The network for 'macroautophagy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ATG9 Atg9p 0.995
ATG13 Atg13p 0.989
ATG12 Atg12p 0.982
ATG3 Atg3p 0.975
KSP1 Ksp1p 0.973
ATG4 Atg4p 0.967
ATG7 Atg7p 0.956
ATG21 Atg21p 0.953
ATG1 Atg1p 0.947
ATG11 Atg11p 0.907
ATG16 Atg16p 0.898
TOR1 Tor1p 0.882
ATG29 Atg29p 0.859
ATG14 Atg14p 0.823
ATG23 Atg23p 0.819
SNX4 Snx4p 0.742
SEC2 Sec2p 0.715
YPT1 Ypt1p 0.688
ATG20 Atg20p 0.667
ATG5 Atg5p 0.665
VPS15 Vps15p 0.618
VPS41 Vps41p 0.599
CIS1 Cis1p 0.593
FUS3 Fus3p 0.592
VPS30 Vps30p 0.580
VAM6 Vam6p 0.566
ATG2 Atg2p 0.553
BMH1 Bmh1p 0.524
VPS28 Vps28p 0.487
VPS36 Vps36p 0.479
ATG26 Atg26p 0.475
TCO89 Tco89p 0.472
PHO81 Pho81p 0.397
VPS38 Vps38p 0.386
COG3 Cog3p 0.385
CCZ1 Ccz1p 0.366
SAS4 Sas4p 0.364
BDF1 Bdf1p 0.332
ATG10 Atg10p 0.325
PCL8 Pcl8p 0.312
VPS3 Vps3p 0.311
COG6 Cog6p 0.300
CDC55 Cdc55p 0.282
PEP5 Pep5p 0.267
SAS5 Sas5p 0.258
KIN2 Kin2p 0.257
HSV2 Hsv2p 0.235
MON1 Mon1p 0.226
GEA2 Gea2p 0.212
YLR211C hypothetical protein 0.182
ARP4 Arp4p 0.178
KGD1 Kgd1p 0.170
TRA1 Tra1p 0.168
KOG1 Kog1p 0.157
YIP4 Yip4p 0.154
NPR2 Npr2p 0.149
VPS21 Vps21p 0.146
CLN1 Cln1p 0.144
TRS85 Trs85p 0.143
HSP33 Hsp33p 0.142
VAC8 Vac8p 0.139
YPT31 Ypt31p 0.138
SEF1 Sef1p 0.134
VPS53 Vps53p 0.134
SAP185 Sap185p 0.133
SNO4 Sno4p 0.127
DNF3 Dnf3p 0.127
BOI1 Boi1p 0.127
BRO1 Bro1p 0.121
PPX1 Ppx1p 0.121
VPS34 Vps34p 0.119
SLG1 Slg1p 0.119
CTR9 Ctr9p 0.114
CLG1 Clg1p 0.113
HAL5 Hal5p 0.106
DSS4 Dss4p 0.106
HSP32 Hsp32p 0.106
VPS16 Vps16p 0.105
COG4 Cog4p 0.101
SNT1 Snt1p 0.101
SEC21 Sec21p 0.098
YIL165C hypothetical protein 0.092
NTO1 Nto1p 0.092
ARG82 Arg82p 0.091
PSY2 Psy2p 0.091
ESA1 Esa1p 0.090
ATG18 Atg18p 0.089
NET1 Net1p 0.088
BET3 Bet3p 0.085
TOM1 Tom1p 0.084
GPR1 Gpr1p 0.084
RRD1 Rrd1p 0.083
PPH3 Pph3p 0.080
ISW1 Isw1p 0.080
LAP4 Lap4p 0.075
TEC1 Tec1p 0.073
KIN1 Kin1p 0.071
SOD1 Sod1p 0.071
SEC7 Sec7p 0.069
ADR1 Adr1p 0.069
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
cids-2 Protein CIDS-2 0.153
atg-18 Protein ATG-18 0.143
hnd-1 Protein HND-1 0.131
ifg-1 Protein IFG-1 0.079
rpn-2 Protein RPN-2 0.062
cnd-1 Protein CND-1 0.061
F57F5.1 Protein F57F5.1 0.059
egl-46 Protein EGL-46 0.058
egl-18 Protein EGL-18 0.055
rps-2 Protein RPS-2 0.049
atg-16.2 Protein ATG-16.2 0.047
pmk-1 Protein PMK-1 0.042
lin-45 Protein LIN-45 0.033
che-13 Protein CHE-13 0.033
ubxn-1 Protein UBXN-1 0.033
dcn-1 Protein DCN-1 0.032
atg-13 Protein ATG-13 0.029
CELE_C44C10.4 Protein C44C10.4 0.026
cfim-2 Protein CFIM-2 0.026
T21H3.1 Protein T21H3.1 0.026
crh-2 Protein CRH-2 0.023
mek-2 Protein MEK-2 0.023
C41H7.4 Protein C41H7.4 0.023
T22C1.11 Protein T22C1.11 0.023
npl-4.1 Protein NPL-4.1 0.022
vps-16 Protein VPS-16 0.022
vps-34 Protein VPS-34 0.022
pnk-1 Protein PNK-1 0.021
osm-6 Protein OSM-6 0.020
amx-1 Protein AMX-1 0.020
tbc-9 Protein TBC-9 0.020
sec-10 Protein SEC-10 0.019
daf-14 Protein DAF-14 0.019
atg-7 Protein ATG-7 0.019
vps-11 Protein VPS-11 0.019
sem-5 Protein SEM-5 0.019
CELE_C01G6.4 Protein C01G6.4 0.019
pal-1 Protein PAL-1 0.018
K07H8.3 Protein K07H8.3 0.018
srj-14 Protein SRJ-14 0.018
nhr-22 Protein NHR-22 0.016
daf-2 Protein DAF-2 0.016
cpd-1 Protein CPD-1 0.016
fdps-1 Protein FDPS-1 0.016
dnj-25 Protein DNJ-25 0.016
Y82E9BR.13 Protein Y82E9BR.13 0.015
gld-2 Protein GLD-2 0.015
C01G5.6 Protein C01G5.6 0.015
K10C8.3 Protein K10C8.3 0.015
rbg-1 Protein RBG-1 0.015
cogc-2 Protein COGC-2 0.015
pad-1 Protein PAD-1 0.015
T16G1.4 Protein T16G1.4 0.015
D2013.6 Protein D2013.6 0.015
lin-12 Protein LIN-12 0.015
CELE_C17F4.7 Protein C17F4.7 0.015
nhr-70 Protein NHR-70 0.014
let-60 Protein LET-60 0.014
ztf-2 Protein ZTF-2 0.014
tat-4 Protein TAT-4 0.014
CELE_W05H9.3 Protein W05H9.3 0.013
gcs-1 Protein GCS-1 0.013
fshr-1 Protein FSHR-1 0.013
R186.3 Protein R186.3 0.013
Y97E10AR.6 Protein Y97E10AR.6 0.012
mdt-27 Protein MDT-27 0.012
F09A5.4 Protein F09A5.4 0.012
vps-37 Protein VPS-37 0.012
aak-2 Protein AAK-2 0.012
F53F10.2 Protein F53F10.2 0.012
eff-1 Protein EFF-1 0.012
CELE_F15A8.6 Protein F15A8.6 0.011
clec-50 Protein CLEC-50 0.011
rab-5 Protein RAB-5 0.011
lon-2 Protein LON-2 0.011
nkcc-1 Protein NKCC-1 0.011
nphp-4 Protein NPHP-4 0.011
tat-5 Protein TAT-5 0.011
scav-3 Protein SCAV-3 0.011
pcaf-1 Protein PCAF-1 0.011
cpr-1 Protein CPR-1 0.011
sft-4 Protein SFT-4 0.011
sdpn-1 Protein SDPN-1 0.011
asah-1 Protein ASAH-1 0.011
T25B9.8 Protein T25B9.8 0.011
CELE_Y57G11C.15 Protein Y57G11C.15 0.011
F26F12.3 Protein F26F12.3 0.010
fozi-1 Protein FOZI-1 0.010
smk-1 Protein SMK-1 0.010
R166.3 Protein R166.3 0.010
drap-1 Protein DRAP-1 0.010
fkh-2 Protein FKH-2 0.010
F21A9.2 Protein F21A9.2 0.010
rfl-1 Protein RFL-1 0.010
uaf-1 Protein UAF-1 0.010
gsp-1 Protein GSP-1 0.010
Y55F3AM.9 Protein Y55F3AM.9 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
igf1rb insulin-like growth factor 1b receptor 0.588
ndr1 nodal-related 1 0.312
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.247
tp73 tumor protein p73 0.245
sdf4 stromal cell derived factor 4 0.244
gro2 groucho 2 0.217
tm9sf2 transmembrane 9 superfamily member 2 0.191
zbtb4 zinc finger and BTB domain containing 4 0.188
rab2a RAB2A, member RAS oncogene family 0.164
odc1 ornithine decarboxylase 1 0.155
hhex hematopoietically expressed homeobox 0.146
apg3l APG3 autophagy 3-like 0.140
npc1 Niemann-Pick disease, type C1 0.138
lrrc6 leucine rich repeat containing 6 0.110
pou5f1 POU domain, class 5, transcription factor 1 0.108
ntla no tail a 0.102
mapk14a mitogen-activated protein kinase 14a 0.093
brd2a bromodomain-containing 2a 0.092
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.087
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.086
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.081
baxa bcl2-associated X protein, a 0.077
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.075
syap1 synapse associated protein 1 0.074
fuca2 fucosidase, alpha-L- 2, plasma 0.074
flh floating head 0.072
adrb2b adrenergic receptor, beta 2b 0.071
nup50 nucleoporin 50 0.070
hgfb hepatocyte growth factor b 0.070
grnb granulin b 0.068
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.068
tpd52l2b tumor protein D52-like 2b 0.068
clcn7 chloride channel 7 0.067
insrb insulin receptor b 0.066
ext2 exostoses (multiple) 2 0.066
ptk2.1 protein tyrosine kinase 2a 0.066
smyd3 SET and MYND domain containing 3 0.065
zgc:112430 zgc:112430 0.064
met met proto-oncogene (hepatocyte growth factor receptor) 0.063
rpl15 ribosomal protein L15 0.063
furinb furin (paired basic amino acid cleaving enzyme) b 0.063
rab5aa RAB5A, member RAS oncogene family, a 0.061
tsga14 testis specific, 14 0.060
tax1bp1b Tax1 (human T-cell leukemia virus type I) binding protein 1b 0.060
vdra vitamin D receptor a 0.059
zgc:92606 zgc:92606 0.058
atp6v1f ATPase, H+ transporting, V1 subunit F 0.058
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.057
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.057
yipf4 Yip1 domain family, member 4 0.057
arcn1l archain 1 like 0.057
sox9b SRY-box containing gene 9b 0.057
rpsa ribosomal protein SA 0.056
fzd5 frizzled homolog 5 0.055
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.055
furina furin (paired basic amino acid cleaving enzyme) a 0.054
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.053
crsp7 cofactor required for Sp1 transcriptional activation, subunit 7 0.053
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.053
mbnl2 muscleblind-like 2 (Drosophila) 0.052
myl9 myosin, light polypeptide 9, regulatory 0.052
ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.051
fermt2 fermitin family homolog 2 (Drosophila) 0.050
brca2 breast cancer 2, early onset 0.050
adipor1a adiponectin receptor 1a 0.049
wipi1 WD repeat domain, phosphoinositide interacting 1 0.049
add1 adducin 1 (alpha) 0.049
pdxdc1 pyridoxal-dependent decarboxylase domain containing 1 0.049
mbtps1 membrane-bound transcription factor protease, site 1 0.048
zgc:56596 zgc:56596 0.048
ush1c Usher syndrome 1C (autosomal recessive, severe) 0.048
rhoaa ras homolog gene family, member Aa 0.047
zgc:66100 zgc:66100 0.047
ppardb peroxisome proliferator-activated receptor delta b 0.047
ap1m2 adaptor-related protein complex 1, mu 2 subunit 0.047
limk2 LIM domain kinase 2 0.047
fgf3 fibroblast growth factor 3 0.047
rab1a RAB1A, member RAS oncogene family 0.046
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.046
si:dkey-108d22.4 si:dkey-108d22.4 0.046
bcl2 B-cell leukemia/lymphoma 2 0.046
h1m linker histone H1M 0.045
acsl4a acyl-CoA synthetase long-chain family member 4a 0.045
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.045
zgc:73134 zgc:73134 0.045
ca15b carbonic anhydrase XV b 0.045
glcci1 glucocorticoid induced transcript 1 0.045
mpp6b membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6) 0.045
wipi2 WD repeat domain, phosphoinositide interacting 2 0.044
mapk4 mitogen-activated protein kinase 4 0.044
rab7 RAB7, member RAS oncogene family 0.044
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.044
zgc:66317 zgc:66317 0.043
ndfip1 Nedd4 family interacting protein 1 0.043
pias4a protein inhibitor of activated STAT, 4a 0.043
zgc:56272 zgc:56272 0.043
cluap1 clusterin associated protein 1 0.043
LOC100006043 Kruppel-like factor 5-like 0.043
lsm12 LSM12 homolog (S. cerevisiae) 0.043
trappc5 trafficking protein particle complex 5 0.043
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 1.000
Atg18 Autophagy-specific gene 18 0.999
Atg8a Autophagy-specific gene 8a 0.999
Atg1 Autophagy-specific gene 1 0.999
CG11347 CG11347 gene product from transcript CG11347-RE 0.996
Rab7 Rab-protein 7 0.992
Rheb CG1081 gene product from transcript CG1081-RA 0.989
Pten CG5671 gene product from transcript CG5671-RB 0.962
Atg2 Autophagy-specific gene 2 0.952
rl rolled 0.942
Vps16A Vacuolar protein sorting 16A 0.924
Ras85D Ras oncogene at 85D 0.905
CG6116 CG6116 gene product from transcript CG6116-RA 0.863
Atg13 Autophagy-specific gene 13 0.863
trpml transient receptor potential mucolipin 0.858
Atg6 Autophagy-specific gene 6 0.848
Syx17 Syntaxin 17 0.785
Rel Relish 0.778
Atg7 Autophagy-specific gene 7 0.765
RagA CG11968 gene product from transcript CG11968-RA 0.737
Atg9 Autophagy-specific gene 9 0.710
CG3004 CG3004 gene product from transcript CG3004-RA 0.647
ird1 immune response deficient 1 0.644
car carnation 0.521
dm diminutive 0.464
gig gigas 0.461
rpr reaper 0.426
S6k RPS6-p70-protein kinase 0.410
th thread 0.404
poly CG9829 gene product from transcript CG9829-RB 0.400
spin spinster 0.366
imd immune deficiency 0.356
Rab5 Rab-protein 5 0.347
CG1347 CG1347 gene product from transcript CG1347-RB 0.305
Dcr-2 Dicer-2 0.302
grim CG4345 gene product from transcript CG4345-RA 0.301
Atg4 Autophagy-specific gene 4 0.292
Vps20 Vacuolar protein sorting 20 0.260
drpr draper 0.259
Akt1 CG4006 gene product from transcript CG4006-RA 0.258
ninaE neither inactivation nor afterpotential E 0.239
CG10277 CG10277 gene product from transcript CG10277-RB 0.224
cpa capping protein alpha 0.223
Pink1 PTEN-induced putative kinase 1 0.211
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.210
Rpn2 CG11888 gene product from transcript CG11888-RA 0.208
rb ruby 0.205
Snap Soluble NSF attachment protein 0.205
CG7611 CG7611 gene product from transcript CG7611-RJ 0.203
hk hook 0.188
bsk basket 0.173
Tor Target of rapamycin 0.167
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.165
Atg5 Autophagy-specific gene 5 0.148
spi spitz 0.143
drd drop dead 0.143
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.140
Tango9 Transport and Golgi organization 9 0.131
cathD CG1548 gene product from transcript CG1548-RA 0.127
Lk6 CG17342 gene product from transcript CG17342-RA 0.124
ltd lightoid 0.120
usnp ubisnap 0.115
SuUR Suppressor of Under-Replication 0.109
key kenny 0.106
CG7146 CG7146 gene product from transcript CG7146-RA 0.099
hep hemipterous 0.097
foxo forkhead box, sub-group O 0.096
step steppke 0.096
CG31033 CG31033 gene product from transcript CG31033-RC 0.093
gammaSnap gamma-soluble NSF attachment protein 0.090
Thor CG8846 gene product from transcript CG8846-RA 0.090
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.088
CdsA CDP diglyceride synthetase 0.086
Vps26 Vacuolar protein sorting 26 0.085
Sir2 CG5216 gene product from transcript CG5216-RA 0.085
Rab1 Rab-protein 1 0.082
Dcp-1 Death caspase-1 0.081
Aut1 CG6877 gene product from transcript CG6877-RA 0.079
TBPH CG10327 gene product from transcript CG10327-RC 0.076
Syb Synaptobrevin 0.074
lt light 0.074
BG4 CG12297 gene product from transcript CG12297-RA 0.073
drk downstream of receptor kinase 0.071
debcl death executioner Bcl-2 homologue 0.071
CG32581 CG32581 gene product from transcript CG32581-RB 0.070
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.070
Sox14 Sox box protein 14 0.069
lsn larsen 0.068
or orange 0.067
vps2 CG14542 gene product from transcript CG14542-RA 0.067
Pcaf CG4107 gene product from transcript CG4107-RA 0.067
CG3632 CG3632 gene product from transcript CG3632-RH 0.066
Ack CG14992 gene product from transcript CG14992-RA 0.066
scny scrawny 0.063
puc puckered 0.063
betaggt-I beta subunit of type I geranylgeranyl transferase 0.062
alpha-Spec alpha Spectrin 0.060
desat1 CG5887 gene product from transcript CG5887-RA 0.060
Egm Enigma 0.060
CG11009 CG11009 gene product from transcript CG11009-RB 0.059
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.000
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.000
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 1.000
GABARAP GABA(A) receptor-associated protein 1.000
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.999
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.997
SQSTM1 sequestosome 1 0.996
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.996
ULK1 unc-51-like kinase 1 (C. elegans) 0.993
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.985
RB1CC1 RB1-inducible coiled-coil 1 0.982
NBR1 neighbor of BRCA1 gene 1 0.971
MAPK1 mitogen-activated protein kinase 1 0.947
GABARAPL1 GABA(A) receptor-associated protein like 1 0.947
SH3KBP1 SH3-domain kinase binding protein 1 0.782
CHMP1A chromatin modifying protein 1A 0.759
MAP2K1 mitogen-activated protein kinase kinase 1 0.757
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.723
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.592
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.533
SIRT1 sirtuin 1 0.464
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.447
ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 0.440
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.435
RRAGA Ras-related GTP binding A 0.433
SESN2 sestrin 2 0.427
OPTN optineurin 0.367
NRBF2 nuclear receptor binding factor 2 0.344
GRB10 growth factor receptor-bound protein 10 0.327
TSC2 tuberous sclerosis 2 0.321
GOLGA2 golgin A2 0.318
IRS2 insulin receptor substrate 2 0.311
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.307
GFM1 G elongation factor, mitochondrial 1 0.277
PDCD6 programmed cell death 6 0.267
CREBBP CREB binding protein 0.264
EGFR epidermal growth factor receptor 0.259
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.255
BCL2 B-cell CLL/lymphoma 2 0.241
AMBRA1 autophagy/beclin-1 regulator 1 0.239
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.218
RHEB Ras homolog enriched in brain 0.211
COASY CoA synthase 0.210
AR androgen receptor 0.209
PDCD6IP programmed cell death 6 interacting protein 0.190
COG7 component of oligomeric golgi complex 7 0.181
MAPK8 mitogen-activated protein kinase 8 0.166
STX7 syntaxin 7 0.154
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.154
KAT2B K(lysine) acetyltransferase 2B 0.154
TTC15 tetratricopeptide repeat domain 15 0.150
USP8 ubiquitin specific peptidase 8 0.146
CLTB clathrin, light chain B 0.146
BECN1 beclin 1, autophagy related 0.142
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.138
UVRAG UV radiation resistance associated gene 0.137
ZFYVE1 zinc finger, FYVE domain containing 1 0.137
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.136
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.134
NCOA2 nuclear receptor coactivator 2 0.131
PINK1 PTEN induced putative kinase 1 0.129
EEF1G eukaryotic translation elongation factor 1 gamma 0.106
ATXN3 ataxin 3 0.102
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.093
MAP2K2 mitogen-activated protein kinase kinase 2 0.092
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.092
ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 0.091
PIK3C3 phosphoinositide-3-kinase, class 3 0.090
DCTN1 dynactin 1 0.088
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.087
RFK riboflavin kinase 0.084
CHMP6 chromatin modifying protein 6 0.083
NCOA1 nuclear receptor coactivator 1 0.083
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.083
APC adenomatous polyposis coli 0.081
PSEN2 presenilin 2 (Alzheimer disease 4) 0.081
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.076
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.076
IRS1 insulin receptor substrate 1 0.074
FUNDC2 FUN14 domain containing 2 0.073
SCHIP1 schwannomin interacting protein 1 0.073
NCOA6 nuclear receptor coactivator 6 0.072
RAB1A RAB1A, member RAS oncogene family 0.070
RICTOR RPTOR independent companion of MTOR, complex 2 0.070
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.068
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.068
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.065
MKRN1 makorin ring finger protein 1 0.063
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.062
PTK2 PTK2 protein tyrosine kinase 2 0.061
KIF5B kinesin family member 5B 0.061
CTSA cathepsin A 0.061
GAB2 GRB2-associated binding protein 2 0.060
SPAG9 sperm associated antigen 9 0.060
STX4 syntaxin 4 0.060
UBXN6 UBX domain protein 6 0.059
BAD BCL2-associated agonist of cell death 0.058
KIAA1377 KIAA1377 0.058
EP300 E1A binding protein p300 0.058
RPS19BP1 ribosomal protein S19 binding protein 1 0.058
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Atg12 autophagy-related 12 (yeast) 1.000
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 1.000
Sqstm1 sequestosome 1 0.999
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.979
Rb1 retinoblastoma 1 0.960
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.926
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.919
Braf Braf transforming gene 0.910
Mdm2 transformed mouse 3T3 cell double minute 2 0.882
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.829
Nf1 neurofibromatosis 1 0.682
Atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.571
Pef1 penta-EF hand domain containing 1 0.513
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.497
Ncstn nicastrin 0.496
Raf1 v-raf-leukemia viral oncogene 1 0.480
Lepr leptin receptor 0.466
Grb10 growth factor receptor bound protein 10 0.450
Foxa2 forkhead box A2 0.434
Apc adenomatosis polyposis coli 0.429
Rnf167 ring finger protein 167 0.426
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.396
Pparg peroxisome proliferator activated receptor gamma 0.362
Ctnnb1 catenin (cadherin associated protein), beta 1 0.352
Gabarap gamma-aminobutyric acid receptor associated protein 0.344
Mapkap1 mitogen-activated protein kinase associated protein 1 0.337
Rptor regulatory associated protein of MTOR, complex 1 0.336
Atg7 autophagy-related 7 (yeast) 0.322
Dctn2 dynactin 2 0.321
Notch2 Notch gene homolog 2 (Drosophila) 0.315
Atf2 activating transcription factor 2 0.313
Sesn2 sestrin 2 0.308
Abtb1 ankyrin repeat and BTB (POZ) domain containing 1 0.300
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.282
Aamp angio-associated migratory protein 0.280
Rictor RPTOR independent companion of MTOR, complex 2 0.280
Atg3 autophagy-related 3 (yeast) 0.275
Mlf2 myeloid leukemia factor 2 0.264
Irs2 insulin receptor substrate 2 0.255
Wbp2 WW domain binding protein 2 0.248
Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 0.232
Hif1a hypoxia inducible factor 1, alpha subunit 0.225
Tsc2 tuberous sclerosis 2 0.215
Esr1 estrogen receptor 1 (alpha) 0.212
Fam134a family with sequence similarity 134, member A 0.208
Ar androgen receptor 0.207
Fkbp8 FK506 binding protein 8 0.203
Ufd1l ubiquitin fusion degradation 1 like 0.198
Rpgrip1l Rpgrip1-like 0.189
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.187
Sav1 salvador homolog 1 (Drosophila) 0.186
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.177
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.174
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.165
Pik3c3 phosphoinositide-3-kinase, class 3 0.163
Bsg basigin 0.157
Cyld cylindromatosis (turban tumor syndrome) 0.152
Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 0.137
Mapk1 mitogen-activated protein kinase 1 0.137
Foxo3 forkhead box O3 0.136
Mdm4 transformed mouse 3T3 cell double minute 4 0.136
Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.134
Rps3 ribosomal protein S3 0.131
Atg2a ATG2 autophagy related 2 homolog A (S. cerevisiae) 0.131
Ift57 intraflagellar transport 57 homolog (Chlamydomonas) 0.127
Ypel3 yippee-like 3 (Drosophila) 0.126
Notch1 Notch gene homolog 1 (Drosophila) 0.119
Igf2r insulin-like growth factor 2 receptor 0.118
Npc1 Niemann Pick type C1 0.117
Kif3a kinesin family member 3A 0.112
Sh3glb2 SH3-domain GRB2-like endophilin B2 0.112
Atg5 autophagy-related 5 (yeast) 0.111
Chmp1a chromatin modifying protein 1A 0.109
Mapk14 mitogen-activated protein kinase 14 0.107
Foxo1 forkhead box O1 0.105
Pdpk1 3-phosphoinositide dependent protein kinase 1 0.105
Eef1a1 eukaryotic translation elongation factor 1 alpha 1 0.104
Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B 0.103
Aes amino-terminal enhancer of split 0.100
Rfwd2 ring finger and WD repeat domain 2 0.099
Tbc1d17 TBC1 domain family, member 17 0.096
Usp5 ubiquitin specific peptidase 5 (isopeptidase T) 0.091
Trp53inp2 transformation related protein 53 inducible nuclear protein 2 0.091
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.089
Vps26b vacuolar protein sorting 26 homolog B (yeast) 0.088
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.085
Wdr45 WD repeat domain 45 0.085
Rab14 RAB14, member RAS oncogene family 0.084
Psap prosaposin 0.084
Trp53 transformation related protein 53 0.083
Spns1 spinster homolog 1 (Drosophila) 0.083
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.081
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.081
Smad2 MAD homolog 2 (Drosophila) 0.080
Mapk3 mitogen-activated protein kinase 3 0.079
Trp73 transformation related protein 73 0.079
Tecr trans-2,3-enoyl-CoA reductase 0.079
Kiss1 KiSS-1 metastasis-suppressor 0.078
Kit kit oncogene 0.078
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.071
Arf1 ADP-ribosylation factor 1 0.060
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.059
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.057
Coasy Coenzyme A synthase 0.056
Hbp1 HMG-box transcription factor 1 0.056
Rraga Ras-related GTP binding A 0.052
Pgrmc1 progesterone receptor membrane component 1 0.050
Kpnb1 karyopherin (importin) beta 1 0.044
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.039
Bnip3l BCL2/adenovirus E1B interacting protein 3-like 0.038
Hiat1 hippocampus abundant gene transcript 1 0.037
Snx4 sorting nexin 4 0.037
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.036
RGD1311122 similar to RIKEN cDNA 1110003E01 0.036
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.036
Tmbim6 transmembrane BAX inhibitor motif containing 6 0.035
Fis1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.035
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.035
Arl1 ADP-ribosylation factor-like 1 0.035
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.034
Cltc clathrin, heavy chain (Hc) 0.034
Capns1 calpain, small subunit 1 0.033
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.033
Rnf4 ring finger protein 4 0.033
Atp6v1b2 ATPase, H transporting, lysosomal V1 subunit B2 0.032
Dazap2 DAZ associated protein 2 0.032
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.032
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.030
Lman1 lectin, mannose-binding, 1 0.029
Morf4l2 mortality factor 4 like 2 0.029
Mapk9 mitogen-activated protein kinase 9 0.029
Map2k2 mitogen activated protein kinase kinase 2 0.028
Adar adenosine deaminase, RNA-specific 0.027
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.027
Tcp11l2 t-complex 11 (mouse) like 2 0.027
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.027
Copb1 coatomer protein complex, subunit beta 1 0.026
Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.026
Serp1 stress-associated endoplasmic reticulum protein 1 0.026
Akap1 A kinase (PRKA) anchor protein 1 0.026
Myo1b myosin Ib 0.026
Eef2 eukaryotic translation elongation factor 2 0.025
Csnk1d casein kinase 1, delta 0.025
Usf1 upstream transcription factor 1 0.024
Apc adenomatous polyposis coli 0.024
Qars glutaminyl-tRNA synthetase 0.024
Gabarapl1 GABA(A) receptor-associated protein like 1 0.024
Zfand6 zinc finger, AN1-type domain 6 0.024
Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C 0.024
Tmem59 transmembrane protein 59 0.024
Uso1 USO1 homolog, vesicle docking protein (yeast) 0.024
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.024
Syngr2 synaptogyrin 2 0.023
Ide insulin degrading enzyme 0.023
Adipor1 adiponectin receptor 1 0.023
Hagh hydroxyacyl glutathione hydrolase 0.023
Rabac1 Rab acceptor 1 (prenylated) 0.023
Ehd1 EH-domain containing 1 0.022
Scamp1 secretory carrier membrane protein 1 0.022
Synrg synergin, gamma 0.022
Cyth1 cytohesin 1 0.022
Prkar1a protein kinase, cAMP-dependent, regulatory, type I, alpha 0.022
Clcn7 chloride channel 7 0.022
Arnt aryl hydrocarbon receptor nuclear translocator 0.022
Lig3 ligase III, DNA, ATP-dependent 0.021
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.021
Plaa phospholipase A2, activating protein 0.021
Zfyve26 zinc finger, FYVE domain containing 26 0.021
Zfp706 zinc finger protein 706 0.021
Rpl10 ribosomal protein L10 0.021
Tm9sf2 transmembrane 9 superfamily member 2 0.020
Pik3c3 phosphoinositide-3-kinase, class 3 0.020
Cyb5b cytochrome b5 type B (outer mitochondrial membrane) 0.020
Nmt1 N-myristoyltransferase 1 0.020
Ube2m ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.020
Trim23 tripartite motif-containing 23 0.020
Lyst lysosomal trafficking regulator 0.019
Hdlbp high density lipoprotein binding protein 0.019
Traf6 Tnf receptor-associated factor 6 0.019
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.019
Bcl2l2 Bcl2-like 2 0.019
Rpn2 ribophorin II 0.018
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.018
Vps33b vacuolar protein sorting 33 homolog B (yeast) 0.018
Bsg basigin 0.018
Tmem49 transmembrane protein 49 0.018
Usp48 ubiquitin specific peptidase 48 0.018
Lin7c lin-7 homolog C (C. elegans) 0.018
Sec24d SEC24 family, member D (S. cerevisiae) 0.018
Lancl1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.018
Lims1 LIM and senescent cell antigen-like domains 1 0.018
Eif4b eukaryotic translation initiation factor 4B 0.017
Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 0.017
Grb2 growth factor receptor bound protein 2 0.017
Sqstm1 sequestosome 1 0.017
Slc20a2 solute carrier family 20 (phosphate transporter), member 2 0.017
Rps8 ribosomal protein S8 0.017
Ctsd cathepsin D 0.017
Wdr45 WD repeat domain 45 0.017