IMP

Process View

Saccharomyces cerevisiae

39 genes annotated in yeast

protein targeting to er

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.

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In addition to gene-name show these genes:

Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein targeting to er"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein targeting to er" (in gray)

Name	Description	Probability	Func Analog Organism
SEC63	Sec63p	1.000
SEC62	Sec62p	0.999
SGT2	Sgt2p	0.999
SRP54	Srp54p	0.995
SPC1	Spc1p	0.988
SEC65	Sec65p	0.988
SRP72	Srp72p	0.988
KAR2	Kar2p	0.988
GET3	Get3p	0.984
SSS1	Sss1p	0.982
SBH1	Sbh1p	0.976
SRP21	Srp21p	0.975
SRP14	Srp14p	0.974
SPC2	Spc2p	0.969
SIS1	Sis1p	0.954
SEC11	Sec11p	0.874
SRP68	Srp68p	0.872
SEC66	Sec66p	0.856
SEC61	Sec61p	0.839
STI1	Sti1p	0.710
SSA2	Ssa2p	0.645
SSH1	Ssh1p	0.640
ERP2	Erp2p	0.633
SEC72	Sec72p	0.597
GET1	Get1p	0.539
SIL1	Sil1p	0.528
LHS1	Lhs1p	0.497
BTN2	Btn2p	0.468
SPC3	Spc3p	0.445
SCJ1	Scj1p	0.432	Yeast
SSA3	Ssa3p	0.398
YDJ1	Ydj1p	0.366
JEM1	Jem1p	0.323
EGD2	Egd2p	0.286
SSA4	Ssa4p	0.286
ERO1	Ero1p	0.281
CAF130	Caf130p	0.235
LCL2	Lcl2p	0.227
OST4	Ost4p	0.151
MDY2	Mdy2p	0.137
EGD1	Egd1p	0.123
HTA2	Hta2p	0.121
ERJ5	Erj5p	0.119	Yeast
BFR1	Bfr1p	0.098
ERD2	Erd2p	0.083
YRB1	Yrb1p	0.074
UBA2	Uba2p	0.068
CUR1	Cur1p	0.066
SBH2	Sbh2p	0.061
LIF1	Lif1p	0.061
FES1	Fes1p	0.060
YLR126C	hypothetical protein	0.059
GET4	Get4p	0.057
UBC4	Ubc4p	0.056
YLR264C-A	hypothetical protein	0.053
CPR6	Cpr6p	0.053
NUP82	Nup82p	0.053
WBP1	Wbp1p	0.052
NMT1	Nmt1p	0.048
YKL063C	hypothetical protein	0.047
PRP45	Prp45p	0.046
OST2	Ost2p	0.045
RPL15B	Rpl15bp	0.044
SWC7	Swc7p	0.044
RPI1	Rpi1p	0.044
SRD1	Srd1p	0.039
BTT1	Btt1p	0.039
PRS2	Prs2p	0.038
YOL038C-A	hypothetical protein	0.038
YJR011C	hypothetical protein	0.038
LEU2	Leu2p	0.037
MPD1	Mpd1p	0.036
SSE1	Sse1p	0.036
CUP1-1	Cup1-1p	0.036
APA1	Apa1p	0.036
SEC20	Sec20p	0.035
OTU1	Otu1p	0.034
NOP10	Nop10p	0.034
YAR068W	hypothetical protein	0.034
EMC4	Emc4p	0.034
YBL029W	hypothetical protein	0.033
ILS1	Ils1p	0.033
SES1	Ses1p	0.032
CUE4	Cue4p	0.031
AHA1	Aha1p	0.031
SFB2	Sfb2p	0.031
GNA1	Gna1p	0.030
GND1	Gnd1p	0.029
YNL155W	hypothetical protein	0.029
YLR162W	hypothetical protein	0.029
SLY1	Sly1p	0.029
URA6	Ura6p	0.028
CRP1	Crp1p	0.028
MER1	Mer1p	0.028
FRS2	Frs2p	0.028
ARP10	Arp10p	0.027
RPS29B	Rps29bp	0.027
HUT1	Hut1p	0.027
YMR130W	hypothetical protein	0.027
PMT1	Pmt1p	0.026
YDL085C-A	hypothetical protein	0.026
CPD1	Cpd1p	0.025
LYS9	Lys9p	0.025
REX2	Rex2p	0.025
URA3	Ura3p	0.025
FAS2	Fas2p	0.024
ARG8	Arg8p	0.024
YLR042C	hypothetical protein	0.024
TYE7	Tye7p	0.024
TSC3	Tsc3p	0.024
RSC8	Rsc8p	0.024
YPR157W	hypothetical protein	0.024
CCT2	Cct2p	0.024
FAA2	Faa2p	0.023
ATP6	Atp6p	0.023
YBR013C	hypothetical protein	0.023
HXT3	Hxt3p	0.023
YAR066W	hypothetical protein	0.023
FMN1	Fmn1p	0.023
NAT5	Nat5p	0.022
GDH1	Gdh1p	0.022
NRK1	Nrk1p	0.022
MMT1	Mmt1p	0.022
THP3	Thp3p	0.021
YKR075C	hypothetical protein	0.021
SED5	Sed5p	0.021
PEX27	Pex27p	0.021
UPS3	Ups3p	0.021
YBT1	Ybt1p	0.021
NCE103	Nce103p	0.021
VMA13	Vma13p	0.021
HO	Hop	0.021
YPL113C	hypothetical protein	0.021
YSY6	Ysy6p	0.021
YGR017W	hypothetical protein	0.021
CLP1	Clp1p	0.021
HPF1	Hpf1p	0.021
MF(ALPHA)2	Mf(alpha)2p	0.021
YOL013W-A	hypothetical protein	0.020
DIC1	Dic1p	0.020
RER1	Rer1p	0.020
AAP1	Aap1p	0.020
YBR085C-A	hypothetical protein	0.020
FPR3	Fpr3p	0.019
SCM4	Scm4p	0.019
AUA1	Aua1p	0.019
ZPS1	Zps1p	0.019
TAD2	Tad2p	0.019
FMT1	Fmt1p	0.019
SPL2	Spl2p	0.019
CAR1	Car1p	0.019
CAB4	Cab4p	0.019
BSC1	Bsc1p	0.018
SUB2	Sub2p	0.018
SWT1	Swt1p	0.018
GYL1	Gyl1p	0.018
YJL213W	hypothetical protein	0.018
YER134C	hypothetical protein	0.018
YCR015C	hypothetical protein	0.018
CLB1	Clb1p	0.018
HLJ1	Hlj1p	0.018
YIR035C	hypothetical protein	0.018
ERV2	Erv2p	0.018
OPT2	Opt2p	0.018
YPR159C-A	hypothetical protein	0.018
MFA2	Mfa2p	0.018
GUK1	Guk1p	0.017
PPX1	Ppx1p	0.017
PGA2	Pga2p	0.017
GCV1	Gcv1p	0.017
IRC6	Irc6p	0.017
YCH1	Ych1p	0.017
YBR016W	hypothetical protein	0.016
ERG25	Erg25p	0.016
YLR278C	hypothetical protein	0.016
ALT2	Alt2p	0.016
ADH6	Adh6p	0.016
YPL067C	hypothetical protein	0.016
YML003W	hypothetical protein	0.016
ERV25	Erv25p	0.016
PCL9	Pcl9p	0.016
SOR2	Sor2p	0.016
YIR042C	hypothetical protein	0.016
YDR210W	hypothetical protein	0.016
MNN9	Mnn9p	0.016
YNL067W-B	hypothetical protein	0.015
YCL021W-A	hypothetical protein	0.015
YAL037C-A	hypothetical protein	0.015
YOL057W	hypothetical protein	0.015
GRE2	Gre2p	0.015
REE1	Ree1p	0.015
YLR040C	hypothetical protein	0.015
YAR029W	hypothetical protein	0.015
YGR126W	hypothetical protein	0.015
SRX1	Srx1p	0.015
YGL006W-A	hypothetical protein	0.015
TRX1	Trx1p	0.015
DIF1	Dif1p	0.015
RNP1	Rnp1p	0.015
DAD3	Dad3p	0.015
RPN14	Rpn14p	0.015
MF(ALPHA)1	Mf(alpha)1p	0.015
YAL064W	hypothetical protein	0.015
YPL168W	hypothetical protein	0.014
LRO1	Lro1p	0.014
VMA4	Vma4p	0.014
ICS2	Ics2p	0.014
YER064C	hypothetical protein	0.014
YNL033W	hypothetical protein	0.014
YNL018C	hypothetical protein	0.014
DOG1	Dog1p	0.014
SRT1	Srt1p	0.014
GIS3	Gis3p	0.014
TIF11	Tif11p	0.014
BAP3	Bap3p	0.014
YEA6	Yea6p	0.014
YNL162W-A	hypothetical protein	0.014
ENA5	Ena5p	0.014
OYE2	Oye2p	0.014
DUR1,2	Dur1,2p	0.014
YPL216W	hypothetical protein	0.014
YPR096C	hypothetical protein	0.014
MET8	Met8p	0.014
CWC22	Cwc22p	0.014
RTT105	Rtt105p	0.014
RRN5	Rrn5p	0.013
PRP8	Prp8p	0.013
YMR122W-A	hypothetical protein	0.013
AAD6	Aad6p	0.013
AQY2	Aqy2p	0.013
TIR3	Tir3p	0.013
OLE1	Ole1p	0.013
YDR222W	hypothetical protein	0.013
YJL160C	hypothetical protein	0.013
MNN4	Mnn4p	0.013
BRE5	Bre5p	0.013
CIT2	Cit2p	0.013
TIM50	Tim50p	0.013
AAD15	Aad15p	0.013
BIO2	Bio2p	0.013
BDS1	Bds1p	0.013
GIM4	Gim4p	0.013
NRG2	Nrg2p	0.013
GLN1	Gln1p	0.013
YML100W-A	hypothetical protein	0.013
NMA2	Nma2p	0.013
CST26	Cst26p	0.013
CTS1	Cts1p	0.013
YDR034C-A	hypothetical protein	0.013
RMD6	Rmd6p	0.013
LCL1	Lcl1p	0.013
YFR035C	hypothetical protein	0.013
MFA1	Mfa1p	0.013
ARO10	Aro10p	0.013
YOR365C	hypothetical protein	0.012
LSB5	Lsb5p	0.012
NTR2	Ntr2p	0.012
COS12	Cos12p	0.012
ECT1	Ect1p	0.012
ZEO1	Zeo1p	0.012
SSA1	Ssa1p	0.012
ICS3	Ics3p	0.012
POR2	Por2p	0.012
YOR012W	hypothetical protein	0.012
YHR192W	hypothetical protein	0.012
ARR2	Arr2p	0.012
BRN1	Brn1p	0.012
RPL10	Rpl10p	0.012
YDL012C	hypothetical protein	0.012
BNA4	Bna4p	0.012
PMI40	Pmi40p	0.012
YSC83	Ysc83p	0.012
YLR412C-A	hypothetical protein	0.012
KSH1	Ksh1p	0.012
PRM3	Prm3p	0.012
YPR027C	hypothetical protein	0.012
YMR317W	hypothetical protein	0.012
YKR041W	hypothetical protein	0.012
YDR056C	hypothetical protein	0.012
PTR2	Ptr2p	0.012
FRE5	Fre5p	0.012
FPR2	Fpr2p	0.012
ASN2	Asn2p	0.011
ENO2	Eno2p	0.011
YNR062C	hypothetical protein	0.011
DSD1	Dsd1p	0.011
RPL24B	Rpl24bp	0.011
TPI1	Tpi1p	0.011
WSC4	Wsc4p	0.011
TIP1	Tip1p	0.011
SEN54	Sen54p	0.011
SFT1	Sft1p	0.011
GCV2	Gcv2p	0.011
YCL001W-B	hypothetical protein	0.011
CAB3	Cab3p	0.011
YKR070W	hypothetical protein	0.011
YHR045W	hypothetical protein	0.011
YIL151C	hypothetical protein	0.011
YNR063W	hypothetical protein	0.011
YER039C-A	hypothetical protein	0.011
HMRA1	Hmra1p	0.011
YKL070W	hypothetical protein	0.011
YIL001W	hypothetical protein	0.011
YNL034W	hypothetical protein	0.011
YLR281C	hypothetical protein	0.011
KNH1	Knh1p	0.011
IMA5	Ima5p	0.011
BI4	Bi4p	0.011
IPP1	Ipp1p	0.011
SSP1	Ssp1p	0.011
SPO74	Spo74p	0.011
YNL234W	hypothetical protein	0.011
BAT2	Bat2p	0.011
ENO1	Eno1p	0.011
CHA1	Cha1p	0.011
YER071C	hypothetical protein	0.011
YOR387C	hypothetical protein	0.011
STE18	Ste18p	0.011
FMP23	Fmp23p	0.011
YLR342W-A	hypothetical protein	0.011
PHD1	Phd1p	0.011
YJL107C	hypothetical protein	0.010
BIO5	Bio5p	0.010
ADD66	Add66p	0.010
YGL235W	hypothetical protein	0.010
YKL106C-A	hypothetical protein	0.010
CAB1	Cab1p	0.010
FMO1	Fmo1p	0.010
YAR028W	hypothetical protein	0.010
PUS9	Pus9p	0.010
YML053C	hypothetical protein	0.010
ADH2	Adh2p	0.010
FRE4	Fre4p	0.010
YER175W-A	hypothetical protein	0.010
ALF1	Alf1p	0.010