IMP

Process View

Saccharomyces cerevisiae

16 genes annotated in yeast

translesion synthesis

GO:0019985

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

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Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "translesion synthesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "translesion synthesis" (in gray)

Name	Description	Probability
REV1	Rev1p	0.862
RAD5	Rad5p	0.757
REV7	Rev7p	0.744
REV3	Rev3p	0.262
RAD9	Rad9p	0.171
POL2	Pol2p	0.167
POL32	Pol32p	0.159
DPB2	Dpb2p	0.103
RFC2	Rfc2p	0.102
RAD24	Rad24p	0.101
RAD30	Rad30p	0.096
POL3	Pol3p	0.083
PIF1	Pif1p	0.074
MGS1	Mgs1p	0.068
PSF1	Psf1p	0.059
POL12	Pol12p	0.057
POL30	Pol30p	0.057
RAD17	Rad17p	0.055
RNH201	Rnh201p	0.053
SHU1	Shu1p	0.051
PMS1	Pms1p	0.045
RNH203	Rnh203p	0.043
RAD57	Rad57p	0.043
SRD1	Srd1p	0.037
UBC13	Ubc13p	0.036
DLS1	Dls1p	0.036
RFC4	Rfc4p	0.035
SMC6	Smc6p	0.032
YLR264C-A	hypothetical protein	0.032
MSH3	Msh3p	0.032
LEU2	Leu2p	0.030
CUP1-1	Cup1-1p	0.030
APN1	Apn1p	0.030
CRP1	Crp1p	0.030
URA3	Ura3p	0.029
MER1	Mer1p	0.029
YOL038C-A	hypothetical protein	0.028
CDC9	Cdc9p	0.028
HXT3	Hxt3p	0.028
MSH6	Msh6p	0.028
YLR162W	hypothetical protein	0.028
YNL155W	hypothetical protein	0.026
ARG8	Arg8p	0.024
EST2	Est2p	0.024
RAD18	Rad18p	0.024
ARP10	Arp10p	0.023
YLR126C	hypothetical protein	0.023
WSS1	Wss1p	0.023
TIP1	Tip1p	0.023
RLF2	Rlf2p	0.023
MPT5	Mpt5p	0.023
HO	Hop	0.023
YLR042C	hypothetical protein	0.022
ATP6	Atp6p	0.022
RAD55	Rad55p	0.022
YPR157W	hypothetical protein	0.022
YAR068W	hypothetical protein	0.022
YPL168W	hypothetical protein	0.022
PRS2	Prs2p	0.022
SWC7	Swc7p	0.021
ZPS1	Zps1p	0.021
PTI1	Pti1p	0.021
OPT2	Opt2p	0.021
AUA1	Aua1p	0.020
IRC5	Irc5p	0.020
HLR1	Hlr1p	0.020
YBR013C	hypothetical protein	0.020
POP6	Pop6p	0.020
PEX15	Pex15p	0.020
YIL151C	hypothetical protein	0.020
SPL2	Spl2p	0.020
HPF1	Hpf1p	0.020
NTG2	Ntg2p	0.019
APT2	Apt2p	0.019
XRS2	Xrs2p	0.019
CSM2	Csm2p	0.019
MF(ALPHA)2	Mf(alpha)2p	0.019
MET8	Met8p	0.019
PRI2	Pri2p	0.019
IZH4	Izh4p	0.019
FMT1	Fmt1p	0.018
YDR222W	hypothetical protein	0.018
YER137C	hypothetical protein	0.018
INM1	Inm1p	0.018
TYE7	Tye7p	0.018
BSC1	Bsc1p	0.018
TAF4	Taf4p	0.018
YOL013W-A	hypothetical protein	0.018
RAD1	Rad1p	0.018
CPD1	Cpd1p	0.018
RAD23	Rad23p	0.017
DUN1	Dun1p	0.017
YAR066W	hypothetical protein	0.017
RPB3	Rpb3p	0.017
CUP1-2	Cup1-2p	0.017
UPS3	Ups3p	0.017
YLR040C	hypothetical protein	0.017
YGR126W	hypothetical protein	0.017
YAR029W	hypothetical protein	0.016
CHZ1	Chz1p	0.016
YKR075C	hypothetical protein	0.016
YAL064W	hypothetical protein	0.016
ADH2	Adh2p	0.016
NRG2	Nrg2p	0.016
RNP1	Rnp1p	0.016
YPL067C	hypothetical protein	0.016
COS12	Cos12p	0.016
YPR096C	hypothetical protein	0.016
ATO3	Ato3p	0.016
CHA1	Cha1p	0.016
YAL037C-A	hypothetical protein	0.016
YIR042C	hypothetical protein	0.016
BIO4	Bio4p	0.016
SFT1	Sft1p	0.016
SCM4	Scm4p	0.016
MF(ALPHA)1	Mf(alpha)1p	0.016
NUT2	Nut2p	0.016
DSS4	Dss4p	0.015
YER186C	hypothetical protein	0.015
HLJ1	Hlj1p	0.015
YJL160C	hypothetical protein	0.015
TOS2	Tos2p	0.015
ALT2	Alt2p	0.015
YLR419W	hypothetical protein	0.015
REE1	Ree1p	0.015
PHM6	Phm6p	0.015
YDR034C-A	hypothetical protein	0.015
DIC1	Dic1p	0.015
YML003W	hypothetical protein	0.015
YIR035C	hypothetical protein	0.015
ARR2	Arr2p	0.015
RRT5	Rrt5p	0.015
SSP1	Ssp1p	0.015
YGL006W-A	hypothetical protein	0.015
YCR102C	hypothetical protein	0.015
YLR363W-A	hypothetical protein	0.015
DUR1,2	Dur1,2p	0.015
ZRT1	Zrt1p	0.015
BRN1	Brn1p	0.015
ENA5	Ena5p	0.015
BNA4	Bna4p	0.015
SPS4	Sps4p	0.014
GLN1	Gln1p	0.014
YLR460C	hypothetical protein	0.014
YBL029W	hypothetical protein	0.014
YMR317W	hypothetical protein	0.014
FCY22	Fcy22p	0.014
TIR3	Tir3p	0.014
GYL1	Gyl1p	0.014
YNL033W	hypothetical protein	0.014
YNL067W-B	hypothetical protein	0.014
RTT105	Rtt105p	0.014
YPL216W	hypothetical protein	0.014
YML100W-A	hypothetical protein	0.014
RRN5	Rrn5p	0.014
MUM3	Mum3p	0.014
YKR041W	hypothetical protein	0.014
SHU2	Shu2p	0.014
CUE2	Cue2p	0.014
YJL218W	hypothetical protein	0.014
PTR2	Ptr2p	0.014
AAD15	Aad15p	0.014
RNH1	Rnh1p	0.014
ARO10	Aro10p	0.013
RAT1	Rat1p	0.013
TFG1	Tfg1p	0.013
BDS1	Bds1p	0.013
RMD6	Rmd6p	0.013
YOR365C	hypothetical protein	0.013
YJL107C	hypothetical protein	0.013
SPO74	Spo74p	0.013
MMS21	Mms21p	0.013
SIZ1	Siz1p	0.013
CAB4	Cab4p	0.013
YNL018C	hypothetical protein	0.013
LIF1	Lif1p	0.013
YHK8	Yhk8p	0.013
SRT1	Srt1p	0.013
SKG6	Skg6p	0.013
YNL162W-A	hypothetical protein	0.013
BI4	Bi4p	0.013
YGR035C	hypothetical protein	0.013
YBL044W	hypothetical protein	0.013
MFA2	Mfa2p	0.013
TSC3	Tsc3p	0.013
YOR012W	hypothetical protein	0.013
YNR062C	hypothetical protein	0.013
YLR412C-A	hypothetical protein	0.013
RAD10	Rad10p	0.013
SDC1	Sdc1p	0.013
AQY2	Aqy2p	0.013
YPR027C	hypothetical protein	0.013
YJL181W	hypothetical protein	0.012
PSF3	Psf3p	0.012
YER077C	hypothetical protein	0.012
YDR524W-C	hypothetical protein	0.012
YGL235W	hypothetical protein	0.012
VBA5	Vba5p	0.012
YKR045C	hypothetical protein	0.012
CTS1	Cts1p	0.012
SAS4	Sas4p	0.012
CAC2	Cac2p	0.012
BIO2	Bio2p	0.012
YPR174C	hypothetical protein	0.012
HOR2	Hor2p	0.012
MMP1	Mmp1p	0.012
YMR122W-A	hypothetical protein	0.012
YNR063W	hypothetical protein	0.012
HXT2	Hxt2p	0.012
ICS3	Ics3p	0.012
GIS3	Gis3p	0.012
SET4	Set4p	0.012
CTR3	Ctr3p	0.012
YNL034W	hypothetical protein	0.012
YJR120W	hypothetical protein	0.012
LIN1	Lin1p	0.012
YPL108W	hypothetical protein	0.012
YLR342W-A	hypothetical protein	0.012
YNL058C	hypothetical protein	0.012
YNL234W	hypothetical protein	0.012
SAM3	Sam3p	0.012
FIT2	Fit2p	0.012
HEM3	Hem3p	0.011
SLD2	Sld2p	0.011
YOR338W	hypothetical protein	0.011
DDC1	Ddc1p	0.011
CUE4	Cue4p	0.011
YCH1	Ych1p	0.011
YIL089W	hypothetical protein	0.011
YSR3	Ysr3p	0.011
SEO1	Seo1p	0.011
TIM22	Tim22p	0.011
ORC6	Orc6p	0.011
DCG1	Dcg1p	0.011
SPO19	Spo19p	0.011
CAR1	Car1p	0.011
LCL1	Lcl1p	0.011
NCE103	Nce103p	0.011
YKL106C-A	hypothetical protein	0.011
YAL037W	hypothetical protein	0.011
YER085C	hypothetical protein	0.011
YCL001W-B	hypothetical protein	0.011
YOR387C	hypothetical protein	0.011
BIO5	Bio5p	0.011
PYC2	Pyc2p	0.011
SWM2	Swm2p	0.011
YER175W-A	hypothetical protein	0.011
SNU23	Snu23p	0.011
YHR035W	hypothetical protein	0.011
LRO1	Lro1p	0.011
HDA2	Hda2p	0.011
DOG1	Dog1p	0.011
YKL070W	hypothetical protein	0.011
SPR6	Spr6p	0.011
SRX1	Srx1p	0.011
DIF1	Dif1p	0.011
BUR6	Bur6p	0.011
FCY21	Fcy21p	0.011
YJL213W	hypothetical protein	0.011
YDL012C	hypothetical protein	0.011
YER064C	hypothetical protein	0.010
CWC24	Cwc24p	0.010
ORC4	Orc4p	0.010
YKL068W-A	hypothetical protein	0.010
YCR015C	hypothetical protein	0.010
MIG2	Mig2p	0.010
KNH1	Knh1p	0.010
GUP2	Gup2p	0.010
KSH1	Ksh1p	0.010
YCR050C	hypothetical protein	0.010
YGL015C	hypothetical protein	0.010
SCT1	Sct1p	0.010
WSC4	Wsc4p	0.010
SOR2	Sor2p	0.010
YLR012C	hypothetical protein	0.010
YFR035C	hypothetical protein	0.010
PEX2	Pex2p	0.010
KRE29	Kre29p	0.010
FRE4	Fre4p	0.010
YPL068C	hypothetical protein	0.010
YDL085C-A	hypothetical protein	0.010
PRP28	Prp28p	0.010
AAD6	Aad6p	0.010
YOR268C	hypothetical protein	0.010
YDR042C	hypothetical protein	0.010
YOL014W	hypothetical protein	0.010