IMP

Process View

Rattus norvegicus

15 genes annotated in rat

negative regulation of cyclic nucleotide metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cyclic nucleotide metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cyclic nucleotide metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Sdc3	syndecan 3	0.241
Hrh3	histamine receptor H3	0.188
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.175
Bcan	brevican	0.154
Tbxa2r	thromboxane A2 receptor	0.141
Chrna4	cholinergic receptor, nicotinic, alpha 4	0.137
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.131
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.122
Calcr	calcitonin receptor	0.119	Rat
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.115
Gpr1	G protein-coupled receptor 1	0.073
Neurog3	neurogenin 3	0.069
Cnga3	cyclic nucleotide gated channel alpha 3	0.067
Thra	thyroid hormone receptor alpha	0.062
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.062
Gja6	gap junction protein, alpha 6	0.060
Mrgprf	MAS-related GPR, member F	0.057
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.055
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.055
Vom1r97	vomeronasal 1 receptor 97	0.053
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.051
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.049
Olr1867	olfactory receptor 1867	0.049
Olr416	olfactory receptor 416	0.045
Grk1	G protein-coupled receptor kinase 1	0.045
Chrna3	cholinergic receptor, nicotinic, alpha 3	0.044
Map6	microtubule-associated protein 6	0.042
Ctsj	cathepsin J	0.041
Lims1	LIM and senescent cell antigen-like domains 1	0.040
Il9r	interleukin 9 receptor	0.037
Uhmk1	U2AF homology motif (UHM) kinase 1	0.035
Tubb3	tubulin, beta 3	0.035
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.034
Dlg4	discs, large homolog 4 (Drosophila)	0.034
Clstn3	calsyntenin 3	0.033
Ncan	neurocan	0.033
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.033
Chrne	cholinergic receptor, nicotinic, epsilon	0.032
Dact3	dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)	0.032
Grp	gastrin releasing peptide	0.031
Hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.030
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.029
Prlhr	prolactin releasing hormone receptor	0.029
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.028
Znf483	zinc finger protein 483	0.028
Gpr6	G protein-coupled receptor 6	0.027
Galr2	galanin receptor 2	0.027	Rat
Sst	somatostatin	0.026
Smad9	SMAD family member 9	0.026
RGD1560871	similar to plexin 1	0.025
Agtr1b	angiotensin II receptor, type 1b	0.025
Aplnr	apelin receptor	0.025
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.025
Hcrt	hypocretin	0.025
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.025
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.024
Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	0.024
Necab1	N-terminal EF-hand calcium binding protein 1	0.024
Cyss	cystatin S	0.024
Spata2L	spermatogenesis associated 2-like	0.024
Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	0.024
Hrh2	histamine receptor H 2	0.023
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.023
RGD1306474	similar to RIKEN cDNA 9530003J23	0.022
Rgs9	regulator of G-protein signaling 9	0.022
Crhr1	corticotropin releasing hormone receptor 1	0.022	Rat
Pcyt1b	phosphate cytidylyltransferase 1, choline, beta	0.022
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.021
Slc7a12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 12	0.021
Gad1	glutamate decarboxylase 1	0.021
Syt7	synaptotagmin VII	0.021
Svs4	seminal vesicle secretory protein 4	0.021
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.021
Prph2	peripherin 2	0.021
Scn3b	sodium channel, voltage-gated, type III, beta	0.021
Grm8	glutamate receptor, metabotropic 8	0.021	Human
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.021
Dgkg	diacylglycerol kinase, gamma	0.020
Drd1a	dopamine receptor D1A	0.020
Smad6	SMAD family member 6	0.020
Fgf11	fibroblast growth factor 11	0.020
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.020
RGD1563533	similar to novel protein	0.019
Epor	erythropoietin receptor	0.019
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.019
Aqp2	aquaporin 2 (collecting duct)	0.018
Vash2	vasohibin 2	0.018
Cbln1	cerebellin 1 precursor	0.018
Krt31	keratin 31	0.018
Kif6	kinesin family member 6	0.018
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.018
Mc5r	melanocortin 5 receptor	0.018
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.018
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.018
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.018
Camkv	CaM kinase-like vesicle-associated	0.018
Mamdc4	MAM domain containing 4	0.017
Capn5	calpain 5	0.017
Il8rb	interleukin 8 receptor, beta	0.017
Utrn	utrophin	0.017
Notch3	Notch homolog 3 (Drosophila)	0.017
Lphn1	latrophilin 1	0.016
Csf1	colony stimulating factor 1 (macrophage)	0.016
Prm3	protamine 3	0.016
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.016
Gpr83	G protein-coupled receptor 83	0.016
Bdkrb1	bradykinin receptor B1	0.016
Rgs12	regulator of G-protein signaling 12	0.016
Cbx6	chromobox homolog 6	0.016
Clcn1	chloride channel 1	0.015
Bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.015
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.015
Hand1	heart and neural crest derivatives expressed 1	0.015
Glp1r	glucagon-like peptide 1 receptor	0.015	Rat
Syt13	synaptotagmin XIII	0.015
Gucy2e	guanylate cyclase 2E	0.015
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.015
Tmem158	transmembrane protein 158	0.015
Acrv1	acrosomal vesicle protein 1	0.015
Rup2	urinary protein 2	0.015
Btbd2	BTB (POZ) domain containing 2	0.015
Ccr4	chemokine (C-C motif) receptor 4	0.014
Nmur2	neuromedin U receptor 2	0.014
Plin	perilipin	0.014
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.014
Cacna1i	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.014
Nxph4	neurexophilin 4	0.014
Tgfbr2	transforming growth factor, beta receptor II	0.013
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.013
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.013
Olr1641	olfactory receptor 1641	0.013
Shox2	short stature homeobox 2	0.013
Adam18	ADAM metallopeptidase domain 18	0.013
Prl2a1	Prolactin family 2, subfamily a, member 1	0.013
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.013
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.013
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.013
Oprl1	opiate receptor-like 1	0.013	Rat
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.013
Grik3	glutamate receptor, ionotropic, kainate 3	0.013
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.012
Slc14a1	solute carrier family 14 (urea transporter), member 1	0.012
Nrcam	neuronal cell adhesion molecule	0.012
Cd4	Cd4 molecule	0.012
Slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.012
Zg16	zymogen granule protein 16	0.012
Neurod2	neurogenic differentiation 2	0.012
LOC246267	resection-induced TPI (rs11)	0.012
Shank2	SH3 and multiple ankyrin repeat domains 2	0.012
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.012
Fev	FEV (ETS oncogene family)	0.012
Olr1278	olfactory receptor 1278	0.012
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.012
Svs1	seminal vesicle secretory protein 1	0.012
Cmtm2a	CKLF-like MARVEL transmembrane domain containing 2A	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Adora1	adenosine A1 receptor	0.011
Pcdhb12	protocadherin beta 12	0.011
Grm2	glutamate receptor, metabotropic 2	0.011
Il1rl2	interleukin 1 receptor-like 2	0.011
Deaf1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.011
Uncx	UNC homeobox	0.011
Ccr3	chemokine (C-C motif) receptor 3	0.011
Gabra6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.011
RT1-A3	RT1 class I, locus A3	0.011
Fgf7	fibroblast growth factor 7	0.011
Mmp10	matrix metallopeptidase 10	0.011
Nfasc	neurofascin	0.011
Lrp3	low density lipoprotein receptor-related protein 3	0.011
Drd5	dopamine receptor D5	0.011
Fgf14	fibroblast growth factor 14	0.011
Casp9	caspase 9, apoptosis-related cysteine peptidase	0.011
Dspp	dentin sialophosphoprotein	0.011
Chrna9	cholinergic receptor, nicotinic, alpha 9	0.011
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.011
Phox2a	paired-like homeobox 2a	0.011
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.011
Ghrl	ghrelin/obestatin prepropeptide	0.011
Tas2r118	taste receptor, type 2, member 118	0.011
Gata4	GATA binding protein 4	0.011
Ucn	urocortin	0.011
Crhbp	corticotropin releasing hormone binding protein	0.010
Pgm3	phosphoglucomutase 3	0.010
Syp	synaptophysin	0.010
Dlx5	distal-less homeobox 5	0.010
Ccbp2	chemokine binding protein 2	0.010
Chrm5	cholinergic receptor, muscarinic 5	0.010
Ddc	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.010
Htr4	5-hydroxytryptamine (serotonin) receptor 4	0.010
Trhr	thyrotropin releasing hormone receptor	0.010