IMP

Process View

8 genes annotated in human

replicative senescence

A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

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Known genes in the process in human Include functional analogs

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Name	Description	Probability	Func Analog Organism
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.497
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.067
WWOX	WW domain containing oxidoreductase	0.026
PML	promyelocytic leukemia	0.019
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.018
KRT5	keratin 5	0.017
FANCD2	Fanconi anemia, complementation group D2	0.017
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.015
DAXX	death-domain associated protein	0.013
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.010	Yeast
CDK6	cyclin-dependent kinase 6	0.010