The network for 'proteasome mediated ubiquitin dependent protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteasome mediated ubiquitin dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
PRE1 Pre1p 0.999
RPT6 Rpt6p 0.994
RPT1 Rpt1p 0.992
RPT4 Rpt4p 0.992
SKP1 Skp1p 0.992
UFD1 Ufd1p 0.991
RAD23 Rad23p 0.986
CDC27 Cdc27p 0.983
PRE2 Pre2p 0.981
UBP6 Ubp6p 0.975
KAR2 Kar2p 0.974
RPT2 Rpt2p 0.973
CDC53 Cdc53p 0.968
CDC23 Cdc23p 0.963
RPN10 Rpn10p 0.962
MND2 Mnd2p 0.957
PRE4 Pre4p 0.952
PPH22 Pph22p 0.950
SWM1 Swm1p 0.947
ECM29 Ecm29p 0.932
NPL4 Npl4p 0.930
RPT3 Rpt3p 0.923
CDC16 Cdc16p 0.916
RPN12 Rpn12p 0.911
SCJ1 Scj1p 0.911
DOC1 Doc1p 0.909
RPN3 Rpn3p 0.906
FYV10 Fyv10p 0.900
PRE5 Pre5p 0.899
GLC7 Glc7p 0.895
PRE10 Pre10p 0.894
PRE9 Pre9p 0.893
RPN11 Rpn11p 0.886
APC2 Apc2p 0.883
RPN7 Rpn7p 0.877
RPN9 Rpn9p 0.877
PRE7 Pre7p 0.867
PUP2 Pup2p 0.867
CDC20 Cdc20p 0.866
VID30 Vid30p 0.850
PRE6 Pre6p 0.845
PUP1 Pup1p 0.838
DSK2 Dsk2p 0.827
UBX2 Ubx2p 0.818
GID7 Gid7p 0.813
HRD3 Hrd3p 0.801
APC4 Apc4p 0.762
CDC26 Cdc26p 0.749
CDC34 Cdc34p 0.743
APC9 Apc9p 0.741
PUP3 Pup3p 0.734
RPN6 Rpn6p 0.729
SCL1 Scl1p 0.723
MET30 Met30p 0.721
YOS9 Yos9p 0.714
RPT5 Rpt5p 0.704
UMP1 Ump1p 0.699
OTU1 Otu1p 0.699
RPN8 Rpn8p 0.694
RMD5 Rmd5p 0.681
KSP1 Ksp1p 0.679
MUB1 Mub1p 0.665
APC1 Apc1p 0.641
RPN2 Rpn2p 0.605
RPN13 Rpn13p 0.585
APC5 Apc5p 0.574
MAD2 Mad2p 0.569
HRD1 Hrd1p 0.569
UFD4 Ufd4p 0.564
PRE8 Pre8p 0.550
VID24 Vid24p 0.546
CTF13 Ctf13p 0.536
UFD2 Ufd2p 0.529
DFM1 Dfm1p 0.523
MOH1 Moh1p 0.519
UBR1 Ubr1p 0.512
YLR352W hypothetical protein 0.504
IRC15 Irc15p 0.485
PPH21 Pph21p 0.479
UBC13 Ubc13p 0.462
PRE3 Pre3p 0.437
HRT1 Hrt1p 0.420
PIG2 Pig2p 0.420
CDC4 Cdc4p 0.419
APC11 Apc11p 0.415
YNL155W hypothetical protein 0.415
CSM1 Csm1p 0.413
YPT1 Ypt1p 0.405
CDC31 Cdc31p 0.359
UBA1 Uba1p 0.358
UBC4 Ubc4p 0.357
RPN5 Rpn5p 0.349
CUR1 Cur1p 0.346
VID28 Vid28p 0.342
MAD3 Mad3p 0.332
CTF3 Ctf3p 0.320
HDA2 Hda2p 0.314
HCH1 Hch1p 0.313
DER1 Der1p 0.311
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
pas-4 Protein PAS-4 0.616
rpn-7 Protein RPN-7 0.610
pas-2 Protein PAS-2 0.512
pbs-3 Protein PBS-3 0.406
rpn-12 Protein RPN-12 0.372
rpn-3 Protein RPN-3 0.353
npl-4.2 Protein NPL-4.2 0.294
rpt-2 Protein RPT-2 0.261
npl-4.1 Protein NPL-4.1 0.259
rpt-5 Protein RPT-5 0.225
rpt-3 Protein RPT-3 0.183
R02F11.4 Protein R02F11.4 0.154
pas-1 Protein PAS-1 0.154
cul-1 Protein CUL-1 0.151
pbs-5 Protein PBS-5 0.144
ima-3 Protein IMA-3 0.122
imb-2 Protein IMB-2 0.120
pas-6 Protein PAS-6 0.110
pbs-2 Protein PBS-2 0.109
mdf-2 Protein MDF-2 0.106
rpn-6.1 Protein RPN-6.1 0.099
pbs-4 Protein PBS-4 0.096
pbs-1 Protein PBS-1 0.095
syx-17 Protein SYX-17 0.092
atx-3 Protein ATX-3 0.088
rpn-2 Protein RPN-2 0.088
R11A8.7 Protein R11A8.7 0.086
tba-2 Protein TBA-2 0.079
app-1 Protein APP-1 0.077
rpt-4 Protein RPT-4 0.075
rnr-1 Protein RNR-1 0.068
rpn-11 Protein RPN-11 0.067
zyg-9 Protein ZYG-9 0.058
mdt-8 Protein MDT-8 0.056
pbs-7 Protein PBS-7 0.055
cdc-48.2 Protein CDC-48.2 0.054
egl-18 Protein EGL-18 0.051
spd-5 Protein SPD-5 0.049
pas-5 Protein PAS-5 0.046
pcn-1 Protein PCN-1 0.045
pbs-6 Protein PBS-6 0.045
skr-1 Protein SKR-1 0.044
dlc-1 Protein DLC-1 0.043
hrp-1 Protein HRP-1 0.041
taf-5 Protein TAF-5 0.040
pas-7 Protein PAS-7 0.040
CELE_C24H12.5 Protein C24H12.5 0.038
dpy-30 Protein DPY-30 0.037
trap-4 Protein TRAP-4 0.036
gmeb-1 Protein GMEB-1 0.035
ubc-3 Protein UBC-3 0.035
bub-1 Protein BUB-1 0.035
rod-1 Protein ROD-1 0.033
dsh-2 Protein DSH-2 0.031
T22F3.2 Protein T22F3.2 0.031
snr-2 Protein SNR-2 0.031
cdc-48.1 Protein CDC-48.1 0.031
Y47D3A.29 Protein Y47D3A.29 0.029
F49C12.9 Protein F49C12.9 0.029
B0454.9 Protein B0454.9 0.028
rpn-10 Protein RPN-10 0.028
rpn-5 Protein RPN-5 0.028
daf-1 Protein DAF-1 0.027
ZK1248.11 Protein ZK1248.11 0.027
vps-53 Protein VPS-53 0.026
cam-1 Protein CAM-1 0.026
lin-3 Protein LIN-3 0.026
zen-4 Protein ZEN-4 0.026
rpn-1 Protein RPN-1 0.025
pap-1 Protein PAP-1 0.025
cki-2 Protein CKI-2 0.024
cdl-1 Protein CDL-1 0.024
his-6 Protein HIS-6 0.024
his-42 Protein HIS-42 0.023
tag-256 Protein TAG-256 0.023
sel-12 Protein SEL-12 0.023
klp-16 Protein KLP-16 0.023
pmr-1 Protein PMR-1 0.023
ZK507.6 Protein ZK507.6 0.022
CELE_K08F4.1 Protein K08F4.1 0.022
pup-2 Protein PUP-2 0.022
gpr-2 Protein GPR-2 0.022
CELE_B0334.5 Protein B0334.5 0.022
CELE_T10C6.6 Protein T10C6.6 0.022
CELE_Y57E12AL.6 Protein Y57E12AL.6 0.022
par-5 Protein PAR-5 0.021
rpt-1 Protein RPT-1 0.021
rpn-9 Protein RPN-9 0.021
tbb-2 Protein TBB-2 0.021
rpt-6 Protein RPT-6 0.021
snr-4 Protein SNR-4 0.020
F08B4.7 Protein F08B4.7 0.020
asb-1 Protein ASB-1 0.020
W09D10.1 Protein W09D10.1 0.020
hsr-9 Protein HSR-9 0.020
psr-1 Protein PSR-1 0.020
B0041.5 Protein B0041.5 0.020
Y71H2AM.20 Protein Y71H2AM.20 0.020
hda-1 Protein HDA-1 0.019
F46F11.6 Protein F46F11.6 0.019
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.959
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.905
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.889
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.873
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.865
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.782
ccnb1 cyclin B1 0.755
zgc:92775 zgc:92775 0.731
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.704
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.687
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.673
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.664
ccna2 cyclin A2 0.663
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.662
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.647
kif23 kinesin family member 23 0.615
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.580
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.537
plk1 polo-like kinase 1 (Drosophila) 0.527
btg2 B-cell translocation gene 2 0.506
vcp valosin containing protein 0.482
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.481
max myc-associated factor X 0.465
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.461
hspa5 heat shock protein 5 0.455
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.410
crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.399
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.393
usp5 ubiquitin specific protease 5 0.373
ck2b casein kinase 2 beta 0.359
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.356
sec24c SEC24 family, member C (S. cerevisiae) 0.341
aurkb aurora kinase B 0.334
zgc:86903 zgc:86903 0.333
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.332
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.313
kpna4 karyopherin alpha 4 (importin alpha 3) 0.305
zgc:56304 zgc:56304 0.305
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.305
baxa bcl2-associated X protein, a 0.286
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.283
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.282
prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.270
ciapin1 cytokine induced apoptosis inhibitor 1 0.268
chuk conserved helix-loop-helix ubiquitous kinase 0.267
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.265
adrm1b adhesion regulating molecule 1b 0.264
rtkn2 rhotekin 2 0.261
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.258
zgc:56596 zgc:56596 0.255
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.250
hspa4b heat shock protein 4b 0.248
zgc:56200 zgc:56200 0.248
fxr2 fragile X mental retardation, autosomal homolog 2 0.245
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.240
zgc:110116 zgc:110116 0.233
dynlrb1 dynein, light chain, roadblock-type 1 0.229
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.229
zgc:111944 zgc:111944 0.228
cul1b cullin 1b 0.225
myf5 myogenic factor 5 0.223
acvr1b activin A receptor, type IB 0.221
cdc20 cell division cycle 20 homolog 0.221
rab1a RAB1A, member RAS oncogene family 0.217
rbl1 retinoblastoma-like 1 (p107) 0.214
smad9 MAD homolog 9 (Drosophila) 0.213
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.211
senp3a SUMO1/sentrin/SMT3 specific peptidase 3a 0.208
plekha3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.205
cnot6 CCR4-NOT transcription complex, subunit 6 0.204
tfpi2 tissue factor pathway inhibitor 2 0.203
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.202
brd3a bromodomain containing 3a 0.198
mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a 0.197
hyou1 hypoxia up-regulated 1 0.197
shfm1 split hand/foot malformation (ectrodactyly) type 1 0.196
glulb glutamate-ammonia ligase (glutamine synthase) b 0.195
gtf2a1 general transcription factor IIA, 1 0.195
ccnb2 cyclin B2 0.193
ccne cyclin E 0.186
psmb11 proteasome (prosome, macropain) subunit, beta type, 11 0.184
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.184
cul3a cullin 3a 0.183
tia1 cytotoxic granule-associated RNA binding protein 1 0.183
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.182
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.180
flii flightless I homolog (Drosophila) 0.176
smad2 MAD homolog 2 (Drosophila) 0.175
dnaja2l DnaJ (Hsp40) homolog, subfamily A, member 2, like 0.174
xrn1 5'-3' exoribonuclease 1 0.173
pppde1 PPPDE peptidase domain containing 1 0.173
csnk1g2a casein kinase 1, gamma 2a 0.173
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.171
glrx3 glutaredoxin 3 0.170
setd7 SET domain containing (lysine methyltransferase) 7 0.170
zfand2a zinc finger, AN1-type domain 2A 0.169
exoc3 exocyst complex component 3 0.169
eif4h eukaryotic translation initiation factor 4h 0.169
bsdc1 BSD domain containing 1 0.168
gsc goosecoid 0.167
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Mov34 CG3416 gene product from transcript CG3416-RA 0.921
Rpn9 CG10230 gene product from transcript CG10230-RB 0.848
tefu telomere fusion 0.819
Pros29 Proteasome 29kD subunit 0.816
Rpt3 CG16916 gene product from transcript CG16916-RA 0.796
Prosbeta2 Proteasome beta2 subunit 0.777
CG12321 CG12321 gene product from transcript CG12321-RA 0.770
CycB Cyclin B 0.760
Rpt4 CG3455 gene product from transcript CG3455-RA 0.744
CG13349 CG13349 gene product from transcript CG13349-RA 0.741
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.735
Rpt1 CG1341 gene product from transcript CG1341-RA 0.718
skpA CG16983 gene product from transcript CG16983-RD 0.675
Pros54 Proteasome 54kD subunit 0.624
Rpn6 Proteasome p44.5 subunit 0.623
UbcD2 Ubiquitin conjugating enzyme 2 0.621
Tbp-1 Tat-binding protein-1 0.612
dco discs overgrown 0.601
Pros28.1 Proteasome 28kD subunit 1 0.597
Rpn2 CG11888 gene product from transcript CG11888-RA 0.571
slmb supernumerary limbs 0.532
polo CG12306 gene product from transcript CG12306-RA 0.504
Rpn1 CG7762 gene product from transcript CG7762-RA 0.504
Prosbeta3 Proteasome beta3 subunit 0.494
Rpn5 CG1100 gene product from transcript CG1100-RA 0.476
Prosbeta1 Proteasome beta1 subunit 0.454
brm brahma 0.452
Incenp Inner centromere protein 0.410
Prosbeta7 Proteasome beta7 subunit 0.370
ncd non-claret disjunctional 0.367
Rpn3 Regulatory particle non-ATPase 3 0.355
Rpd3 CG7471 gene product from transcript CG7471-RA 0.334
Rpn7 CG5378 gene product from transcript CG5378-RA 0.329
Cap-G CG34438 gene product from transcript CG34438-RF 0.288
Ras85D Ras oncogene at 85D 0.282
nej nejire 0.269
Rpn12 CG4157 gene product from transcript CG4157-RA 0.265
Rpn11 CG18174 gene product from transcript CG18174-RA 0.256
p53 CG33336 gene product from transcript CG33336-RB 0.246
Pros35 Proteasome 35kD subunit 0.240
Pros45 CG1489 gene product from transcript CG1489-RA 0.239
lin19 lin-19-like 0.236
flfl falafel 0.234
Fcp1 CG12252 gene product from transcript CG12252-RA 0.231
brat brain tumor 0.217
Cdc37 CG12019 gene product from transcript CG12019-RA 0.214
wdb widerborst 0.195
fzy fizzy 0.193
CycB3 Cyclin B3 0.189
step steppke 0.186
skd skuld 0.164
Iswi Imitation SWI 0.159
Pros25 Proteasome 25kD subunit 0.152
Tak1 TGF-beta activated kinase 1 0.150
Uch-L3 Ubiquitin C-terminal hydrolase 0.147
dsh dishevelled 0.143
Cenp-C CG31258 gene product from transcript CG31258-RA 0.142
wmd wing morphogenesis defect 0.139
wls wntless 0.138
CG4603 CG4603 gene product from transcript CG4603-RA 0.138
Uch Ubiquitin carboxy-terminal hydrolase 0.138
barr barren 0.135
Prosalpha5 Proteasome alpha5 subunit 0.132
hpo hippo 0.130
CSN5 COP9 complex homolog subunit 5 0.127
swm second mitotic wave missing 0.126
CycE Cyclin E 0.123
CG6230 CG6230 gene product from transcript CG6230-RA 0.121
smo smoothened 0.112
CG17331 CG17331 gene product from transcript CG17331-RA 0.111
Prosalpha7 Proteasome alpha7 subunit 0.111
cal1 chromosome alignment defect 1 0.111
ntc nutcracker 0.110
cav caravaggio 0.107
Prosbeta5 Proteasome beta5 subunit 0.107
Dcr-1 Dicer-1 0.106
RpS20 Ribosomal protein S20 0.105
CG3223 CG3223 gene product from transcript CG3223-RA 0.101
jub Ajuba LIM protein 0.101
pr-set7 CG3307 gene product from transcript CG3307-RC 0.099
CG2046 CG2046 gene product from transcript CG2046-RA 0.099
fwd four wheel drive 0.098
CycA Cyclin A 0.095
cdc16 CG6759 gene product from transcript CG6759-RA 0.093
ctp cut up 0.092
Mtl Mig-2-like 0.092
CG32581 CG32581 gene product from transcript CG32581-RB 0.091
shg shotgun 0.091
Psa Puromycin sensitive aminopeptidase 0.090
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.089
CG6540 CG6540 gene product from transcript CG6540-RA 0.086
Hcf Host cell factor 0.086
CG9135 CG9135 gene product from transcript CG9135-RB 0.086
stg string 0.086
Sox14 Sox box protein 14 0.084
gig gigas 0.083
Cul-5 Cullin-5 0.082
Rbf Retinoblastoma-family protein 0.082
dom domino 0.081
CG8290 CG8290 gene product from transcript CG8290-RA 0.081
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
SKP1 S-phase kinase-associated protein 1 1.000
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.000
VCP valosin containing protein 1.000
RNF11 ring finger protein 11 1.000
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.999
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.999
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.998
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.998
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.998
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.997
CUL1 cullin 1 0.995
CUL3 cullin 3 0.995
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.995
BTRC beta-transducin repeat containing 0.995
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.994
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.993
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.990
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.990
SMAD2 SMAD family member 2 0.990
POMP proteasome maturation protein 0.987
CCNB1 cyclin B1 0.984
SKP2 S-phase kinase-associated protein 2 (p45) 0.983
CDK2 cyclin-dependent kinase 2 0.982
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.981
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.980
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.980
TP53 tumor protein p53 0.980
RB1 retinoblastoma 1 0.980
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.977
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.972
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.972
UBQLN1 ubiquilin 1 0.968
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.964
ANAPC4 anaphase promoting complex subunit 4 0.962
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.958
ATXN3 ataxin 3 0.953
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.953
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.948
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.948
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.947
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.946
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.944
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.944
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.944
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.931
CCNA2 cyclin A2 0.929
XIAP X-linked inhibitor of apoptosis 0.928
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.926
BIRC2 baculoviral IAP repeat containing 2 0.924
DERL1 Der1-like domain family, member 1 0.920
AMFR autocrine motility factor receptor 0.918
CUL2 cullin 2 0.905
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.905
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.904
SSR1 signal sequence receptor, alpha 0.901
SMN1 survival of motor neuron 1, telomeric 0.891
ADRM1 adhesion regulating molecule 1 0.889
SMAD3 SMAD family member 3 0.878
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.877
YY1 YY1 transcription factor 0.877
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.876
PLK1 polo-like kinase 1 0.862
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.855
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.852
HDAC1 histone deacetylase 1 0.845
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.844
CSNK1E casein kinase 1, epsilon 0.839
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.826
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.826
ARIH2 ariadne homolog 2 (Drosophila) 0.826
ANAPC11 anaphase promoting complex subunit 11 0.822
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.822
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.819
HDAC2 histone deacetylase 2 0.819
FBXO5 F-box protein 5 0.818
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.816
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.815
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.812
HSPA13 heat shock protein 70kDa family, member 13 0.806
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.789
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.788
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.788
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.788
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.785
ANAPC5 anaphase promoting complex subunit 5 0.784
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.767
NCOR1 nuclear receptor corepressor 1 0.765
GSK3B glycogen synthase kinase 3 beta 0.756
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.750
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.747
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.745
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.727
ANAPC7 anaphase promoting complex subunit 7 0.721
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.706
BRCA1 breast cancer 1, early onset 0.701
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.699
HUWE1 HECT, UBA and WWE domain containing 1 0.699
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.689
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Psen1 presenilin 1 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.996
Trp53 transformation related protein 53 0.995
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.984
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.975
Vcp valosin containing protein 0.962
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.950
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.943
Ncstn nicastrin 0.937
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.926
Axin1 axin 1 0.925
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.890
Ccne1 cyclin E1 0.889
Per2 period homolog 2 (Drosophila) 0.874
Gsk3b glycogen synthase kinase 3 beta 0.873
Clock circadian locomotor output cycles kaput 0.852
Hspa5 heat shock protein 5 0.848
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.842
Bcl2 B-cell leukemia/lymphoma 2 0.839
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.831
Ccnb1 cyclin B1 0.826
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.824
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.824
Cdk1 cyclin-dependent kinase 1 0.804
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.801
Mbd3 methyl-CpG binding domain protein 3 0.798
Akt1 thymoma viral proto-oncogene 1 0.779
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.772
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.747
Cry1 cryptochrome 1 (photolyase-like) 0.737
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.685
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.679
Notch1 Notch gene homolog 1 (Drosophila) 0.666
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.650
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.645
Hif1a hypoxia inducible factor 1, alpha subunit 0.618
Foxm1 forkhead box M1 0.618
Skil SKI-like 0.615
Mdm2 transformed mouse 3T3 cell double minute 2 0.610
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.593
Skp1a S-phase kinase-associated protein 1A 0.593
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.554
App amyloid beta (A4) precursor protein 0.540
Pten phosphatase and tensin homolog 0.534
Trp73 transformation related protein 73 0.531
Bmi1 Bmi1 polycomb ring finger oncogene 0.528
Cul3 cullin 3 0.476
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.474
Ngly1 N-glycanase 1 0.474
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.459
Atf4 activating transcription factor 4 0.452
Per1 period homolog 1 (Drosophila) 0.449
Cry2 cryptochrome 2 (photolyase-like) 0.443
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.434
Fgfr1 fibroblast growth factor receptor 1 0.425
Arid1b AT rich interactive domain 1B (SWI-like) 0.413
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.406
Ncoa3 nuclear receptor coactivator 3 0.405
6330577E15Rik RIKEN cDNA 6330577E15 gene 0.404
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.391
Pomp proteasome maturation protein 0.388
Manf mesencephalic astrocyte-derived neurotrophic factor 0.382
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.380
Cav1 caveolin 1, caveolae protein 0.380
Adrm1 adhesion regulating molecule 1 0.376
Aamp angio-associated migratory protein 0.376
Ncor1 nuclear receptor co-repressor 1 0.375
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.374
Rnf19a ring finger protein 19A 0.371
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.370
Rnf111 ring finger 111 0.366
Birc5 baculoviral IAP repeat-containing 5 0.359
Vdac3 voltage-dependent anion channel 3 0.356
Csnk1e casein kinase 1, epsilon 0.354
Psme4 proteasome (prosome, macropain) activator subunit 4 0.342
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.340
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.338
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.331
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.327
Rnf11 ring finger protein 11 0.323
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.315
Pcna proliferating cell nuclear antigen 0.313
Kif22 kinesin family member 22 0.311
Usp9x ubiquitin specific peptidase 9, X chromosome 0.304
Yap1 yes-associated protein 1 0.301
Smad7 MAD homolog 7 (Drosophila) 0.299
Ube2n ubiquitin-conjugating enzyme E2N 0.290
Ccna2 cyclin A2 0.281
Prc1 protein regulator of cytokinesis 1 0.280
Ranbp9 RAN binding protein 9 0.279
Kif20a kinesin family member 20A 0.278
Stat3 signal transducer and activator of transcription 3 0.275
Ubc ubiquitin C 0.275
Ube3a ubiquitin protein ligase E3A 0.270
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.258
Mdm4 transformed mouse 3T3 cell double minute 4 0.257
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.254
Dab1 disabled homolog 1 (Drosophila) 0.252
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.247
Gclm glutamate-cysteine ligase, modifier subunit 0.245
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.995
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.975
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.949
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.814
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.797
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.793
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.467
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.391
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.372
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.337
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.334
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.292
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.287
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.232
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.196
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.187
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.168
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.164
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.143
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.123
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.116
Psme2 proteasome (prosome, macropain) activator subunit 2 0.098
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.080
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.066
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.057
Rgs19 regulator of G-protein signaling 19 0.056
Arf1 ADP-ribosylation factor 1 0.056
Rbbp7 retinoblastoma binding protein 7 0.052
Ube2c ubiquitin-conjugating enzyme E2C 0.052
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.049
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.047
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.043
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.043
Pdia4 protein disulfide isomerase family A, member 4 0.040
Cand1 cullin-associated and neddylation-dissociated 1 0.040
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.037
Pomp proteasome maturation protein 0.036
Foxm1 forkhead box M1 0.035
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.035
Hspa5 heat shock protein 5 0.032
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.032
Ghitm growth hormone inducible transmembrane protein 0.029
Rab11a RAB11a, member RAS oncogene family 0.028
Eef2 eukaryotic translation elongation factor 2 0.028
Nsfl1c NSFL1 (p97) cofactor (p47) 0.027
Btg1 B-cell translocation gene 1, anti-proliferative 0.026
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.024
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.024
Txnl1 thioredoxin-like 1 0.024
Kif22 kinesin family member 22 0.023
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.023
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.023
Cdca3 cell division cycle associated 3 0.023
Ccnb1 cyclin B1 0.022
Plk1 polo-like kinase 1 (Drosophila) 0.021
Ifrd1 interferon-related developmental regulator 1 0.021
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.020
Hsp90b1 heat shock protein 90, beta, member 1 0.020
Phax phosphorylated adaptor for RNA export 0.020
LOC687711 similar to small nuclear ribonucleoprotein D3 0.020
Dnm1l dynamin 1-like 0.019
Slc35b1 solute carrier family 35, member B1 0.018
LOC362855 P55 0.018
Syngr2 synaptogyrin 2 0.017
Gopc golgi associated PDZ and coiled-coil motif containing 0.017
Vcp valosin-containing protein 0.016
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.016
Eif5a eukaryotic translation initiation factor 5A 0.015
Rpl36 ribosomal protein L36 0.015
Stx12 syntaxin 12 0.015
Manf mesencephalic astrocyte-derived neurotrophic factor 0.015
Thoc7 THO complex 7 homolog (Drosophila) 0.015
Rbm8a RNA binding motif protein 8A 0.014
Top2a topoisomerase (DNA) II alpha 0.014
Ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.014
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.014
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.014
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.013
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.013
Zfand5 zinc finger, AN1-type domain 5 0.013
Traf4af1 TRAF4 associated factor 1 0.013
Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.012
Higd1a HIG1 hypoxia inducible domain family, member 1A 0.012
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.012
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.012
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.011
LOC100365106 rCG32755-like 0.011
Arf4 ADP-ribosylation factor 4 0.011
Cops2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.011
Canx calnexin 0.011
Rad23b RAD23 homolog B (S. cerevisiae) 0.011
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.011
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.011
Pdrg1 p53 and DNA damage regulated 1 0.011
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.010
Rnaseh2a ribonuclease H2, subunit A 0.010
Ube2a ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.010
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.010
Cd82 Cd82 molecule 0.010
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.010