The network for 'response to metal ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to metal ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

Rattus norvegicus
Name Description Probability Func Analog Organism
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.916
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.876
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.837
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.811
Lgals3 lectin, galactoside-binding, soluble, 3 0.733
Gstm1 glutathione S-transferase mu 1 0.712
Krt5 keratin 5 0.705
Fga fibrinogen alpha chain 0.673
Ephx1 epoxide hydrolase 1, microsomal 0.668
Mettl7b methyltransferase like 7B 0.617
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.586
Cps1 carbamoyl-phosphate synthetase 1 0.570
Ifitm3 interferon induced transmembrane protein 3 0.564
Dhfr dihydrofolate reductase 0.548
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.542
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.533
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.529
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.509
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.505
Foxa1 forkhead box A1 0.502
Anxa2 annexin A2 0.490
Mgst1 microsomal glutathione S-transferase 1 0.488
Hpx hemopexin 0.482
Cd80 Cd80 molecule 0.476
Anxa5 annexin A5 0.474
Pla2g2c phospholipase A2, group IIC 0.469
Apoc4 apolipoprotein C-IV 0.456
Cd14 CD14 molecule 0.442
Il8rb interleukin 8 receptor, beta 0.439
Tnr tenascin R 0.436
Ptprh protein tyrosine phosphatase, receptor type, H 0.433
Ahsg alpha-2-HS-glycoprotein 0.432
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.424
Pnlip pancreatic lipase 0.417
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.406
Cyb5a cytochrome b5 type A (microsomal) 0.405
Prdx2 peroxiredoxin 2 0.403
COX2 COXII 0.400
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.400
Cnga3 cyclic nucleotide gated channel alpha 3 0.391
S100a6 S100 calcium binding protein A6 0.389
Mmp3 matrix metallopeptidase 3 0.382
Plau plasminogen activator, urokinase 0.380
Aldoa aldolase A, fructose-bisphosphate 0.379
Agxt2 alanine-glyoxylate aminotransferase 2 0.377
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.376
Aqp8 aquaporin 8 0.371
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.367
Inhbe inhibin beta E 0.363
Myl7 myosin, light chain 7, regulatory 0.359
Ccr3 chemokine (C-C motif) receptor 3 0.357
Gck glucokinase 0.352
Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 0.352
Il12b interleukin 12B 0.350
Igfals insulin-like growth factor binding protein, acid labile subunit 0.343
Gria2 glutamate receptor, ionotropic, AMPA 2 0.341
Dlg4 discs, large homolog 4 (Drosophila) 0.340
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.338
Gstp1 glutathione S-transferase pi 1 0.336
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.336
Crx cone-rod homeobox 0.335
Pklr pyruvate kinase, liver and RBC 0.335
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.333
Timp1 TIMP metallopeptidase inhibitor 1 0.330
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.330
Hspb1 heat shock protein 1 0.329
Zfp37 zinc finger protein 37 0.327
Akr1c14 aldo-keto reductase family 1, member C14 0.327
Gja4 gap junction protein, alpha 4 0.326
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.324
Espn espin 0.320
Mmp8 matrix metallopeptidase 8 0.319
Vim vimentin 0.317
Fbp1 fructose-1,6-bisphosphatase 1 0.316
COX1 cytochrome c oxidase subunit 1 0.316
Cartpt CART prepropeptide 0.315
Ubb ubiquitin B 0.315
Fn1 fibronectin 1 0.315
Pygm phosphorylase, glycogen, muscle 0.315
Col10a1 collagen, type X, alpha 1 0.312
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.309
Actb actin, beta 0.309
Cd40lg CD40 ligand 0.306
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.304
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.304
Pla2g1b phospholipase A2, group IB, pancreas 0.303
Apcs amyloid P component, serum 0.299
C1s complement component 1, s subcomponent 0.295
Nmu neuromedin U 0.294
Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.293
Capn8 calpain 8 0.291
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.291
Rorb RAR-related orphan receptor B 0.286
Arpc1b actin related protein 2/3 complex, subunit 1B 0.285
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.285
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.280
Agtr2 angiotensin II receptor, type 2 0.278
Gp2 glycoprotein 2 (zymogen granule membrane) 0.276
Timp2 TIMP metallopeptidase inhibitor 2 0.274
Cga glycoprotein hormones, alpha polypeptide 0.273
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
cyp-35C1 Protein CYP-35C1 0.073
egl-44 Protein EGL-44 0.039
ncs-2 Protein NCS-2 0.038
CELE_C29F7.2 Protein C29F7.2 0.035
cyp-35A2 Protein CYP-35A2 0.035
sqt-1 Protein SQT-1 0.032
ina-1 Protein INA-1 0.031
CELE_Y47H9C.7 Protein Y47H9C.7 0.030
F14B8.2 Protein F14B8.2 0.030
apy-1 Protein APY-1 0.029
C03A3.2 Protein C03A3.2 0.029
cyp-35A3 Protein CYP-35A3 0.028
ttm-5 Protein TTM-5 0.026
tps-1 Protein TPS-1 0.025
F13H6.3 Protein F13H6.3 0.024
unc-73 Protein UNC-73 0.023
zig-9 Protein ZIG-9 0.023
mig-2 Protein MIG-2 0.022
syd-2 Protein SYD-2 0.022
F47B8.4 Protein F47B8.4 0.022
alx-1 Protein ALX-1 0.022
lec-10 Protein LEC-10 0.021
eps-8 Protein EPS-8 0.020
egl-1 Protein EGL-1 0.019
F13H10.4 Protein F13H10.4 0.019
cyp-35A4 Protein CYP-35A4 0.018
pkg-1 Protein PKG-1 0.018
T16G1.6 Protein T16G1.6 0.018
rig-6 Protein RIG-6 0.018
egl-18 Protein EGL-18 0.018
CELE_K09C4.5 Protein K09C4.5 0.018
F44E7.4 Protein F44E7.4 0.017
pmk-1 Protein PMK-1 0.017
plc-3 Protein PLC-3 0.017
nhr-45 Protein NHR-45 0.017
goa-1 Protein GOA-1 0.017
nhr-2 Protein NHR-2 0.017
ipp-5 Protein IPP-5 0.016
ugt-26 Protein UGT-26 0.016
cdr-2 Protein CDR-2 0.016
C37H5.2 Protein C37H5.2 0.016
vav-1 Protein VAV-1 0.016
clec-72 Protein CLEC-72 0.016
CELE_F42F12.3 Protein F42F12.3 0.016
cyp-35A5 Protein CYP-35A5 0.016
K07C11.4 Protein K07C11.4 0.016
nra-1 Protein NRA-1 0.016
F37C4.5 Protein F37C4.5 0.016
ftn-1 Protein FTN-1 0.016
F35G2.2 Protein F35G2.2 0.015
ugt-62 Protein UGT-62 0.015
abu-12 Protein ABU-12 0.015
toe-4 Protein TOE-4 0.015
pmk-3 Protein PMK-3 0.015
F22E12.1 Protein F22E12.1 0.015
ztf-15 Protein ZTF-15 0.015
snf-11 Protein SNF-11 0.015
ppk-3 Protein PPK-3 0.014
kcc-1 Protein KCC-1 0.014
H03A11.2 Protein H03A11.2 0.014
F09F7.5 Protein F09F7.5 0.014
ced-3 Protein CED-3 0.014
mrp-5 Protein MRP-5 0.014
W04B5.3 Protein W04B5.3 0.014
ddb-1 Protein DDB-1 0.014
ugt-16 Protein UGT-16 0.014
K10C2.1 Protein K10C2.1 0.014
ftt-2 Protein FTT-2 0.014
pgp-6 Protein PGP-6 0.014
cec-1 Protein CEC-1 0.014
cysl-1 Protein CYSL-1 0.014
CELE_C08F11.3 Protein C08F11.3 0.013
W01A11.1 Protein W01A11.1 0.013
cdh-7 Protein CDH-7 0.013
pal-1 Protein PAL-1 0.013
unc-18 Protein UNC-18 0.013
vab-1 Protein VAB-1 0.013
gst-13 Protein GST-13 0.013
dod-3 Protein DOD-3 0.013
pqn-89 Protein PQN-89 0.013
tag-147 Protein TAG-147 0.013
dpf-4 Protein DPF-4 0.013
xpo-1 Protein XPO-1 0.013
itr-1 Protein ITR-1 0.013
tmc-2 Protein TMC-2 0.013
npp-9 Protein NPP-9 0.013
ugt-1 Protein UGT-1 0.013
ugt-22 Protein UGT-22 0.013
cpn-2 Protein CPN-2 0.013
T14F9.2 Protein T14F9.2 0.012
eat-6 Protein EAT-6 0.012
tap-1 Protein TAP-1 0.012
gst-5 Protein GST-5 0.012
fkh-2 Protein FKH-2 0.012
qns-1 Protein QNS-1 0.012
unc-32 Protein UNC-32 0.012
upp-1 Protein UPP-1 0.012
svh-2 Protein SVH-2 0.012
sma-5 Protein SMA-5 0.012
T08G11.1 Protein T08G11.1 0.012
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
bcl2 B-cell leukemia/lymphoma 2 0.784
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.687
myod1 myogenic differentiation 1 0.626
bcl2l1 bcl2-like 1 0.619
mt2 metallothionein 2 0.580
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.550
pcna proliferating cell nuclear antigen 0.515
ca2 carbonic anhydrase II 0.466
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.450
alcama activated leukocyte cell adhesion molecule a 0.426
hspb1 heat shock protein, alpha-crystallin-related, 1 0.323
limk2 LIM domain kinase 2 0.304
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.289
cahz carbonic anhydrase 0.287
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.259
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.258
sod1 superoxide dismutase 1, soluble 0.256
mcl1a myeloid cell leukemia sequence 1a 0.253
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.226
mibp2 muscle-specific beta 1 integrin binding protein 2 0.218
hspa5 heat shock protein 5 0.215
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.204
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.203
copeb core promoter element binding protein 0.194
si:dkey-236e20.2 si:dkey-236e20.2 0.171
fabp7a fatty acid binding protein 7, brain, a 0.168
adrb2a adrenergic receptor, beta 2a 0.168
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.162
cadm2a cell adhesion molecule 2a 0.159
inhbaa inhibin, beta Aa 0.157
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.148
bactin2 bactin2 0.147
prnprs3 prion protein, related sequence 3 0.143
csad cysteine sulfinic acid decarboxylase 0.140
hsp90a.2 heat shock protein 90-alpha 2 0.140
socs1 suppressor of cytokine signaling 1 0.139
uxs1 UDP-glucuronic acid decarboxylase 1 0.139
hand2 heart and neural crest derivatives expressed transcript 2 0.138
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.136
atp1a1a.5 ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide 0.133
epas1b endothelial PAS domain protein 1b 0.132
atf3 activating transcription factor 3 0.130
gata3 GATA-binding protein 3 0.130
bbc3 BCL2 binding component 3 0.128
bida BH3 interacting domain death agonist 0.127
sox9a SRY-box containing gene 9a 0.125
drd2b dopamine receptor D2b 0.125
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.121
cbr1l carbonyl reductase 1-like 0.118
hsp47 heat shock protein 47 0.118
alas2 aminolevulinate, delta-, synthetase 2 0.113
dag1 dystroglycan 1 0.113
cav1 caveolin 1 0.110
ckbb creatine kinase, brain b 0.110
clock clock 0.108
acvr2a activin receptor IIa 0.101
acadl acyl-Coenzyme A dehydrogenase, long chain 0.100
mapk3 mitogen-activated protein kinase 3 0.100
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.098
cxadr coxsackie virus and adenovirus receptor 0.098
inha inhibin, alpha 0.095
mtp microsomal triglyceride transfer protein 0.094
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.094
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.093
nrg1 neuregulin 1 0.092
mapk6 mitogen-activated protein kinase 6 0.091
sod2 superoxide dismutase 2, mitochondrial 0.089
pdlim4 PDZ and LIM domain 4 0.088
mapk7 mitogen-activated protein kinase 7 0.085
si:rp71-39b20.7 si:rp71-39b20.7 0.084
rpl13a ribosomal protein L13a 0.084
slc39a1 solute carrier family 39 (zinc transporter), member 1 0.084
cd63 Cd63 antigen 0.083
ocrl oculocerebrorenal syndrome of Lowe 0.083
nap1l1 nucleosome assembly protein 1, like 1 0.077
tspo translocator protein 0.076
fbln4 fibulin 4 0.075
oprk1 opioid receptor, kappa 1 0.074
jun jun proto-oncogene 0.074
tgfbr2 transforming growth factor, beta receptor II 0.073
grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a 0.073
klf4a Kruppel-like transcription factor 4a 0.073
mmp13a matrix metalloproteinase 13a 0.071
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.071
tmprss4a transmembrane protease, serine 4a 0.071
pcdh2ac protocadherin 2 alpha c 0.070
zgc:136878 zgc:136878 0.069
mcl1b myeloid cell leukemia sequence 1b 0.068
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.068
comta catechol-O-methyltransferase a 0.068
keap1a kelch-like ECH-associated protein 1a 0.068
gfap glial fibrillary acidic protein 0.067
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.067
sb:cb1058 sb:cb1058 0.066
chrm2a cholinergic receptor, muscarinic 2a 0.065
vdra vitamin D receptor a 0.064
notch2 notch homolog 2 0.063
crygm2d1 crystallin, gamma M2d1 0.063
tlr3 toll-like receptor 3 0.062
mvp major vault protein 0.061
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.924
Cdc42 CG12530 gene product from transcript CG12530-RA 0.447
Sod Superoxide dismutase 0.439
Tpi Triose phosphate isomerase 0.386
ci cubitus interruptus 0.328
Fer1HCH Ferritin 1 heavy chain homologue 0.284
ptc patched 0.265
Stat92E Signal-transducer and activator of transcription protein at 92E 0.252
PHGPx CG12013 gene product from transcript CG12013-RC 0.242
Gapdh2 Glyceraldehyde 3 phosphate dehydrogenase 2 0.231
Nlp Nucleoplasmin 0.206
Cyp12a4 CG6042 gene product from transcript CG6042-RA 0.199
Gapdh1 Glyceraldehyde 3 phosphate dehydrogenase 1 0.199
trio CG18214 gene product from transcript CG18214-RA 0.192
Dcr-2 Dicer-2 0.189
Src42A Src oncogene at 42A 0.189
Ugt35a UDP-glycosyltransferase 35a 0.168
Pink1 PTEN-induced putative kinase 1 0.146
Aldh Aldehyde dehydrogenase 0.144
N Notch 0.135
Eno Enolase 0.131
mys myospheroid 0.125
LamC Lamin C 0.109
CG2107 CG2107 gene product from transcript CG2107-RA 0.102
Trx-2 thioredoxin-2 0.102
Jafrac1 thioredoxin peroxidase 1 0.095
Adh Alcohol dehydrogenase 0.093
CG1927 CG1927 gene product from transcript CG1927-RA 0.091
Tequila CG4821 gene product from transcript CG4821-RE 0.090
Cat Catalase 0.090
if inflated 0.088
NPFR1 neuropeptide F receptor 0.084
Ork1 Open rectifier K[+] channel 1 0.083
bsk basket 0.082
Cyp6a21 CG10247 gene product from transcript CG10247-RA 0.077
JhI-26 Juvenile hormone-inducible protein 26 0.074
mth methuselah 0.073
par-1 CG8201 gene product from transcript CG8201-RA 0.073
CG12171 CG12171 gene product from transcript CG12171-RA 0.072
Mpk2 CG5475 gene product from transcript CG5475-RB 0.071
smt3 CG4494 gene product from transcript CG4494-RA 0.071
Jheh2 Juvenile hormone epoxide hydrolase 2 0.070
Rya-r44F Ryanodine receptor 44F 0.070
Cyp6a2 Cytochrome P450-6a2 0.069
CG6834 CG6834 gene product from transcript CG6834-RA 0.066
slo slowpoke 0.066
kay kayak 0.066
l(2)05510 lethal (2) 05510 0.064
Got2 Glutamate oxaloacetate transaminase 2 0.063
CG10863 CG10863 gene product from transcript CG10863-RA 0.062
S6k RPS6-p70-protein kinase 0.061
Tsp29Fb Tetraspanin 29Fb 0.060
Osi6 Osiris 6 0.059
milt milton 0.059
CG17325 CG17325 gene product from transcript CG17325-RA 0.058
Vha16 Vacuolar H[+] ATPase 16kD subunit 0.056
TotA Turandot A 0.055
slow slowdown 0.054
drk downstream of receptor kinase 0.052
pan pangolin 0.052
blow blown fuse 0.050
CG10638 CG10638 gene product from transcript CG10638-RA 0.049
Rala Ras-related protein 0.049
rols rolling pebbles 0.048
kst karst 0.048
Dsor1 Downstream of raf1 0.047
MTF-1 Metal response element-binding Transcription Factor-1 0.046
ImpL3 Ecdysone-inducible gene L3 0.045
CG4860 CG4860 gene product from transcript CG4860-RA 0.044
Cyp6a9 Cytochrome P450-6a9 0.044
Mekk1 CG7717 gene product from transcript CG7717-RB 0.043
Chd64 CG14996 gene product from transcript CG14996-RB 0.042
Cyp6g1 CG8453 gene product from transcript CG8453-RA 0.042
lola longitudinals lacking 0.042
CG15611 CG15611 gene product from transcript CG15611-RB 0.041
Cyp6a23 CG10242 gene product from transcript CG10242-RA 0.041
alpha-Est7 alpha-Esterase-7 0.040
NLaz Neural Lazarillo 0.039
Fer2LCH Ferritin 2 light chain homologue 0.038
CG5362 CG5362 gene product from transcript CG5362-RA 0.036
Abl Abl tyrosine kinase 0.036
ple pale 0.035
Tak1 TGF-beta activated kinase 1 0.034
EcR Ecdysone receptor 0.034
Cg25C Collagen type IV 0.033
Rab11 Rab-protein 11 0.033
spi spitz 0.033
CG11897 CG11897 gene product from transcript CG11897-RA 0.033
Rel Relish 0.033
clt cricklet 0.033
blw bellwether 0.033
eIF4G eukaryotic translation initiation factor 4G 0.032
Argk Arginine kinase 0.031
Clk Clock 0.031
CG2233 CG2233 gene product from transcript CG2233-RA 0.031
sina seven in absentia 0.031
CG2852 CG2852 gene product from transcript CG2852-RA 0.030
CG11674 CG11674 gene product from transcript CG11674-RA 0.029
PGRP-LE Peptidoglycan recognition protein LE 0.029
Yp3 Yolk protein 3 0.029
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
JUN jun proto-oncogene 0.999
MT1H metallothionein 1H 0.987
FOS FBJ murine osteosarcoma viral oncogene homolog 0.985
MT1F metallothionein 1F 0.983
MT1E metallothionein 1E 0.980
BCL2 B-cell CLL/lymphoma 2 0.978
MT2A metallothionein 2A 0.949
CFL1 cofilin 1 (non-muscle) 0.942
MAPK14 mitogen-activated protein kinase 14 0.884
APP amyloid beta (A4) precursor protein 0.861
TEK TEK tyrosine kinase, endothelial 0.837
JUNB jun B proto-oncogene 0.804
MT1X metallothionein 1X 0.781
CDK2 cyclin-dependent kinase 2 0.741
TP53 tumor protein p53 0.717
DLG4 discs, large homolog 4 (Drosophila) 0.706
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.703
MAPK1 mitogen-activated protein kinase 1 0.700
SP1 Sp1 transcription factor 0.663
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.644
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.629
BAD BCL2-associated agonist of cell death 0.622
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.591
FGA fibrinogen alpha chain 0.535
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.512
GSTM2 glutathione S-transferase mu 2 (muscle) 0.467
SMAD4 SMAD family member 4 0.462
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.448
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.448
MT1G metallothionein 1G 0.438
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.438
ANXA1 annexin A1 0.430
NOSTRIN nitric oxide synthase trafficker 0.424
MAP2K1 mitogen-activated protein kinase kinase 1 0.407
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.397
BCL2L1 BCL2-like 1 0.381
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.381
LRP1 low density lipoprotein receptor-related protein 1 0.360
APAF1 apoptotic peptidase activating factor 1 0.348
DUSP1 dual specificity phosphatase 1 0.347
ATF3 activating transcription factor 3 0.340
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.339
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.337
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.333
MAPT microtubule-associated protein tau 0.325
HNF4A hepatocyte nuclear factor 4, alpha 0.317
EP300 E1A binding protein p300 0.316
DLG1 discs, large homolog 1 (Drosophila) 0.313
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.308
SKP2 S-phase kinase-associated protein 2 (p45) 0.300
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.297
FAS Fas (TNF receptor superfamily, member 6) 0.295
IRS1 insulin receptor substrate 1 0.283
ESR1 estrogen receptor 1 0.282
XIAP X-linked inhibitor of apoptosis 0.274
MAP2K4 mitogen-activated protein kinase kinase 4 0.269
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.264
TTR transthyretin 0.260
APOE apolipoprotein E 0.259
EGR1 early growth response 1 0.257
GADD45B growth arrest and DNA-damage-inducible, beta 0.256
PCNA proliferating cell nuclear antigen 0.256
HDAC4 histone deacetylase 4 0.256
ATF2 activating transcription factor 2 0.254
S100A14 S100 calcium binding protein A14 0.253
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.249
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.249
TXN thioredoxin 0.248
PDCD6 programmed cell death 6 0.247
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.242
PTEN phosphatase and tensin homolog 0.242
FGB fibrinogen beta chain 0.239
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.235
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.233
SKP1 S-phase kinase-associated protein 1 0.219
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.208
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.205
PRDX1 peroxiredoxin 1 0.201
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.200
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.197
TGFB1 transforming growth factor, beta 1 0.192
TNNI1 troponin I type 1 (skeletal, slow) 0.189
CFLAR CASP8 and FADD-like apoptosis regulator 0.185
BHLHE40 basic helix-loop-helix family, member e40 0.183
KRT5 keratin 5 0.181
ZFYVE9 zinc finger, FYVE domain containing 9 0.180
IER2 immediate early response 2 0.179
SPRY4 sprouty homolog 4 (Drosophila) 0.179
CAV1 caveolin 1, caveolae protein, 22kDa 0.175
CYR61 cysteine-rich, angiogenic inducer, 61 0.174
EGFR epidermal growth factor receptor 0.171
DSG2 desmoglein 2 0.169
CCNE1 cyclin E1 0.167
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.167
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.161
FGG fibrinogen gamma chain 0.158
TNNC1 troponin C type 1 (slow) 0.158
MCM6 minichromosome maintenance complex component 6 0.158
TRIM63 tripartite motif containing 63 0.154
PGK1 phosphoglycerate kinase 1 0.154
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.963
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.911
Apoe apolipoprotein E 0.855
Egfr epidermal growth factor receptor 0.832
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.831
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.825
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.734
Lyz2 lysozyme 2 0.664
Mapk14 mitogen-activated protein kinase 14 0.654
Cps1 carbamoyl-phosphate synthetase 1 0.589
Hbb-b1 hemoglobin, beta adult major chain 0.576
Emx1 empty spiracles homolog 1 (Drosophila) 0.572
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.571
Tgfbr2 transforming growth factor, beta receptor II 0.567
Cd44 CD44 antigen 0.566
Krt72-ps keratin 72, pseudogene 0.540
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.529
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.526
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.507
Fos FBJ osteosarcoma oncogene 0.506
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.486
Ptgs2 prostaglandin-endoperoxide synthase 2 0.480
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.477
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.468
Tagln transgelin 0.467
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.449
Id3 inhibitor of DNA binding 3 0.437
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.401
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.389
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.386
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.378
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.367
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.367
Mapk8 mitogen-activated protein kinase 8 0.362
Lep leptin 0.362
Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 0.353
Atf2 activating transcription factor 2 0.345
Prkce protein kinase C, epsilon 0.341
Tgfbr1 transforming growth factor, beta receptor I 0.341
Trp53 transformation related protein 53 0.328
Neurod1 neurogenic differentiation 1 0.328
Ccl2 chemokine (C-C motif) ligand 2 0.315
Kl klotho 0.315
Ptprc protein tyrosine phosphatase, receptor type, C 0.311
Id1 inhibitor of DNA binding 1 0.309
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.307
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.288
Dlg4 discs, large homolog 4 (Drosophila) 0.284
Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.279
Ahsg alpha-2-HS-glycoprotein 0.278
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.278
Atf3 activating transcription factor 3 0.276
Pitx2 paired-like homeodomain transcription factor 2 0.276
Bglap bone gamma carboxyglutamate protein 0.261
Smad3 MAD homolog 3 (Drosophila) 0.258
Csf1 colony stimulating factor 1 (macrophage) 0.250
Apob apolipoprotein B 0.243
Uox urate oxidase 0.232
Gcgr glucagon receptor 0.232
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.232
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.231
Myf5 myogenic factor 5 0.231
Akr1c6 aldo-keto reductase family 1, member C6 0.228
Rdh7 retinol dehydrogenase 7 0.226
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.222
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.218
Otc ornithine transcarbamylase 0.217
Shc3 src homology 2 domain-containing transforming protein C3 0.217
Apoa1 apolipoprotein A-I 0.217
Jun Jun oncogene 0.216
Tgfb1 transforming growth factor, beta 1 0.214
Mbl2 mannose-binding lectin (protein C) 2 0.212
Ces1c carboxylesterase 1C 0.210
Tlr4 toll-like receptor 4 0.209
Tcf4 transcription factor 4 0.208
Gja3 gap junction protein, alpha 3 0.208
Il2rg interleukin 2 receptor, gamma chain 0.207
Hrg histidine-rich glycoprotein 0.203
Alb albumin 0.198
Neurod4 neurogenic differentiation 4 0.195
Ttr transthyretin 0.195
Hnf4a hepatic nuclear factor 4, alpha 0.193
Notch2 Notch gene homolog 2 (Drosophila) 0.193
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.184
Cd19 CD19 antigen 0.184
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.183
Gstm1 glutathione S-transferase, mu 1 0.179
Pcna proliferating cell nuclear antigen 0.179
Pitx1 paired-like homeodomain transcription factor 1 0.179
Tcf3 transcription factor 3 0.176
Crp C-reactive protein, pentraxin-related 0.172
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.171
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.169
Aadac arylacetamide deacetylase (esterase) 0.167
Brca1 breast cancer 1 0.167
Gja1 gap junction protein, alpha 1 0.166
Foxc1 forkhead box C1 0.166
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.165
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.165
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.161
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
AFT1 Aft1p 0.140
TSA2 Tsa2p 0.100
AQY2 Aqy2p 0.079
NRG1 Nrg1p 0.065
CKS1 Cks1p 0.059
RPN4 Rpn4p 0.056
YCR102C hypothetical protein 0.056
MIG1 Mig1p 0.047
CUP9 Cup9p 0.045
HSF1 Hsf1p 0.039
CLB3 Clb3p 0.038
CMK1 Cmk1p 0.038
CDC28 Cdc28p 0.036
CLB4 Clb4p 0.036
MIG2 Mig2p 0.035
CNB1 Cnb1p 0.035
SIT1 Sit1p 0.035
ALY1 Aly1p 0.033
SHE3 She3p 0.032
FKH1 Fkh1p 0.032
YCF1 Ycf1p 0.031
TOM1 Tom1p 0.030
CDC4 Cdc4p 0.030
TBS1 Tbs1p 0.029
YLR108C hypothetical protein 0.029
TSA1 Tsa1p 0.028
CPR1 Cpr1p 0.027
PMC1 Pmc1p 0.027
CMP2 Cmp2p 0.027
YNL035C hypothetical protein 0.026
MSN4 Msn4p 0.026
GLN3 Gln3p 0.026
CLB1 Clb1p 0.026
HST1 Hst1p 0.026
TDH2 Tdh2p 0.024
GFA1 Gfa1p 0.024
FMP40 Fmp40p 0.024
NUP157 Nup157p 0.024
VAC7 Vac7p 0.023
PHO80 Pho80p 0.023
KIC1 Kic1p 0.023
GAD1 Gad1p 0.023
RIM101 Rim101p 0.023
CMD1 Cmd1p 0.022
PGM3 Pgm3p 0.022
PTM1 Ptm1p 0.022
CAK1 Cak1p 0.021
YPL014W hypothetical protein 0.021
SEC16 Sec16p 0.021
STR3 Str3p 0.020
TPA1 Tpa1p 0.020
TUS1 Tus1p 0.020
CLN2 Cln2p 0.020
ARP2 Arp2p 0.020
YCK2 Yck2p 0.020
IRA1 Ira1p 0.020
RSN1 Rsn1p 0.020
HXT3 Hxt3p 0.020
GDI1 Gdi1p 0.019
MOB1 Mob1p 0.019
OTU1 Otu1p 0.018
KSS1 Kss1p 0.018
CDC6 Cdc6p 0.018
NUM1 Num1p 0.018
HOR2 Hor2p 0.018
ROX1 Rox1p 0.018
YKR075C hypothetical protein 0.018
UBP7 Ubp7p 0.018
IMD2 Imd2p 0.018
RAD51 Rad51p 0.018
VID24 Vid24p 0.017
MRL1 Mrl1p 0.017
PRD1 Prd1p 0.017
GAL7 Gal7p 0.017
SYG1 Syg1p 0.017
NHX1 Nhx1p 0.017
GSP2 Gsp2p 0.017
GLR1 Glr1p 0.017
ECM30 Ecm30p 0.017
DSS4 Dss4p 0.017
YGR017W hypothetical protein 0.017
ADP1 Adp1p 0.017
COT1 Cot1p 0.017
RLM1 Rlm1p 0.017
TPI1 Tpi1p 0.016
GPT2 Gpt2p 0.016
NCR1 Ncr1p 0.016
HOG1 Hog1p 0.016
HMS1 Hms1p 0.016
SMP1 Smp1p 0.016
CSR2 Csr2p 0.016
RAD28 Rad28p 0.016
YLR460C hypothetical protein 0.016
KTR5 Ktr5p 0.016
MIG3 Mig3p 0.016
CRR1 Crr1p 0.016
NET1 Net1p 0.016
TIP41 Tip41p 0.016
PHM8 Phm8p 0.016
ZAP1 Zap1p 0.016