Mus musculus

362 known processes

Hey2

hairy/enhancer-of-split related with YRPW motif 2

(Aliases: Hrt2,Herp1,CHF1,hesr2,bHLHb32)

Hey2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.999
pulmonary valve development GO:0003177 5 0.999
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.999
regulation of cardiac muscle tissue development GO:0055024 31 0.999
ventricular septum development GO:0003281 42 0.998
mitral valve morphogenesis GO:0003183 4 0.998
activation of mapk activity involved in innate immune response GO:0035419 2 0.997
endocardial cushion to mesenchymal transition GO:0090500 5 0.997
aortic valve morphogenesis GO:0003180 4 0.996
cardioblast migration GO:0003260 1 0.995
pulmonary valve morphogenesis GO:0003184 5 0.995
heart valve development GO:0003170 23 0.995
stem cell development GO:0048864 219 0.993
tricuspid valve development GO:0003175 3 0.987
atrioventricular valve morphogenesis GO:0003181 13 0.987
regulation of rac protein signal transduction GO:0035020 19 0.983
rac protein signal transduction GO:0016601 13 0.979
ventricular septum morphogenesis GO:0060412 27 0.975
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.975
mesenchyme development GO:0060485 152 0.974
tricuspid valve morphogenesis GO:0003186 2 0.971
notochord formation GO:0014028 5 0.967
axon target recognition GO:0007412 4 0.965
muscle adaptation GO:0043500 39 0.962
cardiocyte differentiation GO:0035051 87 0.957
cardiac epithelial to mesenchymal transition GO:0060317 18 0.953
heart valve formation GO:0003188 10 0.950
mitral valve development GO:0003174 4 0.949
axon guidance GO:0007411 141 0.944
extracellular matrix dependent thymocyte migration GO:0072680 1 0.938
cardiac septum morphogenesis GO:0060411 46 0.935
mesenchymal cell development GO:0014031 93 0.933
cell migration to the midline involved in heart development GO:0003318 1 0.930
regulation of heart contraction GO:0008016 77 0.924
clara cell differentiation GO:0060486 4 0.918
regulation of cell adhesion mediated by integrin GO:0033628 13 0.903
heart trabecula formation GO:0060347 14 0.902
positive regulation of cardiac muscle tissue development GO:0055025 19 0.900
heart growth GO:0060419 45 0.900
regulation of dendritic spine morphogenesis GO:0061001 17 0.889
cardiac muscle cell differentiation GO:0055007 69 0.888
atrial septum development GO:0003283 12 0.885
regionalization GO:0003002 337 0.879
atrioventricular valve formation GO:0003190 5 0.864
regulation of rho gtpase activity GO:0032319 58 0.852
atrial septum primum morphogenesis GO:0003289 3 0.846
cardiac atrium development GO:0003230 24 0.840
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.831
dendritic spine development GO:0060996 30 0.828
skeletal muscle organ development GO:0060538 163 0.812
Mouse
heart morphogenesis GO:0003007 178 0.809
atrial septum morphogenesis GO:0060413 11 0.807
epithelial to mesenchymal transition GO:0001837 47 0.801
cardiac muscle tissue morphogenesis GO:0055008 44 0.793
positive regulation of heart growth GO:0060421 18 0.793
positive regulation of thymocyte migration GO:2000412 2 0.791
epithelial cell development GO:0002064 159 0.790
regulation of rac gtpase activity GO:0032314 13 0.786
embryonic heart tube left right pattern formation GO:0060971 5 0.785
ventricular cardiac muscle cell action potential GO:0086005 4 0.783
transcriptional activation by promoter enhancer looping GO:0071733 2 0.782
striated muscle tissue development GO:0014706 293 0.781
pulmonary artery morphogenesis GO:0061156 3 0.776
cell migration involved in heart formation GO:0060974 1 0.768
circulatory system process GO:0003013 197 0.768
negative regulation of cardiac muscle cell apoptotic process GO:0010667 6 0.767
regulation of auditory receptor cell differentiation GO:0045607 4 0.763
positive regulation of cardioblast differentiation GO:0051891 3 0.763
cardiac septum development GO:0003279 59 0.760
cell adhesion mediated by integrin GO:0033627 18 0.752
dorsal aorta morphogenesis GO:0035912 5 0.751
cell recognition GO:0008037 83 0.737
epithelial tube morphogenesis GO:0060562 303 0.726
Mouse
fibronectin dependent thymocyte migration GO:0072681 1 0.725
regulation of dendritic spine development GO:0060998 22 0.721
embryonic organ morphogenesis GO:0048562 276 0.719
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.714
cardiac cell fate determination GO:0060913 2 0.709
regulation of cardiac muscle tissue growth GO:0055021 26 0.708
atrioventricular valve development GO:0003171 15 0.707
leukocyte differentiation GO:0002521 342 0.697
stem cell differentiation GO:0048863 268 0.693
eosinophil migration GO:0072677 3 0.689
heart valve morphogenesis GO:0003179 21 0.681
regulation of eosinophil migration GO:2000416 2 0.679
endocardial cushion development GO:0003197 26 0.667
Mouse
single organismal cell cell adhesion GO:0016337 131 0.662
aorta morphogenesis GO:0035909 22 0.660
striated muscle cell apoptotic process GO:0010658 12 0.660
endocardial cushion formation GO:0003272 13 0.647
Mouse
cardiac left ventricle morphogenesis GO:0003214 9 0.646
gene looping GO:0090202 2 0.643
heart process GO:0003015 94 0.639
epithelial cell migration GO:0010631 63 0.631
pyramidal neuron migration GO:0021852 1 0.627
regulation of epithelial to mesenchymal transition GO:0010717 22 0.625
regulation of gliogenesis GO:0014013 50 0.620
heart contraction GO:0060047 93 0.614
cardiac chamber morphogenesis GO:0003206 93 0.613
av node cell to bundle of his cell communication GO:0086067 2 0.608
axonogenesis GO:0007409 274 0.607
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.603
Mouse
blood vessel endothelial cell migration GO:0043534 23 0.600
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.599
ear development GO:0043583 200 0.596
cellular response to growth factor stimulus GO:0071363 197 0.592
Mouse
mechanoreceptor differentiation GO:0042490 67 0.589
dendrite extension GO:0097484 3 0.583
cardiac right ventricle formation GO:0003219 3 0.579
aortic valve development GO:0003176 5 0.577
coronary vasculature development GO:0060976 12 0.576
negative regulation of cell development GO:0010721 169 0.575
Mouse
coronary vasculature morphogenesis GO:0060977 9 0.572
bundle of his development GO:0003166 4 0.566
s shaped body morphogenesis GO:0072050 6 0.561
Mouse
negative regulation of striated muscle cell apoptotic process GO:0010664 8 0.557
retinal ganglion cell axon guidance GO:0031290 18 0.550
dendritic spine organization GO:0097061 26 0.550
regulation of t cell activation GO:0050863 170 0.546
leukocyte proliferation GO:0070661 172 0.542
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.539
positive regulation of cellular amine metabolic process GO:0033240 5 0.536
cell cell recognition GO:0009988 44 0.532
negative regulation of synapse maturation GO:2000297 2 0.532
regulation of vasculature development GO:1901342 88 0.532
regulation of glial cell differentiation GO:0045685 41 0.524
labyrinthine layer development GO:0060711 49 0.522
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.521
regulation of system process GO:0044057 200 0.517
cardiac ventricle morphogenesis GO:0003208 50 0.516
positive regulation of neuron differentiation GO:0045666 141 0.509
Mouse
ras protein signal transduction GO:0007265 77 0.507
cardiac ventricle development GO:0003231 83 0.499
protein dna complex subunit organization GO:0071824 28 0.498
asymmetric neuroblast division GO:0055059 1 0.492
endocardial cushion morphogenesis GO:0003203 18 0.490
Mouse
cardiac chamber development GO:0003205 108 0.489
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.485
cardiac atrium morphogenesis GO:0003209 23 0.483
thymocyte migration GO:0072679 2 0.482
mesenchymal cell differentiation GO:0048762 107 0.480
skeletal muscle cell differentiation GO:0035914 66 0.480
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.480
epidermis development GO:0008544 187 0.478
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.476
sinoatrial node cell differentiation GO:0060921 3 0.474
muscular septum morphogenesis GO:0003150 4 0.471
left right pattern formation GO:0060972 23 0.469
cell adhesion GO:0007155 329 0.467
amine metabolic process GO:0009308 45 0.467
blood circulation GO:0008015 195 0.466
ventricular cardiac muscle cell differentiation GO:0055012 17 0.465
t cell activation GO:0042110 289 0.462
atrial ventricular junction remodeling GO:0003294 2 0.461
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.457
lymphocyte proliferation GO:0046651 164 0.457
organonitrogen compound catabolic process GO:1901565 264 0.456
neuron projection guidance GO:0097485 141 0.454
septum primum development GO:0003284 4 0.452
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.447
positive regulation of blood circulation GO:1903524 22 0.444
gliogenesis GO:0042063 141 0.441
positive regulation of rac gtpase activity GO:0032855 14 0.439
negative regulation of cell proliferation GO:0008285 296 0.437
cardiac muscle tissue development GO:0048738 130 0.434
cardiac conduction system development GO:0003161 12 0.434
blood vessel morphogenesis GO:0048514 285 0.434
cardiac muscle tissue growth GO:0055017 37 0.433
vascular smooth muscle cell differentiation GO:0035886 11 0.430
tissue migration GO:0090130 68 0.429
glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000701 1 0.429
regulation of mechanoreceptor differentiation GO:0045631 5 0.422
neural precursor cell proliferation GO:0061351 121 0.421
striated muscle hypertrophy GO:0014897 24 0.420
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.415
kidney development GO:0001822 213 0.414
Mouse
outflow tract morphogenesis GO:0003151 53 0.412
blood vessel endothelial cell differentiation GO:0060837 6 0.409
regulation of mast cell differentiation GO:0060375 3 0.405
otolith morphogenesis GO:0032474 3 0.402
gabaergic neuron differentiation GO:0097154 11 0.402
Mouse
positive regulation of cardiac muscle cell differentiation GO:2000727 6 0.401
positive regulation of axon extension GO:0045773 20 0.394
comma shaped body morphogenesis GO:0072049 5 0.393
Mouse
ascending aorta morphogenesis GO:0035910 3 0.391
urogenital system development GO:0001655 261 0.389
Mouse
purine nucleotide metabolic process GO:0006163 302 0.387
binding of sperm to zona pellucida GO:0007339 34 0.387
metanephric capsule specification GO:0072267 1 0.386
post embryonic organ development GO:0048569 17 0.378
regulation of nucleotide metabolic process GO:0006140 169 0.373
regulation of forebrain neuron differentiation GO:2000977 2 0.372
positive regulation of lymphocyte activation GO:0051251 140 0.371
regulation of cellular ketone metabolic process GO:0010565 66 0.371
ascending aorta development GO:0035905 3 0.369
striated muscle cell proliferation GO:0014855 39 0.368
cardiac muscle cell development GO:0055013 39 0.368
dendritic spine morphogenesis GO:0060997 22 0.365
lymphocyte differentiation GO:0030098 242 0.364
small gtpase mediated signal transduction GO:0007264 97 0.364
angiogenesis GO:0001525 201 0.363
ephrin receptor signaling pathway GO:0048013 20 0.360
cardiac vascular smooth muscle cell development GO:0060948 3 0.359
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.359
myelination in peripheral nervous system GO:0022011 19 0.358
prevention of polyspermy GO:0060468 4 0.357
embryonic heart tube morphogenesis GO:0003143 51 0.356
embryonic heart tube anterior posterior pattern specification GO:0035054 3 0.355
muscle cell differentiation GO:0042692 261 0.353
endothelial cell migration GO:0043542 44 0.351
mesodermal cell migration GO:0008078 4 0.351
cardiac muscle adaptation GO:0014887 10 0.350
positive regulation of ossification GO:0045778 47 0.347
Mouse
regulation of homeostatic process GO:0032844 182 0.345
positive regulation of eosinophil migration GO:2000418 2 0.344
endodermal cell fate commitment GO:0001711 12 0.341
positive regulation of nervous system development GO:0051962 221 0.338
Mouse
ossification GO:0001503 216 0.336
Mouse
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.328
fasciculation of motor neuron axon GO:0097156 2 0.327
ureteric bud development GO:0001657 94 0.325
Mouse
parathyroid hormone secretion GO:0035898 2 0.323
positive regulation of striated muscle tissue development GO:0045844 31 0.321
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.321
positive regulation of programmed cell death GO:0043068 218 0.320
guanosine containing compound metabolic process GO:1901068 144 0.320
insulin secretion GO:0030073 89 0.316
prostate gland stromal morphogenesis GO:0060741 2 0.316
locomotory behavior GO:0007626 195 0.315
muscle cell apoptotic process GO:0010657 18 0.314
regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000702 1 0.314
auditory receptor cell differentiation GO:0042491 37 0.313
regulation of heart growth GO:0060420 31 0.306
regulation of blood vessel endothelial cell migration GO:0043535 12 0.305
organ growth GO:0035265 117 0.305
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.304
mesenchyme morphogenesis GO:0072132 32 0.304
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.304
lung lobe formation GO:0060464 1 0.303
positive regulation of fibronectin dependent thymocyte migration GO:2000415 1 0.301
positive regulation of transcription via serum response element binding GO:0010735 1 0.299
notochord development GO:0030903 20 0.299
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.298
megakaryocyte differentiation GO:0030219 26 0.297
immune effector process GO:0002252 321 0.296
regulation of striated muscle cell differentiation GO:0051153 81 0.295
dorsal aorta development GO:0035907 6 0.295
regulation of peptide hormone secretion GO:0090276 75 0.294
fasciculation of sensory neuron axon GO:0097155 3 0.290
antimicrobial peptide biosynthetic process GO:0002777 2 0.290
regulation of neuron differentiation GO:0045664 281 0.289
mesonephric tubule development GO:0072164 94 0.283
Mouse
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.282
mesonephric epithelium development GO:0072163 94 0.281
Mouse
regulation of osteoblast differentiation GO:0045667 67 0.278
Mouse
regulation of thymocyte migration GO:2000410 2 0.276
regulation of epidermal cell differentiation GO:0045604 21 0.275
endodermal cell fate specification GO:0001714 4 0.274
fertilization GO:0009566 127 0.274
regulation of cellular amino acid metabolic process GO:0006521 5 0.272
cartilage development GO:0051216 140 0.268
peptide transport GO:0015833 133 0.267
extracellular matrix organization GO:0030198 147 0.264
cardiac cell development GO:0055006 41 0.264
response to transforming growth factor beta GO:0071559 88 0.264
nitrogen compound transport GO:0071705 271 0.262
platelet morphogenesis GO:0036344 13 0.261
hormone secretion GO:0046879 128 0.261
negative regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000734 1 0.260
cochlea development GO:0090102 35 0.259
epithelial cell proliferation GO:0050673 174 0.258
negative regulation of neuron projection development GO:0010977 50 0.257
wnt signaling pathway involved in kidney development GO:0061289 2 0.257
negative regulation of muscle cell apoptotic process GO:0010656 9 0.257
regulation of secretion GO:0051046 274 0.256
positive regulation of transcription by glucose GO:0046016 3 0.255
renal capsule specification GO:0072130 1 0.252
establishment of t cell polarity GO:0001768 2 0.250
muscle cell proliferation GO:0033002 52 0.250
regulation of inner ear receptor cell differentiation GO:2000980 5 0.249
regulation of muscle cell apoptotic process GO:0010660 17 0.249
embryonic heart tube development GO:0035050 65 0.247
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.246
myeloid leukocyte differentiation GO:0002573 119 0.246
positive regulation of map kinase activity GO:0043406 84 0.245
regulation of cardiac muscle cell proliferation GO:0060043 23 0.245
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.242
lens morphogenesis in camera type eye GO:0002089 24 0.242
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.241
negative regulation of binding GO:0051100 39 0.241
regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000307 1 0.241
positive regulation of osteoblast differentiation GO:0045669 34 0.241
Mouse
myeloid cell differentiation GO:0030099 233 0.238
ventricular cardiac muscle cell development GO:0055015 11 0.237
ear morphogenesis GO:0042471 118 0.237
activation of ras gtpase activity GO:0032856 11 0.234
pattern specification involved in metanephros development GO:0072268 4 0.234
camera type eye development GO:0043010 266 0.234
muscle tissue development GO:0060537 308 0.233
cerebral cortex cell migration GO:0021795 44 0.233
mesangial cell differentiation GO:0072007 4 0.233
regulation of ovulation GO:0060278 3 0.231
regulation of astrocyte differentiation GO:0048710 20 0.230
regulation of purine nucleotide catabolic process GO:0033121 122 0.228
negative regulation of macrophage differentiation GO:0045650 4 0.228
peptide secretion GO:0002790 114 0.226
regulation of hormone secretion GO:0046883 88 0.225
positive regulation of heart contraction GO:0045823 14 0.224
eye photoreceptor cell differentiation GO:0001754 41 0.224
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.223
regulation of ureteric bud formation GO:0072106 3 0.223
cell proliferation involved in mesonephros development GO:0061209 4 0.222
hematopoietic progenitor cell differentiation GO:0002244 143 0.222
regulation of cellular catabolic process GO:0031329 242 0.218
myeloid cell homeostasis GO:0002262 114 0.217
glial cell differentiation GO:0010001 131 0.216
compartment pattern specification GO:0007386 4 0.216
definitive erythrocyte differentiation GO:0060318 7 0.211
negative regulation of dendritic spine development GO:0061000 3 0.211
regulation of nucleotide catabolic process GO:0030811 122 0.210
regulation of cardiac muscle contraction GO:0055117 21 0.210
positive regulation of angiogenesis GO:0045766 46 0.210
glycosyl compound catabolic process GO:1901658 206 0.209
regulation of renin secretion into blood stream GO:1900133 4 0.208
g protein coupled receptor signaling pathway GO:0007186 243 0.207
cellular ketone metabolic process GO:0042180 84 0.207
second messenger mediated signaling GO:0019932 73 0.206
foramen ovale closure GO:0035922 1 0.205
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.205
multicellular organismal signaling GO:0035637 91 0.205
negative regulation of glucokinase activity GO:0033132 4 0.202
his purkinje system cell differentiation GO:0060932 2 0.202
regulation of t cell proliferation GO:0042129 92 0.202
carbon catabolite regulation of transcription GO:0045990 4 0.201
cation homeostasis GO:0055080 212 0.201
cell migration involved in sprouting angiogenesis GO:0002042 9 0.201
peptide hormone secretion GO:0030072 109 0.200
ventricular cardiac myofibril assembly GO:0055005 3 0.200
response to monosaccharide GO:0034284 67 0.199
metanephric capsule morphogenesis GO:0072265 1 0.199
bone morphogenesis GO:0060349 78 0.198
atrial cardiac muscle cell development GO:0055014 2 0.198
ribonucleotide metabolic process GO:0009259 291 0.196
regulation of cell migration GO:0030334 219 0.196
negative regulation of ovulation GO:0060280 1 0.196
cellular amine metabolic process GO:0044106 44 0.195
negative regulation of nervous system development GO:0051961 156 0.193
Mouse
regulation of vascular wound healing GO:0061043 2 0.189
regulation of definitive erythrocyte differentiation GO:0010724 3 0.189
regulation of cell activation GO:0050865 289 0.189
detection of external stimulus GO:0009581 61 0.188
substrate dependent cell migration GO:0006929 18 0.188
positive regulation of ureteric bud formation GO:0072107 3 0.188
peptidyl amino acid modification GO:0018193 336 0.188
cellular homeostasis GO:0019725 240 0.187
regulation of vasculogenesis GO:2001212 9 0.185
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.185
nucleoside metabolic process GO:0009116 246 0.184
synaptic transmission GO:0007268 329 0.183
negative regulation of neuron projection regeneration GO:0070571 3 0.183
nephron morphogenesis GO:0072028 69 0.181
Mouse
notochord morphogenesis GO:0048570 10 0.180
positive regulation of dna templated transcription elongation GO:0032786 2 0.180
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.179
glomerulus development GO:0032835 40 0.179
Mouse
artery development GO:0060840 53 0.178
positive regulation of growth GO:0045927 104 0.178
regulation of wound healing GO:0061041 40 0.178
respiratory system development GO:0060541 190 0.178
cation transport GO:0006812 399 0.178
regulation of histone h3 k4 methylation GO:0051569 12 0.177
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.177
embryonic placenta development GO:0001892 98 0.175
innate immune response GO:0045087 157 0.175
negative regulation of neural precursor cell proliferation GO:2000178 18 0.174
pigment metabolic process GO:0042440 32 0.174
regulation of blood circulation GO:1903522 93 0.173
purine ribonucleotide catabolic process GO:0009154 208 0.173
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.170
endothelial cell differentiation GO:0045446 41 0.169
cardiac right ventricle morphogenesis GO:0003215 13 0.169
regulation of bmp signaling pathway GO:0030510 60 0.168
regulation of ossification GO:0030278 112 0.167
Mouse
regulation of gtp catabolic process GO:0033124 113 0.166
regulation of response to wounding GO:1903034 189 0.166
negative regulation of dendrite development GO:2000171 9 0.163
positive regulation of interleukin 13 production GO:0032736 4 0.163
purine nucleoside metabolic process GO:0042278 241 0.163
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.162
cognition GO:0050890 149 0.162
regulation of striated muscle cell apoptotic process GO:0010662 11 0.161
trabecula morphogenesis GO:0061383 40 0.161
regulation of cell proliferation involved in mesonephros development GO:2000606 1 0.161
cardiac muscle hypertrophy GO:0003300 23 0.160
positive regulation of heart rate GO:0010460 10 0.160
positive regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000309 1 0.160
homeostasis of number of cells GO:0048872 210 0.159
carbon catabolite activation of transcription GO:0045991 4 0.158
adult locomotory behavior GO:0008344 91 0.158
carbon catabolite repression of transcription GO:0045013 1 0.158
erythrocyte maturation GO:0043249 6 0.157
negative regulation of neuron differentiation GO:0045665 101 0.156
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.155
negative regulation of epithelial to mesenchymal transition GO:0010719 6 0.155
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.155
regulation of leukocyte differentiation GO:1902105 159 0.154
mammary gland duct morphogenesis GO:0060603 38 0.153
positive regulation of cell death GO:0010942 224 0.153
pancreatic pp cell differentiation GO:0003312 2 0.153
mammary gland morphogenesis GO:0060443 54 0.153
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.151
muscle cell development GO:0055001 133 0.150
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.147
regulation of cellular amine metabolic process GO:0033238 20 0.146
osteoclast differentiation GO:0030316 62 0.145
septum secundum development GO:0003285 1 0.144
muscle hypertrophy GO:0014896 24 0.143
embryonic heart tube formation GO:0003144 1 0.143
morphogenesis of embryonic epithelium GO:0016331 159 0.143
positive regulation of muscle tissue development GO:1901863 32 0.142
cellular amino acid metabolic process GO:0006520 103 0.142
metanephric capsule formation GO:0072266 1 0.142
cell migration involved in heart development GO:0060973 8 0.142
divalent metal ion transport GO:0070838 172 0.142
cell proliferation involved in heart valve development GO:2000793 2 0.141
ribonucleotide catabolic process GO:0009261 208 0.140
fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000699 1 0.140
regulation of actin filament based process GO:0032970 99 0.140
rho protein signal transduction GO:0007266 32 0.140
renal capsule development GO:0072127 1 0.140
atrial cardiac muscle cell differentiation GO:0055011 2 0.139
tumor necrosis factor ligand superfamily member 11 production GO:0072535 1 0.139
sensory organ morphogenesis GO:0090596 242 0.139
negative regulation of ossification GO:0030279 49 0.138
atrioventricular node development GO:0003162 3 0.138
epithelium migration GO:0090132 63 0.137
regulation of humoral immune response GO:0002920 22 0.134
negative chemotaxis GO:0050919 14 0.134
cardiac muscle cell contraction GO:0086003 7 0.134
ribonucleoside catabolic process GO:0042454 206 0.134
pancreatic pp cell fate commitment GO:0003329 2 0.134
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.132
regulation of muscle tissue development GO:1901861 97 0.132
regulation of glycoprotein biosynthetic process GO:0010559 12 0.131
cell cell signaling involved in kidney development GO:0060995 2 0.130
regulation of rho protein signal transduction GO:0035023 71 0.130
regulation of chemokine production GO:0032642 30 0.130
corpus callosum development GO:0022038 10 0.130
pro t cell differentiation GO:0002572 3 0.129
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.129
embryonic skeletal system development GO:0048706 120 0.129
regulation of cardiac cell fate specification GO:2000043 1 0.128
regulation of cardiac chamber formation GO:1901210 1 0.128
regulation of reproductive process GO:2000241 66 0.128
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.127
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.127
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.127
osteoblast development GO:0002076 17 0.127
Mouse
regulation of endothelial cell migration GO:0010594 22 0.126
sequestering of metal ion GO:0051238 19 0.125
negative regulation of synapse assembly GO:0051964 3 0.125
mesonephros development GO:0001823 97 0.125
Mouse
regulation of cardiac muscle cell differentiation GO:2000725 9 0.124
regulation of keratinocyte proliferation GO:0010837 15 0.124
regulation of protein serine threonine kinase activity GO:0071900 157 0.123
pma inducible membrane protein ectodomain proteolysis GO:0051088 1 0.123
gonad development GO:0008406 141 0.122
embryonic genitalia morphogenesis GO:0030538 4 0.122
regulation of cardioblast differentiation GO:0051890 3 0.121
negative regulation of epithelial cell proliferation GO:0050680 64 0.121
pigment accumulation GO:0043476 1 0.121
regulation of nucleoside metabolic process GO:0009118 130 0.121
regulation of stem cell differentiation GO:2000736 50 0.121
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.120
learning GO:0007612 98 0.120
skin development GO:0043588 220 0.118
vascular process in circulatory system GO:0003018 62 0.118
ovulation GO:0030728 15 0.118
regulation of purine nucleotide metabolic process GO:1900542 169 0.117
regulation of map kinase activity GO:0043405 120 0.116
immune response regulating signaling pathway GO:0002764 125 0.116
cardiac muscle cell proliferation GO:0060038 31 0.116
renal tubule development GO:0061326 87 0.116
Mouse
purine containing compound catabolic process GO:0072523 213 0.116
dendrite development GO:0016358 115 0.115

Hey2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.999
disease of anatomical entity DOID:7 0 0.999
cardiovascular system disease DOID:1287 0 0.999
congenital heart disease DOID:1682 0 0.731
tetralogy of fallot DOID:6419 0 0.380
hepatobiliary disease DOID:3118 0 0.352
gastrointestinal system disease DOID:77 0 0.352
liver disease DOID:409 0 0.352
heart septal defect DOID:1681 0 0.273
ventricular septal defect DOID:1657 0 0.228
musculoskeletal system disease DOID:17 0 0.172