Rattus norvegicus

0 known processes

Irs3

insulin receptor substrate 3

Irs3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.364
lipid metabolic process GO:0006629 283 0.271
Rat
cellular lipid metabolic process GO:0044255 208 0.252
Rat
regulation of transcription dna templated GO:0006355 374 0.245
cellular response to acid chemical GO:0071229 75 0.240
anatomical structure morphogenesis GO:0009653 298 0.239
regulation of rna biosynthetic process GO:2001141 381 0.233
positive regulation of rna metabolic process GO:0051254 203 0.229
rna metabolic process GO:0016070 406 0.213
cellular response to hormone stimulus GO:0032870 247 0.201
Rat
cellular response to oxygen containing compound GO:1901701 386 0.197
Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.184
negative regulation of cellular metabolic process GO:0031324 281 0.174
regulation of cellular component organization GO:0051128 368 0.173
cell type specific apoptotic process GO:0097285 134 0.170
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.167
negative regulation of metabolic process GO:0009892 331 0.160
transcription from rna polymerase ii promoter GO:0006366 252 0.142
positive regulation of transcription dna templated GO:0045893 197 0.138
central nervous system development GO:0007417 311 0.138
enzyme linked receptor protein signaling pathway GO:0007167 116 0.135
Rat
oxidation reduction process GO:0055114 304 0.135
response to growth factor GO:0070848 189 0.130
organophosphate metabolic process GO:0019637 370 0.128
Rat
programmed cell death GO:0012501 392 0.127
negative regulation of macromolecule metabolic process GO:0010605 260 0.126
cellular response to lipid GO:0071396 201 0.123
positive regulation of multicellular organismal process GO:0051240 387 0.122
transcription dna templated GO:0006351 377 0.118
response to other organism GO:0051707 220 0.117
positive regulation of rna biosynthetic process GO:1902680 197 0.117
negative regulation of cellular biosynthetic process GO:0031327 161 0.116
single organism biosynthetic process GO:0044711 342 0.114
rna biosynthetic process GO:0032774 380 0.114
negative regulation of transcription dna templated GO:0045892 116 0.113
monocarboxylic acid metabolic process GO:0032787 152 0.112
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.106
apoptotic process GO:0006915 381 0.104
negative regulation of biosynthetic process GO:0009890 168 0.102
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.100
Rat
response to carbohydrate GO:0009743 183 0.098
response to peptide hormone GO:0043434 278 0.098
Rat
response to peptide GO:1901652 292 0.098
Rat
regulation of nervous system development GO:0051960 264 0.093
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.093
regulation of multicellular organismal development GO:2000026 376 0.093
response to hexose GO:0009746 144 0.092
organonitrogen compound biosynthetic process GO:1901566 167 0.091
cellular component morphogenesis GO:0032989 155 0.091
negative regulation of rna metabolic process GO:0051253 123 0.089
regulation of cell motility GO:2000145 131 0.086
positive regulation of gene expression GO:0010628 244 0.084
nucleic acid templated transcription GO:0097659 379 0.081
positive regulation of cellular biosynthetic process GO:0031328 295 0.077
gland development GO:0048732 155 0.077
negative regulation of nucleic acid templated transcription GO:1903507 117 0.077
response to inorganic substance GO:0010035 377 0.076
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.075
positive regulation of nucleic acid templated transcription GO:1903508 197 0.074
positive regulation of developmental process GO:0051094 283 0.073
b cell differentiation GO:0030183 2 0.072
regulation of nucleic acid templated transcription GO:1903506 380 0.072
oxoacid metabolic process GO:0043436 290 0.072
regulation of signal transduction GO:0009966 318 0.071
Rat
chemical homeostasis GO:0048878 292 0.069
carbohydrate metabolic process GO:0005975 130 0.068
negative regulation of rna biosynthetic process GO:1902679 118 0.068
lipid biosynthetic process GO:0008610 128 0.066
positive regulation of biosynthetic process GO:0009891 319 0.066
intracellular signal transduction GO:0035556 314 0.062
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.061
organ morphogenesis GO:0009887 75 0.061
hexose metabolic process GO:0019318 58 0.060
response to extracellular stimulus GO:0009991 380 0.060
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.059
kidney morphogenesis GO:0060993 13 0.059
tissue development GO:0009888 252 0.059
negative regulation of gene expression GO:0010629 199 0.058
cellular response to insulin stimulus GO:0032869 81 0.058
Rat
regulation of anatomical structure morphogenesis GO:0022603 141 0.058
response to insulin GO:0032868 133 0.056
Rat
cell migration GO:0016477 197 0.056
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.055
cell projection organization GO:0030030 302 0.055
homeostatic process GO:0042592 331 0.055
response to corticosteroid GO:0031960 235 0.054
regulation of cell differentiation GO:0045595 320 0.054
cellular response to organonitrogen compound GO:0071417 197 0.053
Rat
cellular response to endogenous stimulus GO:0071495 377 0.053
Rat
positive regulation of transport GO:0051050 245 0.052
Rat
regulation of cell development GO:0060284 263 0.052
monosaccharide metabolic process GO:0005996 61 0.051
cell substrate adhesion GO:0031589 29 0.048
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.048
single organism reproductive process GO:0044702 297 0.048
cellular component movement GO:0006928 248 0.048
glucose metabolic process GO:0006006 52 0.047
regulation of locomotion GO:0040012 148 0.047
multi organism reproductive process GO:0044703 262 0.047
epiboly GO:0090504 2 0.046
single organism organelle organization GO:1902589 180 0.045
cellular response to peptide GO:1901653 133 0.045
Rat
regeneration GO:0031099 163 0.045
carbohydrate homeostasis GO:0033500 75 0.045
nucleoside phosphate metabolic process GO:0006753 283 0.044
locomotion GO:0040011 237 0.044
protein phosphorylation GO:0006468 345 0.043
positive regulation of cell differentiation GO:0045597 217 0.042
head development GO:0060322 247 0.041
regulation of molecular function GO:0065009 398 0.041
Rat
reproduction GO:0000003 245 0.041
multicellular organism reproduction GO:0032504 233 0.041
hepaticobiliary system development GO:0061008 90 0.041
cellular response to peptide hormone stimulus GO:0071375 120 0.039
Rat
forebrain development GO:0030900 98 0.038
neuron differentiation GO:0030182 368 0.038
negative regulation of kidney development GO:0090185 2 0.037
positive regulation of signaling GO:0023056 270 0.037
Rat
catabolic process GO:0009056 351 0.037
muscle cell proliferation GO:0033002 84 0.036
regulation of lipid metabolic process GO:0019216 68 0.035
Rat
urogenital system development GO:0001655 78 0.034
cardiovascular system development GO:0072358 134 0.034
positive regulation of signal transduction GO:0009967 175 0.034
Rat
gamete generation GO:0007276 124 0.034
multicellular organismal reproductive process GO:0048609 233 0.033
response to oxygen levels GO:0070482 265 0.033
cell morphogenesis GO:0000902 142 0.033
negative regulation of programmed cell death GO:0043069 183 0.032
multi multicellular organism process GO:0044706 138 0.032
regulation of immune system process GO:0002682 123 0.032
regulation of cell migration GO:0030334 128 0.031
cell motility GO:0048870 202 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
Rat
cellular homeostasis GO:0019725 252 0.031
protein homooligomerization GO:0051260 91 0.031
positive regulation of neuron differentiation GO:0045666 126 0.031
tube development GO:0035295 89 0.030
fatty acid metabolic process GO:0006631 99 0.030
nucleobase containing small molecule metabolic process GO:0055086 316 0.030
muscle structure development GO:0061061 87 0.030
regulation of cell proliferation GO:0042127 359 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
negative regulation of epithelial cell proliferation GO:0050680 16 0.029
epiboly involved in wound healing GO:0090505 2 0.029
response to monosaccharide GO:0034284 159 0.029
response to glucocorticoid GO:0051384 223 0.029
nucleoside monophosphate metabolic process GO:0009123 93 0.028
signal transduction by phosphorylation GO:0023014 144 0.028
regulation of neurogenesis GO:0050767 247 0.028
neuron development GO:0048666 286 0.028
positive regulation of cellular protein metabolic process GO:0032270 167 0.028
ribonucleotide metabolic process GO:0009259 231 0.027
wound healing spreading of epidermal cells GO:0035313 2 0.027
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.027
proteolysis GO:0006508 175 0.027
cellular component biogenesis GO:0044085 368 0.027
Rat
negative regulation of cell death GO:0060548 229 0.027
epithelium development GO:0060429 96 0.026
regulation of protein metabolic process GO:0051246 289 0.026
glucose homeostasis GO:0042593 75 0.026
localization of cell GO:0051674 202 0.026
positive regulation of nervous system development GO:0051962 178 0.026
hormone mediated signaling pathway GO:0009755 23 0.026
response to external biotic stimulus GO:0043207 221 0.025
anatomical structure formation involved in morphogenesis GO:0048646 83 0.025
glycerolipid metabolic process GO:0046486 67 0.025
Rat
positive regulation of molecular function GO:0044093 230 0.025
Rat
insulin receptor signaling pathway GO:0008286 24 0.025
Rat
regulation of neuron differentiation GO:0045664 208 0.025
cellular response to growth factor stimulus GO:0071363 162 0.025
epithelial cell proliferation GO:0050673 54 0.025
response to acid chemical GO:0001101 222 0.024
regulation of apoptotic process GO:0042981 335 0.024
osteoblast differentiation GO:0001649 26 0.024
response to nutrient levels GO:0031667 370 0.024
regulation of cell projection organization GO:0031344 175 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
defense response GO:0006952 194 0.024
nuclear transport GO:0051169 49 0.024
response to wounding GO:0009611 254 0.024
regulation of endothelial cell apoptotic process GO:2000351 3 0.024
bmp signaling pathway GO:0030509 4 0.024
carboxylic acid metabolic process GO:0019752 289 0.023
acute inflammatory response GO:0002526 58 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
kidney development GO:0001822 67 0.023
dephosphorylation GO:0016311 98 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
regulation of lipid kinase activity GO:0043550 7 0.022
Rat
motor neuron axon guidance GO:0008045 1 0.022
response to biotic stimulus GO:0009607 226 0.022
triglyceride metabolic process GO:0006641 21 0.022
brain development GO:0007420 247 0.022
embryonic skeletal system development GO:0048706 3 0.022
response to glucose GO:0009749 136 0.022
organ regeneration GO:0031100 101 0.022
response to cytokine GO:0034097 215 0.022
organic acid metabolic process GO:0006082 292 0.021
morphogenesis of an epithelium GO:0002009 20 0.021
reactive oxygen species metabolic process GO:0072593 37 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
erythrocyte differentiation GO:0030218 1 0.021
negative regulation of apoptotic process GO:0043066 181 0.021
response to purine containing compound GO:0014074 126 0.021
Rat
wound healing spreading of cells GO:0044319 2 0.021
regulation of metanephros development GO:0072215 4 0.021
regulation of homotypic cell cell adhesion GO:0034110 4 0.021
regulation of canonical wnt signaling pathway GO:0060828 4 0.021
regulation of neuron projection development GO:0010975 161 0.021
regulation of phosphorylation GO:0042325 248 0.021
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
nucleotide metabolic process GO:0009117 279 0.021
purine containing compound metabolic process GO:0072521 253 0.021
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.021
cellular glucan metabolic process GO:0006073 23 0.020
positive regulation of tumor necrosis factor production GO:0032760 8 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
organophosphate biosynthetic process GO:0090407 143 0.020
negative regulation of metanephros development GO:0072217 2 0.020
regulation of cellular component movement GO:0051270 150 0.020
response to dexamethasone GO:0071548 49 0.020
positive regulation of lipid metabolic process GO:0045834 33 0.020
Rat
regulation of body fluid levels GO:0050878 90 0.020
positive regulation of cellular component movement GO:0051272 102 0.020
negative regulation of signaling GO:0023057 157 0.019
Rat
monocarboxylic acid catabolic process GO:0072329 28 0.019
organelle organization GO:0006996 266 0.019
protein oligomerization GO:0051259 191 0.019
Rat
peptide transport GO:0015833 97 0.019
Rat
regulation of cell growth GO:0001558 85 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
Rat
negative regulation of cell differentiation GO:0045596 99 0.019
blood circulation GO:0008015 183 0.019
peptide hormone secretion GO:0030072 84 0.019
Rat
smooth muscle cell proliferation GO:0048659 77 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
hormone transport GO:0009914 121 0.018
Rat
neuron projection development GO:0031175 273 0.018
regulation of mesenchymal cell proliferation GO:0010464 4 0.018
mesoderm development GO:0007498 2 0.018
protein complex assembly GO:0006461 263 0.018
Rat
response to hypoxia GO:0001666 231 0.018
regulation of system process GO:0044057 208 0.018
telencephalon development GO:0021537 62 0.018
regulation of nephron tubule epithelial cell differentiation GO:0072182 1 0.018
positive regulation of humoral immune response GO:0002922 2 0.018
mesenchymal cell proliferation GO:0010463 4 0.017
aging GO:0007568 241 0.017
salivary gland development GO:0007431 3 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
Rat
response to ketone GO:1901654 182 0.017
purine containing compound biosynthetic process GO:0072522 85 0.017
nitrogen compound transport GO:0071705 229 0.017
Rat
positive regulation of cell development GO:0010720 176 0.017
spermatogenesis GO:0007283 99 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
macromolecular complex subunit organization GO:0043933 339 0.016
Rat
steroid metabolic process GO:0008202 73 0.016
multicellular organism growth GO:0035264 1 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
cellular response to hexose stimulus GO:0071331 65 0.016
protein targeting to nucleus GO:0044744 35 0.016
developmental induction GO:0031128 2 0.016
endothelial cell apoptotic process GO:0072577 3 0.016
cellular response to abiotic stimulus GO:0071214 85 0.016
anterior posterior pattern specification GO:0009952 1 0.016
heart morphogenesis GO:0003007 3 0.016
tissue morphogenesis GO:0048729 22 0.016
gastrulation GO:0007369 2 0.016
nephron development GO:0072006 22 0.016
myelination GO:0042552 39 0.015
regulation of dna metabolic process GO:0051052 60 0.015
regulation of phosphatidylinositol 3 kinase activity GO:0043551 7 0.015
Rat
inner ear morphogenesis GO:0042472 1 0.015
transmission of nerve impulse GO:0019226 42 0.015
morphogenesis of an epithelial sheet GO:0002011 2 0.015
cholesterol homeostasis GO:0042632 3 0.015
positive regulation of immune system process GO:0002684 90 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
embryo development GO:0009790 49 0.015
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 2 0.015
neurological system process GO:0050877 219 0.015
cellular ion homeostasis GO:0006873 184 0.015
regulation of growth GO:0040008 105 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
Rat
skeletal muscle satellite cell proliferation GO:0014841 1 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
cytoskeleton organization GO:0007010 111 0.015
regulation of proteolysis GO:0030162 66 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
b cell mediated immunity GO:0019724 4 0.015
renal system development GO:0072001 67 0.015
positive regulation of interleukin 1 alpha production GO:0032730 1 0.014
behavior GO:0007610 205 0.014
sexual reproduction GO:0019953 148 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
epithelial cell differentiation GO:0030855 71 0.014
t cell homeostasis GO:0043029 2 0.014
regulation of catalytic activity GO:0050790 304 0.014
Rat
generation of precursor metabolites and energy GO:0006091 62 0.014
glycogen metabolic process GO:0005977 23 0.014
cellular chemical homeostasis GO:0055082 247 0.014
myeloid cell differentiation GO:0030099 22 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
regulation of phagocytosis engulfment GO:0060099 4 0.014
response to decreased oxygen levels GO:0036293 237 0.014
multicellular organismal water homeostasis GO:0050891 4 0.014
metanephric comma shaped body morphogenesis GO:0072278 2 0.014
neural crest cell development GO:0014032 2 0.014
liver development GO:0001889 90 0.014
regulation of reactive oxygen species metabolic process GO:2000377 26 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
dna metabolic process GO:0006259 96 0.014
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.013
jak stat cascade GO:0007259 26 0.013
metanephric s shaped body morphogenesis GO:0072284 2 0.013
dicarboxylic acid metabolic process GO:0043648 42 0.013
immune system process GO:0002376 204 0.013
regulation of programmed cell death GO:0043067 341 0.013
protein processing GO:0016485 68 0.013
protein complex biogenesis GO:0070271 263 0.013
Rat
purine nucleotide biosynthetic process GO:0006164 83 0.013
antigen processing and presentation GO:0019882 2 0.013
cellular polysaccharide metabolic process GO:0044264 23 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 14 0.013
fatty acid catabolic process GO:0009062 26 0.013
striated muscle cell differentiation GO:0051146 39 0.013
circulatory system process GO:0003013 183 0.013
response to genistein GO:0033595 4 0.013
protein maturation GO:0051604 68 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.013
regulation of muscle system process GO:0090257 79 0.012
cell adhesion GO:0007155 110 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
Rat
metal ion homeostasis GO:0055065 186 0.012
cellular component assembly GO:0022607 360 0.012
Rat
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
establishment of protein localization to organelle GO:0072594 44 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
cellular glucose homeostasis GO:0001678 66 0.012
positive regulation of glutamate secretion GO:0014049 8 0.012
regulation of cytokine production GO:0001817 56 0.012
developmental process involved in reproduction GO:0003006 159 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
substrate dependent cell migration GO:0006929 1 0.012
regulation of ion transport GO:0043269 245 0.012
immunoglobulin mediated immune response GO:0016064 4 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
immune response GO:0006955 104 0.012
cellular response to carbohydrate stimulus GO:0071322 72 0.012
negative regulation of transport GO:0051051 136 0.012
Rat
regulation of hydrolase activity GO:0051336 143 0.012
anion transport GO:0006820 178 0.012
negative regulation of developmental process GO:0051093 125 0.012
reproductive process GO:0022414 372 0.012
feeding behavior GO:0007631 53 0.012
sodium ion homeostasis GO:0055078 23 0.012
adenohypophysis development GO:0021984 2 0.012
hormone biosynthetic process GO:0042446 25 0.012
amine metabolic process GO:0009308 38 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
respiratory system development GO:0060541 45 0.012
negative regulation of cell matrix adhesion GO:0001953 3 0.012
neuron projection morphogenesis GO:0048812 122 0.012
divalent metal ion transport GO:0070838 132 0.012
response to amino acid GO:0043200 75 0.012
cellular response to monosaccharide stimulus GO:0071326 67 0.012
female pregnancy GO:0007565 122 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
tube morphogenesis GO:0035239 23 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 13 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
cation transport GO:0006812 382 0.011
muscle cell differentiation GO:0042692 52 0.011
muscle cell development GO:0055001 26 0.011
olfactory bulb interneuron differentiation GO:0021889 1 0.011
regulation of cellular localization GO:0060341 263 0.011
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.011
Rat
glycosyl compound metabolic process GO:1901657 182 0.011
chromosome segregation GO:0007059 2 0.011
negative regulation of protein maturation GO:1903318 47 0.011
erythrocyte homeostasis GO:0034101 2 0.011
vascular process in circulatory system GO:0003018 96 0.011
chemotaxis GO:0006935 66 0.011
positive regulation of potassium ion transmembrane transport GO:1901381 4 0.011
response to nutrient GO:0007584 248 0.011
response to testosterone GO:0033574 55 0.011
cell adhesion molecule production GO:0060352 1 0.011
cytokine biosynthetic process GO:0042089 3 0.011
regulation of anatomical structure size GO:0090066 135 0.011
blood vessel development GO:0001568 69 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
male gamete generation GO:0048232 99 0.011
vasculature development GO:0001944 70 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
cellular protein localization GO:0034613 122 0.010
regulation of response to stress GO:0080134 126 0.010
regulation of epithelial cell differentiation involved in kidney development GO:2000696 1 0.010
negative regulation of cell communication GO:0010648 158 0.010
Rat
ribose phosphate biosynthetic process GO:0046390 87 0.010
positive regulation of lamellipodium assembly GO:0010592 4 0.010
lipid storage GO:0019915 1 0.010
regulation of tumor necrosis factor production GO:0032680 13 0.010
lymphoid progenitor cell differentiation GO:0002320 2 0.010
cellular response to dna damage stimulus GO:0006974 19 0.010
reproductive structure development GO:0048608 128 0.010

Irs3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
primary ciliary dyskinesia DOID:9562 0 0.043
respiratory system disease DOID:1579 0 0.039
lower respiratory tract disease DOID:0050161 0 0.039
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.037
disease of metabolism DOID:0014667 0 0.019
nutrition disease DOID:374 0 0.018
acquired metabolic disease DOID:0060158 0 0.018
urinary system disease DOID:18 0 0.018
obesity DOID:9970 0 0.014
overnutrition DOID:654 0 0.014
long qt syndrome DOID:2843 0 0.011