IMP
Process View
canonical wnt signaling pathway involved in metanephric kidney development
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in metanephric kidney development"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Kiss1 | KiSS-1 metastasis-suppressor | 0.992 | ||
| Lhcgr | luteinizing hormone/choriogonadotropin receptor | 0.988 | Mouse | |
| Esr1 | estrogen receptor 1 (alpha) | 0.986 | ||
| Ghr | growth hormone receptor | 0.932 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.927 | ||
| Ar | androgen receptor | 0.897 | ||
| Pax8 | paired box gene 8 | 0.858 | ||
| Rxra | retinoid X receptor alpha | 0.837 | ||
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.583 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.551 | ||
| Gata5 | GATA binding protein 5 | 0.549 | Mouse | |
| Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.525 | ||
| Pax2 | paired box gene 2 | 0.480 | ||
| Foxc1 | forkhead box C1 | 0.474 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.463 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.440 | ||
| Zfpm2 | zinc finger protein, multitype 2 | 0.439 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.411 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.347 | ||
| Jag1 | jagged 1 | 0.319 | ||
| Fgf10 | fibroblast growth factor 10 | 0.312 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.283 | ||
| Gata6 | GATA binding protein 6 | 0.274 | Mouse | |
| Gata4 | GATA binding protein 4 | 0.270 | Mouse | |
| Fshr | follicle stimulating hormone receptor | 0.265 | Mouse | |
| Hoxa1 | homeobox A1 | 0.263 | ||
| Foxc2 | forkhead box C2 | 0.260 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.231 | ||
| Vegfa | vascular endothelial growth factor A | 0.198 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.191 | ||
| Kiss1r | KISS1 receptor | 0.153 | ||
| Thrb | thyroid hormone receptor beta | 0.151 | ||
| Prlr | prolactin receptor | 0.143 | ||
| Foxf2 | forkhead box F2 | 0.138 | ||
| Fgf8 | fibroblast growth factor 8 | 0.125 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.124 | ||
| Gnrh1 | gonadotropin releasing hormone 1 | 0.121 | ||
| Tbx3 | T-box 3 | 0.119 | ||
| Pten | phosphatase and tensin homolog | 0.110 | ||
| Shh | sonic hedgehog | 0.108 | ||
| Inha | inhibin alpha | 0.101 | ||
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.099 | ||
| Wt1 | Wilms tumor 1 homolog | 0.086 | ||
| Lepr | leptin receptor | 0.085 | ||
| Inhba | inhibin beta-A | 0.077 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.075 | ||
| Ppara | peroxisome proliferator activated receptor alpha | 0.069 | ||
| Mesp1 | mesoderm posterior 1 | 0.069 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.064 | ||
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.063 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.061 | ||
| Bglap | bone gamma carboxyglutamate protein | 0.056 | ||
| Cited2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.055 | ||
| Foxf1a | forkhead box F1a | 0.053 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.052 | ||
| Egfr | epidermal growth factor receptor | 0.052 | ||
| Kit | kit oncogene | 0.051 | ||
| Klf3 | Kruppel-like factor 3 (basic) | 0.050 | ||
| Gnrhr | gonadotropin releasing hormone receptor | 0.048 | ||
| Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | 0.047 | ||
| Sox9 | SRY-box containing gene 9 | 0.046 | ||
| Tbx1 | T-box 1 | 0.046 | ||
| Lep | leptin | 0.045 | ||
| Rarb | retinoic acid receptor, beta | 0.045 | ||
| Pax3 | paired box gene 3 | 0.045 | ||
| Ntf3 | neurotrophin 3 | 0.045 | ||
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.044 | ||
| Cga | glycoprotein hormones, alpha subunit | 0.044 | ||
| Rarg | retinoic acid receptor, gamma | 0.043 | ||
| Meox2 | mesenchyme homeobox 2 | 0.043 | ||
| Tead3 | TEA domain family member 3 | 0.041 | ||
| Bnc1 | basonuclin 1 | 0.037 | ||
| Lhx3 | LIM homeobox protein 3 | 0.037 | ||
| Efnb2 | ephrin B2 | 0.037 | ||
| Hoxa10 | homeobox A10 | 0.035 | ||
| Sox7 | SRY-box containing gene 7 | 0.033 | ||
| Duox2 | dual oxidase 2 | 0.032 | ||
| Npr1 | natriuretic peptide receptor 1 | 0.031 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.031 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.030 | ||
| Cftr | cystic fibrosis transmembrane conductance regulator homolog | 0.030 | ||
| Sox4 | SRY-box containing gene 4 | 0.029 | ||
| Ahr | aryl-hydrocarbon receptor | 0.027 | ||
| Slc34a2 | solute carrier family 34 (sodium phosphate), member 2 | 0.027 | ||
| Esr2 | estrogen receptor 2 (beta) | 0.027 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.025 | ||
| Npas2 | neuronal PAS domain protein 2 | 0.024 | ||
| Thra | thyroid hormone receptor alpha | 0.022 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.022 | ||
| Hoxc8 | homeobox C8 | 0.021 | ||
| Lhx9 | LIM homeobox protein 9 | 0.020 | ||
| Plac1 | placental specific protein 1 | 0.020 | ||
| Pcsk5 | proprotein convertase subtilisin/kexin type 5 | 0.020 | ||
| Chst8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | 0.020 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.019 | ||
| Tcf21 | transcription factor 21 | 0.019 | ||
| Lhx1 | LIM homeobox protein 1 | 0.017 | ||
| Irs2 | insulin receptor substrate 2 | 0.017 | ||
| Star | steroidogenic acute regulatory protein | 0.017 | ||
| Amh | anti-Mullerian hormone | 0.017 | ||
| Bglap2 | bone gamma-carboxyglutamate protein 2 | 0.017 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.017 | ||
| Nf1 | neurofibromatosis 1 | 0.017 | ||
| Kcnj5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.017 | ||
| Myl7 | myosin, light polypeptide 7, regulatory | 0.016 | ||
| Gja1 | gap junction protein, alpha 1 | 0.016 | ||
| Tbx2 | T-box 2 | 0.016 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.016 | ||
| Nhlh2 | nescient helix loop helix 2 | 0.016 | ||
| Rara | retinoic acid receptor, alpha | 0.016 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.015 | ||
| Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.015 | ||
| Inhbb | inhibin beta-B | 0.015 | ||
| Six5 | sine oculis-related homeobox 5 homolog (Drosophila) | 0.015 | ||
| Snai1 | snail homolog 1 (Drosophila) | 0.015 | ||
| Wwox | WW domain-containing oxidoreductase | 0.014 | ||
| Drd2 | dopamine receptor D2 | 0.014 | ||
| Tshr | thyroid stimulating hormone receptor | 0.014 | Mouse | |
| Mecom | MDS1 and EVI1 complex locus | 0.014 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.014 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.014 | ||
| Vdr | vitamin D receptor | 0.014 | ||
| Hoxb4 | homeobox B4 | 0.014 | ||
| Fst | follistatin | 0.014 | ||
| Tbx20 | T-box 20 | 0.014 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.014 | ||
| Kl | klotho | 0.013 | ||
| Hoxa13 | homeobox A13 | 0.013 | ||
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.013 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.013 | ||
| Gypa | glycophorin A | 0.013 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.012 | ||
| Hoxd13 | homeobox D13 | 0.012 | ||
| Nr6a1 | nuclear receptor subfamily 6, group A, member 1 | 0.012 | ||
| Zfpm1 | zinc finger protein, multitype 1 | 0.012 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.012 | ||
| Des | desmin | 0.012 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.012 | ||
| Gpr50 | G-protein-coupled receptor 50 | 0.011 | ||
| Epha1 | Eph receptor A1 | 0.011 | ||
| P2rx1 | purinergic receptor P2X, ligand-gated ion channel, 1 | 0.011 | ||
| Hoxb3 | homeobox B3 | 0.011 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.011 | ||
| Nr1h3 | nuclear receptor subfamily 1, group H, member 3 | 0.011 | ||
| Nrk | Nik related kinase | 0.011 | ||
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.011 | ||
| Prr15 | proline rich 15 | 0.011 | ||
| Sema5b | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 0.011 | ||
| Apc | adenomatosis polyposis coli | 0.011 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.011 | ||
| Gata1 | GATA binding protein 1 | 0.011 | Mouse | |
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.011 | ||
| Gab2 | growth factor receptor bound protein 2-associated protein 2 | 0.011 | ||
| Gata2 | GATA binding protein 2 | 0.010 | Mouse | |
| Nkx3-1 | NK-3 transcription factor, locus 1 (Drosophila) | 0.010 | ||
| Kcnmb1 | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 0.010 | ||
| Acvr1 | activin A receptor, type 1 | 0.010 | ||
| Phf7 | PHD finger protein 7 | 0.010 | ||
| Hoxa4 | homeobox A4 | 0.010 | ||
| Hoxa11 | homeobox A11 | 0.010 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.010 |