IMP

Process View

Homo sapiens

2 genes annotated in human

vitamin k catabolic process

The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "vitamin k catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "vitamin k catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.982
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.973	Human
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.957
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.948
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.841
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.757
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.407
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.406
KNG1	kininogen 1	0.400
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.397	Human
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.352	Human
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.266
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.254
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.242
ADH6	alcohol dehydrogenase 6 (class V)	0.233
G6PC	glucose-6-phosphatase, catalytic subunit	0.210
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.203
DAO	D-amino-acid oxidase	0.193
RDH16	retinol dehydrogenase 16 (all-trans)	0.190
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.173
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.168
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.149
HAL	histidine ammonia-lyase	0.137
PLG	plasminogen	0.121
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.118
BHMT	betaine--homocysteine S-methyltransferase	0.114
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.111
MASP2	mannan-binding lectin serine peptidase 2	0.109
HGD	homogentisate 1,2-dioxygenase	0.108
C4BPA	complement component 4 binding protein, alpha	0.107
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.102
DIO1	deiodinase, iodothyronine, type I	0.101
C8A	complement component 8, alpha polypeptide	0.100
GLYAT	glycine-N-acyltransferase	0.098
CFHR4	complement factor H-related 4	0.097
F9	coagulation factor IX	0.094
C8B	complement component 8, beta polypeptide	0.090
FABP1	fatty acid binding protein 1, liver	0.085
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.079
ARG1	arginase, liver	0.073
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.072
HNF4A	hepatocyte nuclear factor 4, alpha	0.072
C6	complement component 6	0.070
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.067
AADAC	arylacetamide deacetylase (esterase)	0.063
GSTA3	glutathione S-transferase alpha 3	0.062
PAH	phenylalanine hydroxylase	0.062
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.061
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.059
HPD	4-hydroxyphenylpyruvate dioxygenase	0.059
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.052
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.051
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.050
FETUB	fetuin B	0.050
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.048
F13B	coagulation factor XIII, B polypeptide	0.046
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.046
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.045
PIP	prolactin-induced protein	0.044
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.043
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	0.043	Human
APOC3	apolipoprotein C-III	0.043
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.042
TMPRSS4	transmembrane protease, serine 4	0.041
AQP7	aquaporin 7	0.041
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.040
CYP4F8	cytochrome P450, family 4, subfamily F, polypeptide 8	0.039	Human
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.039
LIPC	lipase, hepatic	0.037
EPHX2	epoxide hydrolase 2, cytoplasmic	0.036
PKLR	pyruvate kinase, liver and RBC	0.036
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.035
DPYS	dihydropyrimidinase	0.035
C9	complement component 9	0.034
ANXA13	annexin A13	0.034
KHK	ketohexokinase (fructokinase)	0.034
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.033
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.033
TREH	trehalase (brush-border membrane glycoprotein)	0.033
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.031
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.031
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.030
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.030
MAT1A	methionine adenosyltransferase I, alpha	0.030
FMO4	flavin containing monooxygenase 4	0.029
SPP2	secreted phosphoprotein 2, 24kDa	0.029
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.029
NAT8	N-acetyltransferase 8 (GCN5-related, putative)	0.029
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.029
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.029
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.028
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.028
ORM1	orosomucoid 1	0.027
PRLR	prolactin receptor	0.027
KRT13	keratin 13	0.027
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.027
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.026
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.026
SCGB2A1	secretoglobin, family 2A, member 1	0.025
CPB2	carboxypeptidase B2 (plasma)	0.025
LPA	lipoprotein, Lp(a)	0.025
OTC	ornithine carbamoyltransferase	0.024
C8G	complement component 8, gamma polypeptide	0.024
HPX	hemopexin	0.023
APOF	apolipoprotein F	0.023
ADRA1A	adrenergic, alpha-1A-, receptor	0.023
C4BPB	complement component 4 binding protein, beta	0.022
AGXT	alanine-glyoxylate aminotransferase	0.022
IL22RA1	interleukin 22 receptor, alpha 1	0.022
CDHR5	cadherin-related family member 5	0.022
SLC38A3	solute carrier family 38, member 3	0.022
ANGPTL3	angiopoietin-like 3	0.021
ORM2	orosomucoid 2	0.021
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.021
PIPOX	pipecolic acid oxidase	0.021
LECT2	leukocyte cell-derived chemotaxin 2	0.021
F5	coagulation factor V (proaccelerin, labile factor)	0.020
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.020
CNGA1	cyclic nucleotide gated channel alpha 1	0.020
GSTT1	glutathione S-transferase theta 1	0.019
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.018
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.018
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.018
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.018
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.018
CRISP3	cysteine-rich secretory protein 3	0.018
CRP	C-reactive protein, pentraxin-related	0.017
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.017
FABP2	fatty acid binding protein 2, intestinal	0.017
CYP4A22	cytochrome P450, family 4, subfamily A, polypeptide 22	0.017	Human
CA5A	carbonic anhydrase VA, mitochondrial	0.017
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.017
CCL16	chemokine (C-C motif) ligand 16	0.017
ADAM2	ADAM metallopeptidase domain 2	0.017
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.017
VTCN1	V-set domain containing T cell activation inhibitor 1	0.017
TMC5	transmembrane channel-like 5	0.015
CRISP2	cysteine-rich secretory protein 2	0.015
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.015
ALDOB	aldolase B, fructose-bisphosphate	0.015
GYS2	glycogen synthase 2 (liver)	0.015
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.015
AGXT2L1	alanine-glyoxylate aminotransferase 2-like 1	0.014
MTTP	microsomal triglyceride transfer protein	0.014
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.014
CLCA2	chloride channel accessory 2	0.014
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.014
KRT4	keratin 4	0.014
SPINK1	serine peptidase inhibitor, Kazal type 1	0.014
DEFB1	defensin, beta 1	0.014
PRODH	proline dehydrogenase (oxidase) 1	0.014
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.014
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.013
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.013
UPB1	ureidopropionase, beta	0.013
IL1RL2	interleukin 1 receptor-like 2	0.013
SCGB1D2	secretoglobin, family 1D, member 2	0.013
F12	coagulation factor XII (Hageman factor)	0.013
S100A14	S100 calcium binding protein A14	0.013
TMPRSS2	transmembrane protease, serine 2	0.013
CES1	carboxylesterase 1	0.013
UNC93A	unc-93 homolog A (C. elegans)	0.013
PON3	paraoxonase 3	0.013
AFM	afamin	0.013
CPS1	carbamoyl-phosphate synthase 1, mitochondrial	0.012
TTPA	tocopherol (alpha) transfer protein	0.012
FMO5	flavin containing monooxygenase 5	0.012
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.012
LIN7A	lin-7 homolog A (C. elegans)	0.012
TFR2	transferrin receptor 2	0.012
C9orf68	chromosome 9 open reading frame 68	0.012
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.012
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.012
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.012
VIL1	villin 1	0.012
HAO2	hydroxyacid oxidase 2 (long chain)	0.012
FLG	filaggrin	0.012
HPN	hepsin	0.011
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.011
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.011
MGAM	maltase-glucoamylase (alpha-glucosidase)	0.011
CLDN8	claudin 8	0.011
C14orf105	chromosome 14 open reading frame 105	0.011
GJB1	gap junction protein, beta 1, 32kDa	0.011
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.011
HRG	histidine-rich glycoprotein	0.011
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.011
FCGBP	Fc fragment of IgG binding protein	0.011
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.011
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.011
MBL2	mannose-binding lectin (protein C) 2, soluble	0.011
C10orf116	chromosome 10 open reading frame 116	0.011
C2orf54	chromosome 2 open reading frame 54	0.010
SLC26A3	solute carrier family 26, member 3	0.010
DSG1	desmoglein 1	0.010
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.010
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.010
PLEKHG6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.010
APOB	apolipoprotein B (including Ag(x) antigen)	0.010