IMP

Process View

Homo sapiens

36 genes annotated in human

Multi-species View

positive regulation of interleukin 8 production

GO:0032757

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of interleukin 8 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of interleukin 8 production" (in gray)

Name	Description	Probability	Func Analog Organism
BIRC3	baculoviral IAP repeat containing 3	1.000
MYD88	myeloid differentiation primary response gene (88)	0.995
C1QA	complement component 1, q subcomponent, A chain	0.932	Human
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.783
IL1R1	interleukin 1 receptor, type I	0.607
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.604
NLRC4	NLR family, CARD domain containing 4	0.593
TLR4	toll-like receptor 4	0.576
TRAF1	TNF receptor-associated factor 1	0.575
BIRC2	baculoviral IAP repeat containing 2	0.453
C1QC	complement component 1, q subcomponent, C chain	0.374	Human
PLAU	plasminogen activator, urokinase	0.370
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.314
IRAK1	interleukin-1 receptor-associated kinase 1	0.299
TRAF3	TNF receptor-associated factor 3	0.294
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.258
FGA	fibrinogen alpha chain	0.254
TRAF2	TNF receptor-associated factor 2	0.206
IRAK2	interleukin-1 receptor-associated kinase 2	0.200
FAS	Fas (TNF receptor superfamily, member 6)	0.195
CRP	C-reactive protein, pentraxin-related	0.182
TLR2	toll-like receptor 2	0.161
PLAT	plasminogen activator, tissue	0.136
MEFV	Mediterranean fever	0.126
PLAUR	plasminogen activator, urokinase receptor	0.126
C1QB	complement component 1, q subcomponent, B chain	0.121	Human
BMPR1B	bone morphogenetic protein receptor, type IB	0.117
LZTS2	leucine zipper, putative tumor suppressor 2	0.098
CARD11	caspase recruitment domain family, member 11	0.095
TICAM2	toll-like receptor adaptor molecule 2	0.092
TRADD	TNFRSF1A-associated via death domain	0.089
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.080
LY96	lymphocyte antigen 96	0.080
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.077
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.076
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.073
TXN	thioredoxin	0.073
C9orf89	chromosome 9 open reading frame 89	0.070
IRAK3	interleukin-1 receptor-associated kinase 3	0.069
LRP1	low density lipoprotein receptor-related protein 1	0.067
CAV1	caveolin 1, caveolae protein, 22kDa	0.066
TSC22D4	TSC22 domain family, member 4	0.065
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.065
ORM1	orosomucoid 1	0.061
MARCO	macrophage receptor with collagenous structure	0.060
IRAK4	interleukin-1 receptor-associated kinase 4	0.060
IL1R2	interleukin 1 receptor, type II	0.057
MPO	myeloperoxidase	0.055
PYDC2	pyrin domain containing 2	0.053
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.053
IRF7	interferon regulatory factor 7	0.049
SPOP	speckle-type POZ protein	0.048
TANK	TRAF family member-associated NFKB activator	0.048
ELANE	elastase, neutrophil expressed	0.047
IL1RN	interleukin 1 receptor antagonist	0.046	Human
CD14	CD14 molecule	0.044
CD40	CD40 molecule, TNF receptor superfamily member 5	0.043
CAMP	cathelicidin antimicrobial peptide	0.043
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.042
RIPK2	receptor-interacting serine-threonine kinase 2	0.041	Human
ATF3	activating transcription factor 3	0.040
HDAC7	histone deacetylase 7	0.039
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.039
DBP	D site of albumin promoter (albumin D-box) binding protein	0.038
TMEM173	transmembrane protein 173	0.038
FCAR	Fc fragment of IgA, receptor for	0.038
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.037
RNASE3	ribonuclease, RNase A family, 3	0.035
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.033
CXCL3	chemokine (C-X-C motif) ligand 3	0.033
IL8	interleukin 8	0.033
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.032
FASLG	Fas ligand (TNF superfamily, member 6)	0.032
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.032
TLR1	toll-like receptor 1	0.031	Human
IL1RAP	interleukin 1 receptor accessory protein	0.031
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.031
CTSG	cathepsin G	0.031
CCL20	chemokine (C-C motif) ligand 20	0.030
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.030
TLR7	toll-like receptor 7	0.030
IGSF6	immunoglobulin superfamily, member 6	0.030
NOD1	nucleotide-binding oligomerization domain containing 1	0.030
RETN	resistin	0.029
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.029
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.027
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.027
TRIM38	tripartite motif containing 38	0.027
AZU1	azurocidin 1	0.026	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.026
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.026
CLEC4G	C-type lectin domain family 4, member G	0.026
FADD	Fas (TNFRSF6)-associated via death domain	0.026
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.025
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.024
NOG	noggin	0.024
SIGLEC5	sialic acid binding Ig-like lectin 5	0.024
S100A12	S100 calcium binding protein A12	0.023
STAP2	signal transducing adaptor family member 2	0.023
SOD1	superoxide dismutase 1, soluble	0.022
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.022
CCDC50	coiled-coil domain containing 50	0.021
DEFA4	defensin, alpha 4, corticostatin	0.021
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.021
NLRP3	NLR family, pyrin domain containing 3	0.021	Human
TREM1	triggering receptor expressed on myeloid cells 1	0.021
CD48	CD48 molecule	0.021
MT1X	metallothionein 1X	0.021
C3AR1	complement component 3a receptor 1	0.021
CXCR2	chemokine (C-X-C motif) receptor 2	0.020
IL1B	interleukin 1, beta	0.020
PRTN3	proteinase 3	0.020	Human
SAMHD1	SAM domain and HD domain 1	0.020
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.020
HSPA1L	heat shock 70kDa protein 1-like	0.019
AQP9	aquaporin 9	0.019
CLEC7A	C-type lectin domain family 7, member A	0.018
IRF5	interferon regulatory factor 5	0.018
AVPR2	arginine vasopressin receptor 2	0.018
ANXA1	annexin A1	0.018
BST1	bone marrow stromal cell antigen 1	0.018
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.018
NOD2	nucleotide-binding oligomerization domain containing 2	0.018	Human
CD2AP	CD2-associated protein	0.018
HK3	hexokinase 3 (white cell)	0.018
LY86	lymphocyte antigen 86	0.018
MT2A	metallothionein 2A	0.018
SLC15A3	solute carrier family 15, member 3	0.017
CD300C	CD300c molecule	0.017
ITGB5	integrin, beta 5	0.017
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.017
ZC3H12A	zinc finger CCCH-type containing 12A	0.017
LBP	lipopolysaccharide binding protein	0.017
CYBB	cytochrome b-245, beta polypeptide	0.017
SQSTM1	sequestosome 1	0.017
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.016
FOSL1	FOS-like antigen 1	0.016
PTAFR	platelet-activating factor receptor	0.016
CST7	cystatin F (leukocystatin)	0.016
ASGR2	asialoglycoprotein receptor 2	0.016
STAB1	stabilin 1	0.016
CCL8	chemokine (C-C motif) ligand 8	0.016
BID	BH3 interacting domain death agonist	0.016
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.016
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.016
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.016
CFP	complement factor properdin	0.015
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.015
SERPINB10	serpin peptidase inhibitor, clade B (ovalbumin), member 10	0.015
FPR1	formyl peptide receptor 1	0.015
MPEG1	macrophage expressed 1	0.015
MSR1	macrophage scavenger receptor 1	0.015
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.015
ARG1	arginase, liver	0.015
S100A9	S100 calcium binding protein A9	0.015
TFEC	transcription factor EC	0.015
CCR1	chemokine (C-C motif) receptor 1	0.015
SOCS3	suppressor of cytokine signaling 3	0.015
FZD1	frizzled homolog 1 (Drosophila)	0.015
APOA1	apolipoprotein A-I	0.015
PDLIM4	PDZ and LIM domain 4	0.014
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.014
GPR97	G protein-coupled receptor 97	0.014
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.014
C4BPA	complement component 4 binding protein, alpha	0.014
CCL4	chemokine (C-C motif) ligand 4	0.014
CCL7	chemokine (C-C motif) ligand 7	0.014
MBD4	methyl-CpG binding domain protein 4	0.014
FOLR3	folate receptor 3 (gamma)	0.014
CLEC4E	C-type lectin domain family 4, member E	0.014
PDLIM7	PDZ and LIM domain 7 (enigma)	0.014
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.014
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.014
FPR2	formyl peptide receptor 2	0.014
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.014
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.013
PROCR	protein C receptor, endothelial	0.013
SIGLEC9	sialic acid binding Ig-like lectin 9	0.013
DOCK8	dedicator of cytokinesis 8	0.013
SPHK1	sphingosine kinase 1	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
HECTD3	HECT domain containing 3	0.013
LTF	lactotransferrin	0.013
BCL2A1	BCL2-related protein A1	0.013
GPR84	G protein-coupled receptor 84	0.013
CLEC5A	C-type lectin domain family 5, member A	0.013
TLR6	toll-like receptor 6	0.013	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.013
TRIB3	tribbles homolog 3 (Drosophila)	0.013
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.012
AKNA	AT-hook transcription factor	0.012
VNN2	vanin 2	0.012
TRAF6	TNF receptor-associated factor 6	0.012
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.012
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.012
VSIG4	V-set and immunoglobulin domain containing 4	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.012
FFAR2	free fatty acid receptor 2	0.012
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.012
SMAD3	SMAD family member 3	0.012
CSN3	casein kappa	0.012
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.012
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.012
GGT5	gamma-glutamyltransferase 5	0.012
PGLYRP1	peptidoglycan recognition protein 1	0.012
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.012
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.012
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.012
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.012
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
CCRL2	chemokine (C-C motif) receptor-like 2	0.012
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.012
GPBAR1	G protein-coupled bile acid receptor 1	0.012
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.012
INADL	InaD-like (Drosophila)	0.011
AOAH	acyloxyacyl hydrolase (neutrophil)	0.011
SLAMF8	SLAM family member 8	0.011
MAVS	mitochondrial antiviral signaling protein	0.011
SEPT4	septin 4	0.011
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.011
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.011
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	0.011
DEFA1B	defensin, alpha 1B	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.011
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.011
EPX	eosinophil peroxidase	0.011
CDA	cytidine deaminase	0.011
PF4	platelet factor 4	0.011
IFRD1	interferon-related developmental regulator 1	0.011
PTPRE	protein tyrosine phosphatase, receptor type, E	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.011
BATF	basic leucine zipper transcription factor, ATF-like	0.011
IRF4	interferon regulatory factor 4	0.011
BPI	bactericidal/permeability-increasing protein	0.011	Human
LCN2	lipocalin 2	0.011
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.011
GML	glycosylphosphatidylinositol anchored molecule like protein	0.011
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.010
TLR5	toll-like receptor 5	0.010
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.010
SOD2	superoxide dismutase 2, mitochondrial	0.010
PVR	poliovirus receptor	0.010
DHRS9	dehydrogenase/reductase (SDR family) member 9	0.010
CAV2	caveolin 2	0.010
FGB	fibrinogen beta chain	0.010
AIM2	absent in melanoma 2	0.010
CXCR1	chemokine (C-X-C motif) receptor 1	0.010
HAS1	hyaluronan synthase 1	0.010
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.010
BTK	Bruton agammaglobulinemia tyrosine kinase	0.010
UTS2R	urotensin 2 receptor	0.010
SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	0.010
SH3KBP1	SH3-domain kinase binding protein 1	0.010
CSF3	colony stimulating factor 3 (granulocyte)	0.010