The network for 'retinoic acid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

Homo sapiens
Name Description Probability Func Analog Organism
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 1.000
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 1.000
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 1.000
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.992
NQO1 NAD(P)H dehydrogenase, quinone 1 0.384
PIR pirin (iron-binding nuclear protein) 0.318
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.229
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.196
NDRG1 N-myc downstream regulated 1 0.155
NUPR1 nuclear protein, transcriptional regulator, 1 0.105
AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) 0.083
ARG1 arginase, liver 0.066
AADAC arylacetamide deacetylase (esterase) 0.066
GLIS2 GLIS family zinc finger 2 0.062
GPX2 glutathione peroxidase 2 (gastrointestinal) 0.061
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.059
MITF microphthalmia-associated transcription factor 0.055
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.054
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.053
SETD8 SET domain containing (lysine methyltransferase) 8 0.048
LIPC lipase, hepatic 0.047
SLPI secretory leukocyte peptidase inhibitor 0.040
CES1 carboxylesterase 1 0.038
ANXA13 annexin A13 0.037
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 0.035
CLCA2 chloride channel accessory 2 0.034
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.033
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.033
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.033
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 0.032
CRP C-reactive protein, pentraxin-related 0.031
GPX3 glutathione peroxidase 3 (plasma) 0.031
SAA4 serum amyloid A4, constitutive 0.030
RDH16 retinol dehydrogenase 16 (all-trans) 0.030
MAOA monoamine oxidase A 0.029
ACPP acid phosphatase, prostate 0.028
PRSS2 protease, serine, 2 (trypsin 2) 0.028
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.028
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.028
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.027
C9 complement component 9 0.027
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.027
TSPAN8 tetraspanin 8 0.027
ACACA acetyl-CoA carboxylase alpha 0.026
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.025
TRIM16 tripartite motif containing 16 0.024
ANXA10 annexin A10 0.024
NARF nuclear prelamin A recognition factor 0.023
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.023
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.022
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.022
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.022
GJB1 gap junction protein, beta 1, 32kDa 0.022
SEC14L2 SEC14-like 2 (S. cerevisiae) 0.022
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.021
VNN1 vanin 1 0.021
PON3 paraoxonase 3 0.021
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.021
FABP1 fatty acid binding protein 1, liver 0.020
ADH6 alcohol dehydrogenase 6 (class V) 0.020
BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 0.020
SPINK1 serine peptidase inhibitor, Kazal type 1 0.020
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.019
DEFB1 defensin, beta 1 0.019
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.019
MAGEA11 melanoma antigen family A, 11 0.019
ACOX2 acyl-CoA oxidase 2, branched chain 0.019
CLCN2 chloride channel 2 0.019
NTS neurotensin 0.019
GCGR glucagon receptor 0.019
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.019
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.019
S100A2 S100 calcium binding protein A2 0.019
SDC1 syndecan 1 0.019
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.019
GSTT1 glutathione S-transferase theta 1 0.018
OTC ornithine carbamoyltransferase 0.018
MGST1 microsomal glutathione S-transferase 1 0.018
EPHX2 epoxide hydrolase 2, cytoplasmic 0.018
ASS1 argininosuccinate synthase 1 0.018
FHIT fragile histidine triad gene 0.018
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.018
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.018
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 0.018
ARL14 ADP-ribosylation factor-like 14 0.018
ACSM2A acyl-CoA synthetase medium-chain family member 2A 0.018
HABP2 hyaluronan binding protein 2 0.018
IL13RA2 interleukin 13 receptor, alpha 2 0.018
SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 0.018
FST follistatin 0.018
PPARG peroxisome proliferator-activated receptor gamma 0.018
TCF4 transcription factor 4 0.018
BDKRB1 bradykinin receptor B1 0.017
KRT16 keratin 16 0.017
GSTM3 glutathione S-transferase mu 3 (brain) 0.017
MOSC1 MOCO sulphurase C-terminal domain containing 1 0.017
IL22RA1 interleukin 22 receptor, alpha 1 0.017
YBX2 Y box binding protein 2 0.017
CDHR5 cadherin-related family member 5 0.017
ACO1 aconitase 1, soluble 0.017
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ephb4b eph receptor B4b 0.217
tp53 tumor protein p53 0.204
gro1 groucho 1 0.200
bmp2b bone morphogenetic protein 2b 0.161
tbx1 T-box 1 0.131
fabp2 fatty acid binding protein 2, intestinal 0.125
lef1 lymphocyte enhancer binding factor 1 0.125
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.095
axin1 axin 1 0.094
fgf10a fibroblast growth factor 10a 0.083
ahctf1 AT hook containing transcription factor 1 0.081
notch3 notch homolog 3 0.067
wls wntless homolog (Drosophila) 0.064
sox10 SRY-box containing gene 10 0.061
hmx2 H6 family homeobox 2 0.061
nrg1 neuregulin 1 0.053
gata5 GATA-binding protein 5 0.050
sec31a sec31 homolog A (S. cerevisiae) 0.046
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.045
ptch2 patched 2 0.042
dld deltaD 0.041
smad2 MAD homolog 2 (Drosophila) 0.040
six1b sine oculis homeobox homolog 1b 0.035
gro2 groucho 2 0.034
mib mind bomb 0.032
znf503 zinc finger protein 503 0.028
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.028
gpm6ab glycoprotein M6Ab 0.026
hmx3 homeo box (H6 family) 3 0.026
axin2 axin 2 (conductin, axil) 0.026
il17rd interleukin 17 receptor D 0.023
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.023
igf1rb insulin-like growth factor 1b receptor 0.022
ntn1a netrin 1a 0.022
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.022
dlc deltaC 0.021
osr1 odd-skipped related 1 (Drosophila) 0.021
homez homeodomain leucine zipper gene 0.020
tbx5a T-box 5a 0.019
sox11b SRY-box containing gene 11b 0.019
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.018
prdm5 PR domain containing 5 0.018
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.018
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.017
pea3 ETS-domain transcription factor pea3 0.017
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.017
pparg peroxisome proliferator activated receptor gamma 0.017
tbx22 T-box 22 0.016
gbx2 gastrulation brain homeo box 2 0.015
vwf von Willebrand factor 0.015
eya1 eyes absent homolog 1 0.015
ncl nucleolin 0.014
sox1a SRY-box containing gene 1a 0.014
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.014
smad5 MAD homolog 5 (Drosophila) 0.014
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.014
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.014
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.014
traf4a tnf receptor-associated factor 4a 0.013
foxg1a forkhead box G1a 0.013
foxp1b forkhead box P1b 0.013
acvr1b activin A receptor, type IB 0.013
chga chromogranin A 0.013
zgc:171553 zgc:171553 0.013
irx2a iroquois homeobox protein 2, a 0.013
dct dopachrome tautomerase 0.012
bmp7b bone morphogenetic protein 7b 0.012
kdrl kinase insert domain receptor like 0.012
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.012
ptbp2 polypyrimidine tract binding protein 2 0.012
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.011
tm4sf4 transmembrane 4 L six family member 4 0.011
ext2 exostoses (multiple) 2 0.011
pbx4 pre-B-cell leukemia transcription factor 4 0.011
hoxc8a homeo box C8a 0.011
dpf2l D4, zinc and double PHD fingers family 2, like 0.011
snai1a snail homolog 1a (Drosophila) 0.011
ppp6r2 protein phosphatase 6, regulatory subunit 2 0.011
tfa transferrin-a 0.011
bmp1a bone morphogenetic protein 1a 0.010
vcana versican a 0.010
lrig1 leucine-rich repeats and immunoglobulin-like domains 1 0.010
plcg1 phospholipase C, gamma 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 0.988
Rarg retinoic acid receptor, gamma 0.931
Ednra endothelin receptor type A 0.913
Tcf7 transcription factor 7, T-cell specific 0.848
Foxc2 forkhead box C2 0.779
Rarb retinoic acid receptor, beta 0.650
Foxc1 forkhead box C1 0.648
Pax3 paired box gene 3 0.607
Chd7 chromodomain helicase DNA binding protein 7 0.442
Tcfap2a transcription factor AP-2, alpha 0.437
Pitx2 paired-like homeodomain transcription factor 2 0.374
Hoxa3 homeobox A3 0.349
Tbx1 T-box 1 0.299
Rara retinoic acid receptor, alpha 0.281
Ece1 endothelin converting enzyme 1 0.269
Nrp1 neuropilin 1 0.234
Fgfr2 fibroblast growth factor receptor 2 0.208
Vegfa vascular endothelial growth factor A 0.195
Rxra retinoid X receptor alpha 0.195
Mecom MDS1 and EVI1 complex locus 0.168
Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 0.149
Smo smoothened homolog (Drosophila) 0.129
Hoxa1 homeobox A1 0.127
Sox4 SRY-box containing gene 4 0.122
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.102
Tbx3 T-box 3 0.092
Pax2 paired box gene 2 0.091
Hand2 heart and neural crest derivatives expressed transcript 2 0.090
Glyat glycine-N-acyltransferase 0.084
Rdh10 retinol dehydrogenase 10 (all-trans) 0.083
Aadac arylacetamide deacetylase (esterase) 0.080
Ces1c carboxylesterase 1C 0.079
Bmp4 bone morphogenetic protein 4 0.078
Shh sonic hedgehog 0.078
Ces2a carboxylesterase 2A 0.075
Fbln1 fibulin 1 0.068
Gata3 GATA binding protein 3 0.067
Cyp2j5 cytochrome P450, family 2, subfamily j, polypeptide 5 0.062
Rdh7 retinol dehydrogenase 7 0.058
Gsta3 glutathione S-transferase, alpha 3 0.058
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.057
Isl1 ISL1 transcription factor, LIM/homeodomain 0.054
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.052
Slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.052
Iyd iodotyrosine deiodinase 0.048
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.047
Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.037
Bmp7 bone morphogenetic protein 7 0.037
Otx2 orthodenticle homolog 2 (Drosophila) 0.036
Apoc3 apolipoprotein C-III 0.036
Wnt5a wingless-related MMTV integration site 5A 0.036
F13b coagulation factor XIII, beta subunit 0.035
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.035
Clec2h C-type lectin domain family 2, member h 0.034
Aldh8a1 aldehyde dehydrogenase 8 family, member A1 0.033
Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 0.033
Bmper BMP-binding endothelial regulator 0.033
Cdx2 caudal type homeobox 2 0.031
Tgfbr2 transforming growth factor, beta receptor II 0.031
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.030
Ces2e carboxylesterase 2E 0.030
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.028
BC089597 cDNA sequence BC089597 0.027
Ugt3a1 UDP glycosyltransferases 3 family, polypeptide A1 0.027
Pkhd1 polycystic kidney and hepatic disease 1 0.026
Wnk4 WNK lysine deficient protein kinase 4 0.026
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.025
Plxnd1 plexin D1 0.025
Mep1b meprin 1 beta 0.025
Acot4 acyl-CoA thioesterase 4 0.024
Sult1b1 sulfotransferase family 1B, member 1 0.024
Eya1 eyes absent 1 homolog (Drosophila) 0.024
Proc protein C 0.023
Acsm1 acyl-CoA synthetase medium-chain family member 1 0.023
Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 0.021
Acvr1 activin A receptor, type 1 0.020
Dpys dihydropyrimidinase 0.020
Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 0.020
Gbx2 gastrulation brain homeobox 2 0.020
Midn midnolin 0.020
Gys2 glycogen synthase 2 0.020
Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 0.020
Pdzk1 PDZ domain containing 1 0.019
Emx2 empty spiracles homolog 2 (Drosophila) 0.019
Otc ornithine transcarbamylase 0.018
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.018
9530008L14Rik RIKEN cDNA 9530008L14 gene 0.018
Tcf21 transcription factor 21 0.018
Mettl7b methyltransferase like 7B 0.017
Slc17a3 solute carrier family 17 (sodium phosphate), member 3 0.017
Spp2 secreted phosphoprotein 2 0.017
Sgk2 serum/glucocorticoid regulated kinase 2 0.017
Hgd homogentisate 1, 2-dioxygenase 0.017
Slc17a2 solute carrier family 17 (sodium phosphate), member 2 0.017
Mep1a meprin 1 alpha 0.017
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.016
Ces1d carboxylesterase 1D 0.016
Dlx5 distal-less homeobox 5 0.016
Ugt3a2 UDP glycosyltransferases 3 family, polypeptide A2 0.016
Afm afamin 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism