The network for 'cell cycle dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle dna replication

The DNA-dependent DNA replication that takes place as part of the cell cycle.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ORC1 Orc1p 0.989
MCM2 Mcm2p 0.977
CLB5 Clb5p 0.970
MCM5 Mcm5p 0.961
CDC6 Cdc6p 0.928
ORC2 Orc2p 0.927
MCM4 Mcm4p 0.910
DBF4 Dbf4p 0.821
ORC6 Orc6p 0.808
MCM6 Mcm6p 0.808
CDC14 Cdc14p 0.781
ORC3 Orc3p 0.755
ORC5 Orc5p 0.601
MCM10 Mcm10p 0.589
DIA2 Dia2p 0.533
CKS1 Cks1p 0.522
SIC1 Sic1p 0.391
MCM7 Mcm7p 0.373
TOF1 Tof1p 0.361
CDC28 Cdc28p 0.358
MCM3 Mcm3p 0.350
RAD53 Rad53p 0.281
ORC4 Orc4p 0.270
MDN1 Mdn1p 0.263
RSC4 Rsc4p 0.244
NOG1 Nog1p 0.235
CDC5 Cdc5p 0.200
DPB2 Dpb2p 0.192
CLB1 Clb1p 0.187
HAT1 Hat1p 0.174
CLB3 Clb3p 0.156
CLB6 Clb6p 0.154
CDC34 Cdc34p 0.153
TAH11 Tah11p 0.140
CAK1 Cak1p 0.132
MRC1 Mrc1p 0.129
RFC1 Rfc1p 0.128
SLD3 Sld3p 0.118
SLD5 Sld5p 0.114
RSC58 Rsc58p 0.111
IPI3 Ipi3p 0.105
ARP9 Arp9p 0.102
RSC9 Rsc9p 0.089
POL12 Pol12p 0.088
CTF18 Ctf18p 0.084
IME4 Ime4p 0.071
RSC8 Rsc8p 0.069
PSF1 Psf1p 0.067
ARP4 Arp4p 0.066
PIL1 Pil1p 0.066
CDC45 Cdc45p 0.061
SLD2 Sld2p 0.060
HAT2 Hat2p 0.060
SCC2 Scc2p 0.058
RLP7 Rlp7p 0.058
CDC4 Cdc4p 0.055
SEC39 Sec39p 0.055
RIX1 Rix1p 0.054
NOC3 Noc3p 0.053
PDS1 Pds1p 0.049
DUN1 Dun1p 0.048
RHO5 Rho5p 0.044
NOP7 Nop7p 0.040
MYO1 Myo1p 0.040
IES1 Ies1p 0.040
RAD9 Rad9p 0.040
SLN1 Sln1p 0.038
CDC12 Cdc12p 0.037
YPL014W hypothetical protein 0.037
BUB1 Bub1p 0.036
FKH1 Fkh1p 0.035
CLB4 Clb4p 0.035
SFG1 Sfg1p 0.034
BIT61 Bit61p 0.033
CHL1 Chl1p 0.031
RAD5 Rad5p 0.030
CLN1 Cln1p 0.030
SAE2 Sae2p 0.030
CDC7 Cdc7p 0.029
POL1 Pol1p 0.029
YLR264C-A hypothetical protein 0.028
SDA1 Sda1p 0.028
SRD1 Srd1p 0.028
RDH54 Rdh54p 0.028
ADH2 Adh2p 0.028
PRI1 Pri1p 0.027
GAL7 Gal7p 0.027
PRI2 Pri2p 0.027
DBF2 Dbf2p 0.027
YNR014W hypothetical protein 0.027
SPT16 Spt16p 0.027
YLR162W hypothetical protein 0.026
VPS13 Vps13p 0.026
SDS22 Sds22p 0.026
RSA4 Rsa4p 0.026
TIF6 Tif6p 0.025
SWE1 Swe1p 0.025
MSA1 Msa1p 0.025
RSC6 Rsc6p 0.025
CDC20 Cdc20p 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
F55A3.3 Protein F55A3.3 0.027
zyg-9 Protein ZYG-9 0.024
F25B5.2 Protein F25B5.2 0.023
npp-11 Protein NPP-11 0.020
C48B6.3 Protein C48B6.3 0.019
san-1 Protein SAN-1 0.018
brc-1 Protein BRC-1 0.018
mcm-5 Protein MCM-5 0.016
spd-1 Protein SPD-1 0.016
lin-9 Protein LIN-9 0.015
cst-1 Protein CST-1 0.015
scc-3 Protein SCC-3 0.015
xpo-1 Protein XPO-1 0.015
tag-232 Protein TAG-232 0.015
cyk-4 Protein CYK-4 0.014
zen-4 Protein ZEN-4 0.014
bub-1 Protein BUB-1 0.014
fzy-1 Protein FZY-1 0.014
plk-1 Protein PLK-1 0.014
F39B2.1 Protein F39B2.1 0.014
par-2 Protein PAR-2 0.013
nst-1 Protein NST-1 0.013
F55F8.9 Protein F55F8.9 0.013
mes-4 Protein MES-4 0.013
D1081.7 Protein D1081.7 0.013
ndc-80 Protein NDC-80 0.013
set-21 Protein SET-21 0.013
lag-1 Protein LAG-1 0.012
cec-6 Protein CEC-6 0.012
chk-1 Protein CHK-1 0.012
isw-1 Protein ISW-1 0.012
crm-1 Protein CRM-1 0.012
dcn-1 Protein DCN-1 0.012
F11E6.7 Protein F11E6.7 0.012
air-2 Protein AIR-2 0.012
npp-6 Protein NPP-6 0.012
D2085.4 Protein D2085.4 0.012
duo-1 Protein DUO-1 0.012
smo-1 Protein SMO-1 0.012
hcp-3 Protein HCP-3 0.012
emb-27 Protein EMB-27 0.011
cin-4 Protein CIN-4 0.011
mcm-7 Protein MCM-7 0.011
F33H2.5 Protein F33H2.5 0.011
dog-1 Protein DOG-1 0.011
Y44E3A.6 Protein Y44E3A.6 0.011
coh-3 Protein COH-3 0.011
kup-1 Protein KUP-1 0.011
cpt-1 Protein CPT-1 0.011
klp-16 Protein KLP-16 0.011
CELE_F53F4.11 Protein F53F4.11 0.011
F58E10.3 Protein F58E10.3 0.011
eya-1 Protein EYA-1 0.010
R74.6 Protein R74.6 0.010
cdt-1 Protein CDT-1 0.010
mcm-4 Protein MCM-4 0.010
mcm-2 Protein MCM-2 0.010
Y55F3BR.8 Protein Y55F3BR.8 0.010
ima-2 Protein IMA-2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mcm2 Minichromosome maintenance 2 0.974
Orc2 Origin recognition complex subunit 2 0.965
CDC45L CG3658 gene product from transcript CG3658-RA 0.955
Mcm6 Minichromosome maintenance 6 0.954
CycA Cyclin A 0.946
dup double parked 0.937
jumu jumeau 0.876
mus209 mutagen-sensitive 209 0.868
slp1 sloppy paired 1 0.850
dpa disc proliferation abnormal 0.824
hep hemipterous 0.728
CG13350 CG13350 gene product from transcript CG13350-RA 0.696
hd humpty dumpty 0.685
mus101 mutagen-sensitive 101 0.659
Rbf Retinoblastoma-family protein 0.600
gt giant 0.568
Mcm5 Minichromosome maintenance 5 0.551
Orc5 Origin recognition complex subunit 5 0.531
CycB Cyclin B 0.522
dap dacapo 0.486
E2f2 E2F transcription factor 2 0.466
Mcm10 Sensitized chromosome inheritance modifier 19 0.457
CG5524 CG5524 gene product from transcript CG5524-RA 0.456
Mcm7 Minichromosome maintenance 7 0.453
Eip63E Ecdysone-induced protein 63E 0.428
slp2 sloppy paired 2 0.411
cdc2c CG10498 gene product from transcript CG10498-RC 0.405
Rbf2 Retinoblastoma-family protein 2 0.399
barr barren 0.378
CG9772 CG9772 gene product from transcript CG9772-RB 0.370
gsb gooseberry 0.360
Dp DP transcription factor 0.345
Ets97D Ets at 97D 0.312
CG3430 CG3430 gene product from transcript CG3430-RA 0.269
DNApol-alpha73 DNA polymerase alpha 73kD 0.264
CycE Cyclin E 0.264
Slbp Stem-loop binding protein 0.263
piwi CG6122 gene product from transcript CG6122-RA 0.245
Mcm3 Minichromosome maintenance 3 0.218
Orc1 Origin recognition complex subunit 1 0.215
Ndc80 CG9938 gene product from transcript CG9938-RA 0.214
Btk29A Btk family kinase at 29A 0.206
mip120 Myb-interacting protein 120 0.195
run runt 0.191
Traf4 TNF-receptor-associated factor 4 0.189
pic piccolo 0.186
esc extra sexcombs 0.185
mid midline 0.174
tos tosca 0.162
byn brachyenteron 0.160
hkb huckebein 0.160
CG7686 CG7686 gene product from transcript CG7686-RA 0.159
odd odd skipped 0.158
pita CG3941 gene product from transcript CG3941-RA 0.158
btl breathless 0.149
nej nejire 0.146
DNApol-alpha60 DNA polymerase alpha 60kD 0.132
tll tailless 0.129
Wnt4 Wnt oncogene analog 4 0.129
RnrL Ribonucleoside diphosphate reductase large subunit 0.125
Nop60B Nucleolar protein at 60B 0.125
neb nebbish 0.124
cid centromere identifier 0.121
fzy fizzy 0.118
Dref DNA replication-related element factor 0.117
smid smallminded 0.115
RfC4 Replication factor C subunit 4 0.110
fkh fork head 0.109
mus301 mutagen-sensitive 301 0.106
chico CG5686 gene product from transcript CG5686-RB 0.105
os outstretched 0.105
scw screw 0.104
Hmr Hybrid male rescue 0.100
Ric Ras which interacts with Calmodulin 0.097
jub Ajuba LIM protein 0.096
tld tolloid 0.095
prd paired 0.093
pav pavarotti 0.093
plu plutonium 0.088
Cdk4 Cyclin-dependent kinase 4 0.086
SuUR Suppressor of Under-Replication 0.084
l(2)gl lethal (2) giant larvae 0.082
pdm2 POU domain protein 2 0.081
Hsf Heat shock factor 0.080
Rab23 CG2108 gene product from transcript CG2108-RA 0.079
CG14869 CG14869 gene product from transcript CG14869-RB 0.078
HLH54F CG5005 gene product from transcript CG5005-RA 0.077
Top1 Topoisomerase 1 0.077
rad50 CG6339 gene product from transcript CG6339-RD 0.076
lat latheo 0.074
skpA CG16983 gene product from transcript CG16983-RD 0.073
spn-B spindle B 0.070
Ripalpha RPA-interacting protein alpha 0.068
DNApol-epsilon DNA polymerase epsilon 0.066
Nup107 Nucleoporin 107 0.065
CG11284 CG11284 gene product from transcript CG11284-RA 0.065
ssp sunspot 0.065
nkd naked cuticle 0.065
Kr Kruppel 0.064
stg string 0.063
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Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 0.996
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.653
MCM6 minichromosome maintenance complex component 6 0.599
MCM2 minichromosome maintenance complex component 2 0.451
CCNE1 cyclin E1 0.361
SKP2 S-phase kinase-associated protein 2 (p45) 0.355
RBBP8 retinoblastoma binding protein 8 0.266
ORC1 origin recognition complex, subunit 1 0.241
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.184
RBL2 retinoblastoma-like 2 (p130) 0.175
E2F7 E2F transcription factor 7 0.171
MCM7 minichromosome maintenance complex component 7 0.164
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.162
MCM3 minichromosome maintenance complex component 3 0.157
MCM10 minichromosome maintenance complex component 10 0.141
BRCA1 breast cancer 1, early onset 0.126
RAD21 RAD21 homolog (S. pombe) 0.116
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.100
WAPAL wings apart-like homolog (Drosophila) 0.098
CCNA2 cyclin A2 0.096
ORC2 origin recognition complex, subunit 2 0.092
CDC25A cell division cycle 25 homolog A (S. pombe) 0.087
RB1 retinoblastoma 1 0.081
MCMBP minichromosome maintenance complex binding protein 0.079
NBN nibrin 0.079
CDT1 chromatin licensing and DNA replication factor 1 0.076
MCM4 minichromosome maintenance complex component 4 0.075
E2F8 E2F transcription factor 8 0.059
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.056
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.047
CCNB2 cyclin B2 0.046
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.044
E2F1 E2F transcription factor 1 0.040
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.039
DUSP1 dual specificity phosphatase 1 0.036
E2F4 E2F transcription factor 4, p107/p130-binding 0.035
ORC3 origin recognition complex, subunit 3 0.035
ARRB1 arrestin, beta 1 0.033
TFDP1 transcription factor Dp-1 0.031
ORC6 origin recognition complex, subunit 6 0.031
SMC1A structural maintenance of chromosomes 1A 0.030
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.028
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.027
RBL1 retinoblastoma-like 1 (p107) 0.026
ORC4 origin recognition complex, subunit 4 0.026
CCNE2 cyclin E2 0.025
DBF4 DBF4 homolog (S. cerevisiae) 0.025
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.024
STAG2 stromal antigen 2 0.024
PELP1 proline, glutamate and leucine rich protein 1 0.023
RAD50 RAD50 homolog (S. cerevisiae) 0.021
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.021
MAPK1 mitogen-activated protein kinase 1 0.021
SSRP1 structure specific recognition protein 1 0.019
MMS22L MMS22-like, DNA repair protein 0.019
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.019
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.018
YY1 YY1 transcription factor 0.018
BTRC beta-transducin repeat containing 0.018
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.017
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.016
BOP1 block of proliferation 1 0.015
ATF3 activating transcription factor 3 0.015
ORC5 origin recognition complex, subunit 5 0.014
JUB jub, ajuba homolog (Xenopus laevis) 0.014
E2F5 E2F transcription factor 5, p130-binding 0.013
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.013
CPNE6 copine VI (neuronal) 0.013
DDIT3 DNA-damage-inducible transcript 3 0.013
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.013
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.013
MCM5 minichromosome maintenance complex component 5 0.012
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.012
GMNN geminin, DNA replication inhibitor 0.012
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.011
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.011
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.010
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Top2a topoisomerase (DNA) II alpha 0.314
Ube2c ubiquitin-conjugating enzyme E2C 0.258
Cdkn3 cyclin-dependent kinase inhibitor 3 0.221
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.155
Racgap1 Rac GTPase-activating protein 1 0.118
Ccnb1 cyclin B1 0.108
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.076
Pttg1 pituitary tumor-transforming 1 0.075
Syt4 synaptotagmin IV 0.067
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.060
Mcm7 minichromosome maintenance complex component 7 0.058
Rrm2 ribonucleotide reductase M2 0.052
Cdca3 cell division cycle associated 3 0.039
Cdk1 cyclin-dependent kinase 1 0.039
Kifc1 kinesin family member C1 0.039
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.035
Mcm6 minichromosome maintenance complex component 6 0.030
Mcm3 minichromosome maintenance complex component 3 0.024
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.023
Ccne1 cyclin E1 0.023
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.019
LOC689399 hypothetical protein LOC689399 0.018
Snrk SNF related kinase 0.018
Mcm5 minichromosome maintenance complex component 5 0.018
Melk maternal embryonic leucine zipper kinase 0.018
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.017
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.017
Klhl24 kelch-like 24 (Drosophila) 0.017
Stmn1 stathmin 1 0.017
Arhgap11a Rho GTPase activating protein 11A 0.017
Nusap1 nucleolar and spindle associated protein 1 0.016
Fyco1 FYVE and coiled-coil domain containing 1 0.016
Kif22 kinesin family member 22 0.016
Hist1h1a histone cluster 1, H1a 0.016
Tk1 thymidine kinase 1, soluble 0.015
Lig3 ligase III, DNA, ATP-dependent 0.015
Tmpo thymopoietin 0.015
Dapk3 death-associated protein kinase 3 0.015
Jun Jun oncogene 0.015
Traf4af1 TRAF4 associated factor 1 0.014
Aurkb aurora kinase B 0.014
Prc1 protein regulator of cytokinesis 1 0.014
Stxbp3 syntaxin binding protein 3 0.014
Map2k4 mitogen activated protein kinase kinase 4 0.013
Mki67 antigen identified by monoclonal antibody Ki-67 0.013
Birc5 baculoviral IAP repeat-containing 5 0.013
Rgs3 regulator of G-protein signaling 3 0.013
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.013
Map6 microtubule-associated protein 6 0.013
Mrpl37 mitochondrial ribosomal protein L37 0.013
Kif1b kinesin family member 1B 0.013
Kif4 kinesin family member 4 0.012
Kif2c kinesin family member 2C 0.012
Plk4 polo-like kinase 4 (Drosophila) 0.012
Cbln1 cerebellin 1 precursor 0.012
Trmt1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 0.011
Fen1 flap structure-specific endonuclease 1 0.011
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.011
Foxm1 forkhead box M1 0.011
Prkag3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.011
RGD1308448 similar to RIKEN cDNA B130016O10 gene 0.011
Ncf4 neutrophil cytosolic factor 4 0.011
LOC363326 hypothetical LOC363326 0.011
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.011
Cenpe centromere protein E 0.011
Ccnb2 cyclin B2 0.010
Timeless timeless homolog (Drosophila) 0.010
Pbk PDZ binding kinase 0.010
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.010
Akap1 A kinase (PRKA) anchor protein 1 0.010
Rhoh ras homolog gene family, member H 0.010