IMP
Process View
scf dependent proteasomal ubiquitin dependent protein catabolic process
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
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Click on a gene's description to view its network relationships with genes known to be involved in "scf dependent proteasomal ubiquitin dependent protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Vegfa | vascular endothelial growth factor A | 0.746 | ||
| Skp1a | S-phase kinase-associated protein 1A | 0.628 | ||
| Rnf2 | ring finger protein 2 | 0.439 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.219 | ||
| Tead1 | TEA domain family member 1 | 0.214 | ||
| Ring1 | ring finger protein 1 | 0.145 | ||
| Fbxl20 | F-box and leucine-rich repeat protein 20 | 0.145 | ||
| Pcgf2 | polycomb group ring finger 2 | 0.077 | ||
| Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1 | 0.071 | ||
| Kdm2b | lysine (K)-specific demethylase 2B | 0.047 | ||
| Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | 0.046 | ||
| Per1 | period homolog 1 (Drosophila) | 0.042 | ||
| Mpp5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | 0.041 | ||
| Cul1 | cullin 1 | 0.039 | ||
| Htt | huntingtin | 0.035 | ||
| Amot | angiomotin | 0.026 | ||
| Tead2 | TEA domain family member 2 | 0.023 | ||
| Cops2 | COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) | 0.021 | ||
| Zfand5 | zinc finger, AN1-type domain 5 | 0.021 | ||
| Btrc | beta-transducin repeat containing protein | 0.021 | Mouse | |
| Rest | RE1-silencing transcription factor | 0.020 | ||
| Cul4a | cullin 4A | 0.019 | ||
| Txnip | thioredoxin interacting protein | 0.019 | ||
| Cbx3 | chromobox homolog 3 (Drosophila HP1 gamma) | 0.019 | ||
| Cry2 | cryptochrome 2 (photolyase-like) | 0.017 | ||
| Cry1 | cryptochrome 1 (photolyase-like) | 0.017 | ||
| Fbxw2 | F-box and WD-40 domain protein 2 | 0.017 | ||
| Fam103a1 | family with sequence similarity 103, member A1 | 0.016 | ||
| Fermt2 | fermitin family homolog 2 (Drosophila) | 0.016 | ||
| Fbxl3 | F-box and leucine-rich repeat protein 3 | 0.015 | ||
| Ppp2ca | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 0.014 | ||
| Amotl2 | angiomotin-like 2 | 0.014 | ||
| Per2 | period homolog 2 (Drosophila) | 0.013 | ||
| Rbx1 | ring-box 1 | 0.013 | ||
| Abtb1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.012 | ||
| Mcl1 | myeloid cell leukemia sequence 1 | 0.012 | ||
| Rbl2 | retinoblastoma-like 2 | 0.012 | ||
| Pcmt1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 | 0.011 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.011 | ||
| Mgea5 | meningioma expressed antigen 5 (hyaluronidase) | 0.011 | ||
| Sgms1 | sphingomyelin synthase 1 | 0.011 | ||
| Dyrk1a | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a | 0.011 | ||
| Csnk1a1 | casein kinase 1, alpha 1 | 0.011 | ||
| Ppm1b | protein phosphatase 1B, magnesium dependent, beta isoform | 0.010 | ||
| Ddx3x | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked | 0.010 |