The network for 'regulation of chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of chromatin silencing

Any process that affects the rate, extent or location of chromatin silencing.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CTI6 Cti6p 0.791
RPD3 Rpd3p 0.752
SIN3 Sin3p 0.737
RTF1 Rtf1p 0.667
PHO23 Pho23p 0.592
NTO1 Nto1p 0.588
RXT2 Rxt2p 0.587
UME1 Ume1p 0.532
RNR2 Rnr2p 0.485
HOS4 Hos4p 0.447
HHT1 Hht1p 0.410
SIR2 Sir2p 0.381
CKA1 Cka1p 0.357
SDS3 Sds3p 0.357
SNT1 Snt1p 0.341
SET3 Set3p 0.316
SAP30 Sap30p 0.301
BDF1 Bdf1p 0.263
LEO1 Leo1p 0.257
CDC6 Cdc6p 0.236
ORC6 Orc6p 0.229
SIF2 Sif2p 0.220
YTA7 Yta7p 0.215
SIR4 Sir4p 0.205
YML081W hypothetical protein 0.194
ORC3 Orc3p 0.191
HAL5 Hal5p 0.177
HST1 Hst1p 0.176
FKH1 Fkh1p 0.172
DEF1 Def1p 0.158
RPN4 Rpn4p 0.155
CTK1 Ctk1p 0.152
UME6 Ume6p 0.146
AFT1 Aft1p 0.137
RSC4 Rsc4p 0.124
ROX1 Rox1p 0.118
SNF5 Snf5p 0.117
HHO1 Hho1p 0.116
HOT1 Hot1p 0.113
IES2 Ies2p 0.113
IRC8 Irc8p 0.109
ORC4 Orc4p 0.108
NRG1 Nrg1p 0.106
ORC2 Orc2p 0.105
HDA2 Hda2p 0.105
CTK3 Ctk3p 0.099
CPR1 Cpr1p 0.097
YLR455W hypothetical protein 0.097
MTR10 Mtr10p 0.095
MBR1 Mbr1p 0.094
RIM101 Rim101p 0.093
KIC1 Kic1p 0.092
CYC8 Cyc8p 0.092
EAF3 Eaf3p 0.092
MIG1 Mig1p 0.089
CHD1 Chd1p 0.088
EPL1 Epl1p 0.087
SGF29 Sgf29p 0.087
MCM3 Mcm3p 0.087
DIA2 Dia2p 0.086
ARP8 Arp8p 0.083
AGP2 Agp2p 0.082
YKR075C hypothetical protein 0.081
RCO1 Rco1p 0.081
ABF1 Abf1p 0.079
SPT20 Spt20p 0.079
RAP1 Rap1p 0.078
ASF1 Asf1p 0.077
HHF2 Hhf2p 0.074
SPT8 Spt8p 0.074
MRS6 Mrs6p 0.074
GIS4 Gis4p 0.071
YLR278C hypothetical protein 0.068
MOT2 Mot2p 0.065
URE2 Ure2p 0.064
CAT8 Cat8p 0.064
SPT3 Spt3p 0.063
CSR2 Csr2p 0.063
CLB1 Clb1p 0.061
GND2 Gnd2p 0.060
KAP95 Kap95p 0.059
FKH2 Fkh2p 0.059
RGS2 Rgs2p 0.059
CDC4 Cdc4p 0.058
HOS2 Hos2p 0.058
KIN3 Kin3p 0.058
CHL1 Chl1p 0.058
RXT3 Rxt3p 0.058
GAT2 Gat2p 0.057
PUB1 Pub1p 0.056
SPT10 Spt10p 0.056
SET2 Set2p 0.054
NUP1 Nup1p 0.053
YCL042W hypothetical protein 0.053
VAC17 Vac17p 0.053
ASH1 Ash1p 0.052
RIM8 Rim8p 0.052
MET4 Met4p 0.051
CDC14 Cdc14p 0.050
HOS3 Hos3p 0.049
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mod(mdg4) modifier of mdg4 0.995
e(y)3 enhancer of yellow 3 0.881
wapl wings apart-like 0.787
CTCF CG8591 gene product from transcript CG8591-RA 0.785
lid little imaginal discs 0.603
BEAF-32 Boundary element-associated factor of 32kD 0.546
msl-1 male-specific lethal 1 0.506
Chd1 Chromodomain-helicase-DNA-binding protein 1 0.479
His2Av Histone H2A variant 0.408
ash1 absent, small, or homeotic discs 1 0.359
Su(var)3-7 Suppressor of variegation 3-7 0.296
E(var)3-9 Enhancer of variegation 3-9 0.284
crm cramped 0.235
Dek CG5935 gene product from transcript CG5935-RA 0.216
Su(var)2-10 Suppressor of variegation 2-10 0.213
Jarid2 CG3654 gene product from transcript CG3654-RD 0.203
D1 D1 chromosomal protein 0.166
Chro Chromator 0.164
Psc Posterior sex combs 0.163
z zeste 0.156
simj simjang 0.149
CG13474 CG13474 gene product from transcript CG13474-RA 0.142
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.136
cg combgap 0.131
Su(var)3-3 Suppressor of variegation 3-3 0.117
rod rough deal 0.117
Pp1-87B Protein phosphatase 1 at 87B 0.114
CG3875 CG3875 gene product from transcript CG3875-RA 0.113
Pc Polycomb 0.108
CG14204 CG14204 gene product from transcript CG14204-RA 0.107
Nf-YC Nuclear factor Y-box C 0.107
Taf4 TBP-associated factor 4 0.106
msl-2 male-specific lethal 2 0.103
Grip84 gamma-tubulin ring protein 84 0.102
ph-d polyhomeotic distal 0.101
Trl Trithorax-like 0.100
vtd verthandi 0.097
eIF4E-3 CG8023 gene product from transcript CG8023-RA 0.094
Rga Regena 0.093
CG5017 CG5017 gene product from transcript CG5017-RA 0.088
Scm Sex comb on midleg 0.084
CycG Cyclin G 0.084
trx trithorax 0.080
Sir2 CG5216 gene product from transcript CG5216-RA 0.078
CG11504 CG11504 gene product from transcript CG11504-RB 0.074
Slbp Stem-loop binding protein 0.074
pr-set7 CG3307 gene product from transcript CG3307-RC 0.073
barr barren 0.073
msl-3 male-specific lethal 3 0.071
Hcf Host cell factor 0.070
prod proliferation disrupter 0.069
SuUR Suppressor of Under-Replication 0.069
gpp grappa 0.067
Tsp96F Tetraspanin 96F 0.067
CG42709 CG42709 gene product from transcript CG42709-RC 0.067
HmgD High mobility group protein D 0.067
CG6425 CG6425 gene product from transcript CG6425-RA 0.066
HP4 Heterochromatin protein 4 0.063
Dp1 Dodeca-satellite-binding protein 1 0.063
sxc super sex combs 0.062
CG9363 CG9363 gene product from transcript CG9363-RB 0.060
CG8165 CG8165 gene product from transcript CG8165-RA 0.059
sina seven in absentia 0.058
otu ovarian tumor 0.058
bip2 CG2009 gene product from transcript CG2009-RA 0.057
Orc2 Origin recognition complex subunit 2 0.056
Mst87F Male-specific RNA 87F 0.055
ph-p polyhomeotic proximal 0.054
mof males absent on the first 0.053
Mi-2 CG8103 gene product from transcript CG8103-RA 0.051
sced scrambled 0.050
CG2709 CG2709 gene product from transcript CG2709-RA 0.048
Hr4 CG16902 gene product from transcript CG16902-RC 0.048
MRG15 CG6363 gene product from transcript CG6363-RA 0.047
chm chameau 0.046
png pan gu 0.045
U2af38 U2 small nuclear riboprotein auxiliary factor 38 0.045
XNP CG4548 gene product from transcript CG4548-RA 0.045
how held out wings 0.043
Sos Son of sevenless 0.042
msd1 mitotic spindle density 1 0.042
CG10630 CG10630 gene product from transcript CG10630-RA 0.042
Tbp TATA binding protein 0.042
Imp IGF-II mRNA-binding protein 0.042
CG42500 CG42500 gene product from transcript CG42500-RA 0.041
Acf1 ATP-dependent chromatin assembly factor large subunit 0.041
Su(var)205 Suppressor of variegation 205 0.041
InR Insulin-like receptor 0.041
kel kelch 0.039
crp cropped 0.039
Gmer GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase 0.039
sinah sina homologue 0.039
CG4119 CG4119 gene product from transcript CG4119-RA 0.039
dalao CG7055 gene product from transcript CG7055-RA 0.039
dlt discs lost 0.039
CG11399 CG11399 gene product from transcript CG11399-RB 0.038
Nup58 Nucleoporin 58 0.038
Cap-G CG34438 gene product from transcript CG34438-RF 0.037
CG10164 CG10164 gene product from transcript CG10164-RB 0.037
enok enoki mushroom 0.037
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 0.976
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.940
EP300 E1A binding protein p300 0.732
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.666
SP1 Sp1 transcription factor 0.625
HDAC2 histone deacetylase 2 0.578
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.518
CBX5 chromobox homolog 5 0.441
CREBBP CREB binding protein 0.436
RB1 retinoblastoma 1 0.299
ESR1 estrogen receptor 1 0.201
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.173
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.164
PAX3 paired box 3 0.157
MCM6 minichromosome maintenance complex component 6 0.134
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.126
ORC6 origin recognition complex, subunit 6 0.126
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.118
MCM4 minichromosome maintenance complex component 4 0.113
HCFC1 host cell factor C1 (VP16-accessory protein) 0.112
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.107
BCOR BCL6 corepressor 0.098
ARID1A AT rich interactive domain 1A (SWI-like) 0.091
CBX3 chromobox homolog 3 0.089
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.088
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.084
ADNP activity-dependent neuroprotector homeobox 0.068
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.066
RBBP4 retinoblastoma binding protein 4 0.063
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.056
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.046
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.043
ORC2 origin recognition complex, subunit 2 0.042
FOXD3 forkhead box D3 0.041
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.039
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.039
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.038
MCM2 minichromosome maintenance complex component 2 0.037
MCM3 minichromosome maintenance complex component 3 0.037
MAPK14 mitogen-activated protein kinase 14 0.034
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.032
SMAD3 SMAD family member 3 0.029
CHD4 chromodomain helicase DNA binding protein 4 0.028
HTT huntingtin 0.028
SAP30 Sin3A-associated protein, 30kDa 0.027
HIST1H3B histone cluster 1, H3b 0.026
EED embryonic ectoderm development 0.026
MSL2 male-specific lethal 2 homolog (Drosophila) 0.026
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.025
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.023
NCOR2 nuclear receptor corepressor 2 0.023
ORC3 origin recognition complex, subunit 3 0.023
PCNA proliferating cell nuclear antigen 0.021
POGZ pogo transposable element with ZNF domain 0.021
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.021
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.020
SETD7 SET domain containing (lysine methyltransferase) 7 0.019
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.019
CDYL chromodomain protein, Y-like 0.018
CBX1 chromobox homolog 1 0.018
SMAD7 SMAD family member 7 0.017
KAT2B K(lysine) acetyltransferase 2B 0.017
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.017
PARP1 poly (ADP-ribose) polymerase 1 0.017
ARID4B AT rich interactive domain 4B (RBP1-like) 0.017
SOX2 SRY (sex determining region Y)-box 2 0.015
NQO1 NAD(P)H dehydrogenase, quinone 1 0.015
TALDO1 transaldolase 1 0.014
ORC4 origin recognition complex, subunit 4 0.014
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.014
RCOR1 REST corepressor 1 0.014
HMGA1 high mobility group AT-hook 1 0.014
NCOA3 nuclear receptor coactivator 3 0.013
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.013
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.013
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.013
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.012
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.012
CHD3 chromodomain helicase DNA binding protein 3 0.012
DBF4 DBF4 homolog (S. cerevisiae) 0.012
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.011
MBD1 methyl-CpG binding domain protein 1 0.011
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.011
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.011
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.010
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.010
NCOA1 nuclear receptor coactivator 1 0.010
SOCS1 suppressor of cytokine signaling 1 0.010
RBBP7 retinoblastoma binding protein 7 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Sall4 sal-like 4 (Drosophila) 0.997
Nanog Nanog homeobox 0.996
Arid1a AT rich interactive domain 1A (SWI-like) 0.995
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.984
Tcfcp2l1 transcription factor CP2-like 1 0.982
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.949
Hdac1 histone deacetylase 1 0.839
Sp1 trans-acting transcription factor 1 0.771
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.699
Rnf2 ring finger protein 2 0.515
Ncor1 nuclear receptor co-repressor 1 0.485
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.484
Sox2 SRY-box containing gene 2 0.426
Sall1 sal-like 1 (Drosophila) 0.417
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.406
Esrrb estrogen related receptor, beta 0.393
Ep300 E1A binding protein p300 0.380
Hdac2 histone deacetylase 2 0.340
Sin3a transcriptional regulator, SIN3A (yeast) 0.334
Rnf220 ring finger protein 220 0.294
Trim24 tripartite motif-containing 24 0.269
Zfp292 zinc finger protein 292 0.226
Zmym5 zinc finger, MYM-type 5 0.204
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.190
Msh2 mutS homolog 2 (E. coli) 0.188
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.184
Casp2 caspase 2 0.162
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.162
Kdm5b lysine (K)-specific demethylase 5B 0.160
Trp53 transformation related protein 53 0.158
Hist1h2bc histone cluster 1, H2bc 0.158
Chd4 chromodomain helicase DNA binding protein 4 0.155
Ddx3y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 0.153
Ccna2 cyclin A2 0.146
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.142
Mta1 metastasis associated 1 0.124
Ep400 E1A binding protein p400 0.123
Sp3 trans-acting transcription factor 3 0.115
Kiss1 KiSS-1 metastasis-suppressor 0.113
Erbb2ip Erbb2 interacting protein 0.113
Hcfc1 host cell factor C1 0.111
Cnot2 CCR4-NOT transcription complex, subunit 2 0.109
Cdk2 cyclin-dependent kinase 2 0.108
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.108
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.104
Med23 mediator complex subunit 23 0.103
Dbx1 developing brain homeobox 1 0.101
Rb1 retinoblastoma 1 0.101
Cry1 cryptochrome 1 (photolyase-like) 0.095
Kdm1a lysine (K)-specific demethylase 1A 0.086
Mta2 metastasis-associated gene family, member 2 0.086
Crebbp CREB binding protein 0.084
Gatad2b GATA zinc finger domain containing 2B 0.083
Rybp RING1 and YY1 binding protein 0.082
Creb1 cAMP responsive element binding protein 1 0.080
Arid1b AT rich interactive domain 1B (SWI-like) 0.079
Nipbl Nipped-B homolog (Drosophila) 0.078
Mta3 metastasis associated 3 0.077
Mbtd1 mbt domain containing 1 0.073
Mecp2 methyl CpG binding protein 2 0.071
Yy1 YY1 transcription factor 0.067
Igh immunoglobulin heavy chain complex 0.066
Hist3h2bb-ps histone cluster 3, H2bb, pseudogene 0.066
Per2 period homolog 2 (Drosophila) 0.066
Supt16h suppressor of Ty 16 homolog (S. cerevisiae) 0.065
2210018M11Rik RIKEN cDNA 2210018M11 gene 0.064
Bod1l biorientation of chromosomes in cell division 1-like 0.063
L3mbtl2 l(3)mbt-like 2 (Drosophila) 0.062
Pias1 protein inhibitor of activated STAT 1 0.062
Pou5f1 POU domain, class 5, transcription factor 1 0.061
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.061
Zscan4b zinc finger and SCAN domain containing 4B 0.060
Pou2f1 POU domain, class 2, transcription factor 1 0.059
Tet1 tet oncogene 1 0.059
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.056
Sall3 sal-like 3 (Drosophila) 0.055
Zmym2 zinc finger, MYM-type 2 0.051
Prpf8 pre-mRNA processing factor 8 0.050
Tet2 tet oncogene family member 2 0.050
Ctcf CCCTC-binding factor 0.050
Atm ataxia telangiectasia mutated homolog (human) 0.050
Stag1 stromal antigen 1 0.049
Clock circadian locomotor output cycles kaput 0.048
Rif1 Rap1 interacting factor 1 homolog (yeast) 0.048
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.047
Smc3 structural maintenace of chromosomes 3 0.046
Cdk1 cyclin-dependent kinase 1 0.046
Epc1 enhancer of polycomb homolog 1 (Drosophila) 0.046
Ctbp2 C-terminal binding protein 2 0.045
Rest RE1-silencing transcription factor 0.045
Cenpe centromere protein E 0.045
Ghr growth hormone receptor 0.045
Pum2 pumilio 2 (Drosophila) 0.044
Foxp1 forkhead box P1 0.044
Mga MAX gene associated 0.043
Kdm3a lysine (K)-specific demethylase 3A 0.043
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.042
Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked 0.042
Rara retinoic acid receptor, alpha 0.042
Foxo3 forkhead box O3 0.042
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism