The network for 'regulation of sensory perception of pain' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of sensory perception of pain

Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.

Rattus norvegicus
Name Description Probability Func Analog Organism
Hbb hemoglobin, beta 0.504
LOC287167 globin, alpha 0.278
Alas2 aminolevulinate, delta-, synthase 2 0.260
LOC100134871 beta globin minor gene 0.222
LOC689064 beta-globin 0.222
Nmbr neuromedin B receptor 0.109
Hba-a2 hemoglobin alpha, adult chain 2 0.107
Shank2 SH3 and multiple ankyrin repeat domains 2 0.089
Gzmk granzyme K 0.079
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.077
Pnliprp2 pancreatic lipase-related protein 2 0.076
Olr1500 olfactory receptor 1500 0.076
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.074
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.073
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.072
Oprk1 opioid receptor, kappa 1 0.069
Fcgr1a Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.065
Olr226 olfactory receptor 226 0.062
Npy5r neuropeptide Y receptor Y5 0.062
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.057
Il1a interleukin 1 alpha 0.056
Hbb-b1 hemoglobin, beta adult major chain 0.054
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.054
Kcnk1 potassium channel, subfamily K, member 1 0.051
Msx2 msh homeobox 2 0.050
Fgf14 fibroblast growth factor 14 0.049
Hes2 hairy and enhancer of split 2 (Drosophila) 0.048
Gpr83 G protein-coupled receptor 83 0.047
Egr3 early growth response 3 0.046
Ar androgen receptor 0.045
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.044
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.044
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.043
Csf3 colony stimulating factor 3 (granulocyte) 0.042
Fosl1 fos-like antigen 1 0.040
Il1rn interleukin 1 receptor antagonist 0.040
Insrr insulin receptor-related receptor 0.040
Mog myelin oligodendrocyte glycoprotein 0.039
Fat3 FAT tumor suppressor homolog 3 (Drosophila) 0.038
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.038
Gfra2 GDNF family receptor alpha 2 0.038
Cxcl2 chemokine (C-X-C motif) ligand 2 0.038
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.038
Galr1 galanin receptor 1 0.036
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.036
Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A 0.036
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.035
Phkg1 phosphorylase kinase, gamma 1 0.035
Sstr5 somatostatin receptor 5 0.034
Kcns2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 0.034
Gucy2f guanylate cyclase 2F 0.034
Ctsj cathepsin J 0.033
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.031
Cdh17 cadherin 17 0.031
Glp1r glucagon-like peptide 1 receptor 0.031
Mc4r melanocortin 4 receptor 0.031
Ccl4 chemokine (C-C motif) ligand 4 0.031
Ccr4 chemokine (C-C motif) receptor 4 0.030
Sstr1 somatostatin receptor 1 0.030
Tore trispanning orphan 0.030
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.030
Tlr2 toll-like receptor 2 0.030
Adra2c adrenergic, alpha-2C-, receptor 0.029
Mag myelin-associated glycoprotein 0.029
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.029
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.028
Cckar cholecystokinin A receptor 0.027
Cacng8 calcium channel, voltage-dependent, gamma subunit 8 0.027
Folh1 folate hydrolase 1 0.026
Cd244 Cd244 molecule, natural killer cell receptor 2B4 0.026
Chrna5 cholinergic receptor, nicotinic, alpha 5 0.026
Pvrl4 poliovirus receptor-related 4 0.026
Adam7 ADAM metallopeptidase domain 7 0.026
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.025
Col10a1 collagen, type X, alpha 1 0.025
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.024
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.024
Chrna3 cholinergic receptor, nicotinic, alpha 3 0.024
Slc12a1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 0.024
Mmp13 matrix metallopeptidase 13 0.024
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.024
Prl prolactin 0.024
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.023
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.023
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.022
Adam2 ADAM metallopeptidase domain 2 0.022
Psg29 pregnancy-specific glycoprotein 29 0.022
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.022
Gpr26 G protein-coupled receptor 26 0.022
Grp gastrin releasing peptide 0.022
Clec7a C-type lectin domain family 7, member a 0.021
Tmem163 transmembrane protein 163 0.021
Freq frequenin homolog (Drosophila) 0.021
Sp3 Sp3 transcription factor 0.021
Syt2 synaptotagmin II 0.021
Gfap glial fibrillary acidic protein 0.021
Gal galanin prepropeptide 0.020
Kcng3 potassium voltage-gated channel, subfamily G, member 3 0.020
Ptafr platelet-activating factor receptor 0.020
Znf483 zinc finger protein 483 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 0.995
HBB hemoglobin, beta 0.990
HBG2 hemoglobin, gamma G 0.982
CCL4 chemokine (C-C motif) ligand 4 0.954
CXCL9 chemokine (C-X-C motif) ligand 9 0.939
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.918
CCL5 chemokine (C-C motif) ligand 5 0.909
CCL2 chemokine (C-C motif) ligand 2 0.824
IDE insulin-degrading enzyme 0.793
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.763
CCL8 chemokine (C-C motif) ligand 8 0.736
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.711
IL10RA interleukin 10 receptor, alpha 0.679
VAC14 Vac14 homolog (S. cerevisiae) 0.594
CCL22 chemokine (C-C motif) ligand 22 0.570
DLG4 discs, large homolog 4 (Drosophila) 0.544
CCL13 chemokine (C-C motif) ligand 13 0.450
IL1B interleukin 1, beta 0.431
PTEN phosphatase and tensin homolog 0.428
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.424
IL8 interleukin 8 0.415
CCR1 chemokine (C-C motif) receptor 1 0.330
FRS2 fibroblast growth factor receptor substrate 2 0.330
DPP4 dipeptidyl-peptidase 4 0.328
CXCL10 chemokine (C-X-C motif) ligand 10 0.321
CCL7 chemokine (C-C motif) ligand 7 0.307
CCR7 chemokine (C-C motif) receptor 7 0.301
IL6 interleukin 6 (interferon, beta 2) 0.295
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.281
ADORA2A adenosine A2a receptor 0.273
CXCL2 chemokine (C-X-C motif) ligand 2 0.268
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.262
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.225
CXCL13 chemokine (C-X-C motif) ligand 13 0.219
CCL11 chemokine (C-C motif) ligand 11 0.218
LY96 lymphocyte antigen 96 0.217
ARRDC3 arrestin domain containing 3 0.215
CXCL11 chemokine (C-X-C motif) ligand 11 0.184
KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.163
CCR4 chemokine (C-C motif) receptor 4 0.148
CCL3 chemokine (C-C motif) ligand 3 0.148
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.140
FGF2 fibroblast growth factor 2 (basic) 0.138
IL10 interleukin 10 0.133
CAV1 caveolin 1, caveolae protein, 22kDa 0.128
SPRR2A small proline-rich protein 2A 0.126
CXCL3 chemokine (C-X-C motif) ligand 3 0.124
BCL2A1 BCL2-related protein A1 0.110
CD83 CD83 molecule 0.106
UBD ubiquitin D 0.094
ZBTB25 zinc finger and BTB domain containing 25 0.093
CCR3 chemokine (C-C motif) receptor 3 0.092
CCL20 chemokine (C-C motif) ligand 20 0.090
CCKBR cholecystokinin B receptor 0.087
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.085
SELE selectin E 0.084
FPR3 formyl peptide receptor 3 0.082
RGS1 regulator of G-protein signaling 1 0.080
FGFR2 fibroblast growth factor receptor 2 0.079
CCK cholecystokinin 0.077
ARRB1 arrestin, beta 1 0.075
CXCL5 chemokine (C-X-C motif) ligand 5 0.074
TNF tumor necrosis factor 0.069
CCL19 chemokine (C-C motif) ligand 19 0.068
NOSTRIN nitric oxide synthase trafficker 0.067
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.066
CAV2 caveolin 2 0.064
IDO1 indoleamine 2,3-dioxygenase 1 0.064
IL7R interleukin 7 receptor 0.063
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.060
SYK spleen tyrosine kinase 0.058
VCAM1 vascular cell adhesion molecule 1 0.057
IL1A interleukin 1, alpha 0.057
IL2RB interleukin 2 receptor, beta 0.056
CCL17 chemokine (C-C motif) ligand 17 0.056
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.055
CCL3L3 chemokine (C-C motif) ligand 3-like 3 0.054
MYD88 myeloid differentiation primary response gene (88) 0.052
IFNG interferon, gamma 0.052
CH25H cholesterol 25-hydroxylase 0.051
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.050
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.048
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.048
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.047
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.046
TRAF1 TNF receptor-associated factor 1 0.046
STAT4 signal transducer and activator of transcription 4 0.045
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.045
FGF1 fibroblast growth factor 1 (acidic) 0.043
IL1RN interleukin 1 receptor antagonist 0.040
PLCG1 phospholipase C, gamma 1 0.038
DRD2 dopamine receptor D2 0.037
EBI3 Epstein-Barr virus induced 3 0.036
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.036
ICAM1 intercellular adhesion molecule 1 0.036
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.036
CXCR2 chemokine (C-X-C motif) receptor 2 0.035
INHBA inhibin, beta A 0.035
IL2RA interleukin 2 receptor, alpha 0.035
IL18RAP interleukin 18 receptor accessory protein 0.035
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Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 1.000
Drd2 dopamine receptor D2 0.708
Dlg4 discs, large homolog 4 (Drosophila) 0.569
Ryr2 ryanodine receptor 2, cardiac 0.414
Ccl2 chemokine (C-C motif) ligand 2 0.228
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.216
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.214
Ptpn5 protein tyrosine phosphatase, non-receptor type 5 0.197
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.182
Dlg2 discs, large homolog 2 (Drosophila) 0.150
Hbb-b1 hemoglobin, beta adult major chain 0.124
Prrx1 paired related homeobox 1 0.121
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.120
Syt2 synaptotagmin II 0.113
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.082
Kl klotho 0.067
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.064
Myd88 myeloid differentiation primary response gene 88 0.050
Mb myoglobin 0.049
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.049
Ccr2 chemokine (C-C motif) receptor 2 0.048
Cacna2d2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.047
Shank2 SH3/ankyrin domain gene 2 0.046
Mmp9 matrix metallopeptidase 9 0.045
Grm1 glutamate receptor, metabotropic 1 0.045
Bsn bassoon 0.039
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.038
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.037
Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 0.035
Cd44 CD44 antigen 0.033
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.032
Cnr1 cannabinoid receptor 1 (brain) 0.031
Arc activity regulated cytoskeletal-associated protein 0.031
Cit citron 0.030
Prkcc protein kinase C, gamma 0.029
Nos2 nitric oxide synthase 2, inducible 0.029
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.028
Pparg peroxisome proliferator activated receptor gamma 0.026
Gad2 glutamic acid decarboxylase 2 0.025
Emx1 empty spiracles homolog 1 (Drosophila) 0.023
Ccr1 chemokine (C-C motif) receptor 1 0.023
Cacng2 calcium channel, voltage-dependent, gamma subunit 2 0.023
Tlr2 toll-like receptor 2 0.022
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.022
Oprm1 opioid receptor, mu 1 0.022
Epas1 endothelial PAS domain protein 1 0.021
Lepr leptin receptor 0.021
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.021
Klk6 kallikrein related-peptidase 6 0.021
Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta 0.020
Nos1 nitric oxide synthase 1, neuronal 0.020
Adrb1 adrenergic receptor, beta 1 0.020
Ptprt protein tyrosine phosphatase, receptor type, T 0.020
Lin7b lin-7 homolog B (C. elegans) 0.020
Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 0.019
Il6 interleukin 6 0.019
Homer1 homer homolog 1 (Drosophila) 0.018
Grid2 glutamate receptor, ionotropic, delta 2 0.017
Nrg3 neuregulin 3 0.017
Ptgs2 prostaglandin-endoperoxide synthase 2 0.017
Fbxo41 F-box protein 41 0.017
Hrh1 histamine receptor H1 0.017
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.017
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.017
Plat plasminogen activator, tissue 0.016
Drd1a dopamine receptor D1A 0.015
Cux2 cut-like homeobox 2 0.015
Dsg1a desmoglein 1 alpha 0.015
Plcg1 phospholipase C, gamma 1 0.015
Npy2r neuropeptide Y receptor Y2 0.015
Sstr1 somatostatin receptor 1 0.014
Nos3 nitric oxide synthase 3, endothelial cell 0.014
Oprd1 opioid receptor, delta 1 0.014
Ret ret proto-oncogene 0.014
Vip vasoactive intestinal polypeptide 0.013
Stx1b syntaxin 1B 0.013
Sez6 seizure related gene 6 0.013
Gjd3 gap junction protein, delta 3 0.012
Gpr123 G protein-coupled receptor 123 0.012
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.012
Ccr5 chemokine (C-C motif) receptor 5 0.012
Crhr1 corticotropin releasing hormone receptor 1 0.012
ND6 NADH dehydrogenase subunit 6 0.011
Cd14 CD14 antigen 0.011
Neurod6 neurogenic differentiation 6 0.011
Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 0.011
Il12b interleukin 12b 0.011
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.011
Inadl InaD-like (Drosophila) 0.011
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 0.011
Csmd1 CUB and Sushi multiple domains 1 0.011
Cxcl2 chemokine (C-X-C motif) ligand 2 0.011
Grpr gastrin releasing peptide receptor 0.011
Car10 carbonic anhydrase 10 0.010
C3ar1 complement component 3a receptor 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism