IMP

Process View

Mus musculus

9 genes annotated in mouse

negative regulation of cyclin dependent protein serine threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cyclin dependent protein serine threonine kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cyclin dependent protein serine threonine kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Rb1	retinoblastoma 1	0.999
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.996
Pten	phosphatase and tensin homolog	0.995	Human
Apc	adenomatosis polyposis coli	0.994	Human
Casp1	caspase 1	0.949	Mouse
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.919
Braf	Braf transforming gene	0.899
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.891	Mouse
Nf1	neurofibromatosis 1	0.883
Mdm2	transformed mouse 3T3 cell double minute 2	0.820
Esr1	estrogen receptor 1 (alpha)	0.817
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.812
E2f1	E2F transcription factor 1	0.737
Hif1a	hypoxia inducible factor 1, alpha subunit	0.706
Kit	kit oncogene	0.647
Lepr	leptin receptor	0.647
Gbp5	guanylate binding protein 5	0.614
Ptch1	patched homolog 1	0.589
Smad3	MAD homolog 3 (Drosophila)	0.472
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.433
Pycard	PYD and CARD domain containing	0.422
Meox2	mesenchyme homeobox 2	0.389
Tlr4	toll-like receptor 4	0.357
Thbs1	thrombospondin 1	0.337
Ghr	growth hormone receptor	0.318
Smad4	MAD homolog 4 (Drosophila)	0.284
Lyz2	lysozyme 2	0.280
Kitl	kit ligand	0.245
Ahr	aryl-hydrocarbon receptor	0.245
Il18	interleukin 18	0.223
Psen1	presenilin 1	0.220
Aim2	absent in melanoma 2	0.211
Foxo3	forkhead box O3	0.159
Nf2	neurofibromatosis 2	0.146
Vhl	von Hippel-Lindau tumor suppressor	0.141
Smad2	MAD homolog 2 (Drosophila)	0.127
Il1b	interleukin 1 beta	0.126
Col1a1	collagen, type I, alpha 1	0.124
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.121
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.121
Men1	multiple endocrine neoplasia 1	0.114	Human
Notch1	Notch gene homolog 1 (Drosophila)	0.114
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.112
Tgfb1	transforming growth factor, beta 1	0.107
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.102
Notch2	Notch gene homolog 2 (Drosophila)	0.100
Csrp2bp	cysteine and glycine-rich protein 2 binding protein	0.099
Fas	Fas (TNF receptor superfamily member 6)	0.099
Hes1	hairy and enhancer of split 1 (Drosophila)	0.094
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.091
Tsc1	tuberous sclerosis 1	0.090
Zeb1	zinc finger E-box binding homeobox 1	0.090
Ccnd1	cyclin D1	0.087
Traf6	TNF receptor-associated factor 6	0.084
Ar	androgen receptor	0.082
Runx1	runt related transcription factor 1	0.080
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.078
Mdm4	transformed mouse 3T3 cell double minute 4	0.073
Brca1	breast cancer 1	0.069
Ptgs2	prostaglandin-endoperoxide synthase 2	0.069
Bmp4	bone morphogenetic protein 4	0.065
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.064
Fgfr2	fibroblast growth factor receptor 2	0.062
Apaf1	apoptotic peptidase activating factor 1	0.060
Yap1	yes-associated protein 1	0.056
Brca2	breast cancer 2	0.053
Amhr2	anti-Mullerian hormone type 2 receptor	0.052
Fadd	Fas (TNFRSF6)-associated via death domain	0.052
Pparg	peroxisome proliferator activated receptor gamma	0.051
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.051
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.050
Tmpo	thymopoietin	0.048
Nfya	nuclear transcription factor-Y alpha	0.044
Stk11	serine/threonine kinase 11	0.042
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.042
Clock	circadian locomotor output cycles kaput	0.041
Atf3	activating transcription factor 3	0.041
Il6st	interleukin 6 signal transducer	0.041
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.040
Nlrp3	NLR family, pyrin domain containing 3	0.040
Fgfr1	fibroblast growth factor receptor 1	0.039
Csf1	colony stimulating factor 1 (macrophage)	0.037
Sav1	salvador homolog 1 (Drosophila)	0.035
Mr1	major histocompatibility complex, class I-related	0.035
Rxra	retinoid X receptor alpha	0.034
Trp63	transformation related protein 63	0.034
Cdk9	cyclin-dependent kinase 9 (CDC2-related kinase)	0.032
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.032
Traf2	TNF receptor-associated factor 2	0.031
Vav2	vav 2 oncogene	0.031
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.031
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.030
Kiss1	KiSS-1 metastasis-suppressor	0.029
Usp21	ubiquitin specific peptidase 21	0.029
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.029
Nos3	nitric oxide synthase 3, endothelial cell	0.029
Wls	wntless homolog (Drosophila)	0.028
Birc3	baculoviral IAP repeat-containing 3	0.028
Trp73	transformation related protein 73	0.028
Myo6	myosin VI	0.026
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.025
Iqgap3	IQ motif containing GTPase activating protein 3	0.024
Smad5	MAD homolog 5 (Drosophila)	0.024
Axin1	axin 1	0.024
Htt	huntingtin	0.024
Ptgs1	prostaglandin-endoperoxide synthase 1	0.024
Il1r1	interleukin 1 receptor, type I	0.023
Blnk	B-cell linker	0.023
Kiss1r	KISS1 receptor	0.023
Emx1	empty spiracles homolog 1 (Drosophila)	0.023
Ikbkg	inhibitor of kappaB kinase gamma	0.023
Xpa	xeroderma pigmentosum, complementation group A	0.022
Foxa2	forkhead box A2	0.022
Gbp7	guanylate binding protein 7	0.022
Krt14	keratin 14	0.022
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.021
Lrp6	low density lipoprotein receptor-related protein 6	0.021
Wwox	WW domain-containing oxidoreductase	0.021
Foxo1	forkhead box O1	0.020
Wdr5	WD repeat domain 5	0.020
Cdk2	cyclin-dependent kinase 2	0.020
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.020
Ripk3	receptor-interacting serine-threonine kinase 3	0.020
Gata4	GATA binding protein 4	0.019
Stk4	serine/threonine kinase 4	0.019
Stat3	signal transducer and activator of transcription 3	0.019
Cav1	caveolin 1, caveolae protein	0.019
Fgfr3	fibroblast growth factor receptor 3	0.019
Prlr	prolactin receptor	0.019
Per2	period homolog 2 (Drosophila)	0.019
Ogn	osteoglycin	0.018
Taf6l	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor	0.018
Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.018
Skil	SKI-like	0.017
Cd38	CD38 antigen	0.017
Cyld	cylindromatosis (turban tumor syndrome)	0.017
Npc1	Niemann Pick type C1	0.017
E130303B06Rik	RIKEN cDNA E130303B06 gene	0.016
Foxp1	forkhead box P1	0.016
Klf5	Kruppel-like factor 5	0.016
Prss23	protease, serine, 23	0.016
Gas1	growth arrest specific 1	0.016
Foxc1	forkhead box C1	0.016
Vdr	vitamin D receptor	0.015
Dgcr2	DiGeorge syndrome critical region gene 2	0.015
Tsc2	tuberous sclerosis 2	0.015
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.015
Sox9	SRY-box containing gene 9	0.015
Osmr	oncostatin M receptor	0.015
Smad1	MAD homolog 1 (Drosophila)	0.015
Gsk3b	glycogen synthase kinase 3 beta	0.015
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.015
Tnf	tumor necrosis factor	0.014
Lum	lumican	0.014
Sykb	spleen tyrosine kinase	0.014
Mapk14	mitogen-activated protein kinase 14	0.014
Hoxa5	homeobox A5	0.013
Npr3	natriuretic peptide receptor 3	0.013
Cdca8	cell division cycle associated 8	0.013
Rcc2	regulator of chromosome condensation 2	0.013
Kat2a	K(lysine) acetyltransferase 2A	0.013	Mouse
Cbfb	core binding factor beta	0.013
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.013
Hcfc1	host cell factor C1	0.013
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.013
Casp7	caspase 7	0.012	Mouse
Nfib	nuclear factor I/B	0.012
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.012
Adam10	a disintegrin and metallopeptidase domain 10	0.012
Mlph	melanophilin	0.012
Itgav	integrin alpha V	0.012
Lmnb2	lamin B2	0.012
Nmi	N-myc (and STAT) interactor	0.012
Gimap4	GTPase, IMAP family member 4	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.012
Sdpr	serum deprivation response	0.012
Hesx1	homeobox gene expressed in ES cells	0.012
Pgap1	post-GPI attachment to proteins 1	0.011
Esr2	estrogen receptor 2 (beta)	0.011
Id1	inhibitor of DNA binding 1	0.011
Ly96	lymphocyte antigen 96	0.011
Tgif1	TGFB-induced factor homeobox 1	0.011
Sox4	SRY-box containing gene 4	0.011
Wrn	Werner syndrome homolog (human)	0.011
Tgfbr2	transforming growth factor, beta receptor II	0.011
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.011
Atp11c	ATPase, class VI, type 11C	0.011
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
Bach2	BTB and CNC homology 2	0.010
Gbp3	guanylate binding protein 3	0.010
Sgpl1	sphingosine phosphate lyase 1	0.010
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.010
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.010
Mta2	metastasis-associated gene family, member 2	0.010
Ifngr1	interferon gamma receptor 1	0.010
Mdfic	MyoD family inhibitor domain containing	0.010
Ugcg	UDP-glucose ceramide glucosyltransferase	0.010
Vars	valyl-tRNA synthetase	0.010
Tgfbr1	transforming growth factor, beta receptor I	0.010
Cd44	CD44 antigen	0.010