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Process View

Homo sapiens

11 genes annotated in human

meckel syndrome

DOID:0050778

An autosomal recessive disease that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia caused by dysfunction of primary cilia (ciliopathy) during early embryogenesis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "meckel syndrome"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "meckel syndrome" (in gray)

Name	Description	Probability	Func Analog Organism
TTC30B	tetratricopeptide repeat domain 30B	0.998
INVS	inversin	0.986
CP110	CP110 protein	0.868
UNC119B	unc-119 homolog B (C. elegans)	0.689
ZNF423	zinc finger protein 423	0.581
CEP164	centrosomal protein 164kDa	0.408
IQCB1	IQ motif containing B1	0.318
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.281
C9orf116	chromosome 9 open reading frame 116	0.230
GOLGA6L9	golgin A6 family-like 9	0.229
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.131
BBS4	Bardet-Biedl syndrome 4	0.115
POLI	polymerase (DNA directed) iota	0.096
EFHC1	EF-hand domain (C-terminal) containing 1	0.092
DYNC2LI1	dynein, cytoplasmic 2, light intermediate chain 1	0.087
NPHP4	nephronophthisis 4	0.077
TTC30A	tetratricopeptide repeat domain 30A	0.056
AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	0.055
NEURL4	neuralized homolog 4 (Drosophila)	0.053
KIAA0174	KIAA0174	0.049
KIAA2026	KIAA2026	0.042
IFT88	intraflagellar transport 88 homolog (Chlamydomonas)	0.038
TBC1D5	TBC1 domain family, member 5	0.038
ZC3H10	zinc finger CCCH-type containing 10	0.038
GOLGA8H	golgin A8 family, member H	0.036
ANKRD36B	ankyrin repeat domain 36B	0.035
KIF3A	kinesin family member 3A	0.032
FAM46A	family with sequence similarity 46, member A	0.028
C11orf61	chromosome 11 open reading frame 61	0.028
TTC26	tetratricopeptide repeat domain 26	0.026
ATXN2	ataxin 2	0.026
LRRC49	leucine rich repeat containing 49	0.025
DZIP3	DAZ interacting protein 3, zinc finger	0.024
MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	0.023
ZHX2	zinc fingers and homeoboxes 2	0.022
R3HDM2	R3H domain containing 2	0.022
IFT46	intraflagellar transport 46 homolog (Chlamydomonas)	0.022
RAB36	RAB36, member RAS oncogene family	0.022
TMEM231	transmembrane protein 231	0.021
TRIM32	tripartite motif containing 32	0.021
USP54	ubiquitin specific peptidase 54	0.021
WDR19	WD repeat domain 19	0.020
CCDC113	coiled-coil domain containing 113	0.020
NME5	non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)	0.020
ZKSCAN3	zinc finger with KRAB and SCAN domains 3	0.019
SYBU	syntabulin (syntaxin-interacting)	0.019
MPHOSPH8	M-phase phosphoprotein 8	0.019
UNK	unkempt homolog (Drosophila)	0.018
NUMBL	numb homolog (Drosophila)-like	0.018
CLUAP1	clusterin associated protein 1	0.018
ETAA1	Ewing tumor-associated antigen 1	0.017
ANKRD36	ankyrin repeat domain 36	0.017
DNAL4	dynein, axonemal, light chain 4	0.017
GCAT	glycine C-acetyltransferase	0.017
WDR5B	WD repeat domain 5B	0.017
MAP9	microtubule-associated protein 9	0.017
NEK11	NIMA (never in mitosis gene a)- related kinase 11	0.016
KIAA1407	KIAA1407	0.016
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.016
LRRC6	leucine rich repeat containing 6	0.016
RABL5	RAB, member RAS oncogene family-like 5	0.015
NPHP1	nephronophthisis 1 (juvenile)	0.015
C7orf63	chromosome 7 open reading frame 63	0.015
C5orf28	chromosome 5 open reading frame 28	0.015
SPATA17	spermatogenesis associated 17	0.015
GEMIN8	gem (nuclear organelle) associated protein 8	0.015
ZNF514	zinc finger protein 514	0.015
C14orf79	chromosome 14 open reading frame 79	0.014
C8orf37	chromosome 8 open reading frame 37	0.014
OR5M11	olfactory receptor, family 5, subfamily M, member 11	0.014
MCM3AP	minichromosome maintenance complex component 3 associated protein	0.014
MTERFD2	MTERF domain containing 2	0.014
MKS1	Meckel syndrome, type 1	0.014
INTU	inturned planar cell polarity effector homolog (Drosophila)	0.014
WDR35	WD repeat domain 35	0.014
KIAA1009	KIAA1009	0.014
C2orf63	chromosome 2 open reading frame 63	0.013
ACAD11	acyl-CoA dehydrogenase family, member 11	0.013
DNAJC24	DnaJ (Hsp40) homolog, subfamily C, member 24	0.013
OR8H1	olfactory receptor, family 8, subfamily H, member 1	0.013
ALMS1	Alstrom syndrome 1	0.013
PPOX	protoporphyrinogen oxidase	0.013
NLK	nemo-like kinase	0.013
DOLPP1	dolichyl pyrophosphate phosphatase 1	0.013
TMTC3	transmembrane and tetratricopeptide repeat containing 3	0.013
RUFY3	RUN and FYVE domain containing 3	0.013
IFT52	intraflagellar transport 52 homolog (Chlamydomonas)	0.013
CASC1	cancer susceptibility candidate 1	0.013
EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	0.012
RAGE	renal tumor antigen	0.012
ZNF816	zinc finger protein 816	0.012
KIAA0895	KIAA0895	0.012
ZNF83	zinc finger protein 83	0.012
TTC14	tetratricopeptide repeat domain 14	0.012
C16orf93	chromosome 16 open reading frame 93	0.012
CCNK	cyclin K	0.012
ZNF518A	zinc finger protein 518A	0.012
TCTN1	tectonic family member 1	0.012	Human
TTBK2	tau tubulin kinase 2	0.012
BBS9	Bardet-Biedl syndrome 9	0.012
RPGR	retinitis pigmentosa GTPase regulator	0.011
ZNF552	zinc finger protein 552	0.011
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.011
C6orf170	chromosome 6 open reading frame 170	0.011
PARP16	poly (ADP-ribose) polymerase family, member 16	0.011
RLN2	relaxin 2	0.011
MOCS3	molybdenum cofactor synthesis 3	0.011
WDR25	WD repeat domain 25	0.011
OSCP1	organic solute carrier partner 1	0.011
HEATR6	HEAT repeat containing 6	0.011
FBXW9	F-box and WD repeat domain containing 9	0.011
ZNF643	zinc finger protein 643	0.011
PYCRL	pyrroline-5-carboxylate reductase-like	0.011
ZNF155	zinc finger protein 155	0.011
MLF1	myeloid leukemia factor 1	0.011
WDR60	WD repeat domain 60	0.011
KRT10	keratin 10	0.011
ZFP37	zinc finger protein 37 homolog (mouse)	0.011
CCT6B	chaperonin containing TCP1, subunit 6B (zeta 2)	0.011
ZNF25	zinc finger protein 25	0.011
OFD1	oral-facial-digital syndrome 1	0.011
DMTF1	cyclin D binding myb-like transcription factor 1	0.011
ZNF609	zinc finger protein 609	0.011
SPATA6	spermatogenesis associated 6	0.010
FDXR	ferredoxin reductase	0.010
KLF11	Kruppel-like factor 11	0.010
OPHN1	oligophrenin 1	0.010
CNTLN	centlein, centrosomal protein	0.010
GSTT1	glutathione S-transferase theta 1	0.010
CDK20	cyclin-dependent kinase 20	0.010
TTC25	tetratricopeptide repeat domain 25	0.010
TMEM67	transmembrane protein 67	0.009
RPGRIP1L	RPGRIP1-like	0.008
B9D1	B9 protein domain 1	0.007
B9D2	B9 protein domain 2	0.006
CC2D2A	coiled-coil and C2 domain containing 2A	0.005
TMEM216	transmembrane protein 216	0.004
CEP290	centrosomal protein 290kDa	0.003
TCTN2	tectonic family member 2	0.003
NPHP3	nephronophthisis 3 (adolescent)	0.002