IMP

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Rattus norvegicus

0 genes annotated in rat

long qt syndrome

DOID:2843

An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "long qt syndrome" (in gray)

Name	Description	Probability	Func Analog Organism
Inha	inhibin alpha	0.315
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.295
Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.216
Ky	kyphoscoliosis peptidase	0.195
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.193
Phkg1	phosphorylase kinase, gamma 1	0.148
Pgam2	phosphoglycerate mutase 2 (muscle)	0.142
Pou2f3	POU class 2 homeobox 3	0.121
Lrrc14b	leucine rich repeat containing 14B	0.119
Pla2g5	phospholipase A2, group V	0.118
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.108
Myh6	myosin, heavy chain 6, cardiac muscle, alpha	0.106
Fgf16	fibroblast growth factor 16	0.105
Asph	aspartate-beta-hydroxylase	0.104
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.101
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.085
Adcy5	adenylate cyclase 5	0.083
Nlgn2	neuroligin 2	0.079
Rnf207	ring finger protein 207	0.077
Trdn	triadin	0.070
Lrrc4b	leucine rich repeat containing 4B	0.067
Neu3	sialidase 3 (membrane sialidase)	0.065
Rxrg	retinoid X receptor gamma	0.065
Ednra	endothelin receptor type A	0.059
Dchs1	dachsous 1 (Drosophila)	0.056
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.050
Scn5a	sodium channel, voltage-gated, type V, alpha subunit	0.050	Human
Pde4a	phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)	0.048
Rimbp2	RIMS binding protein 2	0.045
Ckm	creatine kinase, muscle	0.044
Casq2	calsequestrin 2 (cardiac muscle)	0.043
Akap14	A kinase (PRKA) anchor protein 14	0.038
Me3	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.037
Gja3	gap junction protein, alpha 3	0.037
Abcc8	ATP-binding cassette, subfamily C (CFTR/MRP), member 8	0.036
Coro6	coronin 6	0.035
Asb2	ankyrin repeat and SOCS box-containing 2	0.032
Gpsm1	G-protein signaling modulator 1 (AGS3-like, C. elegans)	0.032
Ttn	titin	0.031
Cdc25a	cell division cycle 25 homolog A (S. pombe)	0.030
Pik3ip1	phosphoinositide-3-kinase interacting protein 1	0.030
Tfeb	transcription factor EB	0.030
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.029	Human
St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.028
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.028
Kcnk3	potassium channel, subfamily K, member 3	0.028
RGD1310269	hypothetical LOC314472	0.028
Mare	alpha globin regulatory element containing gene	0.027
Gnb3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.027
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.026
Prg2	proteoglycan 2, bone marrow	0.026
Fbxo10	F-box protein 10	0.026
Efnb1	ephrin B1	0.026
B3gntl1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	0.025
RGD1306750	LOC362451	0.025
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.025
Cd247	Cd247 molecule	0.024
Hcn2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.023
Scn1b	sodium channel, voltage-gated, type I, beta	0.023
Tsx	testis specific X-linked gene	0.023
Rpl3l	ribosomal protein L3-like	0.022
Pax8	paired box 8	0.022
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.021
Atxn1	ataxin 1	0.021
Phyhip	phytanoyl-CoA 2-hydroxylase interacting protein	0.021
Vamp1	vesicle-associated membrane protein 1	0.021
Ryr2	ryanodine receptor 2, cardiac	0.020
Wipf3	WAS/WASL interacting protein family, member 3	0.020
Ros1	c-ros oncogene 1 , receptor tyrosine kinase	0.020
Fam148b	family with sequence similarity 148, member B	0.020
Dspp	dentin sialophosphoprotein	0.020
Rho	rhodopsin	0.020
Tmem171	transmembrane protein 171	0.020
Fitm1	fat storage-inducing transmembrane protein 1	0.019
P4htm	prolyl 4-hydroxylase, transmembrane	0.019
Tcp11	t-complex protein 11	0.019
Tubgcp6	tubulin, gamma complex associated protein 6	0.019
RGD1564327	similar to integrin alpha 8	0.019
Map1a	microtubule-associated protein 1A	0.019
LOC56764	dnaj-like protein	0.018
Adra1b	adrenergic, alpha-1B-, receptor	0.018
Cmya5	cardiomyopathy associated 5	0.017
RGD1304737	similar to KIAA1086 protein	0.017
Smg6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.017
Lrrc39	leucine rich repeat containing 39	0.017
Catsper2	cation channel, sperm associated 2	0.017
Mapt	microtubule-associated protein tau	0.017
Cnga2	cyclic nucleotide gated channel alpha 2	0.017
Tcf21	transcription factor 21	0.017
Clcnka	chloride channel Ka	0.017
Slc25a29	solute carrier family 25, member 29	0.017
LOC689926	hypothetical protein LOC689926	0.016
Uncx	UNC homeobox	0.016
Rtn2	reticulon 2	0.016
Coq10a	coenzyme Q10 homolog A (S. cerevisiae)	0.016
Ebf1	early B-cell factor 1	0.016
Prdm2	PR domain containing 2, with ZNF domain	0.016
Shbg	sex hormone binding globulin	0.015
Nt5m	5',3'-nucleotidase, mitochondrial	0.015
Fam63b	family with sequence similarity 63, member B	0.015
Shisa4	shisa homolog 4 (Xenopus laevis)	0.015
Fn3k	fructosamine 3 kinase	0.015
Rab3b	RAB3B, member RAS oncogene family	0.015
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.014
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.014
Slc12a3	solute carrier family 12 (sodium/chloride transporters), member 3	0.014
Bcl2	B-cell CLL/lymphoma 2	0.014
Chrnb4	cholinergic receptor, nicotinic, beta 4	0.014
Fam83f	family with sequence similarity 83, member F	0.014
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.013	Human
Grem1	gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)	0.013
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.013
Neurl2	neuralized homolog 2 (Drosophila)	0.013
Slc30a2	solute carrier family 30 (zinc transporter), member 2	0.013
Krt1	keratin 1	0.013
Pygm	phosphorylase, glycogen, muscle	0.013
Rxrb	retinoid X receptor beta	0.013
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.013
Alpk3	alpha-kinase 3	0.013
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.013
Acacb	acetyl-Coenzyme A carboxylase beta	0.013
Coro2b	coronin, actin binding protein, 2B	0.013
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.012
Ddn	dendrin	0.012
Znf498	zinc finger protein 498	0.012
Hand2	heart and neural crest derivatives expressed 2	0.012
Kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.012	Human
Shc2	SHC (Src homology 2 domain containing) transforming protein 2	0.012
Hhatl	hedgehog acyltransferase-like	0.012
Tmem38a	transmembrane protein 38a	0.012
Mcpt4	mast cell protease 4	0.012
Dio1	deiodinase, iodothyronine, type I	0.012
Acads	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	0.012
Gck	glucokinase	0.012
Tmem101	transmembrane protein 101	0.011
Dhrs7c	dehydrogenase/reductase (SDR family) member 7C	0.011
Hap1	huntingtin-associated protein 1	0.011
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.011
Prl3d1	Prolactin family 3, subfamily d, member 1	0.011
Rps6ka2	ribosomal protein S6 kinase polypeptide 2	0.011
Irs3	insulin receptor substrate 3	0.011
Cav3	caveolin 3	0.011
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.011
Olr337	olfactory receptor 337	0.011
Tle2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.011
Taok2	TAO kinase 2	0.011
Znf575	zinc finger protein 575	0.010
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.010
Myl3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.010