Homo sapiens

267 known processes

TLR4

toll-like receptor 4

(Aliases: TOLL,CD284,hToll,ARMD10)

TLR4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to bacterial lipoprotein GO:0071220 3 1.000
Human
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 1.000
Human
positive regulation of toll like receptor 4 signaling pathway GO:0034145 6 1.000
positive regulation of toll like receptor signaling pathway GO:0034123 10 0.999
Human
cellular response to bacterial lipopeptide GO:0071221 3 0.997
Human
response to bacterial lipopeptide GO:0070339 3 0.990
Human
detection of lipopolysaccharide GO:0032497 3 0.980
response to diacyl bacterial lipopeptide GO:0071724 2 0.979
Human
activation of innate immune response GO:0002218 55 0.979
response to molecule of bacterial origin GO:0002237 82 0.978
cellular response to triacyl bacterial lipopeptide GO:0071727 2 0.978
Human
response to triacyl bacterial lipopeptide GO:0071725 2 0.976
Human
response to lipid GO:0033993 206 0.975
detection of molecule of bacterial origin GO:0032490 10 0.962
negative regulation of growth of symbiont in host GO:0044130 1 0.958
response to lipopolysaccharide GO:0032496 70 0.952
response to bacterial lipoprotein GO:0032493 3 0.951
Human
response to other organism GO:0051707 261 0.941
detection of chemical stimulus GO:0009593 55 0.937
response to biotic stimulus GO:0009607 276 0.935
cellular response to oxygen containing compound GO:1901701 276 0.919
regulation of chemokine production GO:0032642 31 0.904
positive regulation of response to external stimulus GO:0032103 88 0.894
Human Rat
detection of diacyl bacterial lipopeptide GO:0042496 2 0.888
Human
activation of immune response GO:0002253 114 0.887
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.878
innate immune response activating signal transduction GO:0002758 48 0.877
positive regulation of toll like receptor 2 signaling pathway GO:0034137 2 0.846
cytokine production GO:0001816 247 0.833
cellular response to molecule of bacterial origin GO:0071219 62 0.830
regulation of response to external stimulus GO:0032101 222 0.830
Human Mouse Rat
positive regulation of chemokine production GO:0032722 22 0.827
cellular response to biotic stimulus GO:0071216 71 0.823
detection of biotic stimulus GO:0009595 21 0.822
positive regulation of defense response GO:0031349 87 0.815
growth of symbiont involved in interaction with host GO:0044116 2 0.815
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.797
positive regulation of cytokine production GO:0001819 167 0.748
chemokine production GO:0032602 32 0.744
defense response GO:0006952 315 0.744
Human Mouse Rat
detection of bacterial lipoprotein GO:0042494 3 0.741
Human
interferon alpha biosynthetic process GO:0045349 4 0.726
Human
regulation of multi organism process GO:0043900 157 0.706
Human
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.695
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.669
growth of symbiont in host GO:0044117 1 0.655
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.655
interleukin 17 production GO:0032620 12 0.654
Mouse
immune response activating signal transduction GO:0002757 90 0.647
chemokine metabolic process GO:0050755 4 0.645
response to external biotic stimulus GO:0043207 261 0.638
chemokine biosynthetic process GO:0042033 4 0.636
positive regulation of interleukin 6 production GO:0032755 21 0.632
toll like receptor signaling pathway GO:0002224 25 0.626
Human Rat
cellular response to lipopolysaccharide GO:0071222 57 0.600
response to lipoteichoic acid GO:0070391 3 0.585
Mouse
positive regulation of interleukin 17 production GO:0032740 8 0.584
positive regulation of immune system process GO:0002684 283 0.580
positive regulation of interleukin 8 production GO:0032757 36 0.576
regulation of chemokine biosynthetic process GO:0045073 4 0.567
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.562
pattern recognition receptor signaling pathway GO:0002221 48 0.559
regulation of toll like receptor 2 signaling pathway GO:0034135 2 0.551
immune response regulating signaling pathway GO:0002764 97 0.531
i kappab phosphorylation GO:0007252 7 0.524
cellular response to lipid GO:0071396 127 0.497
toll like receptor 4 signaling pathway GO:0034142 12 0.496
response to bacterium GO:0009617 144 0.490
detection of stimulus GO:0051606 85 0.490
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.483
regulation of response to biotic stimulus GO:0002831 55 0.482
Human
growth involved in symbiotic interaction GO:0044110 2 0.482
regulation of innate immune response GO:0045088 97 0.462
cytokine mediated signaling pathway GO:0019221 109 0.447
interleukin 6 production GO:0032635 37 0.443
response to oxygen containing compound GO:1901700 369 0.413
regulation of interferon beta biosynthetic process GO:0045357 4 0.403
Human Mouse
detection of bacterial lipopeptide GO:0070340 3 0.397
Human
regulation of toll like receptor signaling pathway GO:0034121 17 0.383
Human
positive regulation of immune response GO:0050778 159 0.380
cytokine biosynthetic process GO:0042089 37 0.361
positive regulation of interleukin 23 production GO:0032747 4 0.346
response to cytokine GO:0034097 232 0.345
regulation of cytokine biosynthetic process GO:0042035 35 0.338
cellular response to diacyl bacterial lipopeptide GO:0071726 2 0.332
Human
i kappab kinase nf kappab signaling GO:0007249 166 0.331
positive regulation of chemokine biosynthetic process GO:0045080 3 0.327
positive regulation of innate immune response GO:0045089 79 0.318
toll like receptor 2 signaling pathway GO:0034134 4 0.317
regulation of tumor necrosis factor production GO:0032680 43 0.302
regulation of interleukin 17 production GO:0032660 12 0.295
Mouse
cellular response to cytokine stimulus GO:0071345 181 0.291
immune response GO:0006955 307 0.288
Human Mouse Rat
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.287
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.261
myeloid cell differentiation GO:0030099 117 0.260
positive regulation of cytokine biosynthetic process GO:0042108 25 0.257
positive regulation of chemotaxis GO:0050921 57 0.243
detection of triacyl bacterial lipopeptide GO:0042495 2 0.238
Human
regulation of interleukin 6 production GO:0032675 37 0.217
regulation of growth of symbiont in host GO:0044126 1 0.204
regulation of stress activated mapk cascade GO:0032872 84 0.187
Human Mouse
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.186
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.186
positive regulation of tumor necrosis factor production GO:0032760 21 0.181
defense response to bacterium GO:0042742 63 0.181
Mouse
positive regulation of locomotion GO:0040017 186 0.178
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.176
Human Mouse
regulation of kinase activity GO:0043549 314 0.173
Human Mouse
regulation of granulocyte chemotaxis GO:0071622 16 0.170
innate immune response GO:0045087 178 0.165
Human Mouse Rat
hematopoietic or lymphoid organ development GO:0048534 186 0.164
negative regulation of multicellular organismal process GO:0051241 317 0.161
Mouse
3 utr mediated mrna stabilization GO:0070935 8 0.160
positive regulation of leukocyte activation GO:0002696 80 0.158
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.152
Mouse
positive regulation of toll like receptor 3 signaling pathway GO:0034141 1 0.148
tumor necrosis factor production GO:0032640 43 0.147
myd88 independent toll like receptor signaling pathway GO:0002756 2 0.145
immune effector process GO:0002252 159 0.140
Human Mouse Rat
leukocyte proliferation GO:0070661 74 0.140
Mouse
regulation of lymphocyte proliferation GO:0050670 64 0.130
Mouse
regulation of cytokine production GO:0001817 232 0.128
positive regulation of response to biotic stimulus GO:0002833 18 0.127
Human
regulation of lymphocyte activation GO:0051249 103 0.127
Mouse
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.125
rna stabilization GO:0043489 18 0.125
regulation of cellular response to stress GO:0080135 244 0.124
Human Mouse
cellular response to mechanical stimulus GO:0071260 39 0.118
cell activation GO:0001775 213 0.117
regulation of locomotion GO:0040012 329 0.115
positive regulation of map kinase activity GO:0043406 80 0.114
Human Mouse
defense response to other organism GO:0098542 129 0.111
Human Mouse
jnk cascade GO:0007254 80 0.111
Human Mouse
response to virus GO:0009615 126 0.109
Human
defense response to virus GO:0051607 71 0.108
Human
response to fungus GO:0009620 4 0.106
positive regulation of transport GO:0051050 336 0.105
regulation of binding GO:0051098 111 0.105
Rat
cell chemotaxis GO:0060326 112 0.104
regulation of chemotaxis GO:0050920 74 0.104
regulation of cell migration GO:0030334 289 0.101
posttranscriptional regulation of gene expression GO:0010608 213 0.101
positive regulation of kinase activity GO:0033674 204 0.101
Human Mouse
regulation of rna stability GO:0043487 23 0.100
positive regulation of protein phosphorylation GO:0001934 313 0.097
Human Mouse Rat
regulation of mononuclear cell proliferation GO:0032944 65 0.093
Mouse
organophosphate catabolic process GO:0046434 430 0.092
regulation of protein serine threonine kinase activity GO:0071900 179 0.092
Human Mouse
positive regulation of granulocyte chemotaxis GO:0071624 9 0.087
protein localization to organelle GO:0033365 280 0.086
regulation of cytokine mediated signaling pathway GO:0001959 41 0.086
response to peptidoglycan GO:0032494 3 0.085
antifungal humoral response GO:0019732 2 0.082
positive regulation of intracellular transport GO:0032388 104 0.082
interspecies interaction between organisms GO:0044419 156 0.081
regulation of transferase activity GO:0051338 355 0.079
Human Mouse
cytoplasmic transport GO:0016482 379 0.079
negative regulation of multi organism process GO:0043901 92 0.076
regulation of defense response GO:0031347 154 0.076
regulation of interferon alpha biosynthetic process GO:0045354 4 0.074
Human
cellular amine metabolic process GO:0044106 41 0.074
leukocyte activation GO:0045321 164 0.072
regulation of protein kinase activity GO:0045859 289 0.071
Human Mouse
amine metabolic process GO:0009308 44 0.071
positive regulation of cell proliferation GO:0008284 301 0.070
Mouse
response to abiotic stimulus GO:0009628 336 0.069
regulation of jnk cascade GO:0046328 73 0.068
Human Mouse
chemotaxis GO:0006935 157 0.067
type i interferon production GO:0032606 27 0.067
Human Mouse
positive regulation of leukocyte chemotaxis GO:0002690 38 0.067
regulation of intracellular transport GO:0032386 195 0.066
leukocyte migration GO:0050900 107 0.066
positive regulation of phosphorylation GO:0042327 394 0.066
Human Mouse Rat
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.064
mrna stabilization GO:0048255 18 0.063
regulation of cell motility GO:2000145 299 0.063
regulation of nucleotide metabolic process GO:0006140 269 0.063
positive regulation of cellular component movement GO:0051272 181 0.058
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.057
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.056
taxis GO:0042330 157 0.056
hemopoiesis GO:0030097 180 0.055
nucleotide catabolic process GO:0009166 408 0.055
mapk cascade GO:0000165 288 0.055
Human Mouse
defense response to gram positive bacterium GO:0050830 29 0.055
regulation of mrna stability GO:0043488 23 0.054
interleukin 8 production GO:0032637 51 0.054
positive regulation of protein kinase activity GO:0045860 190 0.054
Human Mouse
response to wounding GO:0009611 168 0.054
Mouse Rat
chemokine c x c motif ligand 2 production GO:0072567 3 0.053
regulation of interleukin 8 production GO:0032677 49 0.053
negative regulation of immune system process GO:0002683 136 0.053
regulation of antimicrobial humoral response GO:0002759 1 0.053
negative regulation of chemokine production GO:0032682 9 0.050
nucleoside phosphate catabolic process GO:1901292 412 0.050
positive regulation of lymphocyte proliferation GO:0050671 46 0.049
Mouse
adaptive immune response GO:0002250 49 0.049
Rat
regulation of cellular amine metabolic process GO:0033238 11 0.049
immune system development GO:0002520 195 0.049
stress activated mapk cascade GO:0051403 93 0.049
Human Mouse
regulation of neutrophil chemotaxis GO:0090022 10 0.048
lymphocyte mediated immunity GO:0002449 48 0.048
Rat
defense response to fungus GO:0050832 4 0.048
negative regulation of cytokine production GO:0001818 82 0.048
Mouse
protein ubiquitination GO:0016567 314 0.047
positive regulation of mononuclear cell proliferation GO:0032946 47 0.047
Mouse
positive regulation of cell activation GO:0050867 81 0.046
Mouse
nitrogen compound transport GO:0071705 191 0.046
signal transduction by phosphorylation GO:0023014 297 0.046
Human Mouse
cellular ketone metabolic process GO:0042180 80 0.046
regulation of intracellular protein transport GO:0033157 123 0.046
ribonucleoside catabolic process GO:0042454 406 0.046
erk1 and erk2 cascade GO:0070371 104 0.046
Mouse
regulation of response to cytokine stimulus GO:0060759 46 0.045
regulation of leukocyte chemotaxis GO:0002688 46 0.045
purine nucleotide catabolic process GO:0006195 405 0.045
growth GO:0040007 202 0.045
myeloid leukocyte migration GO:0097529 62 0.045
neutrophil chemotaxis GO:0030593 24 0.044
organophosphate biosynthetic process GO:0090407 163 0.043
negative regulation of growth GO:0045926 97 0.043
purine nucleoside triphosphate metabolic process GO:0009144 412 0.043
stress activated protein kinase signaling cascade GO:0031098 94 0.043
Human Mouse
epithelial cell differentiation GO:0030855 141 0.043
regulation of protein import into nucleus GO:0042306 78 0.042
granulocyte migration GO:0097530 40 0.042
regulation of immune response GO:0050776 201 0.041
multicellular organismal aging GO:0010259 3 0.040
positive regulation of response to cytokine stimulus GO:0060760 13 0.040
protein targeting GO:0006605 187 0.040
positive regulation of nucleotide metabolic process GO:0045981 230 0.040
regulation of cytoplasmic transport GO:1903649 149 0.040
g protein coupled receptor signaling pathway GO:0007186 207 0.040
detection of external biotic stimulus GO:0098581 19 0.039
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.039
nucleoside triphosphate metabolic process GO:0009141 422 0.039
interleukin 6 biosynthetic process GO:0042226 5 0.038
regulation of leukocyte activation GO:0002694 115 0.038
Mouse
positive regulation of antimicrobial humoral response GO:0002760 1 0.038
regulation of inflammatory response GO:0050727 46 0.038
Mouse Rat
epithelium development GO:0060429 227 0.038
lymphocyte activation GO:0046649 133 0.037
Mouse
regulation of cellular component movement GO:0051270 334 0.037
b cell activation GO:0042113 33 0.037
Mouse
cell adhesion GO:0007155 325 0.037
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.036
leukocyte chemotaxis GO:0030595 76 0.035
regulation of mapk cascade GO:0043408 262 0.035
Human Mouse
positive regulation of cell motility GO:2000147 177 0.035
regulation of behavior GO:0050795 82 0.035
negative regulation of phosphate metabolic process GO:0045936 267 0.035
Mouse
positive regulation of lymphocyte activation GO:0051251 73 0.035
Mouse
protein autophosphorylation GO:0046777 123 0.035
regulation of leukocyte proliferation GO:0070663 67 0.035
Mouse
positive regulation of multi organism process GO:0043902 56 0.035
Human
purine ribonucleoside metabolic process GO:0046128 437 0.034
protein catabolic process GO:0030163 325 0.034
nuclear transport GO:0051169 179 0.034
positive regulation of cellular catabolic process GO:0031331 284 0.034
regulation of protein transport GO:0051223 213 0.033
cellular response to dna damage stimulus GO:0006974 379 0.033
cytokine metabolic process GO:0042107 38 0.033
regulation of type i interferon production GO:0032479 26 0.033
Human Mouse
regulation of proteolysis GO:0030162 293 0.032
regulation of cellular ketone metabolic process GO:0010565 50 0.032
regulation of establishment of protein localization GO:0070201 242 0.031
segmentation GO:0035282 4 0.031
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.031
regulation of purine nucleotide metabolic process GO:1900542 264 0.031
positive regulation of immune effector process GO:0002699 40 0.031
Mouse
positive regulation of protein transport GO:0051222 135 0.031
positive regulation of leukocyte proliferation GO:0070665 48 0.030
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.030
positive regulation of interleukin 12 production GO:0032735 8 0.030
establishment of endothelial barrier GO:0061028 16 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.029
response to interleukin 1 GO:0070555 47 0.029
wound healing GO:0042060 115 0.029
Mouse
negative regulation of phosphorus metabolic process GO:0010563 267 0.029
Mouse
activation of protein kinase activity GO:0032147 90 0.029
Mouse
purine containing compound catabolic process GO:0072523 411 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
ribonucleoside triphosphate metabolic process GO:0009199 412 0.028
positive regulation of b cell proliferation GO:0030890 12 0.028
Mouse
negative regulation of toll like receptor 4 signaling pathway GO:0034144 4 0.028
cellular metal ion homeostasis GO:0006875 146 0.028
response to nitrogen compound GO:1901698 184 0.028
Rat
ribonucleoside triphosphate catabolic process GO:0009203 391 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
interferon gamma production GO:0032609 39 0.027
Human Mouse
nucleotide biosynthetic process GO:0009165 109 0.027
protein maturation GO:0051604 233 0.027
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.026
Human Mouse
positive regulation of mapk cascade GO:0043410 190 0.026
Human Mouse
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.026
Human
cellular amino acid metabolic process GO:0006520 116 0.026
positive regulation of cell migration GO:0030335 172 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
positive regulation of catabolic process GO:0009896 310 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
cellular protein catabolic process GO:0044257 261 0.024
system process GO:0003008 349 0.024
Mouse Rat
regulation of transcription factor import into nucleus GO:0042990 39 0.024
regulation of toll like receptor 3 signaling pathway GO:0034139 2 0.024
positive regulation of tumor necrosis factor biosynthetic process GO:0042535 5 0.024
cellular ion homeostasis GO:0006873 168 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
positive regulation of leukocyte migration GO:0002687 46 0.023
post embryonic development GO:0009791 2 0.023
purine ribonucleotide catabolic process GO:0009154 404 0.023
regulation of interferon beta production GO:0032648 22 0.023
Human Mouse
purine ribonucleoside catabolic process GO:0046130 398 0.023
response to organonitrogen compound GO:0010243 156 0.023
Rat
ribonucleotide catabolic process GO:0009261 405 0.023
establishment of protein localization to organelle GO:0072594 172 0.022
gtp catabolic process GO:0006184 237 0.022
toll signaling pathway GO:0008063 2 0.022
cation homeostasis GO:0055080 189 0.022
protein processing GO:0016485 226 0.022
positive regulation of neutrophil migration GO:1902624 7 0.022
positive regulation of proteolysis GO:0045862 142 0.022
protein import GO:0017038 130 0.021
circadian behavior GO:0048512 2 0.021
behavior GO:0007610 112 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
protein modification by small protein conjugation GO:0032446 342 0.021
regulation of cell activation GO:0050865 125 0.021
Mouse
positive regulation of humoral immune response GO:0002922 3 0.021
myeloid leukocyte activation GO:0002274 34 0.021
lymphocyte proliferation GO:0046651 70 0.021
Mouse
glycosyl compound catabolic process GO:1901658 413 0.021
mononuclear cell proliferation GO:0032943 71 0.021
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
interferon beta biosynthetic process GO:0045350 4 0.021
Human Mouse
locomotory behavior GO:0007626 1 0.020
organonitrogen compound biosynthetic process GO:1901566 200 0.020
positive regulation of apoptotic process GO:0043065 246 0.020
Rat
single organismal cell cell adhesion GO:0016337 148 0.020
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.020
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.020
cyclic nucleotide metabolic process GO:0009187 82 0.020
purine containing compound biosynthetic process GO:0072522 88 0.020
memory GO:0007613 3 0.020
positive regulation of nucleotide catabolic process GO:0030813 185 0.020
positive regulation of cellular amine metabolic process GO:0033240 7 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
regulation of gtp catabolic process GO:0033124 180 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
ameboidal type cell migration GO:0001667 135 0.019
cellular response to external stimulus GO:0071496 111 0.019
vesicle mediated transport GO:0016192 371 0.019
gtp metabolic process GO:0046039 239 0.019
positive regulation of interleukin 6 biosynthetic process GO:0045410 1 0.019
interleukin 12 production GO:0032615 15 0.019
positive regulation of type i interferon production GO:0032481 20 0.018
Human Mouse
nucleoside catabolic process GO:0009164 408 0.018
cellular cation homeostasis GO:0030003 163 0.018
positive regulation of jnk cascade GO:0046330 52 0.018
Human Mouse
female gamete generation GO:0007292 2 0.018
rhythmic behavior GO:0007622 2 0.018
inorganic ion transmembrane transport GO:0098660 231 0.018
regulation of immune effector process GO:0002697 91 0.018
Mouse
vasculature development GO:0001944 181 0.018
small molecule biosynthetic process GO:0044283 157 0.018
regulation of nucleotide catabolic process GO:0030811 205 0.018
positive regulation of gtpase activity GO:0043547 166 0.018
positive regulation of cell differentiation GO:0045597 211 0.018
steroid metabolic process GO:0008202 94 0.018
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
positive regulation of neutrophil chemotaxis GO:0090023 7 0.017
positive regulation of nf kappab import into nucleus GO:0042346 13 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
positive regulation of interferon alpha biosynthetic process GO:0045356 4 0.017
Human
regulation of b cell activation GO:0050864 24 0.017
Mouse
negative regulation of hydrolase activity GO:0051346 182 0.017
interferon gamma biosynthetic process GO:0042095 8 0.017
Human
neutrophil migration GO:1990266 25 0.017
nervous system development GO:0007399 293 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
nf kappab import into nucleus GO:0042348 22 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
phagocytosis recognition GO:0006910 3 0.017
cell development GO:0048468 328 0.017
determination of adult lifespan GO:0008340 2 0.016
cell morphogenesis GO:0000902 296 0.016
lipid transport GO:0006869 90 0.016
cellular chemical homeostasis GO:0055082 180 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
intracellular protein transport GO:0006886 270 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
response to radiation GO:0009314 151 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
regulation of small gtpase mediated signal transduction GO:0051056 156 0.016
transmembrane transport GO:0055085 399 0.016
cellular divalent inorganic cation homeostasis GO:0072503 128 0.016
cellular component morphogenesis GO:0032989 314 0.016
secretion by cell GO:0032940 226 0.016
endothelial cell differentiation GO:0045446 26 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
Rat
toll like receptor 3 signaling pathway GO:0034138 4 0.015
macromolecule glycosylation GO:0043413 63 0.015
macrophage activation GO:0042116 12 0.015
chemical homeostasis GO:0048878 306 0.015
regulation of interferon alpha production GO:0032647 11 0.015
Human Mouse
positive regulation of cellular component organization GO:0051130 376 0.015
neurotransmitter secretion GO:0007269 4 0.015
negative regulation of catabolic process GO:0009895 104 0.015
oxidation reduction process GO:0055114 396 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
oogenesis GO:0048477 2 0.015
regulation of protein processing GO:0070613 150 0.014
blood vessel morphogenesis GO:0048514 162 0.014
response to growth factor GO:0070848 205 0.014
protein import into nucleus GO:0006606 104 0.014
positive regulation of interferon alpha production GO:0032727 11 0.014
Human Mouse
secretion GO:0046903 254 0.014
determination of dorsal ventral asymmetry GO:0048262 4 0.014
cell type specific apoptotic process GO:0097285 125 0.014
regulation of leukocyte migration GO:0002685 63 0.014
protein homooligomerization GO:0051260 100 0.014
neuromuscular junction development GO:0007528 3 0.014
cellular macromolecule catabolic process GO:0044265 380 0.014
smooth muscle cell proliferation GO:0048659 28 0.014
endothelial cell development GO:0001885 18 0.014
motor neuron axon guidance GO:0008045 2 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.014
maintenance of location GO:0051235 112 0.014
wnt signaling pathway GO:0016055 156 0.014
neurological system process GO:0050877 163 0.014
Rat
protein glycosylation GO:0006486 62 0.014
negative regulation of protein processing GO:0010955 142 0.014
cellular homeostasis GO:0019725 196 0.014
regulation of growth GO:0040008 165 0.014
positive regulation of transferase activity GO:0051347 227 0.014
Human Mouse
negative regulation of protein maturation GO:1903318 142 0.014
organic hydroxy compound transport GO:0015850 63 0.014
type i interferon biosynthetic process GO:0045351 4 0.014
Human Mouse
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.014
cation transmembrane transport GO:0098655 238 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
cell projection organization GO:0030030 252 0.013
purine nucleotide biosynthetic process GO:0006164 84 0.013
endomembrane system organization GO:0010256 196 0.013
spermatid differentiation GO:0048515 4 0.013
regulation of protein homodimerization activity GO:0043496 9 0.013
long term memory GO:0007616 2 0.013
regulation of secretion GO:0051046 194 0.013
production of molecular mediator of immune response GO:0002440 37 0.013
Mouse
sequestering of metal ion GO:0051238 24 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
sensory perception of pain GO:0019233 4 0.013
Rat
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
peripheral nervous system development GO:0007422 2 0.013
mitotic cell cycle GO:0000278 326 0.013
regulation of cell differentiation GO:0045595 393 0.013
regulation of protein maturation GO:1903317 150 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
regeneration GO:0031099 4 0.013
regulation of cell cycle process GO:0010564 266 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
antimicrobial humoral response GO:0019730 26 0.013
positive regulation of jun kinase activity GO:0043507 23 0.013
Human
positive regulation of cell adhesion GO:0045785 84 0.013
cation transport GO:0006812 331 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
Rat
peptidyl serine phosphorylation GO:0018105 101 0.012
hemostasis GO:0007599 76 0.012
Mouse
ion homeostasis GO:0050801 230 0.012
regulation of interleukin 12 production GO:0032655 15 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
Rat
positive regulation of ras gtpase activity GO:0032320 117 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012

TLR4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease by infectious agent DOID:0050117 34 0.939
Human
parasitic infectious disease DOID:1398 16 0.213
disease of cellular proliferation DOID:14566 174 0.125
cancer DOID:162 167 0.125
parasitic protozoa infectious disease DOID:2789 16 0.120
organ system cancer DOID:0050686 164 0.097
malaria DOID:12365 16 0.052
nervous system disease DOID:863 431 0.018
sensory system disease DOID:0050155 203 0.018
disease of metabolism DOID:0014667 295 0.017
eye disease DOID:5614 149 0.016
eye and adnexa disease DOID:1492 150 0.016
immune system cancer DOID:0060083 36 0.016
hematologic cancer DOID:2531 36 0.016