The network for 'renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure

The physiological response of the kidneys to a decrease in blood flow.

Rattus norvegicus
Name Description Probability Func Analog Organism
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.150
Ar androgen receptor 0.136
Cga glycoprotein hormones, alpha polypeptide 0.129
Insrr insulin receptor-related receptor 0.123
Olr1500 olfactory receptor 1500 0.119
Phkg1 phosphorylase kinase, gamma 1 0.117
Olr1278 olfactory receptor 1278 0.117
Olr1654 olfactory receptor 1654 0.115
Foxe3 forkhead box E3 0.114
Hnmt histamine N-methyltransferase 0.112
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.110
Cckbr cholecystokinin B receptor 0.110
Tacr2 tachykinin receptor 2 0.108
Gna15 guanine nucleotide binding protein, alpha 15 0.103
Svs1 seminal vesicle secretory protein 1 0.087
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.084
Mbl2 mannose-binding lectin (protein C) 2 0.083
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.082
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.078
Fgf14 fibroblast growth factor 14 0.078
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.076
Igfals insulin-like growth factor binding protein, acid labile subunit 0.075
Crhbp corticotropin releasing hormone binding protein 0.074
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.071
Olr287 olfactory receptor 287 0.070
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.068
Epha8 Eph receptor A8 0.068
Pth parathyroid hormone 0.066
Rasa2 RAS p21 protein activator 2 0.064
Inhbe inhibin beta E 0.062
Egr3 early growth response 3 0.062
Dusp4 dual specificity phosphatase 4 0.061
A3galt2 alpha 1,3-galactosyltransferase 2 0.060
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.060
Olr416 olfactory receptor 416 0.060
Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 0.059
Edn1 endothelin 1 0.057
Fosl2 fos-like antigen 2 0.056
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.056
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.055
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.055
Rup2 urinary protein 2 0.053
Syt8 synaptotagmin VIII 0.053
Umod uromodulin 0.051
RGD1564327 similar to integrin alpha 8 0.050
Adora3 adenosine A3 receptor 0.050
Gast gastrin 0.050
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.050
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.049
Cpa3 carboxypeptidase A3, mast cell 0.048
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.048
Svs3a seminal vesicle secretory protein 3A 0.048
Gja3 gap junction protein, alpha 3 0.047
Odf4 outer dense fiber of sperm tails 4 0.047
Col10a1 collagen, type X, alpha 1 0.046
Prp15 proline-rich protein 15 0.046
Clcn5 chloride channel 5 0.045
Akr1c18 aldo-keto reductase family 1, member C18 0.045
Aqp5 aquaporin 5 0.045
Ier5 immediate early response 5 0.044
Pdc phosducin 0.044
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.044
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.044
Olr442 olfactory receptor 442 0.044
Oprd1 opioid receptor, delta 1 0.044
LOC60591 calcium-activated potassium channel beta subunit 0.043
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.043
Selp selectin P 0.043
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.042
Synpo synaptopodin 0.042
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.042
Cxcr5 chemokine (C-X-C motif) receptor 5 0.042
Gria1 glutamate receptor, ionotropic, AMPA 1 0.042
Cartpt CART prepropeptide 0.040
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.040
Vcsa1 variable coding sequence A1 0.039
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.039
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.039
RGD1564664 similar to LOC387763 protein 0.038
Grm6 glutamate receptor, metabotropic 6 0.038
Agtr1a angiotensin II receptor, type 1a 0.038
Cmklr1 chemokine-like receptor 1 0.037
Cma1 chymase 1, mast cell 0.037
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.036
Plau plasminogen activator, urokinase 0.036
Ghr growth hormone receptor 0.036
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.035
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.035
Sstr5 somatostatin receptor 5 0.035
Twist2 twist homolog 2 (Drosophila) 0.035
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.034
Prm2 protamine 2 0.034
Obp3 alpha-2u globulin PGCL4 0.034
Adam7 ADAM metallopeptidase domain 7 0.033
Ptafr platelet-activating factor receptor 0.033
Esr1 estrogen receptor 1 0.032
Fut9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.032
Hrh1 histamine receptor H 1 0.032
Musk muscle, skeletal, receptor tyrosine kinase 0.032
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 1.000
CAV1 caveolin 1, caveolae protein, 22kDa 0.997
ARRB1 arrestin, beta 1 0.590
PTEN phosphatase and tensin homolog 0.183
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.137
PROCR protein C receptor, endothelial 0.129
EDNRB endothelin receptor type B 0.074
PTPRF protein tyrosine phosphatase, receptor type, F 0.046
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.045
GJA1 gap junction protein, alpha 1, 43kDa 0.044
SDPR serum deprivation response 0.040
TXNRD1 thioredoxin reductase 1 0.033
PRKCDBP protein kinase C, delta binding protein 0.031
GFER growth factor, augmenter of liver regeneration 0.030
DLG4 discs, large homolog 4 (Drosophila) 0.025
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.023
CHGB chromogranin B (secretogranin 1) 0.022
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.022
SYT11 synaptotagmin XI 0.020
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.019
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.019
CHRD chordin 0.018
PLIN1 perilipin 1 0.018
ZBTB16 zinc finger and BTB domain containing 16 0.017
TIMP4 TIMP metallopeptidase inhibitor 4 0.016
MPZL2 myelin protein zero-like 2 0.016
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.015
APOB apolipoprotein B (including Ag(x) antigen) 0.015
DLC1 deleted in liver cancer 1 0.015
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.015
FAS Fas (TNF receptor superfamily, member 6) 0.014
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 0.014
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.014
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.013
NEUROD1 neurogenic differentiation 1 0.013
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B 0.013
GFRA1 GDNF family receptor alpha 1 0.013
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.013
SCG2 secretogranin II 0.013
AGTR1 angiotensin II receptor, type 1 0.013
EID3 EP300 interacting inhibitor of differentiation 3 0.013
CCNDBP1 cyclin D-type binding-protein 1 0.013
CHGA chromogranin A (parathyroid secretory protein 1) 0.013
CDO1 cysteine dioxygenase, type I 0.012
ACOX2 acyl-CoA oxidase 2, branched chain 0.012
SCGN secretagogin, EF-hand calcium binding protein 0.012
AOX1 aldehyde oxidase 1 0.012
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.012
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.012
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.011
TAC1 tachykinin, precursor 1 0.011
NPTX1 neuronal pentraxin I 0.011
INSM1 insulinoma-associated 1 0.011
FAM92A1 family with sequence similarity 92, member A1 0.011
EMCN endomucin 0.011
KCNE4 potassium voltage-gated channel, Isk-related family, member 4 0.011
SST somatostatin 0.011
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.011
AMIGO2 adhesion molecule with Ig-like domain 2 0.011
RYR3 ryanodine receptor 3 0.010
KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.010
NPY1R neuropeptide Y receptor Y1 0.010
PLS3 plastin 3 0.010
ADIPOQ adiponectin, C1Q and collagen domain containing 0.010
GYG2 glycogenin 2 0.010
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.010
LSAMP limbic system-associated membrane protein 0.010
NOL4 nucleolar protein 4 0.010
CALCRL calcitonin receptor-like 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ren1 renin 1 structural 0.975
Scn5a sodium channel, voltage-gated, type V, alpha 0.671
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.547
Slc12a1 solute carrier family 12, member 1 0.453
Agtr1a angiotensin II receptor, type 1a 0.398
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.327
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.219
Tbx5 T-box 5 0.181
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.165
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.158
Wt1 Wilms tumor 1 homolog 0.093
Pcdh12 protocadherin 12 0.068
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.067
Fgg fibrinogen gamma chain 0.054
Gjb2 gap junction protein, beta 2 0.050
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.049
Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B 0.047
Tjp1 tight junction protein 1 0.044
Fga fibrinogen alpha chain 0.044
F2 coagulation factor II 0.042
Kel Kell blood group 0.039
Phldb2 pleckstrin homology-like domain, family B, member 2 0.037
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.033
Tbx3 T-box 3 0.033
Lepr leptin receptor 0.032
Agtrap angiotensin II, type I receptor-associated protein 0.030
Umod uromodulin 0.030
Gpr182 G protein-coupled receptor 182 0.028
Kcne1l potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene 0.027
Ahsg alpha-2-HS-glycoprotein 0.026
Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 0.026
Dmkn dermokine 0.025
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.025
Ryr2 ryanodine receptor 2, cardiac 0.024
F12 coagulation factor XII (Hageman factor) 0.024
Eln elastin 0.023
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.021
Gjb6 gap junction protein, beta 6 0.021
Col13a1 collagen, type XIII, alpha 1 0.021
Ptgs2 prostaglandin-endoperoxide synthase 2 0.021
Krt36 keratin 36 0.020
Alb albumin 0.020
Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A 0.019
Sox7 SRY-box containing gene 7 0.019
Spry4 sprouty homolog 4 (Drosophila) 0.018
Apoa1 apolipoprotein A-I 0.018
Prss22 protease, serine, 22 0.017
Pah phenylalanine hydroxylase 0.015
Nr3c2 nuclear receptor subfamily 3, group C, member 2 0.015
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.015
Gjb1 gap junction protein, beta 1 0.015
Fut2 fucosyltransferase 2 0.015
Apof apolipoprotein F 0.014
Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M 0.014
Wnt7a wingless-related MMTV integration site 7A 0.014
Aqp2 aquaporin 2 0.014
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.013
Fbn1 fibrillin 1 0.013
Klk6 kallikrein related-peptidase 6 0.013
Gjb3 gap junction protein, beta 3 0.012
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.012
Dsc3 desmocollin 3 0.012
Apoc4 apolipoprotein C-IV 0.012
Vegfa vascular endothelial growth factor A 0.012
Gja1 gap junction protein, alpha 1 0.012
Akr1c6 aldo-keto reductase family 1, member C6 0.012
Plg plasminogen 0.011
Bmp8b bone morphogenetic protein 8b 0.011
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.011
Ighmbp2 immunoglobulin mu binding protein 2 0.011
Nid1 nidogen 1 0.011
She src homology 2 domain-containing transforming protein E 0.011
Ivl involucrin 0.011
Tmprss11e transmembrane protease, serine 11e 0.011
Gjb5 gap junction protein, beta 5 0.010
Hnf4a hepatic nuclear factor 4, alpha 0.010
Pzp pregnancy zone protein 0.010
Dsc1 desmocollin 1 0.010
Ambp alpha 1 microglobulin/bikunin 0.010
Tm4sf1 transmembrane 4 superfamily member 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism