The network for 'regulation of peptide hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of peptide hormone secretion

Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

Rattus norvegicus
Name Description Probability Func Analog Organism
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.301
Phkg1 phosphorylase kinase, gamma 1 0.293
Neurod2 neurogenic differentiation 2 0.292
Vamp1 vesicle-associated membrane protein 1 0.285
Sftpd surfactant protein D 0.285
Apoa4 apolipoprotein A-IV 0.266
Dnase1 deoxyribonuclease I 0.263
Crhbp corticotropin releasing hormone binding protein 0.243
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.243
Rxrg retinoid X receptor gamma 0.222
G6pc glucose-6-phosphatase, catalytic subunit 0.190
Gast gastrin 0.169
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.161
Ins2 insulin 2 0.159
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.158
Iapp islet amyloid polypeptide 0.150
Syt4 synaptotagmin IV 0.143
Glp1r glucagon-like peptide 1 receptor 0.143
RT1-Ba RT1 class II, locus Ba 0.137
Grk4 G protein-coupled receptor kinase 4 0.132
Adra2c adrenergic, alpha-2C-, receptor 0.126
Prlhr prolactin releasing hormone receptor 0.123
Tshb thyroid stimulating hormone, beta 0.116
Ush1c Usher syndrome 1C homolog (human) 0.116
Sebox SEBOX homeobox 0.116
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.112
Necab2 N-terminal EF-hand calcium binding protein 2 0.111
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.110
Acsl4 acyl-CoA synthetase long-chain family member 4 0.109
Sox17 SRY (sex determining region Y)-box 17 0.108
Esr2 estrogen receptor 2 (ER beta) 0.106
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.102
Lim2 lens intrinsic membrane protein 2 0.101
LOC100362331 rCG59612-like 0.101
Ecel1 endothelin converting enzyme-like 1 0.099
Gper G protein-coupled estrogen receptor 1 0.098
Syt9 synaptotagmin IX 0.098
Capza1 capping protein (actin filament) muscle Z-line, alpha 1 0.097
Fbp1 fructose-1,6-bisphosphatase 1 0.096
Camk2g calcium/calmodulin-dependent protein kinase II gamma 0.094
Tmod2 tropomodulin 2 0.094
Aqp2 aquaporin 2 (collecting duct) 0.094
Ucn urocortin 0.093
Fam57b family with sequence similarity 57, member B 0.093
Rab3b RAB3B, member RAS oncogene family 0.092
Sstr2 somatostatin receptor 2 0.092
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.092
Vom1r90 vomeronasal 1 receptor 90 0.090
Syn1 synapsin I 0.090
Notch4 Notch homolog 4 (Drosophila) 0.089
Pyy peptide YY (mapped) 0.089
Cga glycoprotein hormones, alpha polypeptide 0.089
Egr3 early growth response 3 0.087
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.086
Mapk10 mitogen activated protein kinase 10 0.085
Syt8 synaptotagmin VIII 0.082
Acot12 acyl-CoA thioesterase 12 0.082
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.082
Smad3 SMAD family member 3 0.081
Casp3 caspase 3 0.081
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.080
Pnoc prepronociceptin 0.077
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.077
Gh1 growth hormone 1 0.077
Sytl4 synaptotagmin-like 4 0.076
Trhr2 thyrotropin releasing hormone receptor 2 0.076
Ppara peroxisome proliferator activated receptor alpha 0.076
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.075
Pecam1 platelet/endothelial cell adhesion molecule 1 0.075
Fam108b1 family with sequence similarity 108, member B1 0.075
Reg3g regenerating islet-derived 3 gamma 0.074
Adam1a a disintegrin and metallopeptidase domain 1a 0.074
Cxcr5 chemokine (C-X-C motif) receptor 5 0.073
Socs3 suppressor of cytokine signaling 3 0.073
Gpha2 glycoprotein hormone alpha 2 0.072
Nrsn1 neurensin 1 0.071
Vip vasoactive intestinal peptide 0.071
LOC290595 hypothetical gene supported by AF152002 0.070
Nfasc neurofascin 0.070
Dbp D site of albumin promoter (albumin D-box) binding protein 0.070
Foxa1 forkhead box A1 0.070
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.069
Unc13c unc-13 homolog C (C. elegans) 0.069
Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.068
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.068
Grm7 glutamate receptor, metabotropic 7 0.067
Grm1 glutamate receptor, metabotropic 1 0.067
Pde3a phosphodiesterase 3A, cGMP inhibited 0.067
Cdh22 cadherin 22 0.067
Acrv1 acrosomal vesicle protein 1 0.067
Zfyve20 zinc finger, FYVE domain containing 20 0.067
Grm5 glutamate receptor, metabotropic 5 0.067
Mtmr7 myotubularin related protein 7 0.066
Th tyrosine hydroxylase 0.066
Lifr leukemia inhibitory factor receptor alpha 0.066
Sct secretin 0.065
Scnn1b sodium channel, nonvoltage-gated 1, beta 0.065
Il12b interleukin 12B 0.065
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.064
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
daf-1 Protein DAF-1 0.015
lit-1 Protein LIT-1 0.013
daf-11 Protein DAF-11 0.013
smp-1 Protein SMP-1 0.013
unc-32 Protein UNC-32 0.012
daf-4 Protein DAF-4 0.012
unc-43 Protein UNC-43 0.012
rsd-3 Protein RSD-3 0.012
eat-6 Protein EAT-6 0.012
hif-1 Protein HIF-1 0.012
eat-4 Protein EAT-4 0.011
vab-3 Protein VAB-3 0.011
K03E6.7 Protein K03E6.7 0.011
F13H6.1 Protein F13H6.1 0.011
fox-1 Protein FOX-1 0.011
qui-1 Protein QUI-1 0.011
egl-5 Protein EGL-5 0.011
kin-29 Protein KIN-29 0.010
cdc-42 Protein CDC-42 0.010
egl-36 Protein EGL-36 0.010
ZK54.1 Protein ZK54.1 0.010
lin-7 Protein LIN-7 0.010
T27A3.1 Protein T27A3.1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tim timeless 0.340
Plc21C Phospholipase C at 21C 0.232
Actbeta Activin-beta 0.099
Shaw Shaker cognate w 0.070
unc-13 CG2999 gene product from transcript CG2999-RA 0.067
shn schnurri 0.066
Dat Dopamine N acetyltransferase 0.048
disco disconnected 0.044
Eip63F-1 Ecdysone-induced protein 63F 1 0.039
dnc dunce 0.039
Clk Clock 0.031
usp ultraspiracle 0.025
mav maverick 0.023
CadN Cadherin-N 0.023
Tequila CG4821 gene product from transcript CG4821-RE 0.022
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.020
Atg9 Autophagy-specific gene 9 0.018
CanA1 Calcineurin A1 0.018
Ric Ras which interacts with Calmodulin 0.017
CaMKII Calcium/calmodulin-dependent protein kinase II 0.017
Pka-C1 cAMP-dependent protein kinase 1 0.017
drpr draper 0.016
NPFR1 neuropeptide F receptor 0.015
wit wishful thinking 0.014
Gyc76C Guanylyl cyclase at 76C 0.014
unc-104 CG8566 gene product from transcript CG8566-RB 0.013
myoglianin CG1838 gene product from transcript CG1838-RD 0.013
kibra kibra ortholog 0.013
HDAC6 CG6170 gene product from transcript CG6170-RA 0.013
SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit 0.012
Irk3 Inwardly rectifying potassium channel 3 0.012
Pp2B-14D Protein phosphatase 2B at 14D 0.012
Rab3 Rab-protein 3 0.011
rtGEF rho-type guanine exchange factor 0.011
norpA no receptor potential A 0.010
cry cryptochrome 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.875
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.837
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.808
INSR insulin receptor 0.804
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.777
FGA fibrinogen alpha chain 0.742
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.613
CCR5 chemokine (C-C motif) receptor 5 0.554
FGB fibrinogen beta chain 0.523
CCNY cyclin Y 0.492
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.488
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.477
IGF1R insulin-like growth factor 1 receptor 0.453
CCL4 chemokine (C-C motif) ligand 4 0.452
PPARA peroxisome proliferator-activated receptor alpha 0.439
IL1R1 interleukin 1 receptor, type I 0.437
IL1B interleukin 1, beta 0.380
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.379
LIN7B lin-7 homolog B (C. elegans) 0.303
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.303
CHD8 chromodomain helicase DNA binding protein 8 0.284
HCK hemopoietic cell kinase 0.268
CRHR1 corticotropin releasing hormone receptor 1 0.259
MPDZ multiple PDZ domain protein 0.253
PSEN2 presenilin 2 (Alzheimer disease 4) 0.247
TEK TEK tyrosine kinase, endothelial 0.238
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.232
NOSTRIN nitric oxide synthase trafficker 0.230
ZFYVE9 zinc finger, FYVE domain containing 9 0.228
EGFR epidermal growth factor receptor 0.218
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.213
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.201
IRS1 insulin receptor substrate 1 0.194
CRP C-reactive protein, pentraxin-related 0.183
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.172
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.172
SYK spleen tyrosine kinase 0.168
CLASP1 cytoplasmic linker associated protein 1 0.163
CXCL9 chemokine (C-X-C motif) ligand 9 0.163
HLA-DMA major histocompatibility complex, class II, DM alpha 0.162
CCL2 chemokine (C-C motif) ligand 2 0.157
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.144
SNAP25 synaptosomal-associated protein, 25kDa 0.144
HLA-DMB major histocompatibility complex, class II, DM beta 0.143
CCL8 chemokine (C-C motif) ligand 8 0.140
MEOX1 mesenchyme homeobox 1 0.139
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.137
DLG4 discs, large homolog 4 (Drosophila) 0.133
FGG fibrinogen gamma chain 0.132
ONECUT1 one cut homeobox 1 0.132
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.126
ADORA2A adenosine A2a receptor 0.124
NSF N-ethylmaleimide-sensitive factor 0.122
HNF1B HNF1 homeobox B 0.121
GRB2 growth factor receptor-bound protein 2 0.118
SNAP23 synaptosomal-associated protein, 23kDa 0.117
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.115
BLNK B-cell linker 0.115
CLOCK clock homolog (mouse) 0.113
IL1RN interleukin 1 receptor antagonist 0.112
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.110
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.102
HOXD12 homeobox D12 0.101
ENG endoglin 0.099
IRF2 interferon regulatory factor 2 0.099
GRB7 growth factor receptor-bound protein 7 0.097
INCENP inner centromere protein antigens 135/155kDa 0.094
HNF4A hepatocyte nuclear factor 4, alpha 0.091
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.090
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.087
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.085
CCR1 chemokine (C-C motif) receptor 1 0.085
NKX2-1 NK2 homeobox 1 0.084
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.084
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.082
CDX2 caudal type homeobox 2 0.080
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.080
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.080
CCL5 chemokine (C-C motif) ligand 5 0.079
SH3BP4 SH3-domain binding protein 4 0.078
VAC14 Vac14 homolog (S. cerevisiae) 0.078
UBASH3B ubiquitin associated and SH3 domain containing B 0.077
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.077
CHD7 chromodomain helicase DNA binding protein 7 0.076
GRB10 growth factor receptor-bound protein 10 0.074
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.072
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.072
GJD2 gap junction protein, delta 2, 36kDa 0.071
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.068
IL8 interleukin 8 0.066
HLA-DRA major histocompatibility complex, class II, DR alpha 0.066
SH2B1 SH2B adaptor protein 1 0.064
ITK IL2-inducible T-cell kinase 0.062
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.061
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.059
RGS20 regulator of G-protein signaling 20 0.057
AURKB aurora kinase B 0.057
BMPR1B bone morphogenetic protein receptor, type IB 0.056
BMP4 bone morphogenetic protein 4 0.055
HDAC2 histone deacetylase 2 0.055
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Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 0.993
Nos3 nitric oxide synthase 3, endothelial cell 0.967
Pax8 paired box gene 8 0.929
Kl klotho 0.892
Rxra retinoid X receptor alpha 0.890
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.874
Clock circadian locomotor output cycles kaput 0.846
Fgf8 fibroblast growth factor 8 0.842
Pdx1 pancreatic and duodenal homeobox 1 0.840
Ephb2 Eph receptor B2 0.801
Pparg peroxisome proliferator activated receptor gamma 0.776
Pax2 paired box gene 2 0.772
Tgfb2 transforming growth factor, beta 2 0.709
Efnb2 ephrin B2 0.703
Eya1 eyes absent 1 homolog (Drosophila) 0.698
Lep leptin 0.692
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.684
Prop1 paired like homeodomain factor 1 0.678
Insr insulin receptor 0.661
Bglap bone gamma carboxyglutamate protein 0.643
Prox1 prospero-related homeobox 1 0.618
Ctnnb1 catenin (cadherin associated protein), beta 1 0.613
Fgfr2 fibroblast growth factor receptor 2 0.609
Bmp4 bone morphogenetic protein 4 0.609
Epha4 Eph receptor A4 0.601
Sox9 SRY-box containing gene 9 0.555
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.554
Tbx3 T-box 3 0.552
Jag1 jagged 1 0.540
Gli3 GLI-Kruppel family member GLI3 0.515
Cry2 cryptochrome 2 (photolyase-like) 0.497
Gata6 GATA binding protein 6 0.492
Ghr growth hormone receptor 0.491
Adrb1 adrenergic receptor, beta 1 0.487
Chd7 chromodomain helicase DNA binding protein 7 0.480
Lta lymphotoxin A 0.477
Nkx2-1 NK2 homeobox 1 0.470
Arrb1 arrestin, beta 1 0.443
Fst follistatin 0.441
Sox2 SRY-box containing gene 2 0.434
Smad6 MAD homolog 6 (Drosophila) 0.412
Adra2a adrenergic receptor, alpha 2a 0.410
Gata5 GATA binding protein 5 0.409
Otp orthopedia homolog (Drosophila) 0.402
Foxg1 forkhead box G1 0.400
Per2 period homolog 2 (Drosophila) 0.399
Cd160 CD160 antigen 0.371
Npas1 neuronal PAS domain protein 1 0.358
Nrxn1 neurexin I 0.340
Nrxn3 neurexin III 0.340
Lhx3 LIM homeobox protein 3 0.339
Fshr follicle stimulating hormone receptor 0.332
Hand2 heart and neural crest derivatives expressed transcript 2 0.329
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.324
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.320
Foxc1 forkhead box C1 0.317
Fgf3 fibroblast growth factor 3 0.316
Pitx2 paired-like homeodomain transcription factor 2 0.311
Pten phosphatase and tensin homolog 0.308
Pnpla2 patatin-like phospholipase domain containing 2 0.308
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.303
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.295
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.294
Pou3f3 POU domain, class 3, transcription factor 3 0.292
Adra2b adrenergic receptor, alpha 2b 0.291
Pbx1 pre B-cell leukemia transcription factor 1 0.288
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.287
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.286
Cckbr cholecystokinin B receptor 0.285
Hnf4a hepatic nuclear factor 4, alpha 0.283
Neurog3 neurogenin 3 0.269
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.268
Nf1 neurofibromatosis 1 0.264
Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 0.262
Sfrp2 secreted frizzled-related protein 2 0.258
Ntf3 neurotrophin 3 0.257
Adra2c adrenergic receptor, alpha 2c 0.256
Nkx6-1 NK6 homeobox 1 0.252
Pim1 proviral integration site 1 0.249
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.247
Klf3 Kruppel-like factor 3 (basic) 0.246
Cidec cell death-inducing DFFA-like effector c 0.244
Rs1 retinoschisis (X-linked, juvenile) 1 (human) 0.234
Sstr3 somatostatin receptor 3 0.232
Hes1 hairy and enhancer of split 1 (Drosophila) 0.232
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.231
Thrb thyroid hormone receptor beta 0.227
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.226
Sim1 single-minded homolog 1 (Drosophila) 0.226
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.224
Insm1 insulinoma-associated 1 0.222
Lmx1b LIM homeobox transcription factor 1 beta 0.220
Hif1a hypoxia inducible factor 1, alpha subunit 0.214
Sox4 SRY-box containing gene 4 0.212
Sall3 sal-like 3 (Drosophila) 0.208
Inhbb inhibin beta-B 0.207
U46068 cDNA sequence U46068 0.206
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.203
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.203
Efnb1 ephrin B1 0.201
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism