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Homo sapiens

36 genes annotated in human

hematologic cancer

DOID:2531

An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hematologic cancer"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hematologic cancer" (in gray)

Name	Description	Probability	Func Analog Organism
IGF1R	insulin-like growth factor 1 receptor	0.276
APLF	aprataxin and PNKP like factor	0.240
TAL1	T-cell acute lymphocytic leukemia 1	0.205
CDK6	cyclin-dependent kinase 6	0.177
RHOA	ras homolog gene family, member A	0.121
STAT1	signal transducer and activator of transcription 1, 91kDa	0.120
DAXX	death-domain associated protein	0.111
NXF1	nuclear RNA export factor 1	0.102
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.098
PDIA3	protein disulfide isomerase family A, member 3	0.082
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.075
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.072
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.071
BRCA1	breast cancer 1, early onset	0.059
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.058
EP300	E1A binding protein p300	0.046
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.044
HIPK2	homeodomain interacting protein kinase 2	0.043
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.043
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.042
CCNE1	cyclin E1	0.042
RB1	retinoblastoma 1	0.037
CCND3	cyclin D3	0.036	Human
SH2B1	SH2B adaptor protein 1	0.035	Human
PML	promyelocytic leukemia	0.034
FAS	Fas (TNF receptor superfamily, member 6)	0.033
SMC1A	structural maintenance of chromosomes 1A	0.030
IRAK2	interleukin-1 receptor-associated kinase 2	0.028
FANCD2	Fanconi anemia, complementation group D2	0.027
CBFB	core-binding factor, beta subunit	0.027
RNF144B	ring finger protein 144B	0.026
CFLAR	CASP8 and FADD-like apoptosis regulator	0.026
MDC1	mediator of DNA-damage checkpoint 1	0.026
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.026
IFNGR1	interferon gamma receptor 1	0.025
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.025
RIOK3	RIO kinase 3 (yeast)	0.025
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.025
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.024
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.023
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.023
HOXC4	homeobox C4	0.022
RAD50	RAD50 homolog (S. cerevisiae)	0.022
GAB1	GRB2-associated binding protein 1	0.021
GRB10	growth factor receptor-bound protein 10	0.021
RUNX1	runt-related transcription factor 1	0.021
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.021
KITLG	KIT ligand	0.020
ELF4	E74-like factor 4 (ets domain transcription factor)	0.020	Human
RBBP8	retinoblastoma binding protein 8	0.019
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.018
CREB1	cAMP responsive element binding protein 1	0.018
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.018
SOCS3	suppressor of cytokine signaling 3	0.018
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.017
MAX	MYC associated factor X	0.017
FASLG	Fas ligand (TNF superfamily, member 6)	0.017
PDIA4	protein disulfide isomerase family A, member 4	0.016
TLR4	toll-like receptor 4	0.016
CCND2	cyclin D2	0.016	Human
LAT	linker for activation of T cells	0.016
SOCS1	suppressor of cytokine signaling 1	0.016
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.015
H2AFX	H2A histone family, member X	0.014
PDZK1	PDZ domain containing 1	0.014
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.014
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.014
GAB2	GRB2-associated binding protein 2	0.014
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.013
SH3GLB1	SH3-domain GRB2-like endophilin B1	0.013
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.013
FRS2	fibroblast growth factor receptor substrate 2	0.013
IRAK4	interleukin-1 receptor-associated kinase 4	0.013
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.013
ZBTB16	zinc finger and BTB domain containing 16	0.013
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.013
ARHGAP1	Rho GTPase activating protein 1	0.013
NCOA3	nuclear receptor coactivator 3	0.013
CORO1C	coronin, actin binding protein, 1C	0.013
AFF1	AF4/FMR2 family, member 1	0.013
RNR2	l-rRNA	0.013
RAB5A	RAB5A, member RAS oncogene family	0.012
SCYL2	SCY1-like 2 (S. cerevisiae)	0.012
SS18	synovial sarcoma translocation, chromosome 18	0.012
ETV3	ets variant 3	0.012
QKI	quaking homolog, KH domain RNA binding (mouse)	0.012
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.012
CLIC4	chloride intracellular channel 4	0.012
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.012
SEPT6	septin 6	0.012
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.012	Human
CLTC	clathrin, heavy chain (Hc)	0.011
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
RAD18	RAD18 homolog (S. cerevisiae)	0.011
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.011
ADAM10	ADAM metallopeptidase domain 10	0.011
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.011	Human
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
MNDA	myeloid cell nuclear differentiation antigen	0.011
EPOR	erythropoietin receptor	0.011	Human
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.011
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.010
PRKCSH	protein kinase C substrate 80K-H	0.010
SPRY2	sprouty homolog 2 (Drosophila)	0.010
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.010
CANX	calnexin	0.010
ATM	ataxia telangiectasia mutated	0.010
ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	0.010
SNAP23	synaptosomal-associated protein, 23kDa	0.010
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.007
NF1	neurofibromin 1	0.006
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.006
GATA2	GATA binding protein 2	0.006
MPL	myeloproliferative leukemia virus oncogene	0.006
LIG4	ligase IV, DNA, ATP-dependent	0.006
ETV6	ets variant 6	0.006
ARHGAP26	Rho GTPase activating protein 26	0.006
FLT3	fms-related tyrosine kinase 3	0.005
PAX5	paired box 5	0.005
PICALM	phosphatidylinositol binding clathrin assembly protein	0.005
TERT	telomerase reverse transcriptase	0.005
JAK2	Janus kinase 2	0.005
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.005
LPP	LIM domain containing preferred translocation partner in lipoma	0.005
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.005
NUP214	nucleoporin 214kDa	0.004
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.004
THPO	thrombopoietin	0.004
BCR	breakpoint cluster region	0.004
MYD88	myeloid differentiation primary response gene (88)	0.004
CHIC2	cysteine-rich hydrophobic domain 2	0.004
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.004
MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	0.004
PRF1	perforin 1 (pore forming protein)	0.004
CCND1	cyclin D1	0.004
SH2B3	SH2B adaptor protein 3	0.004
GMPS	guanine monphosphate synthetase	0.003
CALR	calreticulin	0.003
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.003
BAX	BCL2-associated X protein	0.002
NBN	nibrin	0.002
RAD54B	RAD54 homolog B (S. cerevisiae)	0.002
RAD54L	RAD54-like (S. cerevisiae)	0.002