The network for 'ph reduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ph reduction

Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.

Danio rerio
Name Description Probability Func Analog Organism
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.660
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.536
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.387
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.283
cx27.5 connexin 27.5 0.223
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.185
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.150
oxtl oxytocin-like 0.131
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.110
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.100
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.087
atp6v1f ATPase, H+ transporting, V1 subunit F 0.086
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.081
sox11b SRY-box containing gene 11b 0.080
gh1 growth hormone 1 0.077
mmp9 matrix metalloproteinase 9 0.069
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.069
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.066
map1lc3a microtubule-associated protein 1 light chain 3 alpha 0.057
nr2f6b nuclear receptor subfamily 2, group F, member 6b 0.056
ckbb creatine kinase, brain b 0.056
ndfip1 Nedd4 family interacting protein 1 0.052
ctsf cathepsin F 0.051
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.051
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.051
sst3 somatostatin 3 0.050
uts1 urotensin 1 0.048
zeb1 zinc finger E-box binding homeobox 1 0.048
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.046
cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.045
sh3gl2 SH3-domain GRB2-like 2 0.044
cdh23 cadherin-like 23 0.044
zgc:136878 zgc:136878 0.043
esr1 estrogen receptor 1 0.040
ptmaa prothymosin, alpha a 0.040
copb2 coatomer protein complex, subunit beta 2 0.038
calm2a calmodulin 2a (phosphorylase kinase, delta) 0.037
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.035
calm1a calmodulin 1a 0.034
prox1 prospero-related homeobox gene 1 0.034
si:ch211-170d8.2 si:ch211-170d8.2 0.034
slc45a2 solute carrier family 45, member 2 0.033
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.032
zgc:100919 zgc:100919 0.031
dusp2 dual specificity phosphatase 2 0.031
ap2m1a adaptor-related protein complex 2, mu 1 subunit, a 0.031
ca2 carbonic anhydrase II 0.031
cldnh claudin h 0.031
ca15a carbonic anhydrase XV a 0.030
clstn1 calsyntenin 1 0.029
lhx6 LIM homeobox 6 0.029
gabarapa GABA(A) receptor-associated protein a 0.029
pvalb8 parvalbumin 8 0.029
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.029
angptl2 angiopoietin-like 2 0.028
slc4a2b solute carrier family 4, anion exchanger, member 2b 0.028
stc1l stanniocalcin 1, like 0.027
ctsz cathepsin Z 0.027
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.026
mpx myeloid-specific peroxidase 0.026
dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.025
macf1 microtubule-actin crosslinking factor 1 0.025
atp6v1c1b ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b 0.025
snx4 sorting nexin 4 0.024
rhcgb Rhesus blood group, C glycoprotein b 0.024
zgc:123177 zgc:123177 0.024
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.024
opn1lw1 opsin 1 (cone pigments), long-wave-sensitive, 1 0.023
acsl4a acyl-CoA synthetase long-chain family member 4a 0.023
acadl acyl-Coenzyme A dehydrogenase, long chain 0.023
snx5 sorting nexin 5 0.023
gnrh3 gonadotropin-releasing hormone 3 0.023
sdf4 stromal cell derived factor 4 0.023
si:ch211-209p5.2 si:ch211-209p5.2 0.023
LOC555482 tachykinin receptor 3-like 0.023
nt5c2l1 5'-nucleotidase, cytosolic II, like 1 0.023
prnprs3 prion protein, related sequence 3 0.023
gfra1a gdnf family receptor alpha 1a 0.022
tcea2 transcription elongation factor A (SII), 2 0.022
pak1 p21/Cdc42/Rac1-activated kinase 1 0.022
slc39a1 solute carrier family 39 (zinc transporter), member 1 0.022
selt2 selenoprotein T, 2 0.022
dnase1l3 deoxyribonuclease I-like 3 0.022
ctsd cathepsin D 0.021
rnaseka ribonuclease, RNase K a 0.021
kdm5bb lysine (K)-specific demethylase 5Bb 0.021
abca5 ATP-binding cassette, sub-family A (ABC1), member 5 0.021
hk1 hexokinase 1 0.021
atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.021
tert telomerase reverse transcriptase 0.021
abca1a ATP-binding cassette, sub-family A (ABC1), member 1A 0.020
chrm2a cholinergic receptor, muscarinic 2a 0.020
aqp7 aquaporin 7 0.020
esr2b estrogen receptor 2b 0.020
snx3 sorting nexin 3 0.020
si:dkey-228g21.4 si:dkey-228g21.4 0.020
pyya peptide YYa 0.019
sb:cb101 sb:cb101 0.019
alas2 aminolevulinate, delta-, synthetase 2 0.019
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vha-15 Protein VHA-15 0.074
vha-8 Protein VHA-8 0.042
CELE_R09B3.2 Protein R09B3.2 0.014
T27A3.1 Protein T27A3.1 0.013
nep-17 Protein NEP-17 0.013
ogdh-1 Protein OGDH-1 0.011
skr-1 Protein SKR-1 0.011
vha-16 Protein VHA-16 0.011
ctg-1 Protein CTG-1 0.010
idhb-1 Protein IDHB-1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Vha68-2 CG3762 gene product from transcript CG3762-RA 0.999
VhaAC39 Vacuolar H[+]-ATPase C39 subunit 0.975
Vha26 Vacuolar H[+]-ATPase 26kD E subunit 0.967
VhaSFD Vacuolar H[+]-ATPase SFD subunit 0.960
Rab7 Rab-protein 7 0.750
Vha55 Vacuolar H[+]-ATPase 55kD B subunit 0.579
Rab2 Rab-protein 2 0.558
Vha100-2 CG18617 gene product from transcript CG18617-RB 0.481
Rbcn-3A Rabconnectin-3A 0.457
Rab14 Rab-protein 14 0.446
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.278
Vha16 Vacuolar H[+] ATPase 16kD subunit 0.226
Rab6 Rab-protein 6 0.213
Rbcn-3B Rabconnectin-3B 0.172
CG14767 CG14767 gene product from transcript CG14767-RA 0.112
VhaPPA1-1 CG7007 gene product from transcript CG7007-RA 0.104
CG9990 CG9990 gene product from transcript CG9990-RA 0.082
VhaM8.9 CG8444 gene product from transcript CG8444-RA 0.080
Oat Ornithine aminotransferase precursor 0.073
CG12004 CG12004 gene product from transcript CG12004-RC 0.066
Lmpt Limpet 0.052
kar karmoisin 0.045
CG42863 CG42863 gene product from transcript CG42863-RB 0.039
rogdi CG7725 gene product from transcript CG7725-RB 0.035
Vha14 Vacuolar H[+] ATPase 14kD subunit 0.025
CG9947 CG9947 gene product from transcript CG9947-RA 0.025
galectin CG11372 gene product from transcript CG11372-RA 0.025
nahoda CG12781 gene product from transcript CG12781-RA 0.022
CG8974 CG8974 gene product from transcript CG8974-RD 0.022
VhaM9.7-2 CG7625 gene product from transcript CG7625-RA 0.021
Treh Trehalase 0.018
CG9977 CG9977 gene product from transcript CG9977-RA 0.017
CG6439 CG6439 gene product from transcript CG6439-RA 0.016
Clic Chloride intracellular channel 0.015
Pis Phosphatidylinositol synthase 0.014
Rab39 CG12156 gene product from transcript CG12156-RA 0.014
Fer2LCH Ferritin 2 light chain homologue 0.014
Idh Isocitrate dehydrogenase 0.014
CG8029 CG8029 gene product from transcript CG8029-RB 0.014
CanB Calcineurin B 0.013
sda slamdance 0.012
CG3961 CG3961 gene product from transcript CG3961-RC 0.012
CG14629 CG14629 gene product from transcript CG14629-RA 0.012
CG7272 CG7272 gene product from transcript CG7272-RA 0.011
CG42542 CG42542 gene product from transcript CG42542-RE 0.010
CG32486 CG32486 gene product from transcript CG32486-RD 0.010
CG30344 CG30344 gene product from transcript CG30344-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.983
BCL2L1 BCL2-like 1 0.951
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.266
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.156
RAB5A RAB5A, member RAS oncogene family 0.114
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.068
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.065
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.054
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.052
CTSA cathepsin A 0.052
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.047
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.037
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.031
NAGK N-acetylglucosamine kinase 0.022
GOLGA2 golgin A2 0.019
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.017
BAK1 BCL2-antagonist/killer 1 0.017
OCRL oculocerebrorenal syndrome of Lowe 0.016
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.015
BTRC beta-transducin repeat containing 0.015
RAB1A RAB1A, member RAS oncogene family 0.014
NEU1 sialidase 1 (lysosomal sialidase) 0.014
RNR2 l-rRNA 0.014
LAMP1 lysosomal-associated membrane protein 1 0.013
EEA1 early endosome antigen 1 0.013
RNF144B ring finger protein 144B 0.012
ATF2 activating transcription factor 2 0.011
CTSD cathepsin D 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.125
Ank1 ankyrin 1, erythroid 0.048
Hbb-b1 hemoglobin, beta adult major chain 0.041
Tmprss6 transmembrane serine protease 6 0.024
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.023
Bax BCL2-associated X protein 0.023
Tfrc transferrin receptor 0.017
Pcsk4 proprotein convertase subtilisin/kexin type 4 0.016
Spnb1 spectrin beta 1 0.016
Pklr pyruvate kinase liver and red blood cell 0.015
Spna1 spectrin alpha 1 0.014
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.014
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.012
Uros uroporphyrinogen III synthase 0.011
Vamp2 vesicle-associated membrane protein 2 0.011
Klf1 Kruppel-like factor 1 (erythroid) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VMA1 Vma1p 0.284
VMA13 Vma13p 0.212
VMA4 Vma4p 0.137
MOB1 Mob1p 0.041
PEP3 Pep3p 0.030
VMA7 Vma7p 0.025
TLG2 Tlg2p 0.022
RRG8 Rrg8p 0.020
GTR1 Gtr1p 0.020
VMA8 Vma8p 0.019
VMA6 Vma6p 0.019
KIC1 Kic1p 0.017
VPH2 Vph2p 0.016
CDC53 Cdc53p 0.016
CNB1 Cnb1p 0.015
SPO12 Spo12p 0.014
VPS8 Vps8p 0.014
INP52 Inp52p 0.014
CTF13 Ctf13p 0.014
RRI1 Rri1p 0.013
SEC1 Sec1p 0.013
PEP7 Pep7p 0.013
SYS1 Sys1p 0.013
IML1 Iml1p 0.013
VAM6 Vam6p 0.013
SRD1 Srd1p 0.012
COT1 Cot1p 0.012
VMA5 Vma5p 0.012
IRC19 Irc19p 0.012
VPS60 Vps60p 0.012
ARP10 Arp10p 0.012
PCI8 Pci8p 0.011
LEU2 Leu2p 0.011
YPT10 Ypt10p 0.011
ALD6 Ald6p 0.011
CUP1-1 Cup1-1p 0.011
YOL038C-A hypothetical protein 0.011
SNF7 Snf7p 0.011
NEO1 Neo1p 0.011
TOR1 Tor1p 0.011
YLR162W hypothetical protein 0.011
CHZ1 Chz1p 0.011
FZO1 Fzo1p 0.011
SFT1 Sft1p 0.010
YLR264C-A hypothetical protein 0.010
ICS2 Ics2p 0.010
WSC4 Wsc4p 0.010
PAR32 Par32p 0.010
MER1 Mer1p 0.010
BUD5 Bud5p 0.010
VPS29 Vps29p 0.010
SMF2 Smf2p 0.010