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Homo sapiens

2 genes annotated in human

serotonin uptake

The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "serotonin uptake"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "serotonin uptake" (in gray)

Name	Description	Probability	Func Analog Organism
PICK1	protein interacting with PRKCA 1	1.000
MAPT	microtubule-associated protein tau	0.999
VAC14	Vac14 homolog (S. cerevisiae)	0.996
DRD2	dopamine receptor D2	0.981
TPPP	tubulin polymerization promoting protein	0.980
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.917	Human
SNCAIP	synuclein, alpha interacting protein	0.818
APP	amyloid beta (A4) precursor protein	0.687
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.501
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.419	Human
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.259
PRKCG	protein kinase C, gamma	0.241
STX1A	syntaxin 1A (brain)	0.221
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.214
PRLHR	prolactin releasing hormone receptor	0.208
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.137
APLP1	amyloid beta (A4) precursor-like protein 1	0.124
FABP4	fatty acid binding protein 4, adipocyte	0.120
SYN1	synapsin I	0.113
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.080
DLG4	discs, large homolog 4 (Drosophila)	0.069
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.057	Human
MAG	myelin associated glycoprotein	0.046
ATXN7L3	ataxin 7-like 3	0.046
TUB	tubby homolog (mouse)	0.046
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	0.044
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.043	Human
SPTBN1	spectrin, beta, non-erythrocytic 1	0.043
HSPA1B	heat shock 70kDa protein 1B	0.042
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.041
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.037
SEPT4	septin 4	0.037
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.035
GRIK1	glutamate receptor, ionotropic, kainate 1	0.034
AGXT	alanine-glyoxylate aminotransferase	0.034
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.033
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.031
EMX1	empty spiracles homeobox 1	0.031
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.031
SLC7A4	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4	0.031
IRX4	iroquois homeobox 4	0.030
PAX8	paired box 8	0.030
FABP2	fatty acid binding protein 2, intestinal	0.030
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.030
ALOX15	arachidonate 15-lipoxygenase	0.026
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.026
TM4SF5	transmembrane 4 L six family member 5	0.026
BNC1	basonuclin 1	0.026
PHOX2B	paired-like homeobox 2b	0.025
SLC22A6	solute carrier family 22 (organic anion transporter), member 6	0.025
LTK	leukocyte receptor tyrosine kinase	0.025
LRRK2	leucine-rich repeat kinase 2	0.024
GRM2	glutamate receptor, metabotropic 2	0.023
AQP2	aquaporin 2 (collecting duct)	0.023
DOCK7	dedicator of cytokinesis 7	0.023
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.023
PDZK1IP1	PDZK1 interacting protein 1	0.023
SYN2	synapsin II	0.022
SPINK5	serine peptidase inhibitor, Kazal type 5	0.022
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.022
KLK6	kallikrein-related peptidase 6	0.022
RHO	rhodopsin	0.022
PVALB	parvalbumin	0.022
CLCNKB	chloride channel Kb	0.022
MLXIPL	MLX interacting protein-like	0.021
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.021	Human
SHH	sonic hedgehog	0.020
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.020
FGF22	fibroblast growth factor 22	0.020
CHP2	calcineurin B homologous protein 2	0.020
UNC93A	unc-93 homolog A (C. elegans)	0.020
GLRA1	glycine receptor, alpha 1	0.020
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.020
CTNNA2	catenin (cadherin-associated protein), alpha 2	0.020
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.019
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.019
SIX6	SIX homeobox 6	0.019
ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12	0.019
GPC5	glypican 5	0.019
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.019
DRD1	dopamine receptor D1	0.019
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.019
CUBN	cubilin (intrinsic factor-cobalamin receptor)	0.018
ADRB1	adrenergic, beta-1-, receptor	0.018
RELN	reelin	0.018
BHMT	betaine--homocysteine S-methyltransferase	0.017
KRT2	keratin 2	0.017
STAR	steroidogenic acute regulatory protein	0.017
S100A3	S100 calcium binding protein A3	0.017
ITGA10	integrin, alpha 10	0.017
GCM1	glial cells missing homolog 1 (Drosophila)	0.017
SNAP25	synaptosomal-associated protein, 25kDa	0.017
CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.017
GJB1	gap junction protein, beta 1, 32kDa	0.017
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.017
TTYH1	tweety homolog 1 (Drosophila)	0.017
DSG3	desmoglein 3	0.016
AQP6	aquaporin 6, kidney specific	0.016
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.016
SCN1B	sodium channel, voltage-gated, type I, beta	0.016
GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.016
GC	group-specific component (vitamin D binding protein)	0.016
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.016
SPRR1B	small proline-rich protein 1B	0.016
AMN	amnionless homolog (mouse)	0.015
BCAS1	breast carcinoma amplified sequence 1	0.015
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.015
CRYM	crystallin, mu	0.015
DCTN1	dynactin 1	0.015
INSM1	insulinoma-associated 1	0.015
HSPA1A	heat shock 70kDa protein 1A	0.015
PRODH2	proline dehydrogenase (oxidase) 2	0.015
MTNR1A	melatonin receptor 1A	0.015
PCYT1B	phosphate cytidylyltransferase 1, choline, beta	0.015
SLC6A18	solute carrier family 6, member 18	0.015	Human Rat
SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.015
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.015
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.015
CTRL	chymotrypsin-like	0.015
DIO3	deiodinase, iodothyronine, type III	0.014
DPYS	dihydropyrimidinase	0.014
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.014
KRT71	keratin 71	0.014
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.014
NDRG2	NDRG family member 2	0.014
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.014
DEFB1	defensin, beta 1	0.014
FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	0.014
BEST1	bestrophin 1	0.014
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.014
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.014
ITIH3	inter-alpha (globulin) inhibitor H3	0.013
KLK7	kallikrein-related peptidase 7	0.013
LYPD3	LY6/PLAUR domain containing 3	0.013
ADCYAP1R1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	0.013
TMEM151A	transmembrane protein 151A	0.013
SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	0.013
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.013
HES2	hairy and enhancer of split 2 (Drosophila)	0.013
DEFA6	defensin, alpha 6, Paneth cell-specific	0.013
CNTN1	contactin 1	0.013
IGFBP1	insulin-like growth factor binding protein 1	0.013
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.013
SULT1C2	sulfotransferase family, cytosolic, 1C, member 2	0.013
GRK1	G protein-coupled receptor kinase 1	0.013
DUSP9	dual specificity phosphatase 9	0.013
KIF1A	kinesin family member 1A	0.013
BDKRB2	bradykinin receptor B2	0.012
SYT5	synaptotagmin V	0.012
SCGN	secretagogin, EF-hand calcium binding protein	0.012
BMP8A	bone morphogenetic protein 8a	0.012
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.012
NGF	nerve growth factor (beta polypeptide)	0.012
GCKR	glucokinase (hexokinase 4) regulator	0.012
CNTN2	contactin 2 (axonal)	0.012
PIGR	polymeric immunoglobulin receptor	0.012
PKDREJ	polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)	0.012
CADM3	cell adhesion molecule 3	0.012
ITIH2	inter-alpha (globulin) inhibitor H2	0.012
NEUROD2	neurogenic differentiation 2	0.012
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.012
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.012
NKD2	naked cuticle homolog 2 (Drosophila)	0.012
SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)	0.012
PIKFYVE	phosphoinositide kinase, FYVE finger containing	0.012
GRIK3	glutamate receptor, ionotropic, kainate 3	0.012
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.012
KANK4	KN motif and ankyrin repeat domains 4	0.012
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.012
ALOXE3	arachidonate lipoxygenase 3	0.012
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.012	Human
TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
STMN4	stathmin-like 4	0.012
MUC6	mucin 6, oligomeric mucus/gel-forming	0.012
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.012
ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	0.012
LHB	luteinizing hormone beta polypeptide	0.012
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.012
KCNE1L	KCNE1-like	0.012
SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)	0.012
OPRK1	opioid receptor, kappa 1	0.012
OVOL1	ovo-like 1(Drosophila)	0.012
GYS2	glycogen synthase 2 (liver)	0.011
CDHR1	cadherin-related family member 1	0.011
LRP1B	low density lipoprotein receptor-related protein 1B	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
UNC5B	unc-5 homolog B (C. elegans)	0.011
BCMO1	beta-carotene 15,15'-monooxygenase 1	0.011
CADM4	cell adhesion molecule 4	0.011
MEP1B	meprin A, beta	0.011
SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	0.011
DPP6	dipeptidyl-peptidase 6	0.011
ZNF536	zinc finger protein 536	0.011
ASGR1	asialoglycoprotein receptor 1	0.011
DSG1	desmoglein 1	0.011
DPEP1	dipeptidase 1 (renal)	0.011
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.011
PNLIP	pancreatic lipase	0.011
C20orf85	chromosome 20 open reading frame 85	0.011
NOX1	NADPH oxidase 1	0.011
POF1B	premature ovarian failure, 1B	0.011
KL	klotho	0.011
HCRT	hypocretin (orexin) neuropeptide precursor	0.011
CTF1	cardiotrophin 1	0.011
LCE2B	late cornified envelope 2B	0.011
SSTR1	somatostatin receptor 1	0.011
GJC2	gap junction protein, gamma 2, 47kDa	0.011
PTPRN	protein tyrosine phosphatase, receptor type, N	0.011
DRD3	dopamine receptor D3	0.011
WIF1	WNT inhibitory factor 1	0.011
SLC34A2	solute carrier family 34 (sodium phosphate), member 2	0.011
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.011
CALB1	calbindin 1, 28kDa	0.011
KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16	0.011
FGF4	fibroblast growth factor 4	0.011
OR51E2	olfactory receptor, family 51, subfamily E, member 2	0.011
SIGLEC15	sialic acid binding Ig-like lectin 15	0.011
CAPN9	calpain 9	0.011
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.011
HOXC5	homeobox C5	0.011
C19orf21	chromosome 19 open reading frame 21	0.011
LRAT	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	0.011
GPR37L1	G protein-coupled receptor 37 like 1	0.010
GYPA	glycophorin A (MNS blood group)	0.010
PIWIL1	piwi-like 1 (Drosophila)	0.010
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.010	Human
TCHH	trichohyalin	0.010
SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11	0.010
PROX1	prospero homeobox 1	0.010
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.010
SLC38A3	solute carrier family 38, member 3	0.010
IL13RA2	interleukin 13 receptor, alpha 2	0.010
NOVA2	neuro-oncological ventral antigen 2	0.010
HNF4A	hepatocyte nuclear factor 4, alpha	0.010
SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	0.010
GCG	glucagon	0.010
CRHR1	corticotropin releasing hormone receptor 1	0.010
RAPSN	receptor-associated protein of the synapse	0.010
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.010
FOXL2	forkhead box L2	0.010
IL24	interleukin 24	0.010
TTC22	tetratricopeptide repeat domain 22	0.010
SCG2	secretogranin II	0.010
PLD1	phospholipase D1, phosphatidylcholine-specific	0.010
PNOC	prepronociceptin	0.010
HOXD9	homeobox D9	0.010
RABAC1	Rab acceptor 1 (prenylated)	0.010
LDHC	lactate dehydrogenase C	0.010
SLC14A1	solute carrier family 14 (urea transporter), member 1 (Kidd blood group)	0.010