The network for 'eye pigmentation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye pigmentation

Establishment of a pattern of pigment in the eye of an organism.

Drosophila melanogaster
Name Description Probability Func Analog Organism
fw furrowed 0.676
cn cinnabar 0.478
ltd lightoid 0.376
ry rosy 0.359
bw brown 0.333
CG9990 CG9990 gene product from transcript CG9990-RA 0.329
CG11570 CG11570 gene product from transcript CG11570-RA 0.289
kar karmoisin 0.275
ade2 adenosine 2 0.226
tkv thickveins 0.212
CG5958 CG5958 gene product from transcript CG5958-RA 0.205
hh hedgehog 0.173
ninaA neither inactivation nor afterpotential A 0.170
y yellow 0.152
CG10550 CG10550 gene product from transcript CG10550-RB 0.142
CG11786 CG11786 gene product from transcript CG11786-RB 0.132
CG7272 CG7272 gene product from transcript CG7272-RA 0.116
MED4 Mediator complex subunit 4 0.104
CG17919 CG17919 gene product from transcript CG17919-RA 0.092
CG9664 CG9664 gene product from transcript CG9664-RB 0.088
v vermilion 0.088
Pgd Phosphogluconate dehydrogenase 0.086
wdp windpipe 0.085
jar jaguar 0.082
CG15211 CG15211 gene product from transcript CG15211-RC 0.082
Kap3 Kinesin associated protein 3 0.080
CG11147 CG11147 gene product from transcript CG11147-RA 0.076
ptc patched 0.075
lt light 0.074
InR Insulin-like receptor 0.072
CG9628 CG9628 gene product from transcript CG9628-RA 0.069
CG3625 CG3625 gene product from transcript CG3625-RC 0.064
Tsp74F Tetraspanin 74F 0.064
CG5853 CG5853 gene product from transcript CG5853-RA 0.064
CG31743 CG31743 gene product from transcript CG31743-RA 0.064
ph-d polyhomeotic distal 0.063
CG16733 CG16733 gene product from transcript CG16733-RA 0.063
Cyp6d5 CG3050 gene product from transcript CG3050-RA 0.062
kkv krotzkopf verkehrt 0.062
CG42863 CG42863 gene product from transcript CG42863-RB 0.058
Mct1 Monocarboxylate transporter 1 0.054
CG10638 CG10638 gene product from transcript CG10638-RA 0.054
CG5009 CG5009 gene product from transcript CG5009-RA 0.054
rdgC retinal degeneration C 0.051
Oatp58Db Organic anion transporting polypeptide 58Db 0.051
CG32676 CG32676 gene product from transcript CG32676-RA 0.051
toy twin of eyeless 0.047
ade5 CG3989 gene product from transcript CG3989-RA 0.046
CG14526 CG14526 gene product from transcript CG14526-RB 0.045
wus wurst 0.044
CG4822 CG4822 gene product from transcript CG4822-RB 0.044
twi twist 0.043
ninaB neither inactivation nor afterpotential B 0.043
Arr2 Arrestin 2 0.043
CG14767 CG14767 gene product from transcript CG14767-RA 0.043
CG6361 CG6361 gene product from transcript CG6361-RA 0.043
ken ken and barbie 0.042
pn prune 0.042
boss bride of sevenless 0.041
cl clot 0.041
neur neuralized 0.041
Oatp30B Organic anion transporting polypeptide 30B 0.040
CG12926 CG12926 gene product from transcript CG12926-RA 0.040
Hn Henna 0.040
CG6733 CG6733 gene product from transcript CG6733-RA 0.039
CG4306 CG4306 gene product from transcript CG4306-RA 0.038
CG9134 CG9134 gene product from transcript CG9134-RB 0.038
CG2254 CG2254 gene product from transcript CG2254-RA 0.037
CG10376 CG10376 gene product from transcript CG10376-RA 0.036
CG31211 CG31211 gene product from transcript CG31211-RB 0.036
CG12824 CG12824 gene product from transcript CG12824-RA 0.036
CG6762 CG6762 gene product from transcript CG6762-RD 0.036
alpha-Est8 alpha-Esterase-8 0.036
l(2)08717 lethal (2) 08717 0.036
Npc2a Niemann-Pick type C-2a 0.036
W Wrinkled 0.036
kn knot 0.035
CG6969 CG6969 gene product from transcript CG6969-RA 0.035
Gp150 CG5820 gene product from transcript CG5820-RA 0.034
Pbprp2 Pheromone-binding protein-related protein 2 0.034
pb proboscipedia 0.034
Osbp Oxysterol binding protein 0.034
dhd deadhead 0.034
MED9 Mediator complex subunit 9 0.034
Tim9a CG1660 gene product from transcript CG1660-RA 0.034
CG8486 CG8486 gene product from transcript CG8486-RE 0.033
CG3823 CG3823 gene product from transcript CG3823-RA 0.033
CG5171 CG5171 gene product from transcript CG5171-RC 0.033
Cyp28a5 CG8864 gene product from transcript CG8864-RA 0.033
GstE3 Glutathione S transferase E3 0.033
oc ocelliless 0.032
dnd dead end 0.032
CG1544 CG1544 gene product from transcript CG1544-RA 0.032
ft fat 0.031
CG12194 CG12194 gene product from transcript CG12194-RA 0.031
cutlet CG33122 gene product from transcript CG33122-RA 0.030
CG8192 CG8192 gene product from transcript CG8192-RA 0.030
CG9009 CG9009 gene product from transcript CG9009-RB 0.030
CG16786 CG16786 gene product from transcript CG16786-RA 0.030
CG5162 CG5162 gene product from transcript CG5162-RA 0.030
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.556
zgc:112329 zgc:112329 0.308
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.235
slc45a2 solute carrier family 45, member 2 0.230
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.190
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.156
mitfa microphthalmia-associated transcription factor a 0.141
atp6v1f ATPase, H+ transporting, V1 subunit F 0.127
kita kit receptor a 0.085
tyr tyrosinase 0.072
slc24a5 solute carrier family 24, member 5 0.070
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.063
ltk leukocyte tyrosine kinase 0.060
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.060
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.052
csf1ra colony stimulating factor 1 receptor, a 0.045
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.031
mtp microsomal triglyceride transfer protein 0.023
zgc:111821 zgc:111821 0.021
tyrp1b tyrosinase-related protein 1b 0.020
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.019
sc:d812 sc:d812 0.019
dharma dharma 0.017
ednrb1 endothelin receptor B 0.016
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.015
paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.015
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.014
gart phosphoribosylglycinamide formyltransferase 0.014
atp6v1c1b ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b 0.014
dct dopachrome tautomerase 0.014
chm choroideremia 0.014
kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.013
tm4sf4 transmembrane 4 L six family member 4 0.013
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.013
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.013
pmela premelanosome protein a 0.012
adcyap1a adenylate cyclase activating polypeptide 1a 0.012
csnk1a1 casein kinase 1, alpha 1 0.012
cltca clathrin, heavy polypeptide a (Hc) 0.012
zgc:162420 zgc:162420 0.011
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
LAMP2 lysosomal-associated membrane protein 2 0.398
RPN2 ribophorin II 0.218
BBS1 Bardet-Biedl syndrome 1 0.156
SSR1 signal sequence receptor, alpha 0.146
BBS2 Bardet-Biedl syndrome 2 0.144
BBS9 Bardet-Biedl syndrome 9 0.110
EXOC7 exocyst complex component 7 0.072
PDIA3 protein disulfide isomerase family A, member 3 0.071
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.063
TRAM1 translocation associated membrane protein 1 0.053
TMED2 transmembrane emp24 domain trafficking protein 2 0.046
TM9SF2 transmembrane 9 superfamily member 2 0.034
GNS glucosamine (N-acetyl)-6-sulfatase 0.032
NPC2 Niemann-Pick disease, type C2 0.030
TTC8 tetratricopeptide repeat domain 8 0.027
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.025
ARL6 ADP-ribosylation factor-like 6 0.023
PCM1 pericentriolar material 1 0.023
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.022
ITM2B integral membrane protein 2B 0.021
CALU calumenin 0.021
STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 0.019
SCARB2 scavenger receptor class B, member 2 0.017
CPD carboxypeptidase D 0.017
PDIA6 protein disulfide isomerase family A, member 6 0.016
BBS7 Bardet-Biedl syndrome 7 0.015
HEXB hexosaminidase B (beta polypeptide) 0.015
LMAN1 lectin, mannose-binding, 1 0.015
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.015
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.014
SH3BGRL SH3 domain binding glutamic acid-rich protein like 0.013
RPN1 ribophorin I 0.012
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.012
ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0.012
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.012
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.011
CD46 CD46 molecule, complement regulatory protein 0.011
EPRS glutamyl-prolyl-tRNA synthetase 0.011
MFSD1 major facilitator superfamily domain containing 1 0.011
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.011
VIPAR VPS33B interacting protein, apical-basolateral polarity regulator 0.011
YIPF5 Yip1 domain family, member 5 0.010
HSCB HscB iron-sulfur cluster co-chaperone homolog (E. coli) 0.010
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.010
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.010
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.711
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.225
Gli3 GLI-Kruppel family member GLI3 0.213
Bbs2 Bardet-Biedl syndrome 2 (human) 0.199
Ap3b1 adaptor-related protein complex 3, beta 1 subunit 0.190
Pldn pallidin 0.147
Cno cappuccino 0.116
Bbs1 Bardet-Biedl syndrome 1 (human) 0.109
a nonagouti 0.097
Hps6 Hermansky-Pudlak syndrome 6 0.078
Muted muted 0.070
Lyst lysosomal trafficking regulator 0.055
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.054
Hps5 Hermansky-Pudlak syndrome 5 homolog (human) 0.053
Rab27a RAB27A, member RAS oncogene family 0.045
Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D 0.044
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.036
Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 0.030
Mitf microphthalmia-associated transcription factor 0.030
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.028
Magt1 magnesium transporter 1 0.027
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.026
Otx2 orthodenticle homolog 2 (Drosophila) 0.025
Tmx1 thioredoxin-related transmembrane protein 1 0.023
Mfsd1 major facilitator superfamily domain containing 1 0.021
Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) 0.021
Asah1 N-acylsphingosine amidohydrolase 1 0.021
Sdcbp syndecan binding protein 0.019
Pitx1 paired-like homeodomain transcription factor 1 0.018
Hps3 Hermansky-Pudlak syndrome 3 homolog (human) 0.018
Pomc pro-opiomelanocortin-alpha 0.018
Rab38 RAB38, member of RAS oncogene family 0.018
Ctnnb1 catenin (cadherin associated protein), beta 1 0.017
Rim4 recombination induced mutation 4 0.017
Tyrp1 tyrosinase-related protein 1 0.016
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.016
Lamp2 lysosomal-associated membrane protein 2 0.016
Nars asparaginyl-tRNA synthetase 0.016
Rapsn receptor-associated protein of the synapse 0.015
Hspa5 heat shock protein 5 0.015
Rho rhodopsin 0.015
Tff1 trefoil factor 1 0.015
Pthlh parathyroid hormone-like peptide 0.015
Stt3a STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 0.014
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.014
Kl klotho 0.014
Apoe apolipoprotein E 0.014
Oca2 oculocutaneous albinism II 0.014
Hand1 heart and neural crest derivatives expressed transcript 1 0.014
Ssr1 signal sequence receptor, alpha 0.014
Grn granulin 0.013
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.013
Stx7 syntaxin 7 0.013
Rpe ribulose-5-phosphate-3-epimerase 0.013
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.013
Tmem33 transmembrane protein 33 0.012
Dtnbp1 dystrobrevin binding protein 1 0.012
Hexb hexosaminidase B 0.012
Tm9sf3 transmembrane 9 superfamily member 3 0.012
Sct secretin 0.012
Sox9 SRY-box containing gene 9 0.012
Ssr3 signal sequence receptor, gamma 0.012
Pax3 paired box gene 3 0.012
Crh corticotropin releasing hormone 0.012
Bbs7 Bardet-Biedl syndrome 7 (human) 0.012
Pklr pyruvate kinase liver and red blood cell 0.012
Tyr tyrosinase 0.012
Fgf9 fibroblast growth factor 9 0.012
Wnt10a wingless related MMTV integration site 10a 0.012
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.012
Cltc clathrin, heavy polypeptide (Hc) 0.012
Amhr2 anti-Mullerian hormone type 2 receptor 0.012
Prph2 peripherin 2 0.011
Mkks McKusick-Kaufman syndrome protein 0.011
Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.011
Serp1 stress-associated endoplasmic reticulum protein 1 0.011
Rab1 RAB1, member RAS oncogene family 0.011
Lgals2 lectin, galactose-binding, soluble 2 0.011
Amh anti-Mullerian hormone 0.011
Pmel premelanosome protein 0.011
Gsg1 germ cell-specific gene 1 0.011
Vamp7 vesicle-associated membrane protein 7 0.011
Runx2 runt related transcription factor 2 0.011
Ift172 intraflagellar transport 172 homolog (Chlamydomonas) 0.010
Nipa2 non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human) 0.010
Ctsc cathepsin C 0.010
Golga7 golgi autoantigen, golgin subfamily a, 7 0.010
Lrp2 low density lipoprotein receptor-related protein 2 0.010
Sc4mol sterol-C4-methyl oxidase-like 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism