IMP

Process View

Homo sapiens

1 genes annotated in human

estrogen catabolic process

The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "estrogen catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "estrogen catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.978	Human
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.971	Human
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.876
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.651
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.347
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.164
PRLR	prolactin receptor	0.150
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.148
LRRC31	leucine rich repeat containing 31	0.085
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.082
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.079
SI	sucrase-isomaltase (alpha-glucosidase)	0.075
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.074
UGT2B10	UDP glucuronosyltransferase 2 family, polypeptide B10	0.073	Human
UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.069	Human
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.056
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.048
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.048
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.044
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.042
MAPK14	mitogen-activated protein kinase 14	0.041
ALDOB	aldolase B, fructose-bisphosphate	0.039
GSTA3	glutathione S-transferase alpha 3	0.038
AADAC	arylacetamide deacetylase (esterase)	0.036
MTTP	microsomal triglyceride transfer protein	0.036
SLC26A3	solute carrier family 26, member 3	0.035
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.034
F13B	coagulation factor XIII, B polypeptide	0.034
TAT	tyrosine aminotransferase	0.033
PDZK1	PDZ domain containing 1	0.032
HNF4G	hepatocyte nuclear factor 4, gamma	0.030
MBL2	mannose-binding lectin (protein C) 2, soluble	0.029
ADH6	alcohol dehydrogenase 6 (class V)	0.026
PAH	phenylalanine hydroxylase	0.026
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.024
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.023
OTC	ornithine carbamoyltransferase	0.023
ZNF157	zinc finger protein 157	0.023
GYS2	glycogen synthase 2 (liver)	0.023
SLC30A10	solute carrier family 30, member 10	0.023
TSPAN8	tetraspanin 8	0.022
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.022
TPH1	tryptophan hydroxylase 1	0.022
SULT1C2	sulfotransferase family, cytosolic, 1C, member 2	0.022
FRK	fyn-related kinase	0.022
G6PC	glucose-6-phosphatase, catalytic subunit	0.021
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.021
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.021
ANXA10	annexin A10	0.021
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.021	Human
CPB2	carboxypeptidase B2 (plasma)	0.020
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.020
MEP1B	meprin A, beta	0.020
SOSTDC1	sclerostin domain containing 1	0.019
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	0.019
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.019
HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)	0.019
MSTN	myostatin	0.019
C9	complement component 9	0.019
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.018
ACPP	acid phosphatase, prostate	0.018
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.018
LGSN	lengsin, lens protein with glutamine synthetase domain	0.018
HRG	histidine-rich glycoprotein	0.017
CCDC68	coiled-coil domain containing 68	0.017
NPY1R	neuropeptide Y receptor Y1	0.017
AGR2	anterior gradient homolog 2 (Xenopus laevis)	0.017
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.016
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.016
CLDN8	claudin 8	0.016
ALB	albumin	0.016
AKAP7	A kinase (PRKA) anchor protein 7	0.016
MAP2K6	mitogen-activated protein kinase kinase 6	0.016
SLCO1B1	solute carrier organic anion transporter family, member 1B1	0.015
HGD	homogentisate 1,2-dioxygenase	0.015
AFP	alpha-fetoprotein	0.015
FMO5	flavin containing monooxygenase 5	0.015
IL26	interleukin 26	0.015
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.015
FGG	fibrinogen gamma chain	0.015
ACSM2A	acyl-CoA synthetase medium-chain family member 2A	0.014
KNG1	kininogen 1	0.014
NTS	neurotensin	0.014
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.014
IYD	iodotyrosine deiodinase	0.014
CRISP3	cysteine-rich secretory protein 3	0.014
SLC25A21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21	0.014
SLITRK6	SLIT and NTRK-like family, member 6	0.014
CPS1	carbamoyl-phosphate synthase 1, mitochondrial	0.014
FGL1	fibrinogen-like 1	0.013
HEPACAM2	HEPACAM family member 2	0.013
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.013
AFM	afamin	0.013
ALDH8A1	aldehyde dehydrogenase 8 family, member A1	0.013
GSTT1	glutathione S-transferase theta 1	0.013
GAS2	growth arrest-specific 2	0.013
HTN3	histatin 3	0.013
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.013
TMEM27	transmembrane protein 27	0.012
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.012
FMO3	flavin containing monooxygenase 3	0.012
RLN2	relaxin 2	0.012
RGS13	regulator of G-protein signaling 13	0.012
SLC38A4	solute carrier family 38, member 4	0.012
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.012
FSTL5	follistatin-like 5	0.012
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	0.012
LIN7A	lin-7 homolog A (C. elegans)	0.012
ACSM3	acyl-CoA synthetase medium-chain family member 3	0.012
SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.012
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.012
GSTA2	glutathione S-transferase alpha 2	0.011
LRRC19	leucine rich repeat containing 19	0.011
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.011
CLRN3	clarin 3	0.011
ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.011
TRDN	triadin	0.011
PRG4	proteoglycan 4	0.011
GC	group-specific component (vitamin D binding protein)	0.011
EGF	epidermal growth factor	0.011
HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	0.011
SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.011
AGR3	anterior gradient homolog 3 (Xenopus laevis)	0.011
RASSF6	Ras association (RalGDS/AF-6) domain family member 6	0.011
HTN1	histatin 1	0.011
XK	X-linked Kx blood group (McLeod syndrome)	0.011
RP1	retinitis pigmentosa 1 (autosomal dominant)	0.010
ZNF155	zinc finger protein 155	0.010
HHLA2	HERV-H LTR-associating 2	0.010
ACOX2	acyl-CoA oxidase 2, branched chain	0.010
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.010
LEAP2	liver expressed antimicrobial peptide 2	0.010
ARL14	ADP-ribosylation factor-like 14	0.010
MYRIP	myosin VIIA and Rab interacting protein	0.010
SLC16A7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)	0.010
EAF2	ELL associated factor 2	0.010
POF1B	premature ovarian failure, 1B	0.010
RXFP1	relaxin/insulin-like family peptide receptor 1	0.010