The network for 'establishment of protein localization to plasma membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of protein localization to plasma membrane

The directed movement of a protein to a specific location in the plasma membrane.

Danio rerio
Name Description Probability Func Analog Organism
itgb1b.2 integrin, beta 1b.2 0.970
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.323
esyt3 extended synaptotagmin-like protein 3 0.314
itgb1a integrin, beta 1a 0.310
rbpms2 RNA binding protein with multiple splicing 2 0.284
tuba1 tubulin, alpha 1 0.222
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.210
cdh2 cadherin 2, neuronal 0.208
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.196
vps26b vacuolar protein sorting 26 homolog B 0.191
phlda2 pleckstrin homology-like domain, family A, member 2 0.179
igfbp6a insulin-like growth factor binding protein 6a 0.166
itgb1b.1 integrin, beta 1b.1 0.163
mmp14b matrix metalloproteinase 14b (membrane-inserted) 0.149
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.149
ef1a elongation factor 1-alpha 0.145
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.145
tcea2 transcription elongation factor A (SII), 2 0.144
acvr1b activin A receptor, type IB 0.140
spint1a serine peptidase inhibitor, Kunitz type 1 a 0.135
rras related RAS viral (r-ras) oncogene homolog 0.135
b2m beta-2-microglobulin 0.134
sypl2b synaptophysin-like 2b 0.127
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.124
icn ictacalcin 0.123
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.121
krt8 keratin 8 0.118
sdf2 stromal cell-derived factor 2 0.116
slc4a4a solute carrier family 4, member 4a 0.113
rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.112
trappc5 trafficking protein particle complex 5 0.109
igfbp6b insulin-like growth factor binding protein 6b 0.107
krt4 keratin 4 0.107
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.106
zgc:55683 zgc:55683 0.105
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.104
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.101
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.101
iqgap1 IQ motif containing GTPase activating protein 1 0.100
jkamp jnk1/mapk8-associated membrane protein 0.098
trim55a tripartite motif-containing 55a 0.097
fryl furry homolog-like (Drosophila) 0.096
zfpl1 zinc finger protein-like 1 0.093
zgc:153060 zgc:153060 0.093
dspa desmoplakin a 0.091
uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.090
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.090
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.089
sec11a SEC11 homolog A (S. cerevisiae) 0.088
ext2 exostoses (multiple) 2 0.087
zgc:101724 zgc:101724 0.084
derl1 Der1-like domain family, member 1 0.084
asb8 ankyrin repeat and SOCS box-containing 8 0.084
metrnl meteorin, glial cell differentiation regulator-like 0.084
pak2a p21 (CDKN1A)-activated kinase 2a 0.082
dnajb12 DnaJ (Hsp40) homolog, subfamily B, member 12 0.081
zgc:113625 zgc:113625 0.080
slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.080
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.079
cisd2 CDGSH iron sulfur domain 2 0.078
anxa2a annexin A2a 0.078
msxd muscle segment homeobox D 0.077
zgc:86757 zgc:86757 0.076
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.076
ccdc80 coiled-coil domain containing 80 0.076
rap1b RAS related protein 1b 0.075
cyfip2 cytoplasmic FMR1 interacting protein 2 0.075
rab1a RAB1A, member RAS oncogene family 0.074
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.074
vps26a vacuolar protein sorting 26 homolog A (yeast) 0.073
arf1 ADP-ribosylation factor 1 0.073
sept2 septin 2 0.073
alcamb activated leukocyte cell adhesion molecule b 0.073
zgc:101072 zgc:101072 0.072
csrp1a cysteine and glycine-rich protein 1a 0.072
tpm3 tropomyosin 3 0.069
vamp4 vesicle-associated membrane protein 4 0.069
asl argininosuccinate lyase 0.069
slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.068
ms4a17a.5 membrane-spanning 4-domains, subfamily A, member 17A.5 0.068
itgb1b integrin, beta 1b 0.066
osr2 odd-skipped related 2 (Drosophila) 0.066
laptm4a lysosomal-associated protein transmembrane 4 alpha 0.065
b3galt2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.065
flot2a flotillin 2a 0.065
cdh1 cadherin 1, epithelial 0.065
mobkl1aa MOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate a 0.064
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.063
mmp13a matrix metalloproteinase 13a 0.063
s1pr2 sphingosine-1-phosphate receptor 2 0.063
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.062
si:dkey-7c22.1 si:dkey-7c22.1 0.062
zgc:100829 zgc:100829 0.062
zgc:77304 zgc:77304 0.062
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.060
ass1 argininosuccinate synthetase 1 0.060
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.060
fam3c family with sequence similarity 3, member C 0.060
epcam epithelial cell adhesion molecule 0.059
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.059
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
crb crumbs 0.886
Rab11 Rab-protein 11 0.825
cpb capping protein beta 0.536
Mad Mothers against dpp 0.516
sec6 CG5341 gene product from transcript CG5341-RA 0.452
Dlic Dynein light intermediate chain 0.422
kst karst 0.396
baz bazooka 0.298
shot short stop 0.222
l(2)gl lethal (2) giant larvae 0.222
Moe Moesin 0.213
Lnk CG17367 gene product from transcript CG17367-RC 0.192
usp ultraspiracle 0.170
CG3033 CG3033 gene product from transcript CG3033-RA 0.128
hyd hyperplastic discs 0.124
rhea CG6831 gene product from transcript CG6831-RA 0.116
Cdc42 CG12530 gene product from transcript CG12530-RA 0.110
mys myospheroid 0.109
Snap25 Synapse protein 25 0.109
CG13089 CG13089 gene product from transcript CG13089-RA 0.105
arm armadillo 0.085
Tsc1 CG6147 gene product from transcript CG6147-RA 0.081
wdb widerborst 0.080
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.078
Syx1A Syntaxin 1A 0.078
Pten CG5671 gene product from transcript CG5671-RB 0.075
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.075
Fas2 Fasciclin 2 0.071
G-oalpha47A G protein oalpha 47A 0.069
Csp Cysteine string protein 0.068
poe purity of essence 0.065
par-1 CG8201 gene product from transcript CG8201-RA 0.064
neur neuralized 0.062
trio CG18214 gene product from transcript CG18214-RA 0.061
LanB1 CG7123 gene product from transcript CG7123-RA 0.061
unc-104 CG8566 gene product from transcript CG8566-RB 0.060
WASp CG1520 gene product from transcript CG1520-RA 0.057
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.054
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.050
neuroligin CG13772 gene product from transcript CG13772-RA 0.047
Nrx-IV Neurexin IV 0.044
fry furry 0.044
sax saxophone 0.043
CG12945 CG12945 gene product from transcript CG12945-RB 0.037
pasha partner of drosha 0.037
Rheb CG1081 gene product from transcript CG1081-RA 0.037
HDAC6 CG6170 gene product from transcript CG6170-RA 0.037
Arf79F ADP ribosylation factor 79F 0.036
Syb Synaptobrevin 0.036
Rac1 CG2248 gene product from transcript CG2248-RA 0.036
stai stathmin 0.034
msn misshapen 0.034
cpa capping protein alpha 0.033
cdm cadmus 0.033
Rip11 Rab11 interacting protein 0.033
nwk nervous wreck 0.033
Ephrin CG1862 gene product from transcript CG1862-RA 0.033
Tsp86D Tetraspanin 86D 0.032
lolal lola like 0.032
wun wunen 0.029
CG12001 CG12001 gene product from transcript CG12001-RA 0.029
Gprk2 G protein-coupled receptor kinase 2 0.028
frc fringe connection 0.025
asl asterless 0.025
didum dilute class unconventional myosin 0.024
Cip4 CG15015 gene product from transcript CG15015-RA 0.024
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.023
Ank2 Ankyrin 2 0.023
dia diaphanous 0.021
Dab Disabled 0.021
aPKC atypical protein kinase C 0.021
Chc Clathrin heavy chain 0.021
ena enabled 0.019
Rme-8 Receptor mediated endocytosis 8 0.019
unc-13 CG2999 gene product from transcript CG2999-RA 0.019
sec5 CG8843 gene product from transcript CG8843-RA 0.018
CG15609 CG15609 gene product from transcript CG15609-RE 0.018
scu scully 0.018
Khc Kinesin heavy chain 0.018
rok Rho-kinase 0.018
fz2 frizzled 2 0.017
CG12077 CG12077 gene product from transcript CG12077-RB 0.017
H Hairless 0.017
unk unkempt 0.016
eIF4G eukaryotic translation initiation factor 4G 0.016
CG32486 CG32486 gene product from transcript CG32486-RD 0.016
CG5412 CG5412 gene product from transcript CG5412-RA 0.016
alpha-Spec alpha Spectrin 0.016
ttk tramtrack 0.015
Upf2 CG2253 gene product from transcript CG2253-RA 0.015
insc inscuteable 0.015
nero CG2245 gene product from transcript CG2245-RA 0.015
Kap-alpha3 karyopherin alpha3 0.015
if inflated 0.014
dbr debra 0.014
hdc headcase 0.013
CG31120 CG31120 gene product from transcript CG31120-RB 0.013
ci cubitus interruptus 0.013
Hr39 Hormone receptor-like in 39 0.013
hipk homeodomain interacting protein kinase 0.013
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2L1 BCL2-like 1 0.993
ACTB actin, beta 0.984
FHL2 four and a half LIM domains 2 0.983
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.946
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.927
S100A6 S100 calcium binding protein A6 0.899
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.889
SFN stratifin 0.828
ITGB4 integrin, beta 4 0.788
SNAP23 synaptosomal-associated protein, 23kDa 0.775
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.756
FLNA filamin A, alpha 0.753
FLOT2 flotillin 2 0.745
KRT6B keratin 6B 0.732
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.715
KRT14 keratin 14 0.679
S100A9 S100 calcium binding protein A9 0.621
BCL2 B-cell CLL/lymphoma 2 0.613
RAB5A RAB5A, member RAS oncogene family 0.581
FN1 fibronectin 1 0.563
S100B S100 calcium binding protein B 0.550
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.542
S100A8 S100 calcium binding protein A8 0.534
EXOC7 exocyst complex component 7 0.529
DSP desmoplakin 0.516
APC adenomatous polyposis coli 0.484
EHD1 EH-domain containing 1 0.482
PXN paxillin 0.460
IER3 immediate early response 3 0.439
S100A1 S100 calcium binding protein A1 0.413
ANXA2 annexin A2 0.403
PTPRC protein tyrosine phosphatase, receptor type, C 0.386
KRT8 keratin 8 0.383
CTNND1 catenin (cadherin-associated protein), delta 1 0.379
BBS4 Bardet-Biedl syndrome 4 0.374
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.360
FLOT1 flotillin 1 0.351
DSG2 desmoglein 2 0.350
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.349
BAK1 BCL2-antagonist/killer 1 0.347
SNAP25 synaptosomal-associated protein, 25kDa 0.347
PSEN2 presenilin 2 (Alzheimer disease 4) 0.344
LMNA lamin A/C 0.329
EXOC4 exocyst complex component 4 0.313
ZYX zyxin 0.288
KRT6A keratin 6A 0.276
CD63 CD63 molecule 0.274
MARK3 MAP/microtubule affinity-regulating kinase 3 0.263
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.262
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.247
NCF4 neutrophil cytosolic factor 4, 40kDa 0.243
GDA guanine deaminase 0.242
LCK lymphocyte-specific protein tyrosine kinase 0.240
KLHL3 kelch-like 3 (Drosophila) 0.235
SORBS3 sorbin and SH3 domain containing 3 0.233
S100A4 S100 calcium binding protein A4 0.230
S100A11 S100 calcium binding protein A11 0.223
BAD BCL2-associated agonist of cell death 0.218
PLEC plectin 0.217
LGALS1 lectin, galactoside-binding, soluble, 1 0.213
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.205
KIAA1377 KIAA1377 0.203
IGF1R insulin-like growth factor 1 receptor 0.202
PTK2B PTK2B protein tyrosine kinase 2 beta 0.199
JUP junction plakoglobin 0.194
KRT15 keratin 15 0.190
SMO smoothened homolog (Drosophila) 0.176
NCF1 neutrophil cytosolic factor 1 0.174
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.172
PSEN1 presenilin 1 0.164
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.162
KRT5 keratin 5 0.159
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.159
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.156
STX6 syntaxin 6 0.154
RAB1A RAB1A, member RAS oncogene family 0.153
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.152
AHNAK AHNAK nucleoprotein 0.152
LMAN1 lectin, mannose-binding, 1 0.151
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.149
EPS8 epidermal growth factor receptor pathway substrate 8 0.148
NOXA1 NADPH oxidase activator 1 0.146
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.143
HTT huntingtin 0.139
EFNA5 ephrin-A5 0.137
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.136
FLNB filamin B, beta 0.135
EXOC8 exocyst complex component 8 0.134
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.132
BAX BCL2-associated X protein 0.131
CYTH1 cytohesin 1 0.129
PKP3 plakophilin 3 0.127
ENG endoglin 0.125
ALDOB aldolase B, fructose-bisphosphate 0.123
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.123
EXOC1 exocyst complex component 1 0.121
RANBP9 RAN binding protein 9 0.118
EMP3 epithelial membrane protein 3 0.116
BBS1 Bardet-Biedl syndrome 1 0.116
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.115
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Mus musculus
Name Description Probability Func Analog Organism
Lama5 laminin, alpha 5 0.950
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.893
Cd151 CD151 antigen 0.681
Vegfa vascular endothelial growth factor A 0.607
Ptrf polymerase I and transcript release factor 0.556
Rarg retinoic acid receptor, gamma 0.515
Lhx1 LIM homeobox protein 1 0.496
Itga3 integrin alpha 3 0.452
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.367
Hbb-b1 hemoglobin, beta adult major chain 0.331
Vhl von Hippel-Lindau tumor suppressor 0.264
Krt8 keratin 8 0.253
Nrxn1 neurexin I 0.248
Bcl2 B-cell leukemia/lymphoma 2 0.243
Ilk integrin linked kinase 0.232
Nrxn3 neurexin III 0.224
Fgf8 fibroblast growth factor 8 0.211
Ctnnd1 catenin (cadherin associated protein), delta 1 0.174
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.170
Nphs2 nephrosis 2 homolog, podocin (human) 0.148
Fgfr1 fibroblast growth factor receptor 1 0.141
Col4a3 collagen, type IV, alpha 3 0.136
S100a11 S100 calcium binding protein A11 (calgizzarin) 0.135
Ldb3 LIM domain binding 3 0.134
Add2 adducin 2 (beta) 0.131
Krt19 keratin 19 0.130
Nrxn2 neurexin II 0.128
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.122
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.117
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.112
Lmx1b LIM homeobox transcription factor 1 beta 0.112
Ctnnb1 catenin (cadherin associated protein), beta 1 0.110
Flii flightless I homolog (Drosophila) 0.106
Kif3a kinesin family member 3A 0.104
Shh sonic hedgehog 0.103
Add1 adducin 1 (alpha) 0.100
Stx7 syntaxin 7 0.099
Lmna lamin A 0.099
Gsk3b glycogen synthase kinase 3 beta 0.096
Myo1c myosin IC 0.095
Ppl periplakin 0.092
Ehd4 EH-domain containing 4 0.086
Gdnf glial cell line derived neurotrophic factor 0.085
S100a6 S100 calcium binding protein A6 (calcyclin) 0.084
Tsc1 tuberous sclerosis 1 0.079
Clasp1 CLIP associating protein 1 0.079
L1cam L1 cell adhesion molecule 0.078
Spnb2 spectrin beta 2 0.077
Gja1 gap junction protein, alpha 1 0.077
Cldn7 claudin 7 0.077
Capn2 calpain 2 0.075
Fjx1 four jointed box 1 (Drosophila) 0.071
Capn1 calpain 1 0.071
Nf2 neurofibromatosis 2 0.070
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.067
Bmp7 bone morphogenetic protein 7 0.066
Anxa2 annexin A2 0.066
Rrm2b ribonucleotide reductase M2 B (TP53 inducible) 0.066
Nos3 nitric oxide synthase 3, endothelial cell 0.065
Krt7 keratin 7 0.065
Mark4 MAP/microtubule affinity-regulating kinase 4 0.063
Ptprb protein tyrosine phosphatase, receptor type, B 0.063
Rras Harvey rat sarcoma oncogene, subgroup R 0.063
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.063
Fgfr2 fibroblast growth factor receptor 2 0.062
Ctnna1 catenin (cadherin associated protein), alpha 1 0.062
Wfdc2 WAP four-disulfide core domain 2 0.061
Zfp651 zinc finger protein 651 0.058
Itga6 integrin alpha 6 0.057
Dlg4 discs, large homolog 4 (Drosophila) 0.057
Capns1 calpain, small subunit 1 0.055
Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome 0.054
Lamc1 laminin, gamma 1 0.054
Flot2 flotillin 2 0.054
Spint1 serine protease inhibitor, Kunitz type 1 0.052
Smtn smoothelin 0.052
Nos1 nitric oxide synthase 1, neuronal 0.052
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.052
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.051
Cldn3 claudin 3 0.051
Wnt4 wingless-related MMTV integration site 4 0.050
Egln1 EGL nine homolog 1 (C. elegans) 0.049
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.047
Wbp2 WW domain binding protein 2 0.047
Crb3 crumbs homolog 3 (Drosophila) 0.046
Akt2 thymoma viral proto-oncogene 2 0.045
Flot1 flotillin 1 0.045
Fbln1 fibulin 1 0.045
Dmd dystrophin, muscular dystrophy 0.044
Ap2a1 adaptor protein complex AP-2, alpha 1 subunit 0.044
Wasf2 WAS protein family, member 2 0.044
Lamb2 laminin, beta 2 0.044
Spnb1 spectrin beta 1 0.044
Rbl2 retinoblastoma-like 2 0.044
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.043
Apc2 adenomatosis polyposis coli 2 0.043
Hif1a hypoxia inducible factor 1, alpha subunit 0.043
Spna1 spectrin alpha 1 0.042
Ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 0.042
Sypl synaptophysin-like protein 0.042
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GCS1 Gcs1p 0.031
SSO1 Sso1p 0.019
SEC1 Sec1p 0.017
YPT6 Ypt6p 0.017
YPT31 Ypt31p 0.016
YIP3 Yip3p 0.016
KES1 Kes1p 0.014
LSP1 Lsp1p 0.013
YPT7 Ypt7p 0.012
MSO1 Mso1p 0.012
CNB1 Cnb1p 0.012
SSO2 Sso2p 0.011
YPT10 Ypt10p 0.011
SNC2 Snc2p 0.011
SLG1 Slg1p 0.010
YKT6 Ykt6p 0.010