|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
1.000
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
1.000
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
1.000
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
1.000
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
1.000
|
Human |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
1.000
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
1.000
|
Human |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.999
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.999
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.999
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.999
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.999
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.999
|
Human |
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.999
|
Human |
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.999
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.998
|
Mouse |
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.998
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.998
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.998
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.997
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.996
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.996
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.995
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.995
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.994
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.994
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.993
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.992
|
Mouse |
|
|
protein processing
|
GO:0016485 |
226 |
0.992
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.992
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.991
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.991
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.990
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.989
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.988
|
Human |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.988
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.980
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.979
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.979
|
|
|
|
necroptotic process
|
GO:0070266 |
16 |
0.977
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.975
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.973
|
Human |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.973
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.973
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.972
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.972
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.972
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.962
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.961
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.960
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.959
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.959
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.957
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.956
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.955
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.954
|
|
|
|
negative regulation of calcium ion import
|
GO:0090281 |
1 |
0.950
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.950
|
Human |
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.945
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.944
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.942
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.936
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.935
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.934
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.933
|
Human |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.930
|
Human |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.926
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.926
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.926
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.923
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.920
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.919
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.918
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.916
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.914
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.908
|
|
|
|
entry into cell of other organism involved in symbiotic interaction
|
GO:0051806 |
25 |
0.904
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.903
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.899
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.899
|
|
|
|
negative regulation of interleukin 2 secretion
|
GO:1900041 |
2 |
0.898
|
|
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
0.894
|
Human |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.891
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
2 |
0.890
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.888
|
Human |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.886
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.881
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.879
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.876
|
|
|
|
cellular response to increased oxygen levels
|
GO:0036295 |
4 |
0.875
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.870
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.868
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.868
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.867
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.866
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.865
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.865
|
Mouse |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.859
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.857
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.853
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.848
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.841
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.841
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.839
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.838
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.833
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.831
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.831
|
|
|
|
response to cobalt ion
|
GO:0032025 |
1 |
0.829
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.829
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.825
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.824
|
|
|
|
skeletal muscle satellite cell proliferation
|
GO:0014841 |
1 |
0.822
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.821
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.817
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.813
|
Human |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.811
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.810
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.810
|
Human |
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.803
|
Human |
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.803
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.800
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.789
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.787
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.787
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.785
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.784
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.784
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.780
|
|
|
|
negative regulation of protein deubiquitination
|
GO:0090086 |
3 |
0.766
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.765
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.765
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.762
|
|
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.760
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.756
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.747
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.740
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.736
|
Human |
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.736
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.735
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.734
|
Human Mouse |
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.732
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.723
|
Human |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.723
|
Human |
|
|
t cell differentiation in thymus
|
GO:0033077 |
4 |
0.721
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.717
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.714
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.705
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.701
|
|
|
|
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000059 |
3 |
0.699
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.698
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.697
|
|
|
|
positive regulation of viral entry into host cell
|
GO:0046598 |
3 |
0.696
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.692
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.689
|
|
|
|
positive regulation of neutrophil apoptotic process
|
GO:0033031 |
1 |
0.674
|
|
|
|
regulation of atp adp antiporter activity
|
GO:0070926 |
1 |
0.674
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
0.673
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.671
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.670
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.665
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.663
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.661
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.660
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.659
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.659
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.658
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.657
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.653
|
Mouse |
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.650
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.650
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.645
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.644
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.639
|
|
|
|
cellular response to hyperoxia
|
GO:0071455 |
4 |
0.631
|
|
|
|
t cell migration
|
GO:0072678 |
16 |
0.626
|
|
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
7 |
0.622
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.621
|
Mouse |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.618
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.611
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.609
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.607
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.606
|
|
|
|
regulation of intracellular transport of viral material
|
GO:1901252 |
2 |
0.604
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.599
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.591
|
Human |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.586
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902042 |
15 |
0.583
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.580
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.577
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.576
|
Human |
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.571
|
|
|
|
regulation of nucleoside transport
|
GO:0032242 |
1 |
0.571
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.565
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.563
|
|
|
|
t cell homeostasis
|
GO:0043029 |
3 |
0.557
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.552
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.544
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.544
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.542
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.535
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.534
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.533
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.529
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.525
|
|
|
|
positive regulation of hair follicle development
|
GO:0051798 |
3 |
0.524
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.523
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.504
|
Human |
|
|
amyloid fibril formation
|
GO:1990000 |
3 |
0.503
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.503
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.493
|
Human |
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.488
|
|
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.484
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.482
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.481
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.480
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.477
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
9 |
0.471
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.468
|
|
|
|
regulation of viral entry into host cell
|
GO:0046596 |
17 |
0.466
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.465
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.458
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.457
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.453
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.452
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.452
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.451
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
24 |
0.450
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.449
|
|
|
|
negative regulation of protein secretion
|
GO:0050709 |
29 |
0.447
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
7 |
0.444
|
|
|
|
regulation of cell cycle arrest
|
GO:0071156 |
36 |
0.443
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.443
|
|
|
|
positive regulation of type i interferon production
|
GO:0032481 |
20 |
0.431
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.420
|
|
|
|
positive regulation of myeloid cell apoptotic process
|
GO:0033034 |
2 |
0.400
|
|
|
|
regulation of macrophage differentiation
|
GO:0045649 |
9 |
0.400
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.394
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.392
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.389
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.388
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.388
|
Human |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.387
|
|
|
|
spleen development
|
GO:0048536 |
1 |
0.385
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.384
|
|
|
|
entry into host
|
GO:0044409 |
25 |
0.383
|
|
|
|
interleukin 2 secretion
|
GO:0070970 |
3 |
0.382
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.380
|
Human |
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.377
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.375
|
|
|
|
protein destabilization
|
GO:0031648 |
12 |
0.365
|
|
|
|
regulation of myoblast fusion
|
GO:1901739 |
1 |
0.364
|
|
|
|
movement in host environment
|
GO:0052126 |
25 |
0.361
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.360
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.348
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.341
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.341
|
Human |
|
|
regulation of cellular extravasation
|
GO:0002691 |
8 |
0.337
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.336
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.335
|
Human |
|
|
regulation of interleukin 2 secretion
|
GO:1900040 |
2 |
0.335
|
|
|
|
positive regulation of endothelial cell apoptotic process
|
GO:2000353 |
8 |
0.334
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.330
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.330
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.326
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.324
|
Human |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.324
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.323
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.323
|
|
|
|
negative regulation of interleukin 2 production
|
GO:0032703 |
7 |
0.322
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.321
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.319
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.317
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.317
|
|
|
|
movement in environment of other organism involved in symbiotic interaction
|
GO:0052192 |
25 |
0.316
|
|
|
|
regulation of viral process
|
GO:0050792 |
103 |
0.307
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.302
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.302
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.301
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
3 |
0.299
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.298
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.298
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.298
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.297
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.295
|
|
|
|
viral release from host cell
|
GO:0019076 |
21 |
0.288
|
|
|
|
activated t cell proliferation
|
GO:0050798 |
13 |
0.286
|
|
|
|
negative regulation of viral process
|
GO:0048525 |
66 |
0.284
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.282
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.279
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.277
|
|
|
|
t cell apoptotic process
|
GO:0070231 |
12 |
0.275
|
Mouse |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.274
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.273
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.272
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.267
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.267
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.265
|
Mouse |
|
|
thymus development
|
GO:0048538 |
3 |
0.264
|
|
|
|
protein trimerization
|
GO:0070206 |
20 |
0.264
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
12 |
0.257
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.256
|
|
|
|
retrograde transport endosome to golgi
|
GO:0042147 |
45 |
0.253
|
|
|
|
negative regulation of viral release from host cell
|
GO:1902187 |
12 |
0.253
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.252
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.252
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.250
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.247
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.247
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.243
|
|
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.240
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.239
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
34 |
0.239
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.237
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.237
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.235
|
Mouse |
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.231
|
|
|
|
regulation of viral genome replication
|
GO:0045069 |
48 |
0.231
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.230
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.228
|
|
|
|
regulation of viral release from host cell
|
GO:1902186 |
20 |
0.225
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.224
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.224
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.223
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.221
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.218
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.217
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.217
|
|
|
|
positive regulation of rig i signaling pathway
|
GO:1900246 |
4 |
0.217
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.217
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.217
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.215
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.215
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.212
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.212
|
|
|
|
inflammatory cell apoptotic process
|
GO:0006925 |
3 |
0.210
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.210
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.209
|
|
|
|
positive regulation of nf kappab import into nucleus
|
GO:0042346 |
13 |
0.208
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.206
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.205
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.204
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.204
|
Human |
|
|
positive regulation of interleukin 8 biosynthetic process
|
GO:0045416 |
8 |
0.202
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.200
|
Mouse |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.200
|
Mouse |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.199
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
12 |
0.198
|
Human |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.198
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.196
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.196
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.195
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
7 |
0.194
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.193
|
|
|
|
regulation of protein deubiquitination
|
GO:0090085 |
4 |
0.193
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.190
|
|
|
|
negative regulation of serine type peptidase activity
|
GO:1902572 |
2 |
0.189
|
|
|
|
regulation of g1 s transition of mitotic cell cycle
|
GO:2000045 |
40 |
0.189
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.185
|
Human |
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
8 |
0.183
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.183
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.183
|
|
|
|
system process
|
GO:0003008 |
349 |
0.179
|
|
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.179
|
|
|
|
entry into host cell
|
GO:0030260 |
25 |
0.179
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.176
|
Human |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.176
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.173
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.172
|
Human |
|
|
type i interferon production
|
GO:0032606 |
27 |
0.167
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.166
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.163
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.162
|
|
|
|
negative regulation of intracellular transport of viral material
|
GO:1901253 |
2 |
0.161
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.160
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.157
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
38 |
0.157
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.156
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.155
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.155
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.155
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.154
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.154
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.152
|
Human |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.151
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.149
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.149
|
|
|
|
entry into other organism involved in symbiotic interaction
|
GO:0051828 |
25 |
0.149
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.148
|
|
|
|
regulation of serine type peptidase activity
|
GO:1902571 |
2 |
0.148
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.148
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.147
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.146
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.145
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.144
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.143
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.143
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.142
|
|
|
|
interferon beta production
|
GO:0032608 |
23 |
0.142
|
|
|
|
multi organism intracellular transport
|
GO:1902583 |
14 |
0.140
|
|
|
|
cellular response to steroid hormone stimulus
|
GO:0071383 |
37 |
0.140
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.138
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.136
|
|
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.136
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.136
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.135
|
Human |
|
|
neutrophil apoptotic process
|
GO:0001781 |
2 |
0.135
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.134
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.134
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.133
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.132
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.132
|
|
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.130
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.129
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
6 |
0.129
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.129
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.128
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.128
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.128
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.128
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.127
|
Human |
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.125
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.124
|
Human |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.122
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.122
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.120
|
|
|
|
regulation of serine type endopeptidase activity
|
GO:1900003 |
2 |
0.119
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.119
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.119
|
|
|
|
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
|
GO:0035872 |
5 |
0.119
|
Human |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.118
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.116
|
|
|
|
long chain fatty acid transport
|
GO:0015909 |
18 |
0.115
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.114
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.114
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.114
|
|
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.113
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.112
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
2 |
0.112
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.111
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.109
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.109
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.109
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.108
|
|
|
|
regulation of lymphocyte migration
|
GO:2000401 |
22 |
0.108
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.107
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.107
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.106
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.106
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.106
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.106
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.105
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.105
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.104
|
Human |
|
|
lipid transport
|
GO:0006869 |
90 |
0.104
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.104
|
|
|
|
lymphocyte migration
|
GO:0072676 |
28 |
0.101
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
109 |
0.100
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.099
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.099
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.098
|
|
|
|
negative regulation of viral transcription
|
GO:0032897 |
23 |
0.098
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.098
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.096
|
|
|
|
neutrophil degranulation
|
GO:0043312 |
3 |
0.095
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.095
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.094
|
|
|
|
regulation of satellite cell proliferation
|
GO:0014842 |
1 |
0.094
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.093
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.091
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.091
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
15 |
0.090
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.090
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.090
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.089
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.087
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.087
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.086
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.086
|
|
|
|
regulation of viral transcription
|
GO:0046782 |
34 |
0.086
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.085
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.085
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.085
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.084
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.084
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.084
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001241 |
4 |
0.083
|
|
|
|
viral gene expression
|
GO:0019080 |
35 |
0.082
|
|
