The network for 'regulation of dna dependent dna replication initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna dependent dna replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ORC2 Orc2p 0.958
MCM3 Mcm3p 0.926
MCM2 Mcm2p 0.899
MCM7 Mcm7p 0.876
MCM6 Mcm6p 0.828
ORC3 Orc3p 0.754
MCM4 Mcm4p 0.730
MCM10 Mcm10p 0.716
ORC1 Orc1p 0.557
ORC6 Orc6p 0.537
HAT1 Hat1p 0.484
DBF4 Dbf4p 0.475
ORC5 Orc5p 0.444
UME1 Ume1p 0.440
CDC6 Cdc6p 0.411
CLB5 Clb5p 0.388
SIN3 Sin3p 0.365
MDN1 Mdn1p 0.353
SLD3 Sld3p 0.274
ORC4 Orc4p 0.218
SDS3 Sds3p 0.185
MCM5 Mcm5p 0.180
RCO1 Rco1p 0.152
CDC14 Cdc14p 0.111
SIR2 Sir2p 0.103
DIA2 Dia2p 0.097
CDC45 Cdc45p 0.097
UME6 Ume6p 0.095
SLD2 Sld2p 0.093
SLD5 Sld5p 0.092
HST1 Hst1p 0.091
TAH11 Tah11p 0.090
CLB6 Clb6p 0.082
UFO1 Ufo1p 0.080
CHL1 Chl1p 0.069
IPI3 Ipi3p 0.067
SPC97 Spc97p 0.064
HDA2 Hda2p 0.064
IFH1 Ifh1p 0.063
HAT2 Hat2p 0.063
SWC4 Swc4p 0.062
RAD53 Rad53p 0.062
CHD1 Chd1p 0.060
OPI1 Opi1p 0.059
ASH1 Ash1p 0.054
HST3 Hst3p 0.050
SUM1 Sum1p 0.050
NDD1 Ndd1p 0.050
SET2 Set2p 0.050
CDC23 Cdc23p 0.049
UBP10 Ubp10p 0.049
SET3 Set3p 0.048
MOT3 Mot3p 0.042
NOC3 Noc3p 0.040
RPC34 Rpc34p 0.040
YLR264C-A hypothetical protein 0.039
OPT2 Opt2p 0.039
MRC1 Mrc1p 0.039
SIC1 Sic1p 0.038
VAC17 Vac17p 0.038
SAP30 Sap30p 0.038
ARP10 Arp10p 0.038
SRD1 Srd1p 0.037
HDA1 Hda1p 0.037
CDC7 Cdc7p 0.036
YAR068W hypothetical protein 0.034
LEU2 Leu2p 0.034
ARG8 Arg8p 0.034
TFA1 Tfa1p 0.033
SPC98 Spc98p 0.032
THP2 Thp2p 0.032
YLR162W hypothetical protein 0.032
SNT1 Snt1p 0.032
CHA1 Cha1p 0.031
SPL2 Spl2p 0.031
ADH2 Adh2p 0.031
CDC20 Cdc20p 0.031
YOL038C-A hypothetical protein 0.031
YGR079W hypothetical protein 0.031
SET1 Set1p 0.030
MF(ALPHA)2 Mf(alpha)2p 0.030
URA3 Ura3p 0.029
FCY21 Fcy21p 0.029
IPI1 Ipi1p 0.028
MF(ALPHA)1 Mf(alpha)1p 0.028
ERB1 Erb1p 0.028
HXT3 Hxt3p 0.027
PRP45 Prp45p 0.027
MSA1 Msa1p 0.027
POL32 Pol32p 0.027
YLR455W hypothetical protein 0.027
CLB1 Clb1p 0.027
MER1 Mer1p 0.027
HO Hop 0.026
YAR066W hypothetical protein 0.026
ATP6 Atp6p 0.026
RAD9 Rad9p 0.026
CUP1-1 Cup1-1p 0.026
YLR042C hypothetical protein 0.026
FMT1 Fmt1p 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 0.915
ORC1 origin recognition complex, subunit 1 0.670
MCM2 minichromosome maintenance complex component 2 0.335
MCM7 minichromosome maintenance complex component 7 0.275
ANAPC4 anaphase promoting complex subunit 4 0.263
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.139
ANAPC5 anaphase promoting complex subunit 5 0.127
MCM3 minichromosome maintenance complex component 3 0.121
CCNE1 cyclin E1 0.091
CDT1 chromatin licensing and DNA replication factor 1 0.088
ANAPC1 anaphase promoting complex subunit 1 0.079
MCM6 minichromosome maintenance complex component 6 0.066
MCM4 minichromosome maintenance complex component 4 0.066
MCM8 minichromosome maintenance complex component 8 0.065
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.064
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.062
ANAPC7 anaphase promoting complex subunit 7 0.061
CDC26 cell division cycle 26 homolog (S. cerevisiae) 0.053
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.051
FOXM1 forkhead box M1 0.042
SSRP1 structure specific recognition protein 1 0.037
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.036
MCM10 minichromosome maintenance complex component 10 0.029
MORF4L1 mortality factor 4 like 1 0.029
ORC6 origin recognition complex, subunit 6 0.029
MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 0.027
MCMBP minichromosome maintenance complex binding protein 0.022
MMS22L MMS22-like, DNA repair protein 0.021
E2F1 E2F transcription factor 1 0.017
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.017
MRFAP1 Morf4 family associated protein 1 0.015
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.014
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.012
SKP2 S-phase kinase-associated protein 2 (p45) 0.011
ANAPC13 anaphase promoting complex subunit 13 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.646
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.524
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.384
Kdm5b lysine (K)-specific demethylase 5B 0.315
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.307
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.203
Ccna2 cyclin A2 0.149
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.132
Cdk4 cyclin-dependent kinase 4 0.120
Hdac1 histone deacetylase 1 0.120
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.098
Arid1a AT rich interactive domain 1A (SWI-like) 0.085
Ccne1 cyclin E1 0.083
Rrm2 ribonucleotide reductase M2 0.057
Rfc5 replication factor C (activator 1) 5 0.055
Lig1 ligase I, DNA, ATP-dependent 0.046
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.042
Ccnb2 cyclin B2 0.041
Cdt1 chromatin licensing and DNA replication factor 1 0.036
Timeless timeless homolog (Drosophila) 0.034
Tk1 thymidine kinase 1 0.034
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.031
Sap25 sin3 associated polypeptide 0.023
Gmnn geminin 0.022
Rnf220 ring finger protein 220 0.019
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.019
Birc5 baculoviral IAP repeat-containing 5 0.019
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.017
Cdca8 cell division cycle associated 8 0.017
Haus4 HAUS augmin-like complex, subunit 4 0.016
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.015
Pole polymerase (DNA directed), epsilon 0.013
E2f8 E2F transcription factor 8 0.012
Sp1 trans-acting transcription factor 1 0.011
Kif22 kinesin family member 22 0.011
Rcc1 regulator of chromosome condensation 1 0.011
Prc1 protein regulator of cytokinesis 1 0.011
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.011
Cks1b CDC28 protein kinase 1b 0.011
Flna filamin, alpha 0.010
Ncor1 nuclear receptor co-repressor 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism