The network for 'g protein coupled purinergic nucleotide receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g protein coupled purinergic nucleotide receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.

Homo sapiens
Name Description Probability Func Analog Organism
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.666
GZMK granzyme K (granzyme 3; tryptase II) 0.167
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.116
ITK IL2-inducible T-cell kinase 0.115
GIMAP4 GTPase, IMAP family member 4 0.073
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.060
TRAT1 T cell receptor associated transmembrane adaptor 1 0.055
CCR5 chemokine (C-C motif) receptor 5 0.047
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.046
EVI2A ecotropic viral integration site 2A 0.041
GPR18 G protein-coupled receptor 18 0.040
CD2 CD2 molecule 0.038
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.035
FYB FYN binding protein 0.034
AIF1 allograft inflammatory factor 1 0.033
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.032
SELL selectin L 0.028
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.027
BIN2 bridging integrator 2 0.027
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.026
MNDA myeloid cell nuclear differentiation antigen 0.025
CD96 CD96 molecule 0.025
LY86 lymphocyte antigen 86 0.025
CD8A CD8a molecule 0.024
GPR65 G protein-coupled receptor 65 0.023
THEMIS thymocyte selection associated 0.023
CLEC4A C-type lectin domain family 4, member A 0.023
RNASE6 ribonuclease, RNase A family, k6 0.023
IL18RAP interleukin 18 receptor accessory protein 0.020
CD3D CD3d molecule, delta (CD3-TCR complex) 0.020
GPR183 G protein-coupled receptor 183 0.020
CD86 CD86 molecule 0.019
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.018
F13A1 coagulation factor XIII, A1 polypeptide 0.018
CYTIP cytohesin 1 interacting protein 0.018
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.017
IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides 0.017
CCR2 chemokine (C-C motif) receptor 2 0.017
EVI2B ecotropic viral integration site 2B 0.016
CD84 CD84 molecule 0.016
CRTAM cytotoxic and regulatory T cell molecule 0.015
CXCR6 chemokine (C-X-C motif) receptor 6 0.015
ARHGAP15 Rho GTPase activating protein 15 0.014
TLR8 toll-like receptor 8 0.013
IFNG interferon, gamma 0.013
RGS18 regulator of G-protein signaling 18 0.013
CD163 CD163 molecule 0.013
ICOS inducible T-cell co-stimulator 0.013
CYSLTR1 cysteinyl leukotriene receptor 1 0.012
CD1C CD1c molecule 0.012
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.012
IPCEF1 interaction protein for cytohesin exchange factors 1 0.011
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.011
IGSF6 immunoglobulin superfamily, member 6 0.010
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.010
FGL2 fibrinogen-like 2 0.010
IRF8 interferon regulatory factor 8 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Lair1 leukocyte-associated Ig-like receptor 1 0.534
P2ry12 purinergic receptor P2Y, G-protein coupled 12 0.482
Ly86 lymphocyte antigen 86 0.407
P2ry13 purinergic receptor P2Y, G-protein coupled 13 0.347
March1 membrane-associated ring finger (C3HC4) 1 0.327
Clec7a C-type lectin domain family 7, member a 0.327
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.286
Clec4n C-type lectin domain family 4, member n 0.253
Pld4 phospholipase D family, member 4 0.153
C1qb complement component 1, q subcomponent, beta polypeptide 0.152
Clec5a C-type lectin domain family 5, member a 0.151
C1qa complement component 1, q subcomponent, alpha polypeptide 0.127
Plek pleckstrin 0.122
Csf1r colony stimulating factor 1 receptor 0.111
Aif1 allograft inflammatory factor 1 0.100
Mrc1 mannose receptor, C type 1 0.099
Hpgds hematopoietic prostaglandin D synthase 0.095
C1qc complement component 1, q subcomponent, C chain 0.093
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.086
Gpr34 G protein-coupled receptor 34 0.085
Mpeg1 macrophage expressed gene 1 0.080
Ctss cathepsin S 0.078
Clec4a3 C-type lectin domain family 4, member a3 0.070
Cysltr1 cysteinyl leukotriene receptor 1 0.068
Rgs18 regulator of G-protein signaling 18 0.065
Tlr13 toll-like receptor 13 0.060
5430427O19Rik RIKEN cDNA 5430427O19 gene 0.059
Lpxn leupaxin 0.059
Cd83 CD83 antigen 0.058
Cd86 CD86 antigen 0.057
Sash3 SAM and SH3 domain containing 3 0.054
Bank1 B-cell scaffold protein with ankyrin repeats 1 0.054
Cd33 CD33 antigen 0.053
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.050
Cd53 CD53 antigen 0.048
Cd200r1 CD200 receptor 1 0.045
Tyrobp TYRO protein tyrosine kinase binding protein 0.045
Sirpa signal-regulatory protein alpha 0.044
Havcr2 hepatitis A virus cellular receptor 2 0.043
Pilra paired immunoglobin-like type 2 receptor alpha 0.041
Cd84 CD84 antigen 0.036
Arhgap15 Rho GTPase activating protein 15 0.035
Fcgr3 Fc receptor, IgG, low affinity III 0.035
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.035
Evi2a ecotropic viral integration site 2a 0.032
Duoxa1 dual oxidase maturation factor 1 0.032
Alox5ap arachidonate 5-lipoxygenase activating protein 0.031
Tifab TRAF-interacting protein with forkhead-associated domain, family member B 0.030
Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 0.029
Clec4b1 C-type lectin domain family 4, member b1 0.029
Tcfec transcription factor EC 0.029
Cd300ld CD300 molecule-like family member d 0.029
Stap1 signal transducing adaptor family member 1 0.029
A630033H20Rik RIKEN cDNA A630033H20 gene 0.027
Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.026
Cxcr6 chemokine (C-X-C motif) receptor 6 0.024
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.024
Ccr5 chemokine (C-C motif) receptor 5 0.022
Cd48 CD48 antigen 0.021
Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 0.021
Cd300lb CD300 antigen like family member B 0.021
Krt15 keratin 15 0.021
Omg oligodendrocyte myelin glycoprotein 0.021
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.021
Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.019
Igsf6 immunoglobulin superfamily, member 6 0.019
AF251705 cDNA sequence AF251705 0.019
Timd4 T-cell immunoglobulin and mucin domain containing 4 0.019
Slc46a2 solute carrier family 46, member 2 0.018
Sirpb1a signal-regulatory protein beta 1A 0.017
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.017
Slamf9 SLAM family member 9 0.017
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.017
Klra17 killer cell lectin-like receptor, subfamily A, member 17 0.016
Rnase6 ribonuclease, RNase A family, 6 0.016
Tlr8 toll-like receptor 8 0.016
Gm885 predicted gene 885 0.016
Sprr1b small proline-rich protein 1B 0.016
Cd69 CD69 antigen 0.015
Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C 0.015
Lce1d late cornified envelope 1D 0.015
Gm6377 predicted gene 6377 0.015
P2ry10 purinergic receptor P2Y, G-protein coupled 10 0.015
Vcam1 vascular cell adhesion molecule 1 0.015
Il33 interleukin 33 0.015
Fyb FYN binding protein 0.015
Fcgr4 Fc receptor, IgG, low affinity IV 0.015
Gjb6 gap junction protein, beta 6 0.014
Gpr65 G-protein coupled receptor 65 0.014
Tmem54 transmembrane protein 54 0.014
BC013712 cDNA sequence BC013712 0.013
Fcgr2b Fc receptor, IgG, low affinity IIb 0.013
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.013
Trim29 tripartite motif-containing 29 0.013
Il18 interleukin 18 0.013
Rgs10 regulator of G-protein signalling 10 0.013
Lce1f late cornified envelope 1F 0.012
Nts neurotensin 0.012
Calcb calcitonin-related polypeptide, beta 0.012
Tcl1b3 T-cell leukemia/lymphoma 1B, 3 0.012
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Evi2a ecotropic viral integration site 2A 0.181
Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 0.041
Fcrls Fc receptor-like S, scavenger receptor 0.036
Ccr5 chemokine (C-C motif) receptor 5 0.026
Lpxn leupaxin 0.025
Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 0.023
Sash3 SAM and SH3 domain containing 3 0.022
Lepr leptin receptor 0.022
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.021
Aqp4 aquaporin 4 0.019
Btk Bruton agammaglobulinemia tyrosine kinase 0.019
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.019
Fli1 Friend leukemia virus integration 1 0.019
Clec9a C-type lectin domain family 9, member a 0.018
Clecsf6 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6 0.018
Tas2r118 taste receptor, type 2, member 118 0.017
Mpeg1 macrophage expressed 1 0.017
LOC100360169 rCG21044-like 0.016
Crybg3 beta-gamma crystallin domain containing 3 0.014
Zbp1 Z-DNA binding protein 1 0.014
Strn striatin, calmodulin binding protein 0.013
Fgf2 fibroblast growth factor 2 0.013
Mid1 midline 1 0.013
Pld1 phospholipase D1 0.013
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.013
Fshb follicle stimulating hormone, beta polypeptide 0.013
Tipin timeless interacting protein 0.013
Nkg7 natural killer cell group 7 sequence 0.013
Nmbr neuromedin B receptor 0.012
Spata9 spermatogenesis associated 9 0.012
Ifi204 interferon activated gene 204 0.012
Epsti1 epithelial stromal interaction 1 (breast) 0.012
Olr1469 olfactory receptor Olr1469 0.012
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.012
Cysltr1 cysteinyl leukotriene receptor 1 0.011
Sept6 septin 6 0.011
Mrgprx3 MAS-related GPR, member X3 0.011
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.011
Arhgap15 Rho GTPase activating protein 15 0.011
Tgfbr3 transforming growth factor, beta receptor III 0.011
Nmu neuromedin U 0.011
Fndc3a fibronectin type III domain containing 3a 0.010
Syk spleen tyrosine kinase 0.010
Aplnr apelin receptor 0.010
Hcst hematopoietic cell signal transducer 0.010
Gpr37l1 G protein-coupled receptor 37-like 1 0.010
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism