IMP
Process View
negative regulation of erk1 and erk2 cascade
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of erk1 and erk2 cascade"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| LOC100362824 | caveolin 2-like | 0.615 | ||
| Cav1 | caveolin 1, caveolae protein | 0.558 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.356 | ||
| Fos | FBJ osteosarcoma oncogene | 0.310 | ||
| Junb | jun B proto-oncogene | 0.087 | ||
| Egr1 | early growth response 1 | 0.082 | ||
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.077 | ||
| Rabac1 | Rab acceptor 1 (prenylated) | 0.048 | ||
| Gstm1 | glutathione S-transferase mu 1 | 0.044 | ||
| Jdp2 | Jun dimerization protein 2 | 0.044 | ||
| Dusp1 | dual specificity phosphatase 1 | 0.043 | ||
| Grina | glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) | 0.043 | ||
| Tsc22d3 | TSC22 domain family, member 3 | 0.042 | ||
| Jun | Jun oncogene | 0.035 | ||
| Cav2 | caveolin 2 | 0.032 | Rat | |
| Pdk2 | pyruvate dehydrogenase kinase, isozyme 2 | 0.029 | ||
| Fmnl1 | formin-like 1 | 0.029 | ||
| Pink1 | PTEN induced putative kinase 1 | 0.028 | ||
| Ptafr | platelet-activating factor receptor | 0.023 | ||
| Pcdhga11 | protocadherin gamma subfamily A, 11 | 0.023 | ||
| Prkcd | protein kinase C, delta | 0.022 | ||
| Cyb5r3 | cytochrome b5 reductase 3 | 0.022 | ||
| Id3 | inhibitor of DNA binding 3 | 0.020 | ||
| Rab7a | RAB7A, member RAS oncogene family | 0.020 | ||
| Hoxc4 | homeo box C4 | 0.019 | ||
| Emp1 | epithelial membrane protein 1 | 0.019 | ||
| Errfi1 | ERBB receptor feedback inhibitor 1 | 0.017 | ||
| Klf9 | Kruppel-like factor 9 | 0.017 | ||
| LOC100364212 | heterogeneous nuclear ribonucleoprotein K-like | 0.017 | ||
| Cxcr7 | chemokine (C-X-C motif) receptor 7 | 0.016 | ||
| Lin7b | lin-7 homolog b (C. elegans) | 0.016 | ||
| Hspa1a | heat shock 70kD protein 1A | 0.015 | ||
| Rhob | ras homolog gene family, member B | 0.014 | ||
| Ptpro | protein tyrosine phosphatase, receptor type, O | 0.014 | ||
| Myh7 | myosin, heavy chain 7, cardiac muscle, beta | 0.014 | ||
| Gprc5a | G protein-coupled receptor, family C, group 5, member A | 0.014 | ||
| Klf4 | Kruppel-like factor 4 (gut) | 0.013 | ||
| Il18 | interleukin 18 | 0.013 | ||
| Dock8 | dedicator of cytokinesis 8 | 0.013 | ||
| Crygc | crystallin, gamma C | 0.013 | ||
| Vegfa | vascular endothelial growth factor A | 0.013 | ||
| Lamc1 | laminin, gamma 1 | 0.012 | ||
| Cald1 | caldesmon 1 | 0.012 | ||
| Kcnn3 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 0.012 | ||
| Csrnp1 | cysteine-serine-rich nuclear protein 1 | 0.012 | ||
| Klf3 | Kruppel-like factor 3 (basic) | 0.012 | Rat | |
| Smad1 | SMAD family member 1 | 0.012 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.011 | ||
| Cx3cl1 | chemokine (C-X3-C motif) ligand 1 | 0.011 | ||
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.011 | Mouse | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.011 | ||
| Camkk2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.011 | ||
| Nr4a2 | nuclear receptor subfamily 4, group A, member 2 | 0.010 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A | 0.010 | ||
| Zfp36 | zinc finger protein 36 | 0.010 | ||
| Scarb1 | scavenger receptor class B, member 1 | 0.010 |