The network for 'dna templated transcriptional preinitiation complex assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna templated transcriptional preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SPT15 Spt15p 0.999
TAF10 Taf10p 0.999
TAF4 Taf4p 0.987
BUR6 Bur6p 0.964
TAF12 Taf12p 0.887
TAF3 Taf3p 0.872
TOA1 Toa1p 0.854
RPT6 Rpt6p 0.836
TAF7 Taf7p 0.809
TAF6 Taf6p 0.740
SRB6 Srb6p 0.716
MED2 Med2p 0.690
TFG2 Tfg2p 0.671
MOT1 Mot1p 0.597
TAF9 Taf9p 0.559
SUA7 Sua7p 0.538
TFG1 Tfg1p 0.500
TOA2 Toa2p 0.447
MED1 Med1p 0.446
ROX3 Rox3p 0.438
RPN9 Rpn9p 0.392
PGD1 Pgd1p 0.346
TAF8 Taf8p 0.341
SPT16 Spt16p 0.340
TFA1 Tfa1p 0.338
RPT1 Rpt1p 0.290
BRF1 Brf1p 0.251
RAD23 Rad23p 0.243
KAP114 Kap114p 0.236
RPT2 Rpt2p 0.229
MED6 Med6p 0.223
GAL11 Gal11p 0.221
NHP6A Nhp6ap 0.205
TAF5 Taf5p 0.203
CSE2 Cse2p 0.203
TAF11 Taf11p 0.192
MED4 Med4p 0.181
RPN13 Rpn13p 0.175
SPT20 Spt20p 0.162
MED8 Med8p 0.154
RPT3 Rpt3p 0.148
SRB7 Srb7p 0.148
RPT4 Rpt4p 0.146
SAS4 Sas4p 0.141
RPT5 Rpt5p 0.132
SRB4 Srb4p 0.131
SLU7 Slu7p 0.128
SOH1 Soh1p 0.128
SRB2 Srb2p 0.127
CAB3 Cab3p 0.122
RNA15 Rna15p 0.122
CKB1 Ckb1p 0.116
RPN6 Rpn6p 0.115
SUB1 Sub1p 0.115
SPT8 Spt8p 0.114
NUT2 Nut2p 0.113
SRB5 Srb5p 0.106
RPN1 Rpn1p 0.095
HHT1 Hht1p 0.092
RRT5 Rrt5p 0.090
MTC1 Mtc1p 0.088
RPB4 Rpb4p 0.087
SEM1 Sem1p 0.084
RTS2 Rts2p 0.065
HIT1 Hit1p 0.065
SRD1 Srd1p 0.064
HDA2 Hda2p 0.063
IOC4 Ioc4p 0.061
RPN2 Rpn2p 0.060
YLR264C-A hypothetical protein 0.060
LEU2 Leu2p 0.057
ADA2 Ada2p 0.057
RPN10 Rpn10p 0.054
SPT2 Spt2p 0.052
DST1 Dst1p 0.051
YOL038C-A hypothetical protein 0.050
YKL063C hypothetical protein 0.050
TFC4 Tfc4p 0.049
RTF1 Rtf1p 0.047
MER1 Mer1p 0.047
ARP10 Arp10p 0.046
YLR162W hypothetical protein 0.045
TAF2 Taf2p 0.045
ARG8 Arg8p 0.044
YPR157W hypothetical protein 0.044
TYE7 Tye7p 0.044
HXT3 Hxt3p 0.043
RNR2 Rnr2p 0.042
TAF13 Taf13p 0.042
LEO1 Leo1p 0.042
TSC3 Tsc3p 0.042
YIR035C hypothetical protein 0.041
CTK3 Ctk3p 0.041
YER137C hypothetical protein 0.041
PDR16 Pdr16p 0.040
ATP6 Atp6p 0.039
SAS5 Sas5p 0.039
YLR042C hypothetical protein 0.039
PEX19 Pex19p 0.037
PSY4 Psy4p 0.037
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.863
Taf12 TBP-associated factor 12 0.544
Taf4 TBP-associated factor 4 0.500
Rpt4 CG3455 gene product from transcript CG3455-RA 0.443
CG7386 CG7386 gene product from transcript CG7386-RA 0.344
Rpn11 CG18174 gene product from transcript CG18174-RA 0.336
CG8159 CG8159 gene product from transcript CG8159-RB 0.256
Tbp TATA binding protein 0.228
Mov34 CG3416 gene product from transcript CG3416-RA 0.221
Prosalpha7 Proteasome alpha7 subunit 0.211
Rcd1 Reduction in Cnn dots 1 0.191
Rpn9 CG10230 gene product from transcript CG10230-RB 0.175
Prosbeta7 Proteasome beta7 subunit 0.170
Ada2b CG9638 gene product from transcript CG9638-RA 0.149
CG15436 CG15436 gene product from transcript CG15436-RA 0.128
CG12393 CG12393 gene product from transcript CG12393-RB 0.124
CG14317 CG14317 gene product from transcript CG14317-RA 0.111
bab2 CG9102 gene product from transcript CG9102-RA 0.108
Uch-L3 Ubiquitin C-terminal hydrolase 0.108
Pros35 Proteasome 35kD subunit 0.106
Rpn7 CG5378 gene product from transcript CG5378-RA 0.084
Pros45 CG1489 gene product from transcript CG1489-RA 0.082
CG6654 CG6654 gene product from transcript CG6654-RA 0.081
Pros29 Proteasome 29kD subunit 0.070
CG4709 CG4709 gene product from transcript CG4709-RA 0.066
Taf1 TBP-associated factor 1 0.065
Topors Topoisomerase I-interacting protein 0.065
Taf6 TBP-associated factor 6 0.063
Tbp-1 Tat-binding protein-1 0.062
CSN7 COP9 complex homolog subunit 7 0.061
Spt3 CG3169 gene product from transcript CG3169-RA 0.059
BRWD3 CG31132 gene product from transcript CG31132-RA 0.059
CG5146 CG5146 gene product from transcript CG5146-RA 0.059
uex unextended 0.058
Sry-beta Serendipity beta 0.057
Rpt3 CG16916 gene product from transcript CG16916-RA 0.057
CG17568 CG17568 gene product from transcript CG17568-RA 0.056
CG12321 CG12321 gene product from transcript CG12321-RA 0.051
CG1792 CG1792 gene product from transcript CG1792-RA 0.051
l(2)37Ce lethal (2) 37Ce 0.051
Prosbeta2 Proteasome beta2 subunit 0.047
CG13779 CG13779 gene product from transcript CG13779-RA 0.047
pad poils au dos 0.047
Saf6 SAGA factor-like TAF6 0.047
Nipped-A CG33554 gene product from transcript CG33554-RE 0.043
CG17244 CG17244 gene product from transcript CG17244-RA 0.043
Rpt1 CG1341 gene product from transcript CG1341-RA 0.042
CG10435 CG10435 gene product from transcript CG10435-RA 0.041
Rpn1 CG7762 gene product from transcript CG7762-RA 0.039
CG14071 CG14071 gene product from transcript CG14071-RA 0.038
ida imaginal discs arrested 0.038
row relative of woc 0.036
B-H1 BarH1 0.035
Elongin-C Elongin C 0.035
CG9573 CG9573 gene product from transcript CG9573-RA 0.035
CG6163 CG6163 gene product from transcript CG6163-RA 0.034
Sgf29 CG30390 gene product from transcript CG30390-RA 0.034
Taf8 TBP-associated factor 8 0.033
CG3407 CG3407 gene product from transcript CG3407-RA 0.033
CG10333 CG10333 gene product from transcript CG10333-RA 0.033
Lam Lamin 0.033
CG13349 CG13349 gene product from transcript CG13349-RA 0.032
HP1e CG8120 gene product from transcript CG8120-RA 0.031
CG14074 CG14074 gene product from transcript CG14074-RA 0.031
Taf10 TBP-associated factor 10 0.031
Rpn6 Proteasome p44.5 subunit 0.030
CG11188 CG11188 gene product from transcript CG11188-RA 0.027
Pcaf CG4107 gene product from transcript CG4107-RA 0.027
CG10959 CG10959 gene product from transcript CG10959-RA 0.026
CG5147 CG5147 gene product from transcript CG5147-RA 0.026
Roc1a CG16982 gene product from transcript CG16982-RB 0.026
CG11448 CG11448 gene product from transcript CG11448-RA 0.026
CG4424 CG4424 gene product from transcript CG4424-RA 0.025
maf-S CG9954 gene product from transcript CG9954-RA 0.025
CSN4 COP9 complex homolog subunit 4 0.025
CG18764 CG18764 gene product from transcript CG18764-RA 0.025
CG10139 CG10139 gene product from transcript CG10139-RA 0.024
Dpck Dephospho-CoA kinase 0.024
rno rhinoceros 0.024
CG3589 CG3589 gene product from transcript CG3589-RA 0.023
CG9293 CG9293 gene product from transcript CG9293-RB 0.023
tra transformer 0.023
NC2alpha CG10318 gene product from transcript CG10318-RA 0.023
CG6506 CG6506 gene product from transcript CG6506-RA 0.023
CG7879 CG7879 gene product from transcript CG7879-RB 0.022
Rpn12 CG4157 gene product from transcript CG4157-RA 0.022
LSm3 CG31184 gene product from transcript CG31184-RA 0.022
TfIIA-L Transcription factor IIA L 0.022
CG11906 CG11906 gene product from transcript CG11906-RA 0.022
Bap55 Brahma associated protein 55kD 0.022
CG14551 CG14551 gene product from transcript CG14551-RA 0.022
Dll Distal-less 0.021
CG31961 CG31961 gene product from transcript CG31961-RA 0.021
CG3226 CG3226 gene product from transcript CG3226-RA 0.021
CG32685 CG32685 gene product from transcript CG32685-RC 0.021
Su(var)3-3 Suppressor of variegation 3-3 0.020
Lim1 CG11354 gene product from transcript CG11354-RA 0.020
CstF-64 Cleavage stimulation factor 64 kilodalton subunit 0.020
Mfap1 Microfibril-associated protein 1 0.019
CG14546 CG14546 gene product from transcript CG14546-RA 0.019
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Homo sapiens
Name Description Probability Func Analog Organism
TBP TATA box binding protein 1.000
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.992
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 0.903
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.792
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 0.785
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.742
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.734
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.516
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.485
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.460
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.394
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.379
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 0.363
GTF2B general transcription factor IIB 0.343
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.259
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.232
TBPL1 TBP-like 1 0.232
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.230
GTF2A2 general transcription factor IIA, 2, 12kDa 0.202
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 0.144
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.127
NCOA6 nuclear receptor coactivator 6 0.111
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.110
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.105
MED25 mediator complex subunit 25 0.084
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.082
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.077
TRRAP transformation/transcription domain-associated protein 0.074
RXRA retinoid X receptor, alpha 0.074
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.071
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.070
NCOA1 nuclear receptor coactivator 1 0.065
SETD7 SET domain containing (lysine methyltransferase) 7 0.064
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 0.057
MED26 mediator complex subunit 26 0.043
KAT2B K(lysine) acetyltransferase 2B 0.041
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.036
GTF2A1 general transcription factor IIA, 1, 19/37kDa 0.036
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.032
CSNK1A1 casein kinase 1, alpha 1 0.027
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.026
HMGN2 high mobility group nucleosomal binding domain 2 0.026
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.023
SORBS3 sorbin and SH3 domain containing 3 0.022
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.018
ARNT aryl hydrocarbon receptor nuclear translocator 0.016
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.016
FAM190B family with sequence similarity 190, member B 0.016
SET SET nuclear oncogene 0.016
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.015
MED21 mediator complex subunit 21 0.014
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.013
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.012
CDK7 cyclin-dependent kinase 7 0.012
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.011
RARA retinoic acid receptor, alpha 0.011
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 0.011
ATXN7 ataxin 7 0.011
BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) 0.011
NCOA3 nuclear receptor coactivator 3 0.010
MAGED2 melanoma antigen family D, 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.859
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.854
Lhx1 LIM homeobox protein 1 0.598
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.577
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.574
Pax8 paired box gene 8 0.534
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.439
Pax2 paired box gene 2 0.425
Gdnf glial cell line derived neurotrophic factor 0.416
T brachyury 0.384
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.292
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.222
Esr2 estrogen receptor 2 (beta) 0.208
Kl klotho 0.191
Fgf8 fibroblast growth factor 8 0.183
Thrb thyroid hormone receptor beta 0.175
Tbp TATA box binding protein 0.174
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.163
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.148
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.143
Wnt10b wingless related MMTV integration site 10b 0.142
Wnt4 wingless-related MMTV integration site 4 0.136
Wnt3a wingless-related MMTV integration site 3A 0.129
Wnt6 wingless-related MMTV integration site 6 0.119
Rarg retinoic acid receptor, gamma 0.116
Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 0.115
Lmx1a LIM homeobox transcription factor 1 alpha 0.109
Wnt2b wingless related MMTV integration site 2b 0.108
Drg1 developmentally regulated GTP binding protein 1 0.105
Pou3f3 POU domain, class 3, transcription factor 3 0.105
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.103
Porcn porcupine homolog (Drosophila) 0.102
Fzd10 frizzled homolog 10 (Drosophila) 0.099
Ttc7 tetratricopeptide repeat domain 7 0.097
Vax1 ventral anterior homeobox containing gene 1 0.096
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.095
Arnt aryl hydrocarbon receptor nuclear translocator 0.094
BC018465 cDNA sequence BC018465 0.093
Tbcb tubulin folding cofactor B 0.092
Rarb retinoic acid receptor, beta 0.092
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.091
Ncor1 nuclear receptor co-repressor 1 0.090
Otx2 orthodenticle homolog 2 (Drosophila) 0.090
Hoxa13 homeobox A13 0.089
Trp73 transformation related protein 73 0.082
Amhr2 anti-Mullerian hormone type 2 receptor 0.082
Hoxa4 homeobox A4 0.081
Slc34a2 solute carrier family 34 (sodium phosphate), member 2 0.080
Epha1 Eph receptor A1 0.080
Barx2 BarH-like homeobox 2 0.079
Fzd1 frizzled homolog 1 (Drosophila) 0.078
Gli1 GLI-Kruppel family member GLI1 0.078
Hoxa2 homeobox A2 0.077
Gtf2f1 general transcription factor IIF, polypeptide 1 0.076
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.075
Il11 interleukin 11 0.075
Otx1 orthodenticle homolog 1 (Drosophila) 0.074
Rars arginyl-tRNA synthetase 0.074
Mrpl13 mitochondrial ribosomal protein L13 0.072
Wnt9a wingless-type MMTV integration site 9A 0.071
Rab23 RAB23, member RAS oncogene family 0.070
Snrpa1 small nuclear ribonucleoprotein polypeptide A' 0.069
Sim2 single-minded homolog 2 (Drosophila) 0.069
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.068
Emx2 empty spiracles homolog 2 (Drosophila) 0.068
En1 engrailed 1 0.068
Emid2 EMI domain containing 2 0.067
Neurog1 neurogenin 1 0.065
Trp63 transformation related protein 63 0.064
Tnni2 troponin I, skeletal, fast 2 0.062
Gli3 GLI-Kruppel family member GLI3 0.062
Mrpl12 mitochondrial ribosomal protein L12 0.061
Fgf17 fibroblast growth factor 17 0.060
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.059
Col13a1 collagen, type XIII, alpha 1 0.058
Ihh Indian hedgehog 0.058
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.057
Shh sonic hedgehog 0.056
Duox2 dual oxidase 2 0.055
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.054
Scube1 signal peptide, CUB domain, EGF-like 1 0.054
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.053
Fgf18 fibroblast growth factor 18 0.053
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.053
Hars histidyl-tRNA synthetase 0.052
Tbx2 T-box 2 0.052
Efna4 ephrin A4 0.052
Cdx1 caudal type homeobox 1 0.051
Clic3 chloride intracellular channel 3 0.051
Tbpl1 TATA box binding protein-like 1 0.051
3110079O15Rik RIKEN cDNA 3110079O15 gene 0.051
Vstm2b V-set and transmembrane domain containing 2B 0.050
Irs1 insulin receptor substrate 1 0.050
Hes5 hairy and enhancer of split 5 (Drosophila) 0.050
Tctex1d4 Tctex1 domain containing 4 0.050
Fgf15 fibroblast growth factor 15 0.049
Klf5 Kruppel-like factor 5 0.049
Pknox1 Pbx/knotted 1 homeobox 0.049
Rpa1 replication protein A1 0.048
Gli2 GLI-Kruppel family member GLI2 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.789
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.568
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.565
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.249
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.061
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.038
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.036
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.034
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.030
Nsfl1c NSFL1 (p97) cofactor (p47) 0.030
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.027
Strap serine/threonine kinase receptor associated protein 0.020
Vcp valosin-containing protein 0.020
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.019
Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.019
Pfdn2 prefoldin subunit 2 0.016
Kars lysyl-tRNA synthetase 0.016
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.014
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.012
Prmt1 protein arginine methyltransferase 1 0.011