IMP

Process View

Mus musculus

10 genes annotated in mouse

leydig cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "leydig cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "leydig cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.996
Sox9	SRY-box containing gene 9	0.972
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.955
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.936
Amhr2	anti-Mullerian hormone type 2 receptor	0.756
Ctnnb1	catenin (cadherin associated protein), beta 1	0.704
Hand1	heart and neural crest derivatives expressed transcript 1	0.693
Hand2	heart and neural crest derivatives expressed transcript 2	0.686
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.675
Esr1	estrogen receptor 1 (alpha)	0.665
Shh	sonic hedgehog	0.649	Mouse
Trp53	transformation related protein 53	0.609
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.581
Sall4	sal-like 4 (Drosophila)	0.518
Ar	androgen receptor	0.398
Pthlh	parathyroid hormone-like peptide	0.355
Fgfr3	fibroblast growth factor receptor 3	0.350
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.333
Csf1	colony stimulating factor 1 (macrophage)	0.326
Kiss1	KiSS-1 metastasis-suppressor	0.311
Apc	adenomatosis polyposis coli	0.309
Tcf21	transcription factor 21	0.303
Gli3	GLI-Kruppel family member GLI3	0.295
Foxc2	forkhead box C2	0.295
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.292	Rat
Gli2	GLI-Kruppel family member GLI2	0.281
Bmp2	bone morphogenetic protein 2	0.280
Pten	phosphatase and tensin homolog	0.248
Dhh	desert hedgehog	0.242
Fshr	follicle stimulating hormone receptor	0.238
Vegfa	vascular endothelial growth factor A	0.202
Fgf9	fibroblast growth factor 9	0.196
Ptch1	patched homolog 1	0.192
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.170
Foxc1	forkhead box C1	0.166
Nkx3-2	NK3 homeobox 2	0.163	Mouse
Runx2	runt related transcription factor 2	0.158
Pax8	paired box gene 8	0.150
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.141
Amh	anti-Mullerian hormone	0.130
Cdk4	cyclin-dependent kinase 4	0.129
Wwox	WW domain-containing oxidoreductase	0.129
Hoxd3	homeobox D3	0.127
Meox2	mesenchyme homeobox 2	0.123
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.122
Pdx1	pancreatic and duodenal homeobox 1	0.104
Hoxa10	homeobox A10	0.103
Gata4	GATA binding protein 4	0.097
Schip1	schwannomin interacting protein 1	0.096
Zeb1	zinc finger E-box binding homeobox 1	0.093
Hoxd11	homeobox D11	0.091
Nkx6-1	NK6 homeobox 1	0.089
Pou5f1	POU domain, class 5, transcription factor 1	0.085
Bmp4	bone morphogenetic protein 4	0.084
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.082
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.081
Foxa2	forkhead box A2	0.080
Hes3	hairy and enhancer of split 3 (Drosophila)	0.079
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.072
Smo	smoothened homolog (Drosophila)	0.072
Col2a1	collagen, type II, alpha 1	0.071
Gata6	GATA binding protein 6	0.070
Esr2	estrogen receptor 2 (beta)	0.067
Tgfbr2	transforming growth factor, beta receptor II	0.060
Fgf8	fibroblast growth factor 8	0.060
Plekha5	pleckstrin homology domain containing, family A member 5	0.057
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.057
Pgr	progesterone receptor	0.057
Tbx3	T-box 3	0.056
Ahr	aryl-hydrocarbon receptor	0.056
Kdr	kinase insert domain protein receptor	0.055	Mouse
Hnf4a	hepatic nuclear factor 4, alpha	0.054
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.052
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.051
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.049
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.048
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.048
Ptprb	protein tyrosine phosphatase, receptor type, B	0.047
Tbx1	T-box 1	0.046
Cdk6	cyclin-dependent kinase 6	0.046
Prlr	prolactin receptor	0.046
Otp	orthopedia homolog (Drosophila)	0.043
Cbl	Casitas B-lineage lymphoma	0.043
Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.043	Rat
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.041
Sct	secretin	0.039
Cdh5	cadherin 5	0.039
Hoxd13	homeobox D13	0.039
Ldlr	low density lipoprotein receptor	0.038
Sall1	sal-like 1 (Drosophila)	0.037
Nf1	neurofibromatosis 1	0.036
Star	steroidogenic acute regulatory protein	0.035
Fgf10	fibroblast growth factor 10	0.034
Drd2	dopamine receptor D2	0.034
Tnp1	transition protein 1	0.033
Foxb2	forkhead box B2	0.033
Pitx1	paired-like homeodomain transcription factor 1	0.031
Pax3	paired box gene 3	0.030
Foxe1	forkhead box E1	0.030
Gnrh1	gonadotropin releasing hormone 1	0.029
Atoh7	atonal homolog 7 (Drosophila)	0.029
Vax1	ventral anterior homeobox containing gene 1	0.029
Fgf3	fibroblast growth factor 3	0.029
Inhbc	inhibin beta-C	0.029
Tcfap2a	transcription factor AP-2, alpha	0.029
Hsd3b2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.028	Rat
Vegfc	vascular endothelial growth factor C	0.028
Pax2	paired box gene 2	0.027
Trp63	transformation related protein 63	0.027
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.027
Aqp8	aquaporin 8	0.027
Col1a1	collagen, type I, alpha 1	0.026
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.026
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.026	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.025
Tbx5	T-box 5	0.025
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.025
Gnrhr	gonadotropin releasing hormone receptor	0.024
Plcg1	phospholipase C, gamma 1	0.024
Utf1	undifferentiated embryonic cell transcription factor 1	0.023
Mybpc3	myosin binding protein C, cardiac	0.023
Gja1	gap junction protein, alpha 1	0.023
Pbx1	pre B-cell leukemia transcription factor 1	0.023
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.022
Gpx5	glutathione peroxidase 5	0.021
Alx4	aristaless-like homeobox 4	0.021
Arx	aristaless related homeobox	0.020
Ret	ret proto-oncogene	0.020
C9	complement component 9	0.019
Hes1	hairy and enhancer of split 1 (Drosophila)	0.019
Tulp2	tubby-like protein 2	0.018
Fgfr1	fibroblast growth factor receptor 1	0.018
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.018	Mouse
Afm	afamin	0.018
Hdgfl1	hepatoma derived growth factor-like 1	0.018
Bmp7	bone morphogenetic protein 7	0.017
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.017
Sox3	SRY-box containing gene 3	0.017
Mesp1	mesoderm posterior 1	0.017
Hao2	hydroxyacid oxidase 2	0.017
Efnb2	ephrin B2	0.017
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.017
Pax1	paired box gene 1	0.017
Prr15	proline rich 15	0.016
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.016
Znrf4	zinc and ring finger 4	0.016
Ednrb	endothelin receptor type B	0.016
Foxd2	forkhead box D2	0.016
Pcdh12	protocadherin 12	0.016
Kif3a	kinesin family member 3A	0.016
Il4	interleukin 4	0.016
Tmem204	transmembrane protein 204	0.015
Otx2	orthodenticle homolog 2 (Drosophila)	0.015
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.015
Npr2	natriuretic peptide receptor 2	0.015
Rarb	retinoic acid receptor, beta	0.015
Axin2	axin2	0.015
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.015
Hoxd10	homeobox D10	0.015
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.015
Gata5	GATA binding protein 5	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.014
Sox4	SRY-box containing gene 4	0.014
Foxg1	forkhead box G1	0.014
Egr1	early growth response 1	0.014
Alx3	aristaless-like homeobox 3	0.014
Isl1	ISL1 transcription factor, LIM/homeodomain	0.014
Emx2	empty spiracles homolog 2 (Drosophila)	0.013
Fyn	Fyn proto-oncogene	0.013
Ikzf1	IKAROS family zinc finger 1	0.013
Esrrb	estrogen related receptor, beta	0.013
Adra2b	adrenergic receptor, alpha 2b	0.013
Tbx2	T-box 2	0.013
Dmrt1	doublesex and mab-3 related transcription factor 1	0.013
Plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.013
Klk6	kallikrein related-peptidase 6	0.013
Miox	myo-inositol oxygenase	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.013
Inhba	inhibin beta-A	0.012
Hoxd4	homeobox D4	0.012
Evx2	even skipped homeotic gene 2 homolog	0.012
Rhcg	Rhesus blood group-associated C glycoprotein	0.012
Barx1	BarH-like homeobox 1	0.012
Ihh	Indian hedgehog	0.012	Mouse
Mep1a	meprin 1 alpha	0.012
Bmp8b	bone morphogenetic protein 8b	0.012
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.012	Mouse
Kl	klotho	0.012
Gata3	GATA binding protein 3	0.012
Chd7	chromodomain helicase DNA binding protein 7	0.012
Clrn3	clarin 3	0.012
Sardh	sarcosine dehydrogenase	0.012
Lep	leptin	0.012
Rxra	retinoid X receptor alpha	0.011
Osta	organic solute transporter alpha	0.011
Tyrobp	TYRO protein tyrosine kinase binding protein	0.011
Cxcl12	chemokine (C-X-C motif) ligand 12	0.011
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.011
Msx1	homeobox, msh-like 1	0.011
Casc3	cancer susceptibility candidate 3	0.011
Sox7	SRY-box containing gene 7	0.011
Heg1	HEG homolog 1 (zebrafish)	0.011
Akr1c21	aldo-keto reductase family 1, member C21	0.011
Nobox	NOBOX oogenesis homeobox	0.011
Aqp7	aquaporin 7	0.011
Mdfi	MyoD family inhibitor	0.011
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.011
Cdhr5	cadherin-related family member 5	0.011
Gpr37	G protein-coupled receptor 37	0.011
Hoxa13	homeobox A13	0.011
Ces3a	carboxylesterase 3A	0.011
Cyb5	cytochrome b-5	0.011
Kitl	kit ligand	0.011
Podxl	podocalyxin-like	0.010
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.010	Rat
Hhat	hedgehog acyltransferase	0.010
Ctdp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.010
T	brachyury	0.010
Stat3	signal transducer and activator of transcription 3	0.010
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.010
Foxd3	forkhead box D3	0.010
Ghr	growth hormone receptor	0.010
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.010
Wnt5a	wingless-related MMTV integration site 5A	0.010