IMP
Process View
The network for 'telomere maintenance via telomere lengthening' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
telomere maintenance via telomere lengthening
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| EST2 | Est2p | 0.915 | |
| CDC13 | Cdc13p | 0.879 | |
| RFA2 | Rfa2p | 0.722 | |
| MEC1 | Mec1p | 0.688 | |
| RFA1 | Rfa1p | 0.674 | |
| SGS1 | Sgs1p | 0.469 | |
| STN1 | Stn1p | 0.407 | |
| TEL1 | Tel1p | 0.404 | |
| DNA2 | Dna2p | 0.388 | |
| NOP10 | Nop10p | 0.333 | |
| PIF1 | Pif1p | 0.310 | |
| RAD53 | Rad53p | 0.278 | |
| EST1 | Est1p | 0.242 | |
| TEN1 | Ten1p | 0.206 | |
| RIF1 | Rif1p | 0.155 | |
| DUN1 | Dun1p | 0.101 | |
| TTI2 | Tti2p | 0.080 | |
| RAD5 | Rad5p | 0.079 | |
| CSM2 | Csm2p | 0.072 | |
| MSH6 | Msh6p | 0.068 | |
| VAC17 | Vac17p | 0.067 | |
| YKU80 | Yku80p | 0.066 | |
| POL12 | Pol12p | 0.062 | |
| SWM2 | Swm2p | 0.061 | |
| SMC6 | Smc6p | 0.061 | |
| RFA3 | Rfa3p | 0.059 | |
| RIO1 | Rio1p | 0.056 | |
| PRI1 | Pri1p | 0.052 | |
| HHO1 | Hho1p | 0.051 | |
| RMI1 | Rmi1p | 0.050 | |
| POL1 | Pol1p | 0.047 | |
| YLR162W | hypothetical protein | 0.043 | |
| STI1 | Sti1p | 0.040 | |
| YDL156W | hypothetical protein | 0.038 | |
| YLR363W-A | hypothetical protein | 0.038 | |
| TOP3 | Top3p | 0.037 | |
| YOR390W | hypothetical protein | 0.037 | |
| RAD27 | Rad27p | 0.037 | |
| TBF1 | Tbf1p | 0.035 | |
| YBL081W | hypothetical protein | 0.035 | |
| PRS2 | Prs2p | 0.033 | |
| RRP36 | Rrp36p | 0.033 | |
| HHT2 | Hht2p | 0.033 | |
| POL32 | Pol32p | 0.032 | |
| RAP1 | Rap1p | 0.032 | |
| SRD1 | Srd1p | 0.032 | |
| YLR264C-A | hypothetical protein | 0.031 | |
| RIF2 | Rif2p | 0.031 | |
| URA3 | Ura3p | 0.031 | |
| MER1 | Mer1p | 0.030 | |
| SWC7 | Swc7p | 0.029 | |
| ARP10 | Arp10p | 0.029 | |
| LEU2 | Leu2p | 0.028 | |
| YOL038C-A | hypothetical protein | 0.028 | |
| YNR066C | hypothetical protein | 0.028 | |
| HCH1 | Hch1p | 0.027 | |
| GFD2 | Gfd2p | 0.025 | |
| THG1 | Thg1p | 0.025 | |
| HXT3 | Hxt3p | 0.025 | |
| MF(ALPHA)2 | Mf(alpha)2p | 0.025 | |
| FUR4 | Fur4p | 0.025 | |
| YLR126C | hypothetical protein | 0.025 | |
| YJR129C | hypothetical protein | 0.024 | |
| FKH1 | Fkh1p | 0.023 | |
| ARG8 | Arg8p | 0.023 | |
| RAD51 | Rad51p | 0.023 | |
| RAD55 | Rad55p | 0.023 | |
| SAE2 | Sae2p | 0.023 | |
| YLR042C | hypothetical protein | 0.022 | |
| TMA23 | Tma23p | 0.022 | |
| RAD9 | Rad9p | 0.022 | |
| SIR4 | Sir4p | 0.022 | |
| HO | Hop | 0.022 | |
| YAR068W | hypothetical protein | 0.022 | |
| ADH2 | Adh2p | 0.022 | |
| YPR157W | hypothetical protein | 0.022 | |
| MF(ALPHA)1 | Mf(alpha)1p | 0.021 | |
| RTT105 | Rtt105p | 0.021 | |
| STB1 | Stb1p | 0.021 | |
| YKR045C | hypothetical protein | 0.021 | |
| OGG1 | Ogg1p | 0.021 | |
| YHR127W | hypothetical protein | 0.021 | |
| SEN54 | Sen54p | 0.021 | |
| ATP6 | Atp6p | 0.021 | |
| MET8 | Met8p | 0.021 | |
| YNR071C | hypothetical protein | 0.021 | |
| CPR6 | Cpr6p | 0.020 | |
| YBR013C | hypothetical protein | 0.020 | |
| YIR035C | hypothetical protein | 0.020 | |
| BSC1 | Bsc1p | 0.020 | |
| YOL013W-A | hypothetical protein | 0.020 | |
| SFT1 | Sft1p | 0.020 | |
| ZPS1 | Zps1p | 0.020 | |
| DIF1 | Dif1p | 0.019 | |
| RTT107 | Rtt107p | 0.019 | |
| HPF1 | Hpf1p | 0.019 | |
| MIG2 | Mig2p | 0.019 | |
| AUA1 | Aua1p | 0.019 | |
| CUP1-1 | Cup1-1p | 0.019 | |
| REE1 | Ree1p | 0.019 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| TERF1 | telomeric repeat binding factor (NIMA-interacting) 1 | 1.000 | |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 0.999 | |
| TERF2 | telomeric repeat binding factor 2 | 0.998 | |
| NBN | nibrin | 0.994 | |
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.989 | |
| PINX1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | 0.954 | |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.938 | |
| ATM | ataxia telangiectasia mutated | 0.852 | |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.778 | |
| FANCD2 | Fanconi anemia, complementation group D2 | 0.706 | |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.525 | |
| HIF1AN | hypoxia inducible factor 1, alpha subunit inhibitor | 0.492 | |
| WRN | Werner syndrome, RecQ helicase-like | 0.418 | |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.370 | |
| TOP3A | topoisomerase (DNA) III alpha | 0.357 | |
| ORC2 | origin recognition complex, subunit 2 | 0.344 | |
| STAG1 | stromal antigen 1 | 0.221 | |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.160 | |
| HUS1 | HUS1 checkpoint homolog (S. pombe) | 0.145 | |
| POT1 | protection of telomeres 1 homolog (S. pombe) | 0.138 | |
| BLM | Bloom syndrome, RecQ helicase-like | 0.124 | |
| FNBP1 | formin binding protein 1 | 0.104 | |
| H2AFX | H2A histone family, member X | 0.089 | |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.074 | |
| SLX4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) | 0.065 | |
| BANP | BTG3 associated nuclear protein | 0.050 | |
| MSH3 | mutS homolog 3 (E. coli) | 0.048 | |
| MAPK7 | mitogen-activated protein kinase 7 | 0.047 | |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.041 | |
| FBXO4 | F-box protein 4 | 0.038 | |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.032 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.024 | |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.024 | |
| RAD17 | RAD17 homolog (S. pombe) | 0.024 | |
| DCLRE1B | DNA cross-link repair 1B | 0.023 | |
| RPA2 | replication protein A2, 32kDa | 0.020 | |
| DAXX | death-domain associated protein | 0.018 | |
| SMG6 | Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) | 0.012 | |
| AXIN1 | axin 1 | 0.012 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.701 | |
| Chordc1 | cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 | 0.244 | |
| Hspa8 | heat shock protein 8 | 0.047 | |
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.045 | |
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.038 | |
| Rpgrip1l | Rpgrip1-like | 0.035 | |
| Skil | SKI-like | 0.027 | |
| Igh | immunoglobulin heavy chain complex | 0.023 | |
| Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | 0.023 | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.022 | |
| Msh2 | mutS homolog 2 (E. coli) | 0.021 | |
| Nphp1 | nephronophthisis 1 (juvenile) homolog (human) | 0.021 | |
| Wrn | Werner syndrome homolog (human) | 0.021 | |
| Rfc1 | replication factor C (activator 1) 1 | 0.019 | |
| Ahi1 | Abelson helper integration site 1 | 0.017 | |
| Smn1 | survival motor neuron 1 | 0.017 | |
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.016 | |
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.016 | |
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.015 | |
| Gja1 | gap junction protein, alpha 1 | 0.013 | |
| Nup85 | nucleoporin 85 | 0.013 | |
| Daxx | Fas death domain-associated protein | 0.012 | |
| Rrm1 | ribonucleotide reductase M1 | 0.012 | |
| Ttn | titin | 0.011 |