Mus musculus

207 known processes

Esr1

estrogen receptor 1 (alpha)

(Aliases: AU041214,Nr3a1,AA420328,Estra,ERalpha,ERa,Estr,ER[a],ER-alpha,ESR)

Esr1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
neuropeptide signaling pathway GO:0007218 19 1.000
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 1.000
wnt signaling pathway involved in kidney development GO:0061289 2 1.000
cellular response to gonadotropin stimulus GO:0071371 4 0.999
creatinine metabolic process GO:0046449 3 0.999
development of secondary male sexual characteristics GO:0046544 3 0.999
rhythmic process GO:0048511 174 0.999
female sex differentiation GO:0046660 84 0.998
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 4 0.998
regulation of steroid hormone biosynthetic process GO:0090030 4 0.998
regulation of fatty acid oxidation GO:0046320 10 0.998
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.997
cellular amino acid metabolic process GO:0006520 103 0.997
positive regulation of intracellular steroid hormone receptor signaling pathway GO:0033145 4 0.997
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.997
response to extracellular stimulus GO:0009991 127 0.997
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.996
steroid metabolic process GO:0008202 119 0.996
gland development GO:0048732 330 0.995
hormone mediated signaling pathway GO:0009755 23 0.995
Human Zebrafish Mouse Rat
morphogenesis of a branching structure GO:0001763 203 0.995
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.995
development of primary female sexual characteristics GO:0046545 73 0.994
negative regulation of cell proliferation GO:0008285 296 0.994
Mouse Rat
spermatogenesis exchange of chromosomal proteins GO:0035093 4 0.993
regulation of steroid biosynthetic process GO:0050810 26 0.992
sertoli cell proliferation GO:0060011 5 0.991
Rat
glucose homeostasis GO:0042593 128 0.991
carbohydrate metabolic process GO:0005975 230 0.990
regulation of feeding behavior GO:0060259 3 0.990
follicle stimulating hormone secretion GO:0046884 1 0.990
luteinization GO:0001553 8 0.990
creatine metabolic process GO:0006600 4 0.990
taurine metabolic process GO:0019530 4 0.989
steroid hormone mediated signaling pathway GO:0043401 6 0.988
Human Zebrafish Rat
response to peptide hormone GO:0043434 127 0.988
female gonad development GO:0008585 71 0.987
regulation of carbohydrate biosynthetic process GO:0043255 40 0.986
canonical wnt signaling pathway involved in metanephric kidney development GO:0061290 2 0.986
succinate metabolic process GO:0006105 4 0.985
spermatid development GO:0007286 108 0.985
cellular water homeostasis GO:0009992 2 0.984
response to alcohol GO:0097305 48 0.983
Human Zebrafish Rat
regulation of nitrogen cycle metabolic process GO:1903314 1 0.982
cellular response to hormone stimulus GO:0032870 150 0.981
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 18 0.981
Mouse
cyclic nucleotide biosynthetic process GO:0009190 44 0.981
morphogenesis of a branching epithelium GO:0061138 193 0.981
alpha amino acid metabolic process GO:1901605 59 0.980
acetate ester metabolic process GO:1900619 3 0.980
organ growth GO:0035265 117 0.980
development of primary sexual characteristics GO:0045137 143 0.979
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.979
spermatid differentiation GO:0048515 115 0.978
maternal process involved in female pregnancy GO:0060135 32 0.977
regulation of glucose metabolic process GO:0010906 60 0.976
pattern recognition receptor signaling pathway GO:0002221 47 0.975
monocarboxylic acid metabolic process GO:0032787 191 0.975
acylglycerol homeostasis GO:0055090 16 0.972
muscle tissue development GO:0060537 308 0.972
follicle stimulating hormone signaling pathway GO:0042699 3 0.972
development of secondary sexual characteristics GO:0045136 11 0.971
response to organic cyclic compound GO:0014070 198 0.970
sertoli cell differentiation GO:0060008 18 0.970
Rat
epithelial tube morphogenesis GO:0060562 303 0.969
mammary gland epithelium development GO:0061180 65 0.969
regulation of fatty acid metabolic process GO:0019217 28 0.969
gonad development GO:0008406 141 0.967
chromatin modification GO:0016568 187 0.967
cyclic purine nucleotide metabolic process GO:0052652 43 0.966
regulation of toll like receptor signaling pathway GO:0034121 20 0.964
placenta development GO:0001890 140 0.962
Mouse Rat
negative regulation of epithelial cell proliferation GO:0050680 64 0.962
Mouse
valine metabolic process GO:0006573 4 0.960
glucose metabolic process GO:0006006 92 0.959
regulation of blood pressure GO:0008217 93 0.958
multicellular organism growth GO:0035264 161 0.958
spermatogenesis GO:0007283 284 0.957
fatty acid metabolic process GO:0006631 121 0.957
negative regulation of bone resorption GO:0045779 6 0.954
regulation of fatty acid beta oxidation GO:0031998 1 0.954
cellular amine metabolic process GO:0044106 44 0.953
development of primary male sexual characteristics GO:0046546 88 0.953
lipid transport GO:0006869 98 0.952
prostate gland growth GO:0060736 13 0.952
positive regulation of growth GO:0045927 104 0.952
regulation of camp metabolic process GO:0030814 30 0.952
prolactin signaling pathway GO:0038161 5 0.951
ovulation cycle GO:0042698 59 0.951
ovarian follicle development GO:0001541 40 0.951
male gamete generation GO:0048232 285 0.949
regulation of hormone levels GO:0010817 211 0.948
carbohydrate biosynthetic process GO:0016051 74 0.948
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.948
isoleucine metabolic process GO:0006549 4 0.947
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.945
response to organonitrogen compound GO:0010243 246 0.944
mammary gland branching involved in pregnancy GO:0060745 6 0.942
regulation of cellular ketone metabolic process GO:0010565 66 0.940
female genitalia development GO:0030540 14 0.940
intracellular receptor signaling pathway GO:0030522 74 0.940
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.939
circadian rhythm GO:0007623 114 0.939
mapk cascade GO:0000165 281 0.937
Rat
positive regulation of cholesterol homeostasis GO:2000189 2 0.936
regulation of myeloid leukocyte differentiation GO:0002761 58 0.933
regulation of leukocyte differentiation GO:1902105 159 0.931
cell cell signaling involved in kidney development GO:0060995 2 0.930
mammary gland lobule development GO:0061377 22 0.930
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.930
b cell activation GO:0042113 161 0.930
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.929
seminiferous tubule development GO:0072520 14 0.929
positive regulation of carbohydrate metabolic process GO:0045913 30 0.928
positive regulation of mammary gland involution GO:1903521 4 0.928
g protein coupled receptor signaling pathway GO:0007186 243 0.928
Rat
inositol phosphate biosynthetic process GO:0032958 6 0.926
peptidyl amino acid modification GO:0018193 336 0.926
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.926
sertoli cell development GO:0060009 15 0.925
Rat
extrinsic apoptotic signaling pathway GO:0097191 126 0.923
tyrosine phosphorylation of stat protein GO:0007260 23 0.921
negative regulation of bone remodeling GO:0046851 6 0.919
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.919
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.918
male sex differentiation GO:0046661 109 0.917
cell growth GO:0016049 130 0.916
response to peptide GO:1901652 136 0.915
regulation of secretion by cell GO:1903530 249 0.913
response to steroid hormone GO:0048545 56 0.912
regulation of cellular amine metabolic process GO:0033238 20 0.911
cellular lipid metabolic process GO:0044255 323 0.910
Rat
regulation of natural killer cell differentiation GO:0032823 11 0.910
regulation of acetylcholine metabolic process GO:0060408 1 0.909
response to corticosteroid GO:0031960 20 0.909
response to nutrient levels GO:0031667 109 0.909
camp metabolic process GO:0046058 40 0.908
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.905
Mouse
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.905
hormone metabolic process GO:0042445 86 0.904
metanephric glomerulus development GO:0072224 13 0.904
primary ovarian follicle growth GO:0001545 2 0.903
negative regulation of cell growth GO:0030308 44 0.903
myeloid leukocyte activation GO:0002274 83 0.901
regulation of protein serine threonine kinase activity GO:0071900 157 0.899
regulation of lipid biosynthetic process GO:0046890 54 0.897
allantoin metabolic process GO:0000255 3 0.896
positive regulation of camp metabolic process GO:0030816 19 0.895
adrenal gland development GO:0030325 18 0.889
positive regulation of transferase activity GO:0051347 167 0.887
positive regulation of fatty acid oxidation GO:0046321 4 0.886
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.884
citrate metabolic process GO:0006101 3 0.882
tissue remodeling GO:0048771 102 0.882
cellular response to nutrient levels GO:0031669 64 0.882
canonical wnt signaling pathway GO:0060070 130 0.881
regulation of inositol trisphosphate biosynthetic process GO:0032960 3 0.877
activation of adenylate cyclase activity GO:0007190 4 0.877
regulation of transferase activity GO:0051338 263 0.876
alcohol biosynthetic process GO:0046165 43 0.874
regulation of inositol phosphate biosynthetic process GO:0010919 3 0.872
regulation of kinase activity GO:0043549 249 0.870
lipid biosynthetic process GO:0008610 179 0.869
negative regulation of peptide hormone secretion GO:0090278 16 0.868
regulation of carbohydrate metabolic process GO:0006109 75 0.865
regulation of organ morphogenesis GO:2000027 144 0.863
regulation of protein kinase activity GO:0045859 232 0.863
regulation of hormone secretion GO:0046883 88 0.862
regulation of nucleotide biosynthetic process GO:0030808 34 0.862
toll like receptor signaling pathway GO:0002224 38 0.861
ammonia assimilation cycle GO:0019676 2 0.861
metanephric nephron development GO:0072210 34 0.860
amine metabolic process GO:0009308 45 0.859
lymphocyte differentiation GO:0030098 242 0.857
positive regulation of apoptotic signaling pathway GO:2001235 95 0.857
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.856
peptide secretion GO:0002790 114 0.855
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.855
cyclic nucleotide metabolic process GO:0009187 59 0.854
amide transport GO:0042886 138 0.852
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.851
regulation of camp biosynthetic process GO:0030817 25 0.848
positive regulation of inositol trisphosphate biosynthetic process GO:0032962 2 0.847
regulation of platelet derived growth factor receptor signaling pathway GO:0010640 9 0.846
renal tubule development GO:0061326 87 0.846
growth hormone receptor signaling pathway GO:0060396 7 0.845
regulation of morphogenesis of a branching structure GO:0060688 53 0.844
cardiac muscle tissue development GO:0048738 130 0.839
female gamete generation GO:0007292 74 0.838
negative regulation of secretion GO:0051048 61 0.837
regulation of jak stat cascade GO:0046425 34 0.835
ureteric bud development GO:0001657 94 0.835
peptide transport GO:0015833 133 0.835
apoptotic process involved in mammary gland involution GO:0060057 4 0.835
cellular response to organic cyclic compound GO:0071407 87 0.833
cellular ketone metabolic process GO:0042180 84 0.833
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.829
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.828
dicarboxylic acid metabolic process GO:0043648 18 0.827
epithelial cell proliferation GO:0050673 174 0.826
progesterone metabolic process GO:0042448 4 0.822
immune response activating signal transduction GO:0002757 116 0.819
androgen metabolic process GO:0008209 11 0.819
hepatocyte growth factor receptor signaling pathway GO:0048012 3 0.818
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.817
positive regulation of protein kinase activity GO:0045860 144 0.817
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.816
peptidyl tyrosine phosphorylation GO:0018108 143 0.816
cellular ion homeostasis GO:0006873 165 0.815
Rat
nephron tubule development GO:0072080 84 0.813
regulation of vitamin d biosynthetic process GO:0060556 1 0.811
vitamin d biosynthetic process GO:0042368 3 0.811
negative regulation of hormone secretion GO:0046888 20 0.810
inositol trisphosphate metabolic process GO:0032957 5 0.808
negative regulation of insulin secretion GO:0046676 14 0.808
positive regulation of protein phosphorylation GO:0001934 242 0.805
negative regulation of secretion by cell GO:1903531 54 0.804
positive regulation of mapk cascade GO:0043410 170 0.803
Rat
metanephric tubule development GO:0072170 18 0.802
regulation of triglyceride metabolic process GO:0090207 17 0.799
Rat
kidney epithelium development GO:0072073 121 0.790
maternal placenta development GO:0001893 20 0.790
Rat
regulation of innate immune response GO:0045088 91 0.790
vagina development GO:0060068 11 0.789
monosaccharide metabolic process GO:0005996 106 0.785
cell fate commitment GO:0045165 210 0.784
cellular response to extracellular stimulus GO:0031668 81 0.783
drug catabolic process GO:0042737 2 0.781
organic acid transport GO:0015849 101 0.776
carbon catabolite activation of transcription GO:0045991 4 0.776
inositol trisphosphate biosynthetic process GO:0032959 5 0.775
regulation of urea metabolic process GO:0034255 1 0.775
cell adhesion GO:0007155 329 0.774
asymmetric neuroblast division GO:0055059 1 0.774
regulation of cellular amino acid metabolic process GO:0006521 5 0.773
muscle system process GO:0003012 141 0.772
multi multicellular organism process GO:0044706 109 0.772
cellular lactam metabolic process GO:0072338 3 0.772
positive regulation of protein acetylation GO:1901985 9 0.771
cell cell signaling involved in metanephros development GO:0072204 2 0.769
innate immune response activating signal transduction GO:0002758 50 0.769
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.767
Rat
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.767
Human Zebrafish Mouse Rat
metanephric glomerular mesangium development GO:0072223 3 0.761
skin development GO:0043588 220 0.761
cellular carbohydrate metabolic process GO:0044262 119 0.760
glucocorticoid mediated signaling pathway GO:0043402 3 0.758
response to insulin GO:0032868 100 0.756
kidney development GO:0001822 213 0.752
regulation of cell cycle GO:0051726 281 0.750
ovulation from ovarian follicle GO:0001542 9 0.747
carboxylic acid transport GO:0046942 100 0.746
regulation of peptide secretion GO:0002791 77 0.744
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 8 0.738
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.737
cellular response to follicle stimulating hormone stimulus GO:0071372 1 0.736
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.733
metanephric nephron morphogenesis GO:0072273 19 0.732
myeloid cell differentiation GO:0030099 233 0.726
nephron development GO:0072006 109 0.724
multicellular organismal homeostasis GO:0048871 164 0.723
embryonic placenta development GO:0001892 98 0.722
Mouse
small molecule biosynthetic process GO:0044283 132 0.720
response to bile acid GO:1903412 1 0.719
negative regulation of cytokine production GO:0001818 84 0.718
activation of innate immune response GO:0002218 56 0.715
positive regulation of protein modification process GO:0031401 299 0.714
erythrocyte differentiation GO:0030218 88 0.711
response to cholesterol GO:0070723 4 0.710
cellular response to biotic stimulus GO:0071216 92 0.709
regulation of defense response GO:0031347 233 0.707
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.706
regulation of lipid metabolic process GO:0019216 118 0.705
Rat
regulation of tissue remodeling GO:0034103 38 0.701
skeletal system morphogenesis GO:0048705 203 0.698
regulation of blood vessel size GO:0050880 56 0.697
regulation of mapk cascade GO:0043408 248 0.692
Rat
cellular response to peptide GO:1901653 92 0.692
cellular senescence GO:0090398 11 0.688
regulation of lipid kinase activity GO:0043550 14 0.687
response to testosterone GO:0033574 3 0.686
peptidyl tyrosine modification GO:0018212 145 0.684
hormone secretion GO:0046879 128 0.683
jak stat cascade GO:0007259 42 0.681
water homeostasis GO:0030104 27 0.679
inner ear receptor cell differentiation GO:0060113 61 0.678
regulation of myeloid cell differentiation GO:0045637 96 0.676
cellular response to cytokine stimulus GO:0071345 189 0.676
lateral mesoderm morphogenesis GO:0048369 3 0.674
cyclic nucleotide mediated signaling GO:0019935 18 0.672
inner ear receptor stereocilium organization GO:0060122 23 0.671
prostate glandular acinus development GO:0060525 12 0.668
cytokine production GO:0001816 319 0.667
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.666
leydig cell differentiation GO:0033327 10 0.665
cellular response to growth factor stimulus GO:0071363 197 0.665
cellular response to organonitrogen compound GO:0071417 145 0.664
positive regulation of b cell proliferation GO:0030890 24 0.664
muscle cell migration GO:0014812 19 0.663
nucleoside phosphate biosynthetic process GO:1901293 79 0.663
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.660
regulation of kidney development GO:0090183 40 0.653
regulation of camp mediated signaling GO:0043949 7 0.652
cell differentiation involved in kidney development GO:0061005 33 0.649
positive regulation of neuron differentiation GO:0045666 141 0.647
response to lipopolysaccharide GO:0032496 128 0.645
somatostatin receptor signaling pathway GO:0038169 2 0.643
positive regulation of leukocyte differentiation GO:1902107 86 0.642
metanephros morphogenesis GO:0003338 24 0.641
positive regulation of defense response GO:0031349 124 0.639
positive regulation of innate immune response GO:0045089 80 0.637
prostate gland morphogenesis GO:0060512 32 0.636
regulation of tube size GO:0035150 57 0.635
dna metabolic process GO:0006259 303 0.633
wnt signaling pathway GO:0016055 188 0.631
positive regulation of activated t cell proliferation GO:0042104 8 0.629
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.628
carbon catabolite regulation of transcription GO:0045990 4 0.628
trophectodermal cellular morphogenesis GO:0001831 3 0.623
Mouse
metanephric nephron tubule development GO:0072234 16 0.623
camp biosynthetic process GO:0006171 31 0.622
epidermis development GO:0008544 187 0.617
regulation of cytokine production GO:0001817 266 0.615
long term synaptic potentiation GO:0060291 25 0.615
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.613
regulation of organelle organization GO:0033043 289 0.612
ribose phosphate biosynthetic process GO:0046390 59 0.608
cell differentiation involved in metanephros development GO:0072202 12 0.608
ureteric bud morphogenesis GO:0060675 62 0.606
regulation of lyase activity GO:0051339 13 0.606
negative regulation of peptide secretion GO:0002792 16 0.604
trophectodermal cell proliferation GO:0001834 2 0.604
Mouse
positive regulation of translational initiation by iron GO:0045994 2 0.600
leukocyte proliferation GO:0070661 172 0.594
triglyceride homeostasis GO:0070328 15 0.592
regulation of canonical wnt signaling pathway GO:0060828 82 0.592
insulin secretion GO:0030073 89 0.592
regulation of peptide transport GO:0090087 91 0.590
somatostatin signaling pathway GO:0038170 2 0.587
prostate gland development GO:0030850 48 0.582
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.580
negative regulation of cell motility GO:2000146 61 0.580
t cell activation GO:0042110 289 0.580
embryonic organ morphogenesis GO:0048562 276 0.577
regulation of glutamate metabolic process GO:2000211 1 0.576
connective tissue development GO:0061448 179 0.574
positive regulation of map kinase activity GO:0043406 84 0.570
oxidation reduction process GO:0055114 342 0.569
Human
positive regulation of smooth muscle cell migration GO:0014911 4 0.568
carbohydrate derivative biosynthetic process GO:1901137 183 0.566
cellular response to growth hormone stimulus GO:0071378 7 0.565
b cell differentiation GO:0030183 78 0.565
regulation of lymphocyte proliferation GO:0050670 117 0.564
regulation of cell growth GO:0001558 91 0.563
organic anion transport GO:0015711 137 0.563
positive regulation of adenylate cyclase activity GO:0045762 8 0.563
positive regulation of male gonad development GO:2000020 6 0.563
nucleotide biosynthetic process GO:0009165 78 0.561
regulation of lymphocyte activation GO:0051249 240 0.561
innate immune response GO:0045087 157 0.560
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.559
regulation of circadian sleep wake cycle GO:0042749 3 0.557
mesonephric tubule development GO:0072164 94 0.556
polysaccharide metabolic process GO:0005976 39 0.553
cytoplasmic transport GO:0016482 234 0.552
regulation of gluconeogenesis GO:0006111 30 0.551
protein kinase b signaling GO:0043491 74 0.551
embryonic skeletal system development GO:0048706 120 0.548
maintenance of location GO:0051235 89 0.548
developmental maturation GO:0021700 193 0.547
Mouse
activation of mapk activity GO:0000187 59 0.547
positive regulation of cellular amine metabolic process GO:0033240 5 0.544
positive regulation of transcription by galactose GO:0000411 1 0.543
retina development in camera type eye GO:0060041 119 0.542
nephron morphogenesis GO:0072028 69 0.539
regulation of t cell differentiation GO:0045580 83 0.539
immune response regulating signaling pathway GO:0002764 125 0.536
response to estrogen GO:0043627 24 0.535
regulation of intracellular estrogen receptor signaling pathway GO:0033146 8 0.534
regulation of secretion GO:0051046 274 0.534
regulation of catecholamine uptake involved in synaptic transmission GO:0051940 2 0.533
b cell proliferation GO:0042100 53 0.531
positive regulation of histone h3 k9 methylation GO:0051574 4 0.530
hormone biosynthetic process GO:0042446 16 0.529
regulation of integrin biosynthetic process GO:0045113 1 0.528
cytokine mediated signaling pathway GO:0019221 115 0.527
myeloid leukocyte differentiation GO:0002573 119 0.526
sperm chromatin condensation GO:0035092 8 0.526
cell proliferation in hindbrain GO:0021534 10 0.525
anatomical structure homeostasis GO:0060249 145 0.525
camp mediated signaling GO:0019933 15 0.525
regulation of tolerance induction to self antigen GO:0002649 1 0.524
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.524
Human
regulation of hormone metabolic process GO:0032350 15 0.524
regulation of osteoclast differentiation GO:0045670 36 0.523
negative regulation of lipid metabolic process GO:0045833 30 0.522
Rat
regulation of leukocyte proliferation GO:0070663 121 0.517
regulation of monooxygenase activity GO:0032768 7 0.515
Human
positive regulation of cyclic nucleotide metabolic process GO:0030801 24 0.508
alpha amino acid catabolic process GO:1901606 18 0.507
fat soluble vitamin biosynthetic process GO:0042362 4 0.504
regulation of cyclase activity GO:0031279 13 0.504
histone acetylation GO:0016573 41 0.503
negative regulation of homeostatic process GO:0032845 71 0.503
lipid storage GO:0019915 36 0.501
purine nucleotide biosynthetic process GO:0006164 65 0.498
plasma membrane long chain fatty acid transport GO:0015911 1 0.497
mesonephric tubule morphogenesis GO:0072171 63 0.493
positive regulation of kinase activity GO:0033674 155 0.493
renal system development GO:0072001 225 0.492
biological phase GO:0044848 20 0.491
metanephric nephron epithelium development GO:0072243 19 0.491
positive regulation of lymphocyte differentiation GO:0045621 61 0.491
chromatin organization GO:0006325 206 0.489
g protein coupled receptor signaling pathway involved in heart process GO:0086103 4 0.488
cellular chemical homeostasis GO:0055082 215 0.485
Rat
negative regulation of protein secretion GO:0050709 20 0.484
spermatid nucleus differentiation GO:0007289 19 0.482
negative regulation of cell development GO:0010721 169 0.480
regulation of adenylate cyclase activity GO:0045761 10 0.479
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.477
positive regulation of kidney development GO:0090184 28 0.475
uterus development GO:0060065 16 0.475
negative regulation of molecular function GO:0044092 258 0.472
Human
cellular response to x ray GO:0071481 2 0.468
nephron epithelium morphogenesis GO:0072088 68 0.468
regulation of intracellular transport GO:0032386 159 0.467
prostate glandular acinus morphogenesis GO:0060526 7 0.463
kidney morphogenesis GO:0060993 83 0.462
negative regulation of proteolysis GO:0045861 74 0.458
regulation of endopeptidase activity GO:0052548 89 0.457
fatty acid biosynthetic process GO:0006633 41 0.454
protein localization to nucleus GO:0034504 121 0.454
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.453
regulation of neurotransmitter levels GO:0001505 87 0.451
eating behavior GO:0042755 15 0.450
reactive oxygen species biosynthetic process GO:1903409 8 0.449
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.448
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.447
wound healing GO:0042060 157 0.447
muscle cell differentiation GO:0042692 261 0.443
positive regulation of lipid biosynthetic process GO:0046889 18 0.442
protein localization to organelle GO:0033365 185 0.442
myotube differentiation GO:0014902 105 0.441
cellular response to lipopolysaccharide GO:0071222 77 0.440
covalent chromatin modification GO:0016569 163 0.438
acetylcholine metabolic process GO:0008291 3 0.434
synaptic transmission GO:0007268 329 0.434
regulation of cell migration GO:0030334 219 0.434
monosaccharide biosynthetic process GO:0046364 44 0.433
urogenital system development GO:0001655 261 0.430
negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 7 0.429
regulation of map kinase activity GO:0043405 120 0.429
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.428
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.428
mesoderm structural organization GO:0048338 1 0.427
positive regulation of lymphocyte proliferation GO:0050671 70 0.426
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.424
regulation of histone acetylation GO:0035065 19 0.419
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.417
monocarboxylic acid transport GO:0015718 44 0.417
negative regulation of fatty acid metabolic process GO:0045922 10 0.417
regulation of the force of heart contraction GO:0002026 17 0.410
cellular response to bile acid GO:1903413 1 0.409
mast cell proliferation GO:0070662 4 0.408
acute inflammatory response GO:0002526 41 0.407
response to estradiol GO:0032355 12 0.405
Human Zebrafish Rat
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.402
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.402
regulation of calcidiol 1 monooxygenase activity GO:0060558 1 0.402
positive regulation of programmed cell death GO:0043068 218 0.401
internal protein amino acid acetylation GO:0006475 42 0.397
cation homeostasis GO:0055080 212 0.397
Rat
leukocyte differentiation GO:0002521 342 0.396
axonogenesis GO:0007409 274 0.392
regulation of cellular response to stress GO:0080135 159 0.389
negative regulation of nervous system development GO:0051961 156 0.389
positive regulation of t cell activation GO:0050870 101 0.387
transcytosis GO:0045056 5 0.386
establishment of protein localization to organelle GO:0072594 118 0.382
regulation of hormone biosynthetic process GO:0046885 9 0.380
hexose metabolic process GO:0019318 98 0.380
transcription from rna polymerase iii promoter GO:0006383 3 0.379

Esr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
female reproductive system disease DOID:229 0 0.983
disease of anatomical entity DOID:7 0 0.983
Human
reproductive system disease DOID:15 0 0.983
prostate cancer DOID:10283 0 0.827
male reproductive organ cancer DOID:3856 0 0.827
reproductive organ cancer DOID:193 0 0.827
cancer DOID:162 0 0.827
disease of cellular proliferation DOID:14566 0 0.827
organ system cancer DOID:0050686 0 0.827
ovarian disease DOID:1100 0 0.649
bone remodeling disease DOID:0080005 0 0.412
bone disease DOID:0080001 0 0.412
musculoskeletal system disease DOID:17 0 0.412
connective tissue disease DOID:65 0 0.412