IMP
Process View
cell surface pattern recognition receptor signaling pathway
Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
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Click on a gene's description to view its network relationships with genes known to be involved in "cell surface pattern recognition receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CRP | C-reactive protein, pentraxin-related | 0.862 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.230 | ||
| IGSF6 | immunoglobulin superfamily, member 6 | 0.194 | ||
| TLR2 | toll-like receptor 2 | 0.167 | ||
| FGB | fibrinogen beta chain | 0.159 | ||
| CCR1 | chemokine (C-C motif) receptor 1 | 0.144 | ||
| S100A9 | S100 calcium binding protein A9 | 0.120 | ||
| CLEC4A | C-type lectin domain family 4, member A | 0.114 | ||
| S100A8 | S100 calcium binding protein A8 | 0.110 | ||
| PLEK | pleckstrin | 0.105 | ||
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.093 | ||
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.079 | ||
| S100A12 | S100 calcium binding protein A12 | 0.066 | ||
| FPR1 | formyl peptide receptor 1 | 0.061 | ||
| HK3 | hexokinase 3 (white cell) | 0.057 | ||
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.056 | ||
| CFP | complement factor properdin | 0.052 | ||
| ITGB5 | integrin, beta 5 | 0.050 | ||
| CCR2 | chemokine (C-C motif) receptor 2 | 0.043 | ||
| AQP9 | aquaporin 9 | 0.041 | ||
| CYBB | cytochrome b-245, beta polypeptide | 0.039 | ||
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.036 | ||
| MARCO | macrophage receptor with collagenous structure | 0.036 | ||
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.033 | ||
| CD163 | CD163 molecule | 0.033 | ||
| NYX | nyctalopin | 0.030 | ||
| CLEC4D | C-type lectin domain family 4, member D | 0.030 | ||
| FCAR | Fc fragment of IgA, receptor for | 0.028 | ||
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.028 | ||
| IL1R2 | interleukin 1 receptor, type II | 0.027 | ||
| ORM1 | orosomucoid 1 | 0.027 | ||
| CXCR2 | chemokine (C-X-C motif) receptor 2 | 0.027 | ||
| ALOX5 | arachidonate 5-lipoxygenase | 0.026 | ||
| FPR2 | formyl peptide receptor 2 | 0.026 | ||
| RETN | resistin | 0.025 | ||
| MASP2 | mannan-binding lectin serine peptidase 2 | 0.023 | ||
| C1QA | complement component 1, q subcomponent, A chain | 0.022 | ||
| IL1RN | interleukin 1 receptor antagonist | 0.022 | ||
| C5AR1 | complement component 5a receptor 1 | 0.021 | ||
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.019 | ||
| LILRA3 | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 | 0.019 | ||
| IL1B | interleukin 1, beta | 0.018 | ||
| CLEC4E | C-type lectin domain family 4, member E | 0.018 | ||
| HP | haptoglobin | 0.017 | ||
| ASGR2 | asialoglycoprotein receptor 2 | 0.016 | ||
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.016 | ||
| FOLR3 | folate receptor 3 (gamma) | 0.015 | ||
| KNG1 | kininogen 1 | 0.015 | ||
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.015 | ||
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | 0.015 | ||
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.015 | ||
| CAMP | cathelicidin antimicrobial peptide | 0.014 | ||
| MPEG1 | macrophage expressed 1 | 0.014 | ||
| CLEC5A | C-type lectin domain family 5, member A | 0.014 | ||
| LILRA1 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 | 0.014 | ||
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.013 | ||
| APOF | apolipoprotein F | 0.013 | ||
| FYB | FYN binding protein | 0.013 | ||
| MNDA | myeloid cell nuclear differentiation antigen | 0.013 | ||
| SIGLEC9 | sialic acid binding Ig-like lectin 9 | 0.013 | ||
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.013 | ||
| STAB1 | stabilin 1 | 0.013 | ||
| NLRP3 | NLR family, pyrin domain containing 3 | 0.012 | ||
| APCS | amyloid P component, serum | 0.012 | ||
| ALB | albumin | 0.012 | ||
| CLEC10A | C-type lectin domain family 10, member A | 0.011 | ||
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.011 | ||
| LILRA5 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 | 0.011 | ||
| STEAP4 | STEAP family member 4 | 0.011 | ||
| EMR1 | egf-like module containing, mucin-like, hormone receptor-like 1 | 0.011 | ||
| ITGAX | integrin, alpha X (complement component 3 receptor 4 subunit) | 0.011 | ||
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.011 | ||
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | 0.010 | ||
| KCNJ15 | potassium inwardly-rectifying channel, subfamily J, member 15 | 0.010 | ||
| SIGLEC5 | sialic acid binding Ig-like lectin 5 | 0.010 | ||
| ARG1 | arginase, liver | 0.010 | ||
| AOAH | acyloxyacyl hydrolase (neutrophil) | 0.010 | ||
| MMP8 | matrix metallopeptidase 8 (neutrophil collagenase) | 0.010 | ||
| EMR3 | egf-like module containing, mucin-like, hormone receptor-like 3 | 0.010 |