IMP

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Rattus norvegicus

0 genes annotated in rat

acquired metabolic disease

DOID:0060158

A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "acquired metabolic disease" (in gray)

Name	Description	Probability	Func Analog Organism
Aqp7	aquaporin 7	0.257
Gna12	guanine nucleotide binding protein (G protein) alpha 12	0.163
Lep	leptin	0.107
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.081
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.077
Pdk4	pyruvate dehydrogenase kinase, isozyme 4	0.068
Scnn1b	sodium channel, nonvoltage-gated 1, beta	0.062
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.061
Unc5b	unc-5 homolog B (C. elegans)	0.060
Tusc5	tumor suppressor candidate 5	0.057
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.056
Nxph4	neurexophilin 4	0.055
Pck1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.054
Rab1b	RAB1B, member RAS oncogene family	0.054
Apoe	apolipoprotein E	0.053
Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.052
Crybb1	crystallin, beta B1	0.052
Rbp7	retinol binding protein 7, cellular	0.049
Cyth1	cytohesin 1	0.046
Cpa3	carboxypeptidase A3, mast cell	0.044
Cmklr1	chemokine-like receptor 1	0.042
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.039
Irf7	interferon regulatory factor 7	0.039
Hrh2	histamine receptor H 2	0.038
Dhrs7c	dehydrogenase/reductase (SDR family) member 7C	0.038
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.038	Human
Cyp4b1	cytochrome P450, family 4, subfamily b, polypeptide 1	0.037
Mgst2	microsomal glutathione S-transferase 2	0.036
Ptgdr	prostaglandin D receptor	0.036
Phkg1	phosphorylase kinase, gamma 1	0.036
Pnma1	paraneoplastic antigen MA1	0.035
Abcc8	ATP-binding cassette, subfamily C (CFTR/MRP), member 8	0.034	Human
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.034
Pla2g5	phospholipase A2, group V	0.032
Akap1	A kinase (PRKA) anchor protein 1	0.031
LOC363331	similar to plasma membrane associated protein, S3-12	0.031
Fabp1	fatty acid binding protein 1, liver	0.031
Lat	linker for activation of T cells	0.031
Rhd	Rh blood group, D antigen	0.030
Prlh	prolactin releasing hormone	0.030
Rps29	ribosomal protein S29	0.029
Mx1	myxovirus (influenza virus) resistance 1	0.029
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.028
Atxn1	ataxin 1	0.028
Ehf	ets homologous factor	0.028
Fabp4	fatty acid binding protein 4, adipocyte	0.028
Fgf16	fibroblast growth factor 16	0.028
Grk4	G protein-coupled receptor kinase 4	0.028
Usf2	upstream transcription factor 2, c-fos interacting	0.027
Cntfr	ciliary neurotrophic factor receptor	0.026
Il3	interleukin 3	0.026
Ghrh	growth hormone releasing hormone	0.026
Krtap1-5	keratin associated protein 1-5	0.026
Defb1	defensin beta 1	0.025
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.025	Human
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.025
Myl3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.025
Acot2	acyl-CoA thioesterase 2	0.023
Hmga2	high mobility group AT-hook 2	0.023
Ceacam3	carcinoembryonic antigen-related cell adhesion molecule 3	0.023
Syngr2	synaptogyrin 2	0.022
Nos3	nitric oxide synthase 3, endothelial cell	0.022
Emp1	epithelial membrane protein 1	0.022
LOC100360403	ATP-binding cassette, sub-family C, member 9-like	0.021
Ecel1	endothelin converting enzyme-like 1	0.021
Pcdhgc3	protocadherin gamma subfamily C, 3	0.021
Aqp2	aquaporin 2 (collecting duct)	0.021
Asgr1	asialoglycoprotein receptor 1	0.021
Sgp158	proline-rich glycoprotein (sgp158)	0.021
Isg15	ISG15 ubiquitin-like modifier	0.021
Itm2b	integral membrane protein 2B	0.021
Gpihbp1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.020
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.020
Wdfy1	WD repeat and FYVE domain containing 1	0.020
Mug1	murinoglobulin 1	0.020
Stat3	signal transducer and activator of transcription 3	0.020
Arf3	ADP-ribosylation factor 3	0.020
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.019
Ceacam11	carcinoembryonic antigen-related cell adhesion molecule 11	0.019
Tacr2	tachykinin receptor 2	0.019
Eef2	eukaryotic translation elongation factor 2	0.019
Myo1c	myosin IC	0.019
Fbp1	fructose-1,6-bisphosphatase 1	0.019
Tmsb4x	thymosin beta 4, X-linked	0.019
Snrk	SNF related kinase	0.019
Gip	gastric inhibitory polypeptide	0.019
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.018
Oas1a	2'-5' oligoadenylate synthetase 1A	0.018
Orm1	orosomucoid 1	0.018
Homer2	homer homolog 2 (Drosophila)	0.018
Irs3	insulin receptor substrate 3	0.018
Edn1	endothelin 1	0.018
Shh	sonic hedgehog	0.018
Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	0.018
Adrb3	adrenergic, beta-3-, receptor	0.018	Human
Asmt	acetylserotonin O-methyltransferase	0.017
Pitx3	paired-like homeodomain 3	0.017
Cidea	cell death-inducing DFFA-like effector a	0.017
Ehhadh	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	0.017
Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)	0.017
Cpb1	carboxypeptidase B1 (tissue)	0.017
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.017
Acan	aggrecan	0.017
Aanat	arylalkylamine N-acetyltransferase	0.017
Znrf2	zinc and ring finger 2	0.017
Ambp	alpha-1-microglobulin/bikunin precursor	0.017
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.017
Cd302	CD302 molecule	0.017
Hpd	4-hydroxyphenylpyruvate dioxygenase	0.017
LOC100364485	mCG1051031-like	0.017
Slc7a12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 12	0.016
LOC100360737	rCG54380-like	0.016
Rtp4	receptor (chemosensory) transporter protein 4	0.016
Akr1c18	aldo-keto reductase family 1, member C18	0.016
Sdc3	syndecan 3	0.016	Human
Ros1	c-ros oncogene 1 , receptor tyrosine kinase	0.016
Cpt1b	carnitine palmitoyltransferase 1b, muscle	0.016
Casq2	calsequestrin 2 (cardiac muscle)	0.016
Akr1c14	aldo-keto reductase family 1, member C14	0.016
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.016
Pzp	pregnancy-zone protein	0.016
Bche	butyrylcholinesterase	0.016
Cfd	complement factor D (adipsin)	0.016
Tpo	thyroid peroxidase	0.016
Tmem59	transmembrane protein 59	0.015
Scn1b	sodium channel, voltage-gated, type I, beta	0.015
Cldn19	claudin 19	0.015
Pfkfb4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	0.015
C1qtnf6	C1q and tumor necrosis factor related protein 6	0.015
Spp2	secreted phosphoprotein 2	0.015
Cort	cortistatin	0.015
Cox8b	cytochrome c oxidase, subunit VIIIb	0.015
Sox17	SRY (sex determining region Y)-box 17	0.015
Pdzk1ip1	PDZK1 interacting protein 1	0.015
Dag1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.015
Kcng1	potassium voltage-gated channel, subfamily G, member 1	0.015
Hist1h1d	histone cluster 1, H1d	0.015
Apoa1	apolipoprotein A-I	0.015
Crhbp	corticotropin releasing hormone binding protein	0.015
Klkb1	kallikrein B, plasma 1	0.015
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.014
Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3	0.014
Timp3	TIMP metallopeptidase inhibitor 3	0.014
Afp	alpha-fetoprotein	0.014
Degs2	degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)	0.014
Ar	androgen receptor	0.014
Arc	activity-regulated cytoskeleton-associated protein	0.014
Gys2	glycogen synthase 2	0.014
Pyy	peptide YY (mapped)	0.014	Human
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.014
Prl4a1	prolactin family 4, subfamily a, member 1	0.014
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.014
Prss3	protease, serine, 3	0.014
Fgg	fibrinogen gamma chain	0.014
Ldb3	LIM domain binding 3	0.014
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.014
Scnn1g	sodium channel, nonvoltage-gated 1, gamma	0.014
Rara	retinoic acid receptor, alpha	0.014
Bmp7	bone morphogenetic protein 7	0.014
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.014
Fam148b	family with sequence similarity 148, member B	0.014
Mcpt8	mast cell protease 8	0.014
Pygm	phosphorylase, glycogen, muscle	0.014
Kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.014
Plg	plasminogen	0.014
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.014
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.014
Psap	prosaposin	0.014
Hist1h2aa	histone cluster 1, H2aa	0.014
Tmod4	tropomodulin 4	0.013
Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11	0.013
C4bpa	complement component 4 binding protein, alpha	0.013
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.013
Gabrr2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.013
Sgta	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.013
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.013
Ctsb	cathepsin B	0.013
Wt1	Wilms tumor 1	0.013
Lrrc14b	leucine rich repeat containing 14B	0.013
Kng1	kininogen 1	0.013
Aldob	aldolase B, fructose-bisphosphate	0.013
Neurog1	neurogenin 1	0.013
Rdh7	retinol dehydrogenase 7	0.013
Jak1	Janus kinase 1	0.013
Syngr1	synaptogyrin 1	0.013
Hand2	heart and neural crest derivatives expressed 2	0.013
Grifin	galectin-related inter-fiber protein	0.013
Mthfr	methylenetetrahydrofolate reductase (NAD(P)H)	0.013
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.013
Il13	interleukin 13	0.013
Myt1l	myelin transcription factor 1-like	0.013
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.013
Alb	albumin	0.013
Cbl	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
Plin	perilipin	0.013
Acsl6	acyl-CoA synthetase long-chain family member 6	0.013
Megf10	multiple EGF-like domains 10	0.013
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.013
RT1-S3	RT1 class Ib, locus S3	0.012
Cfh	complement factor H	0.012
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.012
Pde4a	phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)	0.012
Sycn	syncollin	0.012
Uba7	ubiquitin-like modifier activating enzyme 7	0.012
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.012
Mip	major intrinsic protein of lens fiber	0.012
Gjb4	gap junction protein, beta 4	0.012
Ldlr	low density lipoprotein receptor	0.012
Dio1	deiodinase, iodothyronine, type I	0.012
Clca4	chloride channel accessory 4	0.012
Mep1b	meprin 1 beta	0.012
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.012
Cel	carboxyl ester lipase	0.012
Rimbp2	RIMS binding protein 2	0.012
Tmem171	transmembrane protein 171	0.012
Tgfbr2	transforming growth factor, beta receptor II	0.012
C4bpb	complement component 4 binding protein, beta	0.012
Dlg4	discs, large homolog 4 (Drosophila)	0.012
Arhgap4	Rho GTPase activating protein 4	0.012
Slc12a3	solute carrier family 12 (sodium/chloride transporters), member 3	0.012
Nat1	N-acetyltransferase 1	0.012
Lhb	luteinizing hormone beta	0.012
C3	complement component 3	0.012
Barhl2	BarH-like homeobox 2	0.012
Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.012
Fgf1	fibroblast growth factor 1	0.012
Sftpa1	surfactant protein A1	0.012
Fzd4	frizzled homolog 4 (Drosophila)	0.011
Tmem45b	transmembrane protein 45b	0.011
LOC685244	similar to IQ motif and Sec7 domain 2	0.011
Hoxa4	homeo box A4	0.011
Hk1	hexokinase 1	0.011
Rap2ip	Rap2 interacting protein	0.011
Slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.011
Il7r	interleukin 7 receptor	0.011
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.011
Cd14	CD14 molecule	0.011
Obp1f	odorant binding protein I f	0.011
Gkn1	gastrokine 1	0.011
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.011
Sptan1	spectrin, alpha, non-erythrocytic 1	0.011
Vamp1	vesicle-associated membrane protein 1	0.011
Apoa4	apolipoprotein A-IV	0.011
Dnajc6	DnaJ (Hsp40) homolog, subfamily C, member 6	0.011
LOC246267	resection-induced TPI (rs11)	0.011
Gja3	gap junction protein, alpha 3	0.011
Rho	rhodopsin	0.011
Mcpt4	mast cell protease 4	0.011
Pou2f3	POU class 2 homeobox 3	0.011
Art1	ADP-ribosyltransferase 1	0.011
Krt1	keratin 1	0.011
Pfkm	phosphofructokinase, muscle	0.011
Fabp12	fatty acid binding protein 12	0.011
Acaa1b	acetyl-Coenzyme A acyltransferase 1B	0.011
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.011
Pgam2	phosphoglycerate mutase 2 (muscle)	0.011
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.011
Akt1	v-akt murine thymoma viral oncogene homolog 1	0.011
Ak1	adenylate kinase 1	0.011
Cr1l	complement component (3b/4b) receptor 1-like	0.011
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.011
Grb2	growth factor receptor bound protein 2	0.011
Dmgdh	dimethylglycine dehydrogenase	0.011
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.011	Human
RGD1305347	similar to RIKEN cDNA 2610528J11	0.011
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.011
Dnah1	dynein, axonemal, heavy chain 1	0.011
Adarb2	adenosine deaminase, RNA-specific, B2	0.011
Nfasc	neurofascin	0.011
Gcgr	glucagon receptor	0.011	Human
Pawr	PRKC, apoptosis, WT1, regulator	0.011
Gulo	gulonolactone (L-) oxidase	0.011
Acacb	acetyl-Coenzyme A carboxylase beta	0.010
Clrn3	clarin 3	0.010
Prnp	prion protein	0.010
Pik3r2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.010
Prlr	prolactin receptor	0.010
Sult1b1	sulfotransferase family, cytosolic, 1B, member 1	0.010
Fn1	fibronectin 1	0.010
Hrasls5	HRAS-like suppressor family, member 5	0.010
Hal	histidine ammonia lyase	0.010
RGD1565168	similar to RAP2A, member of RAS oncogene family	0.010
LOC100361007	rCG32064-like	0.010
Atp2b3	ATPase, Ca++ transporting, plasma membrane 3	0.010
Ckm	creatine kinase, muscle	0.010
Cma1	chymase 1, mast cell	0.010
Igfbp1	insulin-like growth factor binding protein 1	0.010
Lrrc39	leucine rich repeat containing 39	0.010
Aqp8	aquaporin 8	0.010
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.010
Oxtr	oxytocin receptor	0.010
Dchs1	dachsous 1 (Drosophila)	0.010
Clcn1	chloride channel 1	0.010
Prodh2	proline dehydrogenase (oxidase) 2	0.010
Pqcp	polyglutamine-containing protein	0.010