IMP

Process View

Homo sapiens

19 genes annotated in human

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "drug metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "drug metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	1.000	Rat
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	1.000	Rat
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	1.000	Rat
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.998
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.994
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.905	Human Rat
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.856	Human
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.797
HNF4A	hepatocyte nuclear factor 4, alpha	0.759
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.752
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.724	Human Rat
NCOR2	nuclear receptor corepressor 2	0.693
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.649
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.641
C8B	complement component 8, beta polypeptide	0.568
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.523
VAC14	Vac14 homolog (S. cerevisiae)	0.465
GLYAT	glycine-N-acyltransferase	0.454
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.435
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.416
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.410	Human
C6	complement component 6	0.358
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.312
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.289	Human
MASP2	mannan-binding lectin serine peptidase 2	0.250
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.247
ADH6	alcohol dehydrogenase 6 (class V)	0.213
C8A	complement component 8, alpha polypeptide	0.199
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.179	Human
KNG1	kininogen 1	0.142
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.139
HRG	histidine-rich glycoprotein	0.137
F9	coagulation factor IX	0.133
DAO	D-amino-acid oxidase	0.127
HR	hairless homolog (mouse)	0.122
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.105
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.094
MAT1A	methionine adenosyltransferase I, alpha	0.093
APOC4	apolipoprotein C-IV	0.090
CHD9	chromodomain helicase DNA binding protein 9	0.086
TTPA	tocopherol (alpha) transfer protein	0.078
HABP2	hyaluronan binding protein 2	0.070
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.064
FMO4	flavin containing monooxygenase 4	0.060	Human Mouse
ALDOB	aldolase B, fructose-bisphosphate	0.058
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.058
APCS	amyloid P component, serum	0.057
CCL16	chemokine (C-C motif) ligand 16	0.051
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.050	Human
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.049
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.048	Human
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.048	Human
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.047	Rat
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.046
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.046
AADAC	arylacetamide deacetylase (esterase)	0.045
BHMT	betaine--homocysteine S-methyltransferase	0.044
C4BPA	complement component 4 binding protein, alpha	0.042
A1CF	APOBEC1 complementation factor	0.038
FETUB	fetuin B	0.038
RAB35	RAB35, member RAS oncogene family	0.038
CFHR4	complement factor H-related 4	0.037
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.037
OTC	ornithine carbamoyltransferase	0.036
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.035
MTTP	microsomal triglyceride transfer protein	0.035
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.033
F11	coagulation factor XI	0.032
ACRV1	acrosomal vesicle protein 1	0.032
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.031
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.031
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.030
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.030
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.029
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.028
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.027
G6PC	glucose-6-phosphatase, catalytic subunit	0.027
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.027
AFM	afamin	0.026
PON1	paraoxonase 1	0.025
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.025
XDH	xanthine dehydrogenase	0.024
TAT	tyrosine aminotransferase	0.024
FABP1	fatty acid binding protein 1, liver	0.023
HAL	histidine ammonia-lyase	0.023
HIPK2	homeodomain interacting protein kinase 2	0.022
GSTA3	glutathione S-transferase alpha 3	0.022
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.021
PLG	plasminogen	0.020
F13B	coagulation factor XIII, B polypeptide	0.020
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.020
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.020
MEP1B	meprin A, beta	0.018
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	0.018
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.018
AGXT2	alanine--glyoxylate aminotransferase 2	0.017
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.017
HGD	homogentisate 1,2-dioxygenase	0.017
LECT2	leukocyte cell-derived chemotaxin 2	0.017
CNGA1	cyclic nucleotide gated channel alpha 1	0.016
HPD	4-hydroxyphenylpyruvate dioxygenase	0.016
LAMC3	laminin, gamma 3	0.016
C9	complement component 9	0.016
GYS2	glycogen synthase 2 (liver)	0.016
RDH16	retinol dehydrogenase 16 (all-trans)	0.015
NCOR1	nuclear receptor corepressor 1	0.015
CRP	C-reactive protein, pentraxin-related	0.015
DPYS	dihydropyrimidinase	0.015
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.014
TM4SF4	transmembrane 4 L six family member 4	0.014
SLC17A4	solute carrier family 17 (sodium phosphate), member 4	0.014
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.014
PIPOX	pipecolic acid oxidase	0.014
ARG1	arginase, liver	0.014
LGALS4	lectin, galactoside-binding, soluble, 4	0.014
TMPRSS6	transmembrane protease, serine 6	0.013
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.013
PZP	pregnancy-zone protein	0.013
DNASE1L3	deoxyribonuclease I-like 3	0.013
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.013
APOC3	apolipoprotein C-III	0.013
ITIH2	inter-alpha (globulin) inhibitor H2	0.013
ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	0.013
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.013
ATP10B	ATPase, class V, type 10B	0.013
CA5A	carbonic anhydrase VA, mitochondrial	0.013
RORC	RAR-related orphan receptor C	0.013
MUC3A	mucin 3A, cell surface associated	0.012
PAH	phenylalanine hydroxylase	0.012
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.012
SAA4	serum amyloid A4, constitutive	0.012
MBL2	mannose-binding lectin (protein C) 2, soluble	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012	Human
AGXT	alanine-glyoxylate aminotransferase	0.012
GCKR	glucokinase (hexokinase 4) regulator	0.012
IL22RA1	interleukin 22 receptor, alpha 1	0.012
CPB2	carboxypeptidase B2 (plasma)	0.012
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.012
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.012
DIO1	deiodinase, iodothyronine, type I	0.011
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.011
SGK2	serum/glucocorticoid regulated kinase 2	0.011
SLC7A9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.011
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.011
CYP4A22	cytochrome P450, family 4, subfamily A, polypeptide 22	0.011	Human
RXRA	retinoid X receptor, alpha	0.011
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.011
HNF1B	HNF1 homeobox B	0.011
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.011
C4BPB	complement component 4 binding protein, beta	0.011
RARA	retinoic acid receptor, alpha	0.011
APOB	apolipoprotein B (including Ag(x) antigen)	0.010
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.010
VIL1	villin 1	0.010
CIDEB	cell death-inducing DFFA-like effector b	0.010
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.010	Human