The network for 'protein localization to vacuole' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein localization to vacuole

A process in which a protein is transported to, or maintained at, a location in a vacuole.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VPS28 Vps28p 0.999
VPS21 Vps21p 0.998
VPS36 Vps36p 0.992
ATG7 Atg7p 0.988
ATG9 Atg9p 0.981
COG6 Cog6p 0.981
APL5 Apl5p 0.971
COG8 Cog8p 0.971
VPS35 Vps35p 0.964
VPS41 Vps41p 0.953
COG5 Cog5p 0.938
ATG3 Atg3p 0.933
SNX4 Snx4p 0.922
YPT6 Ypt6p 0.905
SRN2 Srn2p 0.894
BRO1 Bro1p 0.865
VPS3 Vps3p 0.857
ATG4 Atg4p 0.842
COG3 Cog3p 0.842
ATG11 Atg11p 0.816
ATG12 Atg12p 0.815
COG7 Cog7p 0.810
ATG21 Atg21p 0.803
APL6 Apl6p 0.788
LSB3 Lsb3p 0.783
VPS20 Vps20p 0.775
VPS17 Vps17p 0.743
PEP5 Pep5p 0.733
COG1 Cog1p 0.720
ATG23 Atg23p 0.716
COG4 Cog4p 0.712
ATG20 Atg20p 0.703
VTI1 Vti1p 0.684
ATG16 Atg16p 0.673
VPS16 Vps16p 0.630
VPS30 Vps30p 0.618
ATG8 Atg8p 0.614
VPS4 Vps4p 0.614
YPT52 Ypt52p 0.611
TRS85 Trs85p 0.594
ATG5 Atg5p 0.579
APM3 Apm3p 0.563
ATG1 Atg1p 0.563
RIC1 Ric1p 0.499
BBC1 Bbc1p 0.488
DID4 Did4p 0.471
ATG13 Atg13p 0.442
PEP3 Pep3p 0.436
TLG2 Tlg2p 0.429
SYS1 Sys1p 0.422
ATG10 Atg10p 0.416
RGP1 Rgp1p 0.416
ATG29 Atg29p 0.413
ATG14 Atg14p 0.404
VAM6 Vam6p 0.390
ATG26 Atg26p 0.387
BZZ1 Bzz1p 0.382
YIP4 Yip4p 0.373
BSD2 Bsd2p 0.362
PEP1 Pep1p 0.315
VAM7 Vam7p 0.299
SNF8 Snf8p 0.297
GYL1 Gyl1p 0.297
VPS5 Vps5p 0.277
MON1 Mon1p 0.276
VPS52 Vps52p 0.255
SEC4 Sec4p 0.252
VMA16 Vma16p 0.243
ASI1 Asi1p 0.240
PEP8 Pep8p 0.232
APS3 Aps3p 0.222
PIN3 Pin3p 0.215
CSR2 Csr2p 0.214
APM2 Apm2p 0.213
ECM21 Ecm21p 0.211
TRE1 Tre1p 0.211
YPT10 Ypt10p 0.206
VPS9 Vps9p 0.205
COG2 Cog2p 0.204
VMA8 Vma8p 0.202
GET1 Get1p 0.196
VPS45 Vps45p 0.183
GDI1 Gdi1p 0.176
HSV2 Hsv2p 0.173
YPT53 Ypt53p 0.168
VPS15 Vps15p 0.168
VPS53 Vps53p 0.167
BPT1 Bpt1p 0.166
CIS1 Cis1p 0.155
KTR4 Ktr4p 0.150
YPT7 Ypt7p 0.147
ATG17 Atg17p 0.147
SLG1 Slg1p 0.145
VPS33 Vps33p 0.143
YBR056W hypothetical protein 0.142
CCZ1 Ccz1p 0.142
VPH2 Vph2p 0.142
EMP47 Emp47p 0.140
YLR211C hypothetical protein 0.139
MON2 Mon2p 0.136
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
paqr8 progestin and adipoQ receptor family member VIII 0.224
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.123
rab5aa RAB5A, member RAS oncogene family, a 0.120
vps26bl vacuolar protein sorting 26 homolog B, like 0.070
rspo1 R-spondin homolog (Xenopus laevis) 0.039
inha inhibin, alpha 0.036
arid4a AT rich interactive domain 4A (RBP1-like) 0.035
clcn7 chloride channel 7 0.034
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.033
zgc:77849 zgc:77849 0.032
gdf9 growth differentiation factor 9 0.030
zgc:56010 zgc:56010 0.026
mxd4 MAX dimerization protein 4 0.025
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.025
wipi1 WD repeat domain, phosphoinositide interacting 1 0.024
zgc:123180 zgc:123180 0.024
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.022
cltca clathrin, heavy polypeptide a (Hc) 0.021
ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.021
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.020
rab5c RAB5C, member RAS oncogene family 0.020
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.020
tmem30a transmembrane protein 30A 0.018
jak1 Janus kinase 1 0.018
si:dkey-220f10.6 si:dkey-220f10.6 0.018
inhbab inhibin, beta Ab 0.017
ccdc40 coiled-coil domain containing 40 0.017
cldn2 claudin 2 0.017
stambpa STAM binding protein a 0.017
tmem50a transmembrane protein 50A 0.016
atp6v1f ATPase, H+ transporting, V1 subunit F 0.016
im:7164961 im:7164961 0.016
pfn2 profilin 2 0.015
cratb carnitine O-acetyltransferase b 0.015
zgc:73134 zgc:73134 0.015
cyba cytochrome b-245, alpha polypeptide 0.015
me3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.015
asb8 ankyrin repeat and SOCS box-containing 8 0.015
ndrg3b N-myc downstream regulated family member 3b 0.015
chmp4b chromatin modifying protein 4B 0.015
wdr8 WD repeat domain 8 0.015
zgc:175140 zgc:175140 0.014
stk17b serine/threonine kinase 17b (apoptosis-inducing) 0.014
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.014
zgc:112084 zgc:112084 0.014
sc:d411 sc:d411 0.014
uap1l1 UDP-N-acteylglucosamine pyrophosphorylase 1, like 1 0.014
syap1 synapse associated protein 1 0.014
zgc:152900 zgc:152900 0.014
sbf1 SET binding factor 1 0.014
brap BRCA1 associated protein 0.014
atf4b2 activating transcription factor 4b2 0.014
zgc:152984 zgc:152984 0.014
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.013
ttll6 tubulin tyrosine ligase-like family, member 6 0.013
csrnp1a cysteine-serine-rich nuclear protein 1a 0.013
zgc:55573 zgc:55573 0.013
nap1l4b nucleosome assembly protein 1-like 4b 0.013
plekha3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.013
apg3l APG3 autophagy 3-like 0.013
cldn1 claudin 1 0.013
dtnbp1a dystrobrevin binding protein 1a 0.013
cul1b cullin 1b 0.013
ift122 intraflagellar transport 122 homolog (Chlamydomonas) 0.013
aldh2b aldehyde dehydrogenase 2b 0.013
zgc:56049 zgc:56049 0.012
igf2r insulin-like growth factor 2 receptor 0.012
zgc:92217 zgc:92217 0.012
selt2 selenoprotein T, 2 0.012
serinc5 serine incorporator 5 0.012
cldn8 claudin 8 0.012
tax1bp1b Tax1 (human T-cell leukemia virus type I) binding protein 1b 0.012
zgc:103658 zgc:103658 0.012
ctsz cathepsin Z 0.012
brms1 breast cancer metastasis-suppressor 1 0.012
im:7138016 im:7138016 0.012
laptm4a lysosomal-associated protein transmembrane 4 alpha 0.012
zgc:162698 zgc:162698 0.012
wdfy1 WD repeat and FYVE domain containing 1 0.011
rab7 RAB7, member RAS oncogene family 0.011
tmem198b transmembrane protein 198b 0.011
ivns1abpa influenza virus NS1A binding protein a 0.011
pdcd6ip programmed cell death 6 interacting protein 0.011
capza1b capping protein (actin filament) muscle Z-line, alpha 1b 0.011
capza1a capping protein (actin filament) muscle Z-line, alpha 1a 0.011
gabarapa GABA(A) receptor-associated protein a 0.011
mtmr6 myotubularin related protein 6 0.011
exoc7 exocyst complex component 7 0.011
pik3c3 phosphoinositide-3-kinase, class 3 0.011
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.011
igf3 insulin-like growth factor 3 0.011
slc30a5 solute carrier family 30 (zinc transporter), member 5 0.011
si:ch211-184m19.1 si:ch211-184m19.1 0.011
cpne1 copine I 0.011
klhl11 kelch-like 11 (Drosophila) 0.011
mettl11a methyltransferase like 11A 0.011
ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 0.010
tmem9b TMEM9 domain family, member B 0.010
letm1 leucine zipper-EF-hand containing transmembrane protein 1 0.010
zgc:172136 zgc:172136 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.842
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.766
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.360
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.259
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.191
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.180
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.137
SORT1 sortilin 1 0.094
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.093
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.083
GABARAP GABA(A) receptor-associated protein 0.082
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.079
EEA1 early endosome antigen 1 0.066
DNM2 dynamin 2 0.062
PDCD6IP programmed cell death 6 interacting protein 0.061
ANKRD13A ankyrin repeat domain 13A 0.056
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.051
LRRK2 leucine-rich repeat kinase 2 0.049
SQSTM1 sequestosome 1 0.048
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.046
SYNRG synergin, gamma 0.044
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.043
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.038
CHMP4B chromatin modifying protein 4B 0.034
ELL elongation factor RNA polymerase II 0.032
ZFYVE9 zinc finger, FYVE domain containing 9 0.031
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.029
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.025
IGF2R insulin-like growth factor 2 receptor 0.025
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.025
COG7 component of oligomeric golgi complex 7 0.022
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.020
FBXL15 F-box and leucine-rich repeat protein 15 0.020
RAB22A RAB22A, member RAS oncogene family 0.020
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.019
NBR1 neighbor of BRCA1 gene 1 0.019
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.018
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.016
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.015
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.015
TMED2 transmembrane emp24 domain trafficking protein 2 0.015
RAB1A RAB1A, member RAS oncogene family 0.015
OCRL oculocerebrorenal syndrome of Lowe 0.015
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.015
SMAD4 SMAD family member 4 0.014
RHOA ras homolog gene family, member A 0.013
CALCOCO2 calcium binding and coiled-coil domain 2 0.013
ATG10 ATG10 autophagy related 10 homolog (S. cerevisiae) 0.013
SH3GL2 SH3-domain GRB2-like 2 0.012
SEPT2 septin 2 0.012
ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 0.012
CIZ1 CDKN1A interacting zinc finger protein 1 0.012
SCFD1 sec1 family domain containing 1 0.011
CANX calnexin 0.011
RABIF RAB interacting factor 0.011
COG1 component of oligomeric golgi complex 1 0.011
CAPRIN2 caprin family member 2 0.011
SNX9 sorting nexin 9 0.011
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.011
CTTN cortactin 0.010
RAB6A RAB6A, member RAS oncogene family 0.010
ZRANB1 zinc finger, RAN-binding domain containing 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Atg12 autophagy-related 12 (yeast) 0.316
Rnf11 ring finger protein 11 0.249
Gsk3b glycogen synthase kinase 3 beta 0.231
Ar androgen receptor 0.159
Stx7 syntaxin 7 0.148
Rnf103 ring finger protein 103 0.116
Grb10 growth factor receptor bound protein 10 0.102
Chmp1b chromatin modifying protein 1B 0.096
Kiss1r KISS1 receptor 0.095
8430410K20Rik RIKEN cDNA 8430410K20 gene 0.094
Pldn pallidin 0.089
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.089
Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.086
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.084
Ndfip1 Nedd4 family interacting protein 1 0.076
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.075
Lyst lysosomal trafficking regulator 0.067
Rab18 RAB18, member RAS oncogene family 0.065
Axin1 axin 1 0.055
Hps1 Hermansky-Pudlak syndrome 1 homolog (human) 0.055
Dmxl1 Dmx-like 1 0.051
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.049
Traf6 TNF receptor-associated factor 6 0.049
Ctnnb1 catenin (cadherin associated protein), beta 1 0.048
Rragc Ras-related GTP binding C 0.048
Fgfr2 fibroblast growth factor receptor 2 0.045
Ap3d1 adaptor-related protein complex 3, delta 1 subunit 0.045
Lamp2 lysosomal-associated membrane protein 2 0.044
Ghr growth hormone receptor 0.043
Rab27a RAB27A, member RAS oncogene family 0.042
Rnf115 ring finger protein 115 0.041
Tbx3 T-box 3 0.039
Chm choroidermia 0.039
Lrrk2 leucine-rich repeat kinase 2 0.038
Bglap bone gamma carboxyglutamate protein 0.038
Mesdc2 mesoderm development candidate 2 0.037
Pofut1 protein O-fucosyltransferase 1 0.036
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.036
Dram2 VDNA-damage regulated autophagy modulator 2 0.035
Epn1 epsin 1 0.034
Prrg2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 0.034
Rbbp9 retinoblastoma binding protein 9 0.033
C78339 expressed sequence C78339 0.033
Hps5 Hermansky-Pudlak syndrome 5 homolog (human) 0.032
Atg7 autophagy-related 7 (yeast) 0.032
Rap1b RAS related protein 1b 0.032
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.031
Wls wntless homolog (Drosophila) 0.031
Sec23a SEC23A (S. cerevisiae) 0.031
Pdcl phosducin-like 0.030
Crtc3 CREB regulated transcription coactivator 3 0.029
Pgrmc1 progesterone receptor membrane component 1 0.029
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.029
Samd4b sterile alpha motif domain containing 4B 0.029
Rab33b RAB33B, member of RAS oncogene family 0.028
Mfsd1 major facilitator superfamily domain containing 1 0.028
Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 0.028
Inha inhibin alpha 0.027
Lrp5 low density lipoprotein receptor-related protein 5 0.027
Syap1 synapse associated protein 1 0.027
T brachyury 0.027
Esr1 estrogen receptor 1 (alpha) 0.027
Mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.026
Pi4kb phosphatidylinositol 4-kinase, catalytic, beta polypeptide 0.026
Dpy19l4 dpy-19-like 4 (C. elegans) 0.025
Fam18b family with sequence similarity 18, member B 0.025
D19Wsu162e DNA segment, Chr 19, Wayne State University 162, expressed 0.024
Mitf microphthalmia-associated transcription factor 0.024
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.024
Kdelr1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.024
Asah1 N-acylsphingosine amidohydrolase 1 0.024
Star steroidogenic acute regulatory protein 0.024
Hdlbp high density lipoprotein (HDL) binding protein 0.024
Pls3 plastin 3 (T-isoform) 0.023
Cxcr2 chemokine (C-X-C motif) receptor 2 0.023
Wbp2 WW domain binding protein 2 0.023
Atg5 autophagy-related 5 (yeast) 0.023
Cltc clathrin, heavy polypeptide (Hc) 0.023
Blnk B-cell linker 0.023
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) 0.023
Hps6 Hermansky-Pudlak syndrome 6 0.023
Sdcbp syndecan binding protein 0.023
Nr1h3 nuclear receptor subfamily 1, group H, member 3 0.022
Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.022
Map2k1 mitogen-activated protein kinase kinase 1 0.022
Osbpl11 oxysterol binding protein-like 11 0.022
Sacm1l SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae) 0.022
Sertad2 SERTA domain containing 2 0.022
Prrx2 paired related homeobox 2 0.022
Mospd2 motile sperm domain containing 2 0.022
Secisbp2l SECIS binding protein 2-like 0.021
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.021
Chmp5 chromatin modifying protein 5 0.021
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.021
Pmepa1 prostate transmembrane protein, androgen induced 1 0.020
3110043O21Rik RIKEN cDNA 3110043O21 gene 0.020
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.020
Copa coatomer protein complex subunit alpha 0.020
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.020
Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism