similar to sin3 associated polypeptide	0.033
Gck	glucokinase	0.031
Gpr173	G-protein coupled receptor 173	0.031
Cckbr	cholecystokinin B receptor	0.030
Mr1	major histocompatibility complex, class I-related	0.030
Aqp2	aquaporin 2 (collecting duct)	0.030
Syt13	synaptotagmin XIII	0.029
Tubb3	tubulin, beta 3	0.029
Ncan	neurocan	0.029
Slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.027
Clcn1	chloride channel 1	0.027
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.027
Phox2a	paired-like homeobox 2a	0.027
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.026
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.026
Aqp8	aquaporin 8	0.025
Tdo2	tryptophan 2,3-dioxygenase	0.025
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.024
Pnliprp2	pancreatic lipase-related protein 2	0.024
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.023
Cnga4	cyclic nucleotide gated channel alpha 4	0.023
Pctk3	PCTAIRE protein kinase 3	0.023
Odf4	outer dense fiber of sperm tails 4	0.022
Rgs8	regulator of G-protein signaling 8	0.022
Msx2	msh homeobox 2	0.022
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.022
Neurog3	neurogenin 3	0.022
Tac2	tachykinin 2	0.022
Nxph1	neurexophilin 1	0.022
Phkg1	phosphorylase kinase, gamma 1	0.021
Rnf207	ring finger protein 207	0.021
Ctsj	cathepsin J	0.021
Slc22a13	solute carrier family 22 (organic anion transporter), member 13	0.021
Epor	erythropoietin receptor	0.021
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.021
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.021
Olr416	olfactory receptor 416	0.021
Freq	frequenin homolog (Drosophila)	0.020
Gjb5	gap junction protein, beta 5	0.020
Gabrd	gamma-aminobutyric acid (GABA) A receptor, delta	0.020
Chrnb3	cholinergic receptor, nicotinic, beta 3	0.020
Crybg3	beta-gamma crystallin domain containing 3	0.020
Hnf4a	hepatocyte nuclear factor 4, alpha	0.020
Ucn2	urocortin 2	0.020
Trim9	tripartite motif-containing 9	0.019
Sstr5	somatostatin receptor 5	0.019	Rat
Duox2	dual oxidase 2	0.019
Drd3	dopamine receptor D3	0.019
N5	DNA binding protein N5	0.019
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.019
Apoa5	apolipoprotein A-V	0.018
Ngb	neuroglobin	0.018
Rgs9	regulator of G-protein signaling 9	0.018
Cpne9	copine family member IX	0.018
Ncr1	natural cytotoxicity triggering receptor 1	0.018
Tbx2	T-box 2	0.018
Notch4	Notch homolog 4 (Drosophila)	0.018
Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16	0.017
Necab1	N-terminal EF-hand calcium binding protein 1	0.017
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.017
Accn2	amiloride-sensitive cation channel 2, neuronal	0.017
Il24	interleukin 24	0.017
Rims3	regulating synaptic membrane exocytosis 3	0.017
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.017
Amn	amnionless homolog (mouse)	0.017
RGD1563533	similar to novel protein	0.017
Slc6a7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.017
Npy5r	neuropeptide Y receptor Y5	0.016
Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.016
Fam148b	family with sequence similarity 148, member B	0.016
Tshb	thyroid stimulating hormone, beta	0.015
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.015
Drd1a	dopamine receptor D1A	0.015
Dbc1	deleted in bladder cancer 1 (human)	0.015
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.015
Tas2r107	taste receptor, type 2, member 107	0.015
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.014
Ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.014
Tulp1	tubby like protein 1	0.014
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.014
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.014
Il8rb	interleukin 8 receptor, beta	0.014
Camkv	CaM kinase-like vesicle-associated	0.014
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.013
Slc6a18	solute carrier family 6, member 18	0.013
Gpr6	G protein-coupled receptor 6	0.013
Il10	interleukin 10	0.013
Isl2	ISL LIM homeobox 2	0.013
RGD1310262	hypothetical LOC304650	0.012
Syn2	synapsin II	0.012
Nrl	neural retina leucine zipper	0.012
Chst10	carbohydrate sulfotransferase 10	0.012
Crhr1	corticotropin releasing hormone receptor 1	0.012
Ina	internexin neuronal intermediate filament protein, alpha	0.012
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.012
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.012
Tas2r119	taste receptor, type 2, member 119	0.012
Il9r	interleukin 9 receptor	0.012
Prp2	proline rich protein 2	0.012
Smad9	SMAD family member 9	0.012
Cdx2	caudal type homeo box 2	0.012
Hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.012
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.011
Ecel1	endothelin converting enzyme-like 1	0.011
Syt5	synaptotagmin V	0.011
Cacng8	calcium channel, voltage-dependent, gamma subunit 8	0.011
Engase	endo-beta-N-acetylglucosaminidase	0.011
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.011
Dclk2	doublecortin-like kinase 2	0.011
Prap1	proline-rich acidic protein 1	0.011
Gucy2e	guanylate cyclase 2E	0.010
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.010
Csn2	casein beta	0.010
Pax6	paired box 6	0.010
Olr1500	olfactory receptor 1500	0.010
RGD1308544	LOC361192	0.010