IMP
Process View
positive regulation of tumor necrosis factor biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of tumor necrosis factor biosynthetic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| HSPB8 | heat shock 22kDa protein 8 | 0.319 | ||
| TRAF5 | TNF receptor-associated factor 5 | 0.111 | ||
| LY96 | lymphocyte antigen 96 | 0.096 | ||
| SYK | spleen tyrosine kinase | 0.085 | ||
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.079 | ||
| BAG3 | BCL2-associated athanogene 3 | 0.072 | ||
| CYBB | cytochrome b-245, beta polypeptide | 0.048 | ||
| CRYAB | crystallin, alpha B | 0.045 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 0.033 | ||
| TRAF2 | TNF receptor-associated factor 2 | 0.030 | ||
| LY86 | lymphocyte antigen 86 | 0.027 | ||
| TLR4 | toll-like receptor 4 | 0.024 | ||
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 0.023 | ||
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.023 | ||
| CCR1 | chemokine (C-C motif) receptor 1 | 0.022 | ||
| TLR1 | toll-like receptor 1 | 0.021 | Human Mouse | |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.020 | ||
| FGL2 | fibrinogen-like 2 | 0.019 | ||
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.018 | ||
| RNASE6 | ribonuclease, RNase A family, k6 | 0.017 | ||
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.016 | ||
| IGSF6 | immunoglobulin superfamily, member 6 | 0.015 | ||
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | 0.014 | ||
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.013 | ||
| CD33 | CD33 molecule | 0.013 | ||
| PLEK | pleckstrin | 0.012 | ||
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.011 | ||
| TLR2 | toll-like receptor 2 | 0.011 | ||
| HSF1 | heat shock transcription factor 1 | 0.011 | ||
| CLEC4A | C-type lectin domain family 4, member A | 0.010 |