The network for 'chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HHT1 Hht1p 0.999
SIR2 Sir2p 0.998
SIN3 Sin3p 0.996
RPD3 Rpd3p 0.996
SIR4 Sir4p 0.993
RLF2 Rlf2p 0.990
HHF1 Hhf1p 0.987
SET1 Set1p 0.972
ORC2 Orc2p 0.970
RXT2 Rxt2p 0.961
RCO1 Rco1p 0.951
MMS22 Mms22p 0.939
RAP1 Rap1p 0.926
HDA1 Hda1p 0.926
SET3 Set3p 0.910
ORC5 Orc5p 0.900
SAS2 Sas2p 0.894
HAT1 Hat1p 0.883
SDS3 Sds3p 0.875
SNT1 Snt1p 0.872
ORC1 Orc1p 0.839
SPT10 Spt10p 0.832
BDF1 Bdf1p 0.830
HMO1 Hmo1p 0.829
SWD3 Swd3p 0.819
SIR3 Sir3p 0.804
CTI6 Cti6p 0.787
SET2 Set2p 0.777
HOS4 Hos4p 0.772
NET1 Net1p 0.768
ARP4 Arp4p 0.750
SDC1 Sdc1p 0.750
ORC6 Orc6p 0.733
CHL1 Chl1p 0.720
HHO1 Hho1p 0.714
NUP133 Nup133p 0.709
YTA7 Yta7p 0.702
FKH1 Fkh1p 0.673
FOB1 Fob1p 0.668
CHD1 Chd1p 0.667
UME1 Ume1p 0.659
RIF1 Rif1p 0.658
ISW1 Isw1p 0.621
SUM1 Sum1p 0.618
CDC6 Cdc6p 0.606
STH1 Sth1p 0.591
UBP8 Ubp8p 0.590
RSC2 Rsc2p 0.589
RTT106 Rtt106p 0.584
DEF1 Def1p 0.583
MCM3 Mcm3p 0.559
IFH1 Ifh1p 0.557
CTF18 Ctf18p 0.551
TAF14 Taf14p 0.550
FHL1 Fhl1p 0.543
ASF1 Asf1p 0.540
ORC3 Orc3p 0.527
ITC1 Itc1p 0.524
HOS2 Hos2p 0.522
ISW2 Isw2p 0.522
BRE1 Bre1p 0.486
PHO23 Pho23p 0.484
BRE2 Bre2p 0.474
NUP120 Nup120p 0.473
HHT2 Hht2p 0.463
SAS5 Sas5p 0.460
HST1 Hst1p 0.458
SPP1 Spp1p 0.453
SAS4 Sas4p 0.441
HST3 Hst3p 0.438
SIC1 Sic1p 0.437
FUN30 Fun30p 0.435
ZDS1 Zds1p 0.420
CPR1 Cpr1p 0.419
GCN5 Gcn5p 0.419
HDA3 Hda3p 0.416
SPT21 Spt21p 0.415
SWD1 Swd1p 0.405
MIG2 Mig2p 0.387
RAD9 Rad9p 0.385
GLC7 Glc7p 0.382
CKA1 Cka1p 0.381
CTK1 Ctk1p 0.381
SAP30 Sap30p 0.376
VPS27 Vps27p 0.373
ORC4 Orc4p 0.372
HAT2 Hat2p 0.361
PAP2 Pap2p 0.354
RSC8 Rsc8p 0.352
RAD17 Rad17p 0.344
NGG1 Ngg1p 0.343
NTO1 Nto1p 0.341
RFM1 Rfm1p 0.340
RVB2 Rvb2p 0.335
MIG3 Mig3p 0.330
MCM6 Mcm6p 0.329
LYS5 Lys5p 0.317
HOS3 Hos3p 0.309
MRS6 Mrs6p 0.300
SGF29 Sgf29p 0.291
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CTCF CG8591 gene product from transcript CG8591-RA 1.000
His2Av Histone H2A variant 0.999
E(var)3-9 Enhancer of variegation 3-9 0.998
Su(var)3-7 Suppressor of variegation 3-7 0.997
egg eggless 0.995
Su(var)205 Suppressor of variegation 205 0.995
ash1 absent, small, or homeotic discs 1 0.994
Sir2 CG5216 gene product from transcript CG5216-RA 0.992
Pc Polycomb 0.991
pr-set7 CG3307 gene product from transcript CG3307-RC 0.990
gpp grappa 0.988
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.988
Scm Sex comb on midleg 0.986
Pp1-87B Protein phosphatase 1 at 87B 0.979
D1 D1 chromosomal protein 0.972
Snr1 Snf5-related 1 0.970
Acf1 ATP-dependent chromatin assembly factor large subunit 0.967
Dp1 Dodeca-satellite-binding protein 1 0.956
esc extra sexcombs 0.937
Rpd3 CG7471 gene product from transcript CG7471-RA 0.935
Iswi Imitation SWI 0.933
trx trithorax 0.912
BRWD3 CG31132 gene product from transcript CG31132-RA 0.907
BEAF-32 Boundary element-associated factor of 32kD 0.901
crm cramped 0.900
Jarid2 CG3654 gene product from transcript CG3654-RD 0.884
r2d2 CG7138 gene product from transcript CG7138-RB 0.878
E(z) Enhancer of zeste 0.878
mod(mdg4) modifier of mdg4 0.876
XNP CG4548 gene product from transcript CG4548-RA 0.816
HmgD High mobility group protein D 0.815
G9a CG2995 gene product from transcript CG2995-RA 0.812
SMC1 CG6057 gene product from transcript CG6057-RA 0.790
SuUR Suppressor of Under-Replication 0.780
RecQ4 CG7487 gene product from transcript CG7487-RA 0.773
e(y)3 enhancer of yellow 3 0.765
cg combgap 0.724
Pcl Polycomblike 0.692
lid little imaginal discs 0.670
Parp Poly-(ADP-ribose) polymerase 0.616
SMC2 CG10212 gene product from transcript CG10212-RA 0.597
Rga Regena 0.581
Hel25E Helicase at 25E 0.579
JIL-1 CG6297 gene product from transcript CG6297-RA 0.576
trr trithorax-related 0.568
Pli Pellino 0.544
Rac1 CG2248 gene product from transcript CG2248-RA 0.543
Su(var)2-10 Suppressor of variegation 2-10 0.524
sxc super sex combs 0.516
MRG15 CG6363 gene product from transcript CG6363-RA 0.471
mus209 mutagen-sensitive 209 0.467
p53 CG33336 gene product from transcript CG33336-RB 0.464
not non-stop 0.451
Psc Posterior sex combs 0.441
CG8165 CG8165 gene product from transcript CG8165-RA 0.434
Mt2 Methyltransferase 2 0.414
barr barren 0.380
mof males absent on the first 0.366
eff effete 0.347
vas vasa 0.344
HP4 Heterochromatin protein 4 0.326
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.320
rin rasputin 0.315
ph-p polyhomeotic proximal 0.300
CG3363 CG3363 gene product from transcript CG3363-RB 0.297
smt3 CG4494 gene product from transcript CG4494-RA 0.289
stau staufen 0.284
Moe Moesin 0.274
chm chameau 0.274
Trn Transportin 0.260
mor moira 0.255
Suv4-20 CG13363 gene product from transcript CG13363-RA 0.246
Chd1 Chromodomain-helicase-DNA-binding protein 1 0.235
CG5899 CG5899 gene product from transcript CG5899-RA 0.234
pho pleiohomeotic 0.232
Chro Chromator 0.232
wapl wings apart-like 0.230
Trl Trithorax-like 0.228
Rho1 CG8416 gene product from transcript CG8416-RB 0.211
glu gluon 0.211
lolal lola like 0.209
B52 CG10851 gene product from transcript CG10851-RB 0.208
CG5720 CG5720 gene product from transcript CG5720-RA 0.206
msl-2 male-specific lethal 2 0.198
how held out wings 0.197
Mi-2 CG8103 gene product from transcript CG8103-RA 0.196
MBD-like CG8208 gene product from transcript CG8208-RA 0.196
ari-2 ariadne 2 0.191
Ravus CG15889 gene product from transcript CG15889-RA 0.190
dlt discs lost 0.187
Su(var)3-3 Suppressor of variegation 3-3 0.183
CG3078 CG3078 gene product from transcript CG3078-RA 0.181
east enhanced adult sensory threshold 0.179
Sep2 Septin-2 0.178
lwr lesswright 0.176
w white 0.174
pasha partner of drosha 0.172
crp cropped 0.168
Alh Alhambra 0.165
CG10630 CG10630 gene product from transcript CG10630-RA 0.162
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 1.000
HDAC2 histone deacetylase 2 0.996
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.995
RB1 retinoblastoma 1 0.984
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.970
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.950
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.916
TP53 tumor protein p53 0.844
EED embryonic ectoderm development 0.822
PARP1 poly (ADP-ribose) polymerase 1 0.786
RBBP4 retinoblastoma binding protein 4 0.773
MCM7 minichromosome maintenance complex component 7 0.756
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.665
WDR5 WD repeat domain 5 0.619
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.549
BMI1 BMI1 polycomb ring finger oncogene 0.542
H2AFX H2A histone family, member X 0.514
ACTL6A actin-like 6A 0.498
PCNA proliferating cell nuclear antigen 0.497
MCM5 minichromosome maintenance complex component 5 0.488
ESR1 estrogen receptor 1 0.486
CBX5 chromobox homolog 5 0.483
EP300 E1A binding protein p300 0.475
HIST1H3B histone cluster 1, H3b 0.469
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.446
HCFC1 host cell factor C1 (VP16-accessory protein) 0.414
CHD4 chromodomain helicase DNA binding protein 4 0.410
SIRT1 sirtuin 1 0.408
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.380
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.380
BRCA1 breast cancer 1, early onset 0.360
CREBBP CREB binding protein 0.354
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.353
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.338
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.317
SP1 Sp1 transcription factor 0.300
RUVBL1 RuvB-like 1 (E. coli) 0.298
MCM2 minichromosome maintenance complex component 2 0.262
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.242
NBN nibrin 0.216
MCM6 minichromosome maintenance complex component 6 0.201
MCM3 minichromosome maintenance complex component 3 0.194
TMPO thymopoietin 0.191
DAXX death-domain associated protein 0.186
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.176
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.164
HIST1H3D histone cluster 1, H3d 0.156
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.155
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.152
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.145
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.132
THOC4 THO complex 4 0.132
HIST1H2BG histone cluster 1, H2bg 0.131
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.128
HDAC3 histone deacetylase 3 0.125
HIST1H2AE histone cluster 1, H2ae 0.123
KDM1A lysine (K)-specific demethylase 1A 0.117
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.113
BCOR BCL6 corepressor 0.107
TRIM28 tripartite motif containing 28 0.105
SSRP1 structure specific recognition protein 1 0.096
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.093
MRFAP1 Morf4 family associated protein 1 0.090
MTA1 metastasis associated 1 0.089
MSH6 mutS homolog 6 (E. coli) 0.087
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.083
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.070
SAP30 Sin3A-associated protein, 30kDa 0.069
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.068
HIST2H3C histone cluster 2, H3c 0.068
NCOR2 nuclear receptor corepressor 2 0.067
HIST1H2AM histone cluster 1, H2am 0.066
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.063
TOP2B topoisomerase (DNA) II beta 180kDa 0.056
MYST1 MYST histone acetyltransferase 1 0.054
HIST1H3A histone cluster 1, H3a 0.054
USP11 ubiquitin specific peptidase 11 0.053
HIST1H4H histone cluster 1, H4h 0.049
HIST1H2AI histone cluster 1, H2ai 0.049
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.047
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.047
HIST1H4B histone cluster 1, H4b 0.046
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.046
DICER1 dicer 1, ribonuclease type III 0.044
E2F3 E2F transcription factor 3 0.043
NCAPH non-SMC condensin I complex, subunit H 0.043
HIST1H4D histone cluster 1, H4d 0.043
NCOR1 nuclear receptor corepressor 1 0.041
HDGF hepatoma-derived growth factor 0.041
MEN1 multiple endocrine neoplasia I 0.040
CBX8 chromobox homolog 8 0.040
TFDP1 transcription factor Dp-1 0.039
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.038
ORC3 origin recognition complex, subunit 3 0.038
SMAD3 SMAD family member 3 0.037
SETD7 SET domain containing (lysine methyltransferase) 7 0.037
GATAD2A GATA zinc finger domain containing 2A 0.037
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.037
HIST1H2AL histone cluster 1, H2al 0.036
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.036
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Mus musculus
Name Description Probability Func Analog Organism
Rnf2 ring finger protein 2 0.999
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.992
Hdac1 histone deacetylase 1 0.983
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.979
Pou5f1 POU domain, class 5, transcription factor 1 0.961
Nanog Nanog homeobox 0.941
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.924
Arid1b AT rich interactive domain 1B (SWI-like) 0.903
Rybp RING1 and YY1 binding protein 0.896
Ctcf CCCTC-binding factor 0.852
Hdac2 histone deacetylase 2 0.791
Dnmt3a DNA methyltransferase 3A 0.764
Wdr5 WD repeat domain 5 0.747
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.701
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.681
Dnmt3b DNA methyltransferase 3B 0.632
Pcgf2 polycomb group ring finger 2 0.629
Trp53 transformation related protein 53 0.613
H3f3a H3 histone, family 3A 0.553
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.547
Rbbp4 retinoblastoma binding protein 4 0.478
Bmi1 Bmi1 polycomb ring finger oncogene 0.462
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.443
Mta2 metastasis-associated gene family, member 2 0.400
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.380
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.349
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.336
Kdm2b lysine (K)-specific demethylase 2B 0.330
Nipbl Nipped-B homolog (Drosophila) 0.322
Trim28 tripartite motif-containing 28 0.322
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.320
Chd4 chromodomain helicase DNA binding protein 4 0.318
Ep400 E1A binding protein p400 0.312
Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.297
Smc1a structural maintenance of chromosomes 1A 0.275
Crebbp CREB binding protein 0.266
Mta1 metastasis associated 1 0.258
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.252
Ep300 E1A binding protein p300 0.238
Phc2 polyhomeotic-like 2 (Drosophila) 0.231
Brca1 breast cancer 1 0.227
Mecp2 methyl CpG binding protein 2 0.219
Rb1 retinoblastoma 1 0.216
Brca2 breast cancer 2 0.210
Smc3 structural maintenace of chromosomes 3 0.209
Sin3a transcriptional regulator, SIN3A (yeast) 0.202
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.200
E2f1 E2F transcription factor 1 0.198
Sall4 sal-like 4 (Drosophila) 0.198
Bptf bromodomain PHD finger transcription factor 0.195
Matr3 matrin 3 0.188
Hist1h3g histone cluster 1, H3g 0.176
Arid1a AT rich interactive domain 1A (SWI-like) 0.171
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.162
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.158
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.154
Lmnb1 lamin B1 0.144
Rbbp7 retinoblastoma binding protein 7 0.133
Hmgb1 high mobility group box 1 0.129
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.127
Sp1 trans-acting transcription factor 1 0.125
Stag1 stromal antigen 1 0.122
Sp4 trans-acting transcription factor 4 0.122
Trim24 tripartite motif-containing 24 0.106
Rbl2 retinoblastoma-like 2 0.105
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.105
Tcfcp2l1 transcription factor CP2-like 1 0.100
Parp1 poly (ADP-ribose) polymerase family, member 1 0.099
Dnmt3l DNA (cytosine-5-)-methyltransferase 3-like 0.095
Mga MAX gene associated 0.094
Cdk4 cyclin-dependent kinase 4 0.091
L3mbtl2 l(3)mbt-like 2 (Drosophila) 0.090
Brd4 bromodomain containing 4 0.088
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.084
Men1 multiple endocrine neoplasia 1 0.081
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.079
Scaf11 SR-related CTD-associated factor 11 0.076
Nup85 nucleoporin 85 0.073
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.070
Mbtd1 mbt domain containing 1 0.069
Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.067
Usp9x ubiquitin specific peptidase 9, X chromosome 0.065
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.064
Rfc5 replication factor C (activator 1) 5 0.063
Erbb2ip Erbb2 interacting protein 0.062
Csnk1a1 casein kinase 1, alpha 1 0.061
Mdm4 transformed mouse 3T3 cell double minute 4 0.061
Msh2 mutS homolog 2 (E. coli) 0.060
Tcf3 transcription factor 3 0.059
Ran RAN, member RAS oncogene family 0.058
Zmym5 zinc finger, MYM-type 5 0.058
Rpa2 replication protein A2 0.057
Ccna2 cyclin A2 0.057
Zfp292 zinc finger protein 292 0.056
Eed embryonic ectoderm development 0.056
Jarid2 jumonji, AT rich interactive domain 2 0.052
Hells helicase, lymphoid specific 0.051
Rcc2 regulator of chromosome condensation 2 0.050
Cdk2 cyclin-dependent kinase 2 0.049
Rrm1 ribonucleotide reductase M1 0.049
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Rattus norvegicus
Name Description Probability Func Analog Organism