IMP

Process View

Rattus norvegicus

4 genes annotated in rat

negative regulation of multicellular organismal metabolic process

Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of multicellular organismal metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of multicellular organismal metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Crybb1	crystallin, beta B1	0.065
Apoe	apolipoprotein E	0.062
Uox	urate oxidase	0.055
Hr	hairless	0.054
Avpr2	arginine vasopressin receptor 2	0.041
Rabac1	Rab acceptor 1 (prenylated)	0.040
Pou3f2	POU class 3 homeobox 2	0.040
Plcb2	phospholipase C, beta 2	0.039
Ppara	peroxisome proliferator activated receptor alpha	0.031	Rat
Cyp2d4	cytochrome P450, family 2, subfamily d, polypeptide 4	0.030
P2ry4	pyrimidinergic receptor P2Y, G-protein coupled, 4	0.028
Pla2g2c	phospholipase A2, group IIC	0.025
Fgf1	fibroblast growth factor 1	0.024
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.024
Dpp7	dipeptidylpeptidase 7	0.023
Neurog1	neurogenin 1	0.023
Olr837	olfactory receptor 837	0.023
Myl6l	myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like	0.022
Scnn1a	sodium channel, nonvoltage-gated 1 alpha	0.022
Gzmb	granzyme B	0.021
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.021
Tas2r118	taste receptor, type 2, member 118	0.021
LOC305103	cell surface glycoprotein gp42	0.021
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.021
Ptafr	platelet-activating factor receptor	0.020
Adora2a	adenosine A2a receptor	0.020	Rat
Cfd	complement factor D (adipsin)	0.020
Ptprh	protein tyrosine phosphatase, receptor type, H	0.019
Il1a	interleukin 1 alpha	0.019
Gabrr2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.018
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.018
Cyp4b1	cytochrome P450, family 4, subfamily b, polypeptide 1	0.018
Lrch4	leucine-rich repeats and calponin homology (CH) domain containing 4	0.018
Acox3	acyl-Coenzyme A oxidase 3, pristanoyl	0.017
Dlgap2	discs, large (Drosophila) homolog-associated protein 2	0.017
Zp1	zona pellucida glycoprotein 1 (sperm receptor)	0.017
Aqp2	aquaporin 2 (collecting duct)	0.017
Accn2	amiloride-sensitive cation channel 2, neuronal	0.017
Lhx5	LIM homeobox 5	0.017
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.016
Tpo	thyroid peroxidase	0.016
Prdm2	PR domain containing 2, with ZNF domain	0.016
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.016
G6pc	glucose-6-phosphatase, catalytic subunit	0.016
Tmsb4x	thymosin beta 4, X-linked	0.015
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.015
Galr3	galanin receptor 3	0.015
Ppp1r3b	protein phosphatase 1, regulatory (inhibitor) subunit 3B	0.015
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.015
Pip	prolactin induced protein	0.015
Sox17	SRY (sex determining region Y)-box 17	0.015
Slc5a1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.015
Phkg1	phosphorylase kinase, gamma 1	0.015
Cd81	Cd81 molecule	0.015
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.015
Tfec	transcription factor EC	0.014
Pfkfb4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	0.014
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.014
Ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	0.014
Tcn2	transcobalamin 2	0.014
Grik1	glutamate receptor, ionotropic, kainate 1	0.014
Hipk3	homeodomain interacting protein kinase 3	0.014
Naaladl1	N-acetylated alpha-linked acidic dipeptidase-like 1	0.014
Abcb9	ATP-binding cassette, subfamily B (MDR/TAP), member 9	0.014
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.014
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.014
Acot12	acyl-CoA thioesterase 12	0.014
Pdk4	pyruvate dehydrogenase kinase, isozyme 4	0.014
Arc	activity-regulated cytoskeleton-associated protein	0.013
Tsc22d3	TSC22 domain family, member 3	0.013
Igfbp7	insulin-like growth factor binding protein 7	0.013
Grm6	glutamate receptor, metabotropic 6	0.013
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.013
Cdh17	cadherin 17	0.013
Gjb3	gap junction protein, beta 3	0.013
Ghrhr	growth hormone releasing hormone receptor	0.013
Tef	thyrotrophic embryonic factor	0.013
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.013
Crhr1	corticotropin releasing hormone receptor 1	0.013
Cyp4f1	cytochrome P450, family 4, subfamily f, polypeptide 1	0.012
Shd	src homology 2 domain-containing transforming protein D	0.012
Cyp2b1	cytochrome P450, family 2, subfamily b, polypeptide 1	0.012
RT1-M5	RT1 class Ib, locus M5	0.012
Slc2a5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.012
Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.012
Foxe1	forkhead box E1 (thyroid transcription factor 2)	0.012
Trib1	tribbles homolog 1 (Drosophila)	0.012
Olr1362	olfactory receptor 1362	0.012
Tacr1	tachykinin receptor 1	0.012
Mfsd2	major facilitator superfamily domain containing 2	0.012
Mlxipl	MLX interacting protein-like	0.012
Prlr	prolactin receptor	0.012
RT1-DOa	RT1 class II, locus DOa	0.012
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.011
Pbld	phenazine biosynthesis-like protein domain containing	0.011
Fgf6	fibroblast growth factor 6	0.011
Nmbr	neuromedin B receptor	0.011
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.011
Hnf4a	hepatocyte nuclear factor 4, alpha	0.011
Adm	adrenomedullin	0.011
RGD1306750	LOC362451	0.011
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.011
Synpo	synaptopodin	0.011
Errfi1	ERBB receptor feedback inhibitor 1	0.011
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.011
Adra2b	adrenergic, alpha-2B-, receptor	0.011
Pglyrp1	peptidoglycan recognition protein 1	0.011
Fcer2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
Gse1	genetic suppressor element 1	0.011
Padi2	peptidyl arginine deiminase, type II	0.011
Fosl2	fos-like antigen 2	0.011
Ech1	enoyl coenzyme A hydratase 1, peroxisomal	0.011
Il8ra	interleukin 8 receptor, alpha	0.011
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.011
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.011
Slco2a1	solute carrier organic anion transporter family, member 2a1	0.010
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.010
Kcnh5	potassium voltage-gated channel, subfamily H (eag-related), member 5	0.010
Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.010
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.010
Shc3	SHC (Src homology 2 domain containing) transforming protein 3	0.010
Pcdhga11	protocadherin gamma subfamily A, 11	0.010
Cps1	carbamoyl-phosphate synthetase 1	0.010
Nppb	natriuretic peptide precursor B	0.010
Gna11	guanine nucleotide binding protein, alpha 11	0.010
Dnase1	deoxyribonuclease I	0.010