IMP

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Homo sapiens

1 genes annotated in human

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fibroblast growth factor receptor signaling pathway involved in mammary gland specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fibroblast growth factor receptor signaling pathway involved in mammary gland specification" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	1.000	Mouse
FGF10	fibroblast growth factor 10	1.000
FGF1	fibroblast growth factor 1 (acidic)	1.000	Human
FGFR1	fibroblast growth factor receptor 1	1.000
FGF7	fibroblast growth factor 7	1.000	Human
FGF8	fibroblast growth factor 8 (androgen-induced)	0.996
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.992
PLCG1	phospholipase C, gamma 1	0.964
FGFR3	fibroblast growth factor receptor 3	0.948
FRS2	fibroblast growth factor receptor substrate 2	0.948
FGF3	fibroblast growth factor 3	0.495	Human
CTGF	connective tissue growth factor	0.471
FGF2	fibroblast growth factor 2 (basic)	0.443	Human
FGFBP1	fibroblast growth factor binding protein 1	0.314
FGF4	fibroblast growth factor 4	0.257	Human
WNT1	wingless-type MMTV integration site family, member 1	0.253
FGF6	fibroblast growth factor 6	0.129	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.109
FGF19	fibroblast growth factor 19	0.093
THBS1	thrombospondin 1	0.082
PSG9	pregnancy specific beta-1-glycoprotein 9	0.082
PRDM8	PR domain containing 8	0.082
LHX5	LIM homeobox 5	0.070
GFAP	glial fibrillary acidic protein	0.064
CNTN1	contactin 1	0.063
ECEL1	endothelin converting enzyme-like 1	0.061
FGF5	fibroblast growth factor 5	0.059	Human
WNT3	wingless-type MMTV integration site family, member 3	0.057
MOS	v-mos Moloney murine sarcoma viral oncogene homolog	0.054
NKX2-1	NK2 homeobox 1	0.053
T	T, brachyury homolog (mouse)	0.053
SEZ6L	seizure related 6 homolog (mouse)-like	0.053
PSG6	pregnancy specific beta-1-glycoprotein 6	0.049
PRDM12	PR domain containing 12	0.049
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.047
NKX6-2	NK6 homeobox 2	0.046
CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	0.043
FOXN4	forkhead box N4	0.042
PGR	progesterone receptor	0.042
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.042
KAL1	Kallmann syndrome 1 sequence	0.041
KRT34	keratin 34	0.040
LBX1	ladybird homeobox 1	0.040
PTH	parathyroid hormone	0.040
WNT9B	wingless-type MMTV integration site family, member 9B	0.039
VSX1	visual system homeobox 1	0.039
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.036
PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	0.034
GJC2	gap junction protein, gamma 2, 47kDa	0.032
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.032
BDNF	brain-derived neurotrophic factor	0.032
JPH2	junctophilin 2	0.030
TMEM59L	transmembrane protein 59-like	0.029
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.028
ERAS	ES cell expressed Ras	0.027
CRHR1	corticotropin releasing hormone receptor 1	0.027
ADRA1A	adrenergic, alpha-1A-, receptor	0.026
DGKI	diacylglycerol kinase, iota	0.025
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.025
GBX1	gastrulation brain homeobox 1	0.025
FOXL1	forkhead box L1	0.024
DNMT3L	DNA (cytosine-5-)-methyltransferase 3-like	0.023
FGFR4	fibroblast growth factor receptor 4	0.023
TMSB4Y	thymosin beta 4, Y-linked	0.023
GDF3	growth differentiation factor 3	0.023
ZNF536	zinc finger protein 536	0.022
RSPO3	R-spondin 3 homolog (Xenopus laevis)	0.022
EVX1	even-skipped homeobox 1	0.022
OGN	osteoglycin	0.022
KCNK2	potassium channel, subfamily K, member 2	0.022
SIX6	SIX homeobox 6	0.021
HAS2	hyaluronan synthase 2	0.021
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.021
BARHL1	BarH-like homeobox 1	0.021
NEUROG2	neurogenin 2	0.021
EPHA5	EPH receptor A5	0.020
TBX5	T-box 5	0.020
DRD2	dopamine receptor D2	0.020
PAX1	paired box 1	0.020
CALB1	calbindin 1, 28kDa	0.020
FOXD3	forkhead box D3	0.020
RSPO2	R-spondin 2 homolog (Xenopus laevis)	0.020
NPY1R	neuropeptide Y receptor Y1	0.019
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.019
NOL4	nucleolar protein 4	0.019
GSC	goosecoid homeobox	0.019
NTSR2	neurotensin receptor 2	0.019
PAX8	paired box 8	0.018
BHLHE23	basic helix-loop-helix family, member e23	0.018
GDNF	glial cell derived neurotrophic factor	0.018
B3GALT1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.018
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.018
ESRRB	estrogen-related receptor beta	0.018
CCL24	chemokine (C-C motif) ligand 24	0.017
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.017
DNAJB8	DnaJ (Hsp40) homolog, subfamily B, member 8	0.017
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.017
POU4F2	POU class 4 homeobox 2	0.017
DPEP3	dipeptidase 3	0.017
CDH8	cadherin 8, type 2	0.016
NKD2	naked cuticle homolog 2 (Drosophila)	0.016
TLX1	T-cell leukemia homeobox 1	0.016
SHB	Src homology 2 domain containing adaptor protein B	0.016
AMN	amnionless homolog (mouse)	0.016
LHX3	LIM homeobox 3	0.016
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.016
HES7	hairy and enhancer of split 7 (Drosophila)	0.016
KCNJ14	potassium inwardly-rectifying channel, subfamily J, member 14	0.016
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.015
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.015
ZFHX4	zinc finger homeobox 4	0.015
NOVA1	neuro-oncological ventral antigen 1	0.015
KIF25	kinesin family member 25	0.015
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.015
MIXL1	Mix1 homeobox-like 1 (Xenopus laevis)	0.015
IFNA8	interferon, alpha 8	0.015
KLHL1	kelch-like 1 (Drosophila)	0.015
MYL10	myosin, light chain 10, regulatory	0.015
HBZ	hemoglobin, zeta	0.014
FOXA2	forkhead box A2	0.014
NGF	nerve growth factor (beta polypeptide)	0.014
LRAT	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	0.014
EDIL3	EGF-like repeats and discoidin I-like domains 3	0.014
FRMPD4	FERM and PDZ domain containing 4	0.014
CRH	corticotropin releasing hormone	0.014
SCTR	secretin receptor	0.014
KLF15	Kruppel-like factor 15	0.013
ALX1	ALX homeobox 1	0.013
HAND1	heart and neural crest derivatives expressed 1	0.013
HOXC5	homeobox C5	0.013
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.013
PSPN	persephin	0.013
ADRA1D	adrenergic, alpha-1D-, receptor	0.013
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.013
KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.013
DPP10	dipeptidyl-peptidase 10 (non-functional)	0.013
ANGPT4	angiopoietin 4	0.013
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.013
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.013
CALCA	calcitonin-related polypeptide alpha	0.013
PSG3	pregnancy specific beta-1-glycoprotein 3	0.013
EGF	epidermal growth factor	0.013
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.012
TRPM1	transient receptor potential cation channel, subfamily M, member 1	0.012
CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	0.012
MAB21L1	mab-21-like 1 (C. elegans)	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
RIC3	resistance to inhibitors of cholinesterase 3 homolog (C. elegans)	0.012
SLC6A19	solute carrier family 6 (neutral amino acid transporter), member 19	0.012
DRD1	dopamine receptor D1	0.012
HOXD1	homeobox D1	0.012
DCC	deleted in colorectal carcinoma	0.012
SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	0.012
RGS4	regulator of G-protein signaling 4	0.012
EPHA8	EPH receptor A8	0.012
MSTN	myostatin	0.012
C11orf41	chromosome 11 open reading frame 41	0.012
PSG5	pregnancy specific beta-1-glycoprotein 5	0.012
CBLN1	cerebellin 1 precursor	0.012
BNC1	basonuclin 1	0.012
DPF3	D4, zinc and double PHD fingers, family 3	0.011
AFF2	AF4/FMR2 family, member 2	0.011
NAV3	neuron navigator 3	0.011
CDX4	caudal type homeobox 4	0.011
PDE10A	phosphodiesterase 10A	0.011
TLX3	T-cell leukemia homeobox 3	0.011
SLC16A8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.011
SSTR1	somatostatin receptor 1	0.011
CHRND	cholinergic receptor, nicotinic, delta	0.011
GRB14	growth factor receptor-bound protein 14	0.011
NOS1	nitric oxide synthase 1 (neuronal)	0.011
CD70	CD70 molecule	0.011
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.011
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
GALR1	galanin receptor 1	0.010
CPA1	carboxypeptidase A1 (pancreatic)	0.010
SOX1	SRY (sex determining region Y)-box 1	0.010
ACSL6	acyl-CoA synthetase long-chain family member 6	0.010
GPR45	G protein-coupled receptor 45	0.010
TP73	tumor protein p73	0.010
BCAN	brevican	0.010
LRTM2	leucine-rich repeats and transmembrane domains 2	0.010
ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif, 3	0.010
KRT83	keratin 83	0.010