IMP

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Homo sapiens

37 genes annotated in human

interleukin 6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 6 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 6 production" (in gray)

Name	Description	Probability	Func Analog Organism
IRAK2	interleukin-1 receptor-associated kinase 2	1.000	Human
MYD88	myeloid differentiation primary response gene (88)	1.000	Mouse
IRAK1	interleukin-1 receptor-associated kinase 1	0.997	Human
TRAF6	TNF receptor-associated factor 6	0.993	Mouse
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.985
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.977	Mouse
RIPK2	receptor-interacting serine-threonine kinase 2	0.874	Mouse
IL1R1	interleukin 1 receptor, type I	0.853
MAP2K4	mitogen-activated protein kinase kinase 4	0.844
BIRC3	baculoviral IAP repeat containing 3	0.728
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.707
TICAM2	toll-like receptor adaptor molecule 2	0.687
NLRC4	NLR family, CARD domain containing 4	0.681
TLR2	toll-like receptor 2	0.600
MAPK14	mitogen-activated protein kinase 14	0.509	Human
IL6	interleukin 6 (interferon, beta 2)	0.469
IL8	interleukin 8	0.464
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.458
LAMP1	lysosomal-associated membrane protein 1	0.447
TLR4	toll-like receptor 4	0.443
TRAF1	TNF receptor-associated factor 1	0.396
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.384
ARRB1	arrestin, beta 1	0.364
CXCL2	chemokine (C-X-C motif) ligand 2	0.332
IRAK3	interleukin-1 receptor-associated kinase 3	0.330
ZNF496	zinc finger protein 496	0.316
IL10RA	interleukin 10 receptor, alpha	0.291
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.289
SOD2	superoxide dismutase 2, mitochondrial	0.271
TRADD	TNFRSF1A-associated via death domain	0.271
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.260
IL22RA2	interleukin 22 receptor, alpha 2	0.246
IL6R	interleukin 6 receptor	0.236
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.233
HLA-A	major histocompatibility complex, class I, A	0.220
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.212
ZC3H12A	zinc finger CCCH-type containing 12A	0.211
GATA2	GATA binding protein 2	0.205
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.180
CD14	CD14 molecule	0.168
HLA-C	major histocompatibility complex, class I, C	0.166
CCL20	chemokine (C-C motif) ligand 20	0.164
SOCS3	suppressor of cytokine signaling 3	0.158
CPNE6	copine VI (neuronal)	0.142
JUN	jun proto-oncogene	0.137
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.137	Rat
TRAF2	TNF receptor-associated factor 2	0.135
FZD1	frizzled homolog 1 (Drosophila)	0.134
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.134
TNF	tumor necrosis factor	0.132
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.132
PELI3	pellino homolog 3 (Drosophila)	0.130
SETD8	SET domain containing (lysine methyltransferase) 8	0.129
IL1B	interleukin 1, beta	0.128	Mouse Rat
CXCL3	chemokine (C-X-C motif) ligand 3	0.122
IL1RAP	interleukin 1 receptor accessory protein	0.121
SMAD3	SMAD family member 3	0.119
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.105
LAPTM5	lysosomal protein transmembrane 5	0.101
TRAF3	TNF receptor-associated factor 3	0.099
HLA-G	major histocompatibility complex, class I, G	0.098
B2M	beta-2-microglobulin	0.094
AXL	AXL receptor tyrosine kinase	0.091
BIRC2	baculoviral IAP repeat containing 2	0.088
MEFV	Mediterranean fever	0.087
HLA-F	major histocompatibility complex, class I, F	0.084
HSPB1	heat shock 27kDa protein 1	0.079
IRAK4	interleukin-1 receptor-associated kinase 4	0.077
PYDC2	pyrin domain containing 2	0.076
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.075
C19orf50	chromosome 19 open reading frame 50	0.071
UBASH3B	ubiquitin associated and SH3 domain containing B	0.070
SYK	spleen tyrosine kinase	0.064
HSF1	heat shock transcription factor 1	0.064
MARK2	MAP/microtubule affinity-regulating kinase 2	0.063
NOD2	nucleotide-binding oligomerization domain containing 2	0.063
IL22RA1	interleukin 22 receptor, alpha 1	0.063
IRF7	interferon regulatory factor 7	0.059
TOLLIP	toll interacting protein	0.058
HDAC9	histone deacetylase 9	0.057
IL4R	interleukin 4 receptor	0.056
HLA-E	major histocompatibility complex, class I, E	0.056
GNMT	glycine N-methyltransferase	0.056
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.055
JAK1	Janus kinase 1	0.055
IL1RN	interleukin 1 receptor antagonist	0.054
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.054
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.053
SQSTM1	sequestosome 1	0.053
ICAM1	intercellular adhesion molecule 1	0.052
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.052
TCF12	transcription factor 12	0.051
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.049
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.048
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.047
TRIM34	tripartite motif containing 34	0.046
DUSP1	dual specificity phosphatase 1	0.045
EPOR	erythropoietin receptor	0.044
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.043
MYH9	myosin, heavy chain 9, non-muscle	0.041
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.039
LIMK1	LIM domain kinase 1	0.038
NOD1	nucleotide-binding oligomerization domain containing 1	0.038	Mouse
SLAMF1	signaling lymphocytic activation molecule family member 1	0.036
MAPK10	mitogen-activated protein kinase 10	0.036	Human
PTAFR	platelet-activating factor receptor	0.035
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.035
SP1	Sp1 transcription factor	0.032
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.031
HMGA1	high mobility group AT-hook 1	0.031
TXN	thioredoxin	0.031
IL10	interleukin 10	0.030
FANCD2	Fanconi anemia, complementation group D2	0.030
LY96	lymphocyte antigen 96	0.030
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.029
SPOP	speckle-type POZ protein	0.029
LY86	lymphocyte antigen 86	0.029
CREBBP	CREB binding protein	0.029
ELF4	E74-like factor 4 (ets domain transcription factor)	0.028
TNIP1	TNFAIP3 interacting protein 1	0.028
STAP2	signal transducing adaptor family member 2	0.028
CFL1	cofilin 1 (non-muscle)	0.027
XIAP	X-linked inhibitor of apoptosis	0.027
IRF1	interferon regulatory factor 1	0.027
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.027
TLR1	toll-like receptor 1	0.027	Human Mouse
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.025
STAT5A	signal transducer and activator of transcription 5A	0.025
SBNO2	strawberry notch homolog 2 (Drosophila)	0.024
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.024
BID	BH3 interacting domain death agonist	0.023
HSPH1	heat shock 105kDa/110kDa protein 1	0.023
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.023
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.023
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.023
CYBB	cytochrome b-245, beta polypeptide	0.023
ZC3H12C	zinc finger CCCH-type containing 12C	0.022	Human
C4BPA	complement component 4 binding protein, alpha	0.022
BTK	Bruton agammaglobulinemia tyrosine kinase	0.022
CLEC7A	C-type lectin domain family 7, member A	0.021
LMO2	LIM domain only 2 (rhombotin-like 1)	0.021
VSX1	visual system homeobox 1	0.021
CCL2	chemokine (C-C motif) ligand 2	0.021
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.021
IL19	interleukin 19	0.021	Human
GJD2	gap junction protein, delta 2, 36kDa	0.021
IL17RA	interleukin 17 receptor A	0.021
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.021
IGF1R	insulin-like growth factor 1 receptor	0.020
CCR1	chemokine (C-C motif) receptor 1	0.020
DDR2	discoidin domain receptor tyrosine kinase 2	0.020
MAPK15	mitogen-activated protein kinase 15	0.019
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.019
MAP2K3	mitogen-activated protein kinase kinase 3	0.019
CD44	CD44 molecule (Indian blood group)	0.019
PRKCD	protein kinase C, delta	0.019
TREM1	triggering receptor expressed on myeloid cells 1	0.019
BLNK	B-cell linker	0.019
CSF3	colony stimulating factor 3 (granulocyte)	0.019
VNN2	vanin 2	0.019
POU4F3	POU class 4 homeobox 3	0.018
ANKRD28	ankyrin repeat domain 28	0.018
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.018
TLR7	toll-like receptor 7	0.018	Human Mouse
SARM1	sterile alpha and TIR motif containing 1	0.018
FCAR	Fc fragment of IgA, receptor for	0.018
DOK3	docking protein 3	0.018
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.018
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.018
IL1A	interleukin 1, alpha	0.018
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.018
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.018
IL4	interleukin 4	0.017
PHC2	polyhomeotic homolog 2 (Drosophila)	0.017
IL13	interleukin 13	0.017
KRT81	keratin 81	0.017
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.017
DDN	dendrin	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
CD83	CD83 molecule	0.017
CXCL5	chemokine (C-X-C motif) ligand 5	0.017
FGF3	fibroblast growth factor 3	0.017
PKN1	protein kinase N1	0.017
MYOD1	myogenic differentiation 1	0.017
POU4F2	POU class 4 homeobox 2	0.017
AQP9	aquaporin 9	0.017
MAVS	mitochondrial antiviral signaling protein	0.016
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.016
ADRB2	adrenergic, beta-2-, receptor, surface	0.016
TICAM1	toll-like receptor adaptor molecule 1	0.016	Mouse
BST1	bone marrow stromal cell antigen 1	0.016
RNASE6	ribonuclease, RNase A family, k6	0.016
HRH1	histamine receptor H1	0.016
CH25H	cholesterol 25-hydroxylase	0.016
LRRN2	leucine rich repeat neuronal 2	0.016
LRP6	low density lipoprotein receptor-related protein 6	0.016
PLEK	pleckstrin	0.016
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.016
ATF2	activating transcription factor 2	0.016
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.016
HOXD12	homeobox D12	0.015
CDX4	caudal type homeobox 4	0.015
BCL2A1	BCL2-related protein A1	0.015
PELI1	pellino homolog 1 (Drosophila)	0.015
C10orf54	chromosome 10 open reading frame 54	0.015
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.015
LST1	leukocyte specific transcript 1	0.015
RNF31	ring finger protein 31	0.015
TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	0.015
ENG	endoglin	0.015
TFE3	transcription factor binding to IGHM enhancer 3	0.015
FOXO1	forkhead box O1	0.015
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.015
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.015
LHX5	LIM homeobox 5	0.015
POU2F2	POU class 2 homeobox 2	0.014
KIF26A	kinesin family member 26A	0.014
IRF4	interferon regulatory factor 4	0.014
TLR6	toll-like receptor 6	0.014	Human
CCL8	chemokine (C-C motif) ligand 8	0.014
BCL2	B-cell CLL/lymphoma 2	0.014
LMO1	LIM domain only 1 (rhombotin 1)	0.014
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.014
BAG3	BCL2-associated athanogene 3	0.014
TFEC	transcription factor EC	0.014
HCP5	HLA complex P5	0.014
TNIP2	TNFAIP3 interacting protein 2	0.014
TRAF3IP2	TRAF3 interacting protein 2	0.014
GPR84	G protein-coupled receptor 84	0.014
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.014
MAPK11	mitogen-activated protein kinase 11	0.014	Human
PTX3	pentraxin 3, long	0.014
RNASE4	ribonuclease, RNase A family, 4	0.014
PRMT2	protein arginine methyltransferase 2	0.014
STX11	syntaxin 11	0.013
S100A12	S100 calcium binding protein A12	0.013
DUSP9	dual specificity phosphatase 9	0.013
ANG	angiogenin, ribonuclease, RNase A family, 5	0.013
LMX1A	LIM homeobox transcription factor 1, alpha	0.013
CD163	CD163 molecule	0.013
OBSL1	obscurin-like 1	0.013
IL24	interleukin 24	0.013	Human
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.013
CD300C	CD300c molecule	0.013
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.013
TBK1	TANK-binding kinase 1	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.013
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.013
HOXD13	homeobox D13	0.013
TIFA	TRAF-interacting protein with forkhead-associated domain	0.012
NPAS1	neuronal PAS domain protein 1	0.012
MR1	major histocompatibility complex, class I-related	0.012
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.012
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.012
HIST2H2AB	histone cluster 2, H2ab	0.012
CCL1	chemokine (C-C motif) ligand 1	0.012
HMGA2	high mobility group AT-hook 2	0.012
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.012
DUSP23	dual specificity phosphatase 23	0.012
IL1R2	interleukin 1 receptor, type II	0.012
CCL4	chemokine (C-C motif) ligand 4	0.012
INADL	InaD-like (Drosophila)	0.012
DOCK8	dedicator of cytokinesis 8	0.012
CLEC5A	C-type lectin domain family 5, member A	0.012
CDK6	cyclin-dependent kinase 6	0.012
ALX4	ALX homeobox 4	0.012
MYO1C	myosin IC	0.012
CCRL2	chemokine (C-C motif) receptor-like 2	0.012
CSK	c-src tyrosine kinase	0.012	Rat
KIAA1712	KIAA1712	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
NLRP3	NLR family, pyrin domain containing 3	0.012	Human
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.012
CD86	CD86 molecule	0.012
IFT20	intraflagellar transport 20 homolog (Chlamydomonas)	0.012
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.012
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.012
IL1F9	interleukin 1 family, member 9	0.012	Mouse
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.012
C17orf62	chromosome 17 open reading frame 62	0.012
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.012
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.012
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
FOXE3	forkhead box E3	0.012
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.011
LDHB	lactate dehydrogenase B	0.011
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.011
HDAC7	histone deacetylase 7	0.011
CLEC4E	C-type lectin domain family 4, member E	0.011
CYTIP	cytohesin 1 interacting protein	0.011
TMEM173	transmembrane protein 173	0.011
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.011
MYT1	myelin transcription factor 1	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
RHBDF2	rhomboid 5 homolog 2 (Drosophila)	0.011
MTA2	metastasis associated 1 family, member 2	0.011
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.011
CD180	CD180 molecule	0.011	Human
ZBTB25	zinc finger and BTB domain containing 25	0.011
TLR5	toll-like receptor 5	0.011	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.011
DENND3	DENN/MADD domain containing 3	0.011
FZD8	frizzled homolog 8 (Drosophila)	0.011
CD93	CD93 molecule	0.011
PANX2	pannexin 2	0.011
KDM2A	lysine (K)-specific demethylase 2A	0.011
GHSR	growth hormone secretagogue receptor	0.011
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.011
SAMHD1	SAM domain and HD domain 1	0.011
GTF2I	general transcription factor IIi	0.011
CHRD	chordin	0.011
C15orf39	chromosome 15 open reading frame 39	0.011
HAS1	hyaluronan synthase 1	0.011
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
NAMPT	nicotinamide phosphoribosyltransferase	0.011
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.011
EGFL7	EGF-like-domain, multiple 7	0.011
RAB5C	RAB5C, member RAS oncogene family	0.011
GPR6	G protein-coupled receptor 6	0.011
FKBP4	FK506 binding protein 4, 59kDa	0.011
FEV	FEV (ETS oncogene family)	0.011
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.011
KIAA0930	KIAA0930	0.011
WNT6	wingless-type MMTV integration site family, member 6	0.011
PROCR	protein C receptor, endothelial	0.011
GBP5	guanylate binding protein 5	0.011
TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.011
GPR183	G protein-coupled receptor 183	0.011
HAND2	heart and neural crest derivatives expressed 2	0.011	Human
TRIM6	tripartite motif containing 6	0.010
IL2RA	interleukin 2 receptor, alpha	0.010
CXCL16	chemokine (C-X-C motif) ligand 16	0.010
BHLHE23	basic helix-loop-helix family, member e23	0.010
DGKZ	diacylglycerol kinase, zeta	0.010
FPR2	formyl peptide receptor 2	0.010
CCL11	chemokine (C-C motif) ligand 11	0.010
SH3GL2	SH3-domain GRB2-like 2	0.010
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
GSX2	GS homeobox 2	0.010
C10orf46	chromosome 10 open reading frame 46	0.010
GATA4	GATA binding protein 4	0.010
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.010
GRM6	glutamate receptor, metabotropic 6	0.010
CUL7	cullin 7	0.010
OPN4	opsin 4	0.010
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.010
FZD2	frizzled homolog 2 (Drosophila)	0.010
FFAR2	free fatty acid receptor 2	0.010
C1orf38	chromosome 1 open reading frame 38	0.010