The network for 'leukocyte aggregation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte aggregation

The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules.

Rattus norvegicus
Name Description Probability Func Analog Organism
S100a9 S100 calcium binding protein A9 0.825
S100a8 S100 calcium binding protein A8 0.431
Ccl3 chemokine (C-C motif) ligand 3 0.167
Lcp1 lymphocyte cytosolic protein 1 0.162
Il1b interleukin 1 beta 0.098
Plek pleckstrin 0.079
Ptprc protein tyrosine phosphatase, receptor type, C 0.074
Hck hemopoietic cell kinase 0.071
Cd53 Cd53 molecule 0.049
Igsf6 immunoglobulin superfamily, member 6 0.047
Ripk3 receptor-interacting serine-threonine kinase 3 0.039
Ccl2 chemokine (C-C motif) ligand 2 0.038
Glipr1 GLI pathogenesis-related 1 0.032
Socs3 suppressor of cytokine signaling 3 0.031
Cxcl10 chemokine (C-X-C motif) ligand 10 0.026
Vcan versican 0.025
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.024
Srgn serglycin 0.023
LOC24906 RoBo-1 0.023
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.022
Ccl4 chemokine (C-C motif) ligand 4 0.021
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.018
Plaur plasminogen activator, urokinase receptor 0.017
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.017
Coro1a coronin, actin binding protein 1A 0.017
Slpi secretory leukocyte peptidase inhibitor 0.017
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.017
Top2a topoisomerase (DNA) II alpha 0.016
Sla src-like adaptor 0.015
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.015
Stfa2l3 stefin A2-like 3 0.014
Hmox1 heme oxygenase (decycling) 1 0.014
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.014
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.014
Lcn2 lipocalin 2 0.013
RGD1561143 similar to cell surface receptor FDFACT 0.013
Plau plasminogen activator, urokinase 0.013
Cxcl16 chemokine (C-X-C motif) ligand 16 0.012
Laptm5 lysosomal protein transmembrane 5 0.012
Slfn2 schlafen 2 0.012
Syk spleen tyrosine kinase 0.012
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.011
Vav1 vav 1 guanine nucleotide exchange factor 0.011
Csf1r colony stimulating factor 1 receptor 0.011
Fgl2 fibrinogen-like 2 0.011
Myo1f myosin IF 0.011
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.011
Ctse cathepsin E 0.010
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.010
Cd14 CD14 molecule 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.984
S100A6 S100 calcium binding protein A6 0.976
S100A1 S100 calcium binding protein A1 0.965
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.931
S100A11 S100 calcium binding protein A11 0.905
S100B S100 calcium binding protein B 0.870
ANXA2 annexin A2 0.833
S100A14 S100 calcium binding protein A14 0.819
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.805
IL1R1 interleukin 1 receptor, type I 0.776
MSN moesin 0.643
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.582
S100A4 S100 calcium binding protein A4 0.552
PLAUR plasminogen activator, urokinase receptor 0.442
IL1B interleukin 1, beta 0.379
IL8 interleukin 8 0.298
EMP3 epithelial membrane protein 3 0.291
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.280
S100A9 S100 calcium binding protein A9 0.230
AREG amphiregulin 0.220
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.199
IL1RN interleukin 1 receptor antagonist 0.171
S100A2 S100 calcium binding protein A2 0.167
TMSB10 thymosin beta 10 0.161
IL1R2 interleukin 1 receptor, type II 0.156
S100A8 S100 calcium binding protein A8 0.103
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.085
NCF2 neutrophil cytosolic factor 2 0.084
AGER advanced glycosylation end product-specific receptor 0.083
BMPR1B bone morphogenetic protein receptor, type IB 0.083
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.081
EZR ezrin 0.079
TIMP1 TIMP metallopeptidase inhibitor 1 0.077
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.063
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.060
SORBS1 sorbin and SH3 domain containing 1 0.052
RHOC ras homolog gene family, member C 0.050
PLXND1 plexin D1 0.049
PI3 peptidase inhibitor 3, skin-derived 0.047
S100P S100 calcium binding protein P 0.042
IL1RAP interleukin 1 receptor accessory protein 0.040
PTPRC protein tyrosine phosphatase, receptor type, C 0.038
RHOG ras homolog gene family, member G (rho G) 0.036
CAPG capping protein (actin filament), gelsolin-like 0.034
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.032
EHD1 EH-domain containing 1 0.030
NOG noggin 0.028
FKBP4 FK506 binding protein 4, 59kDa 0.027
LGALS1 lectin, galactoside-binding, soluble, 1 0.026
S100A12 S100 calcium binding protein A12 0.025
CCL20 chemokine (C-C motif) ligand 20 0.023
CD97 CD97 molecule 0.023
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.022
SH3RF1 SH3 domain containing ring finger 1 0.022
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.021
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.021
CD44 CD44 molecule (Indian blood group) 0.020
RHOA ras homolog gene family, member A 0.019
BCL2A1 BCL2-related protein A1 0.018
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.018
IL6 interleukin 6 (interferon, beta 2) 0.017
EMP1 epithelial membrane protein 1 0.016
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.016
PLAU plasminogen activator, urokinase 0.015
CSTA cystatin A (stefin A) 0.014
LGALS3 lectin, galactoside-binding, soluble, 3 0.013
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.013
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.013
CXCL3 chemokine (C-X-C motif) ligand 3 0.013
TREM1 triggering receptor expressed on myeloid cells 1 0.013
EFHD2 EF-hand domain family, member D2 0.012
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.011
JUP junction plakoglobin 0.011
RYBP RING1 and YY1 binding protein 0.011
GPR109B G protein-coupled receptor 109B 0.011
S100A10 S100 calcium binding protein A10 0.011
HIPK2 homeodomain interacting protein kinase 2 0.011
FPR1 formyl peptide receptor 1 0.011
COTL1 coactosin-like 1 (Dictyostelium) 0.011
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Mus musculus
Name Description Probability Func Analog Organism
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.908
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.883
Mmp9 matrix metallopeptidase 9 0.469
Ccr1 chemokine (C-C motif) receptor 1 0.220
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.183
Camp cathelicidin antimicrobial peptide 0.156
Ngp neutrophilic granule protein 0.104
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.085
Ccr2 chemokine (C-C motif) receptor 2 0.082
Lcn2 lipocalin 2 0.081
Ifitm6 interferon induced transmembrane protein 6 0.079
Stag1 stromal antigen 1 0.074
Chi3l3 chitinase 3-like 3 0.072
Clec4d C-type lectin domain family 4, member d 0.072
Selplg selectin, platelet (p-selectin) ligand 0.061
Tlr4 toll-like receptor 4 0.058
Cd52 CD52 antigen 0.055
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.054
Cul3 cullin 3 0.050
Prrx1 paired related homeobox 1 0.049
Mmp8 matrix metallopeptidase 8 0.048
Ccl2 chemokine (C-C motif) ligand 2 0.047
Slfn4 schlafen 4 0.046
Ltf lactotransferrin 0.042
Itgb2 integrin beta 2 0.039
Icam1 intercellular adhesion molecule 1 0.039
Adam17 a disintegrin and metallopeptidase domain 17 0.038
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.038
Plaur plasminogen activator, urokinase receptor 0.038
Il1r1 interleukin 1 receptor, type I 0.034
Tgfb1 transforming growth factor, beta 1 0.033
Cxcl2 chemokine (C-X-C motif) ligand 2 0.032
Nfe2 nuclear factor, erythroid derived 2 0.031
Fxyd5 FXYD domain-containing ion transport regulator 5 0.031
Arhgap9 Rho GTPase activating protein 9 0.030
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.029
Tlr2 toll-like receptor 2 0.029
Thbs1 thrombospondin 1 0.029
Glipr2 GLI pathogenesis-related 2 0.028
Adam8 a disintegrin and metallopeptidase domain 8 0.028
Sell selectin, lymphocyte 0.027
Pglyrp1 peptidoglycan recognition protein 1 0.026
Il6 interleukin 6 0.024
Fpr1 formyl peptide receptor 1 0.024
Lilrb3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.023
Smad3 MAD homolog 3 (Drosophila) 0.023
2310014H01Rik RIKEN cDNA 2310014H01 gene 0.022
Slpi secretory leukocyte peptidase inhibitor 0.022
Ncf4 neutrophil cytosolic factor 4 0.021
Bmp4 bone morphogenetic protein 4 0.021
Lsp1 lymphocyte specific 1 0.021
Il1rn interleukin 1 receptor antagonist 0.020
Il1r2 interleukin 1 receptor, type II 0.019
Hck hemopoietic cell kinase 0.019
Lin7c lin-7 homolog C (C. elegans) 0.019
Chi3l1 chitinase 3-like 1 0.018
Fpr2 formyl peptide receptor 2 0.018
Il1b interleukin 1 beta 0.018
Rac2 RAS-related C3 botulinum substrate 2 0.018
Clec4e C-type lectin domain family 4, member e 0.017
Il1a interleukin 1 alpha 0.017
1100001G20Rik RIKEN cDNA 1100001G20 gene 0.017
Il6st interleukin 6 signal transducer 0.016
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.016
Myd88 myeloid differentiation primary response gene 88 0.016
Tnf tumor necrosis factor 0.016
Tnfaip2 tumor necrosis factor, alpha-induced protein 2 0.015
Ltb lymphotoxin B 0.015
Asprv1 aspartic peptidase, retroviral-like 1 0.015
Was Wiskott-Aldrich syndrome homolog (human) 0.015
Foxc1 forkhead box C1 0.015
Lyz2 lysozyme 2 0.015
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.014
Slfn2 schlafen 2 0.013
Sox9 SRY-box containing gene 9 0.013
Nlrp3 NLR family, pyrin domain containing 3 0.013
Selp selectin, platelet 0.013
Sykb spleen tyrosine kinase 0.013
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.013
Il18rap interleukin 18 receptor accessory protein 0.013
Bmp2 bone morphogenetic protein 2 0.013
Smo smoothened homolog (Drosophila) 0.012
Cd37 CD37 antigen 0.012
Hmha1 histocompatibility (minor) HA-1 0.012
Il17ra interleukin 17 receptor A 0.012
Ctnnb1 catenin (cadherin associated protein), beta 1 0.012
Prrx2 paired related homeobox 2 0.012
Dusp2 dual specificity phosphatase 2 0.012
C5ar1 complement component 5a receptor 1 0.011
Msx1 homeobox, msh-like 1 0.011
Fermt3 fermitin family homolog 3 (Drosophila) 0.011
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.011
Plat plasminogen activator, tissue 0.011
Lst1 leukocyte specific transcript 1 0.011
Itgal integrin alpha L 0.010
Ncf1 neutrophil cytosolic factor 1 0.010
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.010
Cd14 CD14 antigen 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism